Cnn2 (calponin 2) - Rat Genome Database

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Gene: Cnn2 (calponin 2) Rattus norvegicus
Analyze
Symbol: Cnn2
Name: calponin 2
RGD ID: 1589807
Description: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within several processes, including cellular response to mechanical stimulus; negative regulation of macrophage migration; and negative regulation of phagocytosis. Predicted to be located in stress fiber. Predicted to be active in actin cytoskeleton. Orthologous to human CNN2 (calponin 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calponin-2; LOC690976; similar to Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,363,141 - 10,370,312 (-)NCBIGRCr8
mRatBN7.279,712,505 - 9,719,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,712,516 - 9,719,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,594,690 - 12,601,905 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,470,026 - 14,477,227 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,331,153 - 12,338,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,782,459 - 12,787,977 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,782,491 - 12,787,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,952,193 - 12,957,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,223,451 - 11,232,524 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera77,888,183 - 7,895,312 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
andrographolide  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
isobutanol  (ISO)
ivermectin  (ISO)
leflunomide  (EXP,ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
propanal  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16236705   PMID:18617524   PMID:19946888   PMID:21423176   PMID:23376485   PMID:25468996  


Genomics

Comparative Map Data
Cnn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,363,141 - 10,370,312 (-)NCBIGRCr8
mRatBN7.279,712,505 - 9,719,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,712,516 - 9,719,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,594,690 - 12,601,905 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,470,026 - 14,477,227 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,331,153 - 12,338,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,782,459 - 12,787,977 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,782,491 - 12,787,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,952,193 - 12,957,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,223,451 - 11,232,524 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera77,888,183 - 7,895,312 (-)NCBICelera
Cytogenetic Map7q11NCBI
CNN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,026,608 - 1,039,065 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,026,586 - 1,039,068 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,026,607 - 1,039,064 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619977,298 - 990,064 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419977,297 - 990,063NCBI
Celera19958,638 - 969,897 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19799,427 - 811,654 (+)NCBIHuRef
CHM1_1191,025,455 - 1,037,339 (+)NCBICHM1_1
T2T-CHM13v2.019989,277 - 1,001,734 (+)NCBIT2T-CHM13v2.0
Cnn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,824,434 - 79,831,234 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,824,418 - 79,831,896 (+)EnsemblGRCm39 Ensembl
GRCm381079,988,600 - 79,995,400 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,988,584 - 79,996,062 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,451,345 - 79,458,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,391,763 - 79,398,518 (+)NCBIMGSCv36mm8
Celera1081,003,407 - 81,010,207 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Cnn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,839,436 - 6,848,207 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,839,436 - 6,848,208 (-)NCBIChiLan1.0ChiLan1.0
CNN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,356,334 - 5,373,918 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,595,936 - 4,610,232 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,502,394 - 40,504,543 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,005,670 - 1,015,133 (+)NCBIpanpan1.1PanPan1.1panPan2
CNN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,684,959 - 57,691,621 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,637,796 - 57,691,896 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,487,080 - 57,493,718 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,426,988 - 58,433,632 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,426,991 - 58,433,910 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,482,356 - 57,488,965 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,961,891 - 57,968,481 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,164,870 - 58,171,514 (-)NCBIUU_Cfam_GSD_1.0
Cnn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,375,132 - 217,380,885 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588453,876 - 460,015 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588453,908 - 459,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,375,983 - 77,385,571 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,376,020 - 77,385,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,612,076 - 77,621,630 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660818,122,406 - 8,139,092 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,593,116 - 7,601,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,594,995 - 7,601,639 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnn2
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:88
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000065093
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat

Markers in Region
RH127486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,712,644 - 9,712,846 (+)MAPPERmRatBN7.2
Rnor_6.0712,763,622 - 12,763,823NCBIRnor6.0
Rnor_5.0712,933,344 - 12,933,545UniSTSRnor5.0
RGSC_v3.4711,225,323 - 11,225,524UniSTSRGSC3.4
Celera77,888,321 - 7,888,522UniSTS
RH 3.4 Map725.2UniSTS
Cytogenetic Map7q11UniSTS
RH131872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,720,615 - 9,720,813 (-)MAPPERmRatBN7.2
Rnor_6.0712,781,358 - 12,781,555NCBIRnor6.0
Rnor_5.0712,951,080 - 12,951,277UniSTSRnor5.0
Celera77,896,219 - 7,896,416UniSTS
RH 3.4 Map725.6UniSTS
Cytogenetic Map7q11UniSTS
RH139166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,713,029 - 9,713,169 (+)MAPPERmRatBN7.2
Rnor_6.0712,764,007 - 12,764,146NCBIRnor6.0
Rnor_5.0712,933,729 - 12,933,868UniSTSRnor5.0
RGSC_v3.4711,225,708 - 11,225,847UniSTSRGSC3.4
Celera77,888,706 - 7,888,845UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 43 27 19 27 5 8 58 35 35 11 5
Low 14 14 14 3 3 16 6 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065093   ⟹   ENSRNOP00000063042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,712,516 - 9,719,656 (-)Ensembl
Rnor_6.0 Ensembl712,782,491 - 12,787,750 (+)Ensembl
RefSeq Acc Id: NM_001399010   ⟹   NP_001385939
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,363,141 - 10,370,312 (-)NCBI
mRatBN7.279,712,505 - 9,719,678 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385939 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063042.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000063042   ⟸   ENSRNOT00000065093
RefSeq Acc Id: NP_001385939   ⟸   NM_001399010
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRX9-F1-model_v2 AlphaFold D3ZRX9 1-219 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695052
Promoter ID:EPDNEW_R5574
Type:initiation region
Name:Cnn2_1
Description:calponin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,782,489 - 12,782,549EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589807 AgrOrtholog
BioCyc Gene G2FUF-34910 BioCyc
Ensembl Genes ENSRNOG00000043044 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065093.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
InterPro Calponin UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_repeat UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  SM22_calponin UniProtKB/TrEMBL
NCBI Gene 690976 ENTREZGENE
PANTHER CALPONIN UniProtKB/TrEMBL
  CALPONIN-2 UniProtKB/TrEMBL
Pfam Calponin UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
PhenoGen Cnn2 PhenoGen
PRINTS CALPONIN UniProtKB/TrEMBL
  SM22CALPONIN UniProtKB/TrEMBL
PROSITE CALPONIN_1 UniProtKB/TrEMBL
  CALPONIN_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043044 RatGTEx
SMART SM00033 UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/TrEMBL
UniProt D3ZRX9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Cnn2  calponin 2  LOC690976  similar to Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC690976  similar to Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)      Symbol and Name status set to provisional 70820 PROVISIONAL