Pikfyve (phosphoinositide kinase, FYVE-type zinc finger containing) - Rat Genome Database

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Gene: Pikfyve (phosphoinositide kinase, FYVE-type zinc finger containing) Rattus norvegicus
Analyze
Symbol: Pikfyve
Name: phosphoinositide kinase, FYVE-type zinc finger containing
RGD ID: 1592067
Description: Predicted to enable phosphatidylinositol kinase activity; protein serine/threonine kinase activity; and zinc ion binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; phosphatidylinositol metabolic process; and vesicle organization. Predicted to act upstream of or within myelin assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle and vesicle membrane. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; LOC316457; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; Pip5k3; similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8974,057,488 - 74,151,610 (+)NCBIGRCr8
mRatBN7.2966,563,747 - 66,657,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,563,727 - 66,657,868 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0971,911,744 - 72,005,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,566,016 - 70,660,374 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,798,743 - 63,890,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera963,959,029 - 64,052,994 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9858586   PMID:11112776   PMID:12477932   PMID:14551253   PMID:15046600   PMID:15546921   PMID:16448788   PMID:16954148   PMID:17556371   PMID:17909029   PMID:19056739   PMID:19841139  
PMID:20110679   PMID:22028665   PMID:23793062   PMID:25578879   PMID:26232680   PMID:32221306  


Genomics

Comparative Map Data
Pikfyve
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8974,057,488 - 74,151,610 (+)NCBIGRCr8
mRatBN7.2966,563,747 - 66,657,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,563,727 - 66,657,868 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0971,911,744 - 72,005,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,566,016 - 70,660,374 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,798,743 - 63,890,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera963,959,029 - 64,052,994 (+)NCBICelera
Cytogenetic Map9q32NCBI
PIKFYVE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,266,056 - 208,358,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,266,255 - 208,358,746 (+)EnsemblGRCh38hg38GRCh38
GRCh372209,130,979 - 209,223,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,839,236 - 208,931,720 (+)NCBINCBI36Build 36hg18NCBI36
Celera2202,898,915 - 202,991,410 (+)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2200,978,970 - 201,070,591 (+)NCBIHuRef
CHM1_12209,136,843 - 209,229,320 (+)NCBICHM1_1
T2T-CHM13v2.02208,744,537 - 208,838,556 (+)NCBIT2T-CHM13v2.0
Pikfyve
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,225,796 - 65,317,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,225,842 - 65,317,854 (+)EnsemblGRCm39 Ensembl
GRCm38165,186,640 - 65,278,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,186,683 - 65,278,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv37165,233,259 - 65,325,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,120,978 - 65,208,034 (+)NCBIMGSCv36mm8
Celera165,677,339 - 65,769,254 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map132.94NCBI
Pikfyve
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554576,748,534 - 6,842,489 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554576,749,226 - 6,841,855 (-)NCBIChiLan1.0ChiLan1.0
PIKFYVE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,875,873 - 110,968,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,891,072 - 110,983,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,505,376 - 95,597,792 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,628,997 - 213,721,299 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,628,997 - 213,721,299 (+)Ensemblpanpan1.1panPan2
PIKFYVE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,537,095 - 16,620,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,541,562 - 16,619,554 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,419,766 - 17,503,074 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,472,780 - 16,556,108 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,472,913 - 16,554,451 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,416,782 - 16,500,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,390,154 - 16,473,467 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,399,401 - 16,482,715 (+)NCBIUU_Cfam_GSD_1.0
Pikfyve
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,903,831 - 164,987,854 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936950242,522 - 320,078 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936950242,071 - 323,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIKFYVE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,372,173 - 111,467,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115111,372,148 - 111,468,720 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,893,751 - 122,991,762 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIKFYVE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11094,051,096 - 94,144,968 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1094,056,923 - 94,145,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,226,813 - 105,319,971 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pikfyve
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247657,681,875 - 7,790,704 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247657,684,770 - 7,806,381 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pikfyve
319 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:45
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000020447, ENSRNOT00000058045
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
D9Rat176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,604,477 - 66,604,697 (+)MAPPERmRatBN7.2
Rnor_6.0971,952,431 - 71,952,650NCBIRnor6.0
Rnor_5.0970,619,305 - 70,619,524UniSTSRnor5.0
RGSC_v3.4963,839,861 - 63,840,081RGDRGSC3.4
RGSC_v3.4963,839,862 - 63,840,081UniSTSRGSC3.4
RGSC_v3.1963,986,843 - 63,987,063RGD
Celera963,999,670 - 63,999,889UniSTS
SHRSP x BN Map945.5498UniSTS
SHRSP x BN Map945.5498RGD
Cytogenetic Map9q32UniSTS
RH130569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,569,205 - 66,569,418 (+)MAPPERmRatBN7.2
Rnor_6.0971,917,194 - 71,917,406NCBIRnor6.0
Rnor_5.0970,654,670 - 70,654,882UniSTSRnor5.0
RGSC_v3.4963,804,093 - 63,804,305UniSTSRGSC3.4
Celera963,964,479 - 63,964,691UniSTS
RH 3.4 Map9580.1UniSTS
Cytogenetic Map9q32UniSTS
RH143099  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,564,203 - 66,564,380 (+)MAPPERmRatBN7.2
Rnor_6.0971,912,193 - 71,912,369NCBIRnor6.0
Rnor_5.0970,659,707 - 70,659,883UniSTSRnor5.0
RGSC_v3.4963,799,092 - 63,799,268UniSTSRGSC3.4
Celera963,959,478 - 63,959,654UniSTS
RH 3.4 Map9569.1UniSTS
Cytogenetic Map9q32UniSTS
AI179196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,612,624 - 66,612,783 (+)MAPPERmRatBN7.2
Rnor_6.0971,960,578 - 71,960,736NCBIRnor6.0
Rnor_5.0970,611,219 - 70,611,377UniSTSRnor5.0
RGSC_v3.4963,848,009 - 63,848,167UniSTSRGSC3.4
Celera964,007,817 - 64,007,975UniSTS
RH 3.4 Map9581.7UniSTS
Cytogenetic Map9q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 5 28 12 19 12 5 5 74 35 37 11 5
Low 1 38 29 29 29 3 6 4 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC089984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020447   ⟹   ENSRNOP00000020447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,563,778 - 66,657,868 (+)Ensembl
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100337   ⟹   ENSRNOP00000088892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,563,727 - 66,657,868 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117064   ⟹   ENSRNOP00000078503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,563,734 - 66,657,868 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117606   ⟹   ENSRNOP00000076715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,564,088 - 66,657,868 (+)Ensembl
RefSeq Acc Id: NM_001427277   ⟹   NP_001414206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,514 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_006245071   ⟹   XP_006245133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245072   ⟹   XP_006245134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245073   ⟹   XP_006245135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245074   ⟹   XP_006245136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,540 - 74,151,610 (+)NCBI
mRatBN7.2966,563,780 - 66,657,873 (+)NCBI
Rnor_6.0971,911,744 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245076   ⟹   XP_006245138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
mRatBN7.2966,563,747 - 66,657,873 (+)NCBI
Rnor_6.0971,911,744 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245077   ⟹   XP_006245139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,509 - 74,151,610 (+)NCBI
mRatBN7.2966,563,748 - 66,657,873 (+)NCBI
Rnor_6.0971,911,744 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245079   ⟹   XP_006245141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084595   ⟹   XP_038940523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,547 - 74,151,610 (+)NCBI
mRatBN7.2966,563,795 - 66,657,873 (+)NCBI
RefSeq Acc Id: XM_039084596   ⟹   XP_038940524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
RefSeq Acc Id: XM_039084597   ⟹   XP_038940525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,112,229 - 74,151,610 (+)NCBI
mRatBN7.2966,618,084 - 66,657,873 (+)NCBI
RefSeq Acc Id: XM_063267219   ⟹   XP_063123289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267220   ⟹   XP_063123290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267221   ⟹   XP_063123291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267222   ⟹   XP_063123292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267223   ⟹   XP_063123293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,128,204 (+)NCBI
RefSeq Acc Id: XM_063267224   ⟹   XP_063123294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,092,015 (+)NCBI
RefSeq Acc Id: XM_063267225   ⟹   XP_063123295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,092,015 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006245138   ⟸   XM_006245076
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245139   ⟸   XM_006245077
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245136   ⟸   XM_006245074
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245135   ⟸   XM_006245073
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245141   ⟸   XM_006245079
- Peptide Label: isoform X8
- UniProtKB: A6IPK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245134   ⟸   XM_006245072
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245133   ⟸   XM_006245071
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YBG1 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020447   ⟸   ENSRNOT00000020447
RefSeq Acc Id: XP_038940523   ⟸   XM_039084595
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940524   ⟸   XM_039084596
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940525   ⟸   XM_039084597
- Peptide Label: isoform X12
RefSeq Acc Id: ENSRNOP00000076715   ⟸   ENSRNOT00000117606
RefSeq Acc Id: ENSRNOP00000088892   ⟸   ENSRNOT00000100337
RefSeq Acc Id: ENSRNOP00000078503   ⟸   ENSRNOT00000117064
RefSeq Acc Id: XP_063123289   ⟸   XM_063267219
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063123290   ⟸   XM_063267220
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063123292   ⟸   XM_063267222
- Peptide Label: isoform X10
RefSeq Acc Id: NP_001414206   ⟸   NM_001427277
RefSeq Acc Id: XP_063123291   ⟸   XM_063267221
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AAS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123293   ⟸   XM_063267223
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063123294   ⟸   XM_063267224
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063123295   ⟸   XM_063267225
- Peptide Label: isoform X14
Protein Domains
DEP   FYVE-type   PIPK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYT8-F1-model_v2 AlphaFold D3ZYT8 1-2109 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592067 AgrOrtholog
BioCyc Gene G2FUF-27299 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000015158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020447.9 UniProtKB/TrEMBL
  ENSRNOT00000100337.1 UniProtKB/TrEMBL
  ENSRNOT00000117064.1 UniProtKB/TrEMBL
  ENSRNOT00000117606.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2-Layer Sandwich UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.800.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
InterPro Cpn60/TCP-1 UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  GroEL-like_apical_dom UniProtKB/TrEMBL
  PIKfyve UniProtKB/TrEMBL
  PIKfyve_DEP UniProtKB/TrEMBL
  PIKfyve_PIPKc UniProtKB/TrEMBL
  PInositol-4-P-4/5-kinase_C_sf UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_core UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_N UniProtKB/TrEMBL
  TCP-1-like_intermed UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:316457 UniProtKB/TrEMBL
NCBI Gene 316457 ENTREZGENE
PANTHER 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE UniProtKB/TrEMBL
  PTHR46715 UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  FYVE UniProtKB/TrEMBL
  PIP5K UniProtKB/TrEMBL
PhenoGen Pikfyve PhenoGen
PROSITE DEP UniProtKB/TrEMBL
  PIPK UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015158 RatGTEx
SMART DEP UniProtKB/TrEMBL
  FYVE UniProtKB/TrEMBL
  PIPKc UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SAICAR synthase-like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
UniProt A0A8I5YBG1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL06 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAS9 ENTREZGENE, UniProtKB/TrEMBL
  A6IPK0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYT8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-19 Pikfyve  phosphoinositide kinase, FYVE-type zinc finger containing  Pikfyve  phosphoinositide kinase, FYVE finger containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Pikfyve  phosphoinositide kinase, FYVE finger containing  Pip5k3  phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Pip5k3  phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III  LOC316457  similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC316457  similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL