Eid2 (EP300 interacting inhibitor of differentiation 2) - Rat Genome Database

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Gene: Eid2 (EP300 interacting inhibitor of differentiation 2) Rattus norvegicus
Analyze
Symbol: Eid2
Name: EP300 interacting inhibitor of differentiation 2
RGD ID: 1591322
Description: Predicted to enable SMAD binding activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transforming growth factor beta receptor complex assembly. Predicted to be active in nucleoplasm. Orthologous to human EID2 (EP300 interacting inhibitor of differentiation 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EP300-interacting inhibitor of differentiation 2; LOC685691; similar to CREBBP/EP300 inhibitor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,665,837 - 92,667,162 (+)NCBIGRCr8
mRatBN7.2183,538,274 - 83,539,599 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx188,950,031 - 88,951,356 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,408,374 - 97,409,699 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,705,890 - 90,707,215 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,515,610 - 85,517,516 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,516,653 - 85,517,360 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,727,248 - 86,728,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,349,864 - 83,351,093 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera177,937,290 - 77,939,197 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14612439  


Genomics

Comparative Map Data
Eid2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,665,837 - 92,667,162 (+)NCBIGRCr8
mRatBN7.2183,538,274 - 83,539,599 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx188,950,031 - 88,951,356 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,408,374 - 97,409,699 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,705,890 - 90,707,215 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,515,610 - 85,517,516 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,516,653 - 85,517,360 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,727,248 - 86,728,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,349,864 - 83,351,093 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera177,937,290 - 77,939,197 (+)NCBICelera
Cytogenetic Map1q21NCBI
EID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,538,707 - 39,540,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,538,707 - 39,540,161 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,029,347 - 40,030,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,721,286 - 44,722,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,721,288 - 44,722,664NCBI
Celera1936,831,159 - 36,832,551 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,475,800 - 36,477,192 (-)NCBIHuRef
CHM1_11940,030,067 - 40,031,459 (-)NCBICHM1_1
T2T-CHM13v2.01942,342,965 - 42,344,419 (-)NCBIT2T-CHM13v2.0
Eid2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,967,306 - 27,968,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,967,306 - 27,968,697 (+)EnsemblGRCm39 Ensembl
GRCm38728,267,881 - 28,269,168 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,267,881 - 28,269,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,052,900 - 29,054,187 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,976,641 - 27,977,928 (+)NCBIMGSCv36mm8
Celera722,829,501 - 22,830,788 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
Eid2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546830,076 - 31,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546829,927 - 32,947 (+)NCBIChiLan1.0ChiLan1.0
EID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,834,023 - 45,835,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,704,605 - 47,706,071 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,636,855 - 36,638,308 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,184,477 - 45,185,988 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC612523
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,712,193 - 113,713,420 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,115,982 - 113,117,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,312,730 - 114,313,924 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,312,799 - 114,313,350 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,871,796 - 113,872,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,505,019 - 113,506,226 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,499,292 - 114,500,486 (+)NCBIUU_Cfam_GSD_1.0
Eid2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,936,110 - 13,938,675 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,365,861 - 2,366,586 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,364,179 - 2,366,739 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100520248
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,184,566 - 48,185,203 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,182,580 - 48,185,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,968,287 - 43,971,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,144,294 - 34,145,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,144,860 - 34,145,570 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,167,612 - 12,169,134 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eid2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,857,055 - 12,857,894 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,855,406 - 12,858,032 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eid2
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:77
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000026114
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

Markers in Region
RH137801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,539,170 - 83,539,415 (-)MAPPERmRatBN7.2
Rnor_6.0185,516,318 - 85,516,562NCBIRnor6.0
Rnor_5.0186,727,432 - 86,727,676UniSTSRnor5.0
RGSC_v3.4183,350,662 - 83,350,906UniSTSRGSC3.4
Celera177,938,245 - 77,938,489UniSTS
RH 3.4 Map1841.1UniSTS
Cytogenetic Map1q21UniSTS
UniSTS:493185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,538,335 - 83,539,328 (-)MAPPERmRatBN7.2
Rnor_6.0185,516,405 - 85,517,397NCBIRnor6.0
Rnor_5.0186,727,519 - 86,728,511UniSTSRnor5.0
RGSC_v3.4183,349,827 - 83,350,819UniSTSRGSC3.4
Celera177,937,410 - 77,938,402UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 73 16
Low 3 43 54 38 19 38 8 11 1 35 25 11 8
Below cutoff 3 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026114   ⟹   ENSRNOP00000026114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl185,516,653 - 85,517,360 (-)Ensembl
RefSeq Acc Id: NM_001401675   ⟹   NP_001388604
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,665,837 - 92,667,162 (+)NCBI
mRatBN7.2183,538,274 - 83,539,599 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388604 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000026114   ⟸   ENSRNOT00000026114
RefSeq Acc Id: NP_001388604   ⟸   NM_001401675

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACB5-F1-model_v2 AlphaFold D4ACB5 1-235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689882
Promoter ID:EPDNEW_R403
Type:multiple initiation site
Name:Eid2_1
Description:EP300 interacting inhibitor of differentiation 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,517,459 - 85,517,519EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591322 AgrOrtholog
BioCyc Gene G2FUF-60260 BioCyc
Ensembl Genes ENSRNOG00000019310 Ensembl
NCBI Gene 685691 ENTREZGENE
PhenoGen Eid2 PhenoGen
RatGTEx ENSRNOG00000019310 RatGTEx


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-08 Eid2  EP300 interacting inhibitor of differentiation 2  LOC687359  similar to CREBBP/EP300 inhibitor 2  Data merged from RGD:1586538 1643240 APPROVED
2008-03-05 Eid2  EP300 interacting inhibitor of differentiation 2  LOC685691  similar to CREBBP/EP300 inhibitor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685691  similar to CREBBP/EP300 inhibitor 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687359  similar to CREBBP/EP300 inhibitor 2      Symbol and Name status set to provisional 70820 PROVISIONAL