Rhoxf2b (Rhox homeobox family member 2B) - Rat Genome Database

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Gene: Rhoxf2b (Rhox homeobox family member 2B) Rattus norvegicus
Analyze
Symbol: Rhoxf2b
Name: Rhox homeobox family member 2B
RGD ID: 1588607
Description: Predicted to enable DNA binding activity. Predicted to be involved in positive regulation of gene expression. Predicted to be located in nucleus; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proline-rich extensin-like protein EPR1; reproductive homeobox on X chromosome 2; reproductive homeobox on X chromosome 3; Rhox homeobox family member 2; Rhox2; Rhox3; uncharacterized protein Rhoxf2b
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,373,153 - 121,379,870 (-)NCBIGRCr8
mRatBN7.2X116,507,488 - 116,514,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,507,488 - 116,513,870 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X123,887,968 - 123,993,591 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,887,988 - 123,993,542 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,980,343 - 123,986,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,638,875 - 7,645,253 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,734,829 - 115,741,207 (-)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function
DNA binding  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Rhoxf2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,373,153 - 121,379,870 (-)NCBIGRCr8
mRatBN7.2X116,507,488 - 116,514,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,507,488 - 116,513,870 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X123,887,968 - 123,993,591 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,887,988 - 123,993,542 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,980,343 - 123,986,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,638,875 - 7,645,253 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,734,829 - 115,741,207 (-)NCBICelera
Cytogenetic MapXq35NCBI
RHOXF2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X120,072,264 - 120,077,690 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX120,072,264 - 120,077,690 (-)EnsemblGRCh38hg38GRCh38
GRCh37X119,206,229 - 119,211,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X119,090,257 - 119,095,735 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX119,660,827 - 119,666,305 (-)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX108,744,620 - 108,750,098 (+)NCBIHuRef
CHM1_1X119,117,670 - 119,122,704 (-)NCBICHM1_1
T2T-CHM13v2.0X118,447,422 - 118,452,848 (-)NCBIT2T-CHM13v2.0
Rhox6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X36,915,932 - 36,918,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX36,915,787 - 36,918,734 (+)EnsemblGRCm39 Ensembl
GRCm38X37,827,055 - 37,829,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX37,826,910 - 37,829,857 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X35,180,232 - 35,183,034 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X34,071,682 - 34,074,484 (+)NCBIMGSCv36mm8
CeleraX25,479,708 - 25,482,510 (+)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX22.08NCBI
LOC102154408
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X92,119,491 - 92,130,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX78,131,827 - 78,142,717 (-)NCBIDog10K_Boxer_Tasha

Variants

.
Variants in Rhoxf2b
40 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000034083
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium 4
Low 18
Below cutoff 1 1 1 1 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034083   ⟹   ENSRNOP00000028981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,507,488 - 116,513,870 (-)Ensembl
Rnor_6.0 EnsemblX123,888,033 - 123,894,411 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085170   ⟹   ENSRNOP00000074495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,887,988 - 123,993,542 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,507,575 - 116,513,870 (-)Ensembl
Rnor_6.0 EnsemblX123,888,033 - 123,894,411 (-)Ensembl
RefSeq Acc Id: XM_017602099   ⟹   XP_017457588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,373,153 - 121,379,870 (-)NCBI
mRatBN7.2X116,507,488 - 116,514,240 (-)NCBI
Rnor_6.0X123,887,968 - 123,894,688 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017457588 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAY58261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028981.6
  ENSRNOP00000087243.1
Reference Protein Sequences
RefSeq Acc Id: XP_017457588   ⟸   XM_017602099
- Sequence:
RefSeq Acc Id: ENSRNOP00000074495   ⟸   ENSRNOT00000085170
RefSeq Acc Id: ENSRNOP00000028981   ⟸   ENSRNOT00000034083
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F6Q5M9-F1-model_v2 AlphaFold F6Q5M9 1-496 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588607 AgrOrtholog
BioCyc Gene G2FUF-1288 BioCyc
Ensembl Genes ENSRNOG00000040013 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034083.6 UniProtKB/TrEMBL
  ENSRNOT00000092603.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:363439 UniProtKB/TrEMBL
NCBI Gene Rhoxf2b ENTREZGENE
PANTHER MCG113260-RELATED-RELATED UniProtKB/TrEMBL
  REPRODUCTIVE HOMEOBOX 1-RELATED UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Rhoxf2b PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000040013 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A8I6A7L6_RAT UniProtKB/TrEMBL
  Q4TU80_RAT UniProtKB/TrEMBL
UniProt Secondary F6Q5M9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-04 Rhoxf2b  Rhox homeobox family member 2B  Rhox2  Rhox homeobox family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-07-14 Rhox2  Rhox homeobox family member 2  Rhox2  reproductive homeobox on X chromosome 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-08 Rhox2  reproductive homeobox on X chromosome 2  Rhox3  reproductive homeobox on X chromosome 3  Data merged from RGD:1561568 737654 APPROVED
2006-11-19 Rhox2  reproductive homeobox on X chromosome 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 Rhox3  reproductive homeobox on X chromosome 3      Symbol and Name status set to provisional 70820 PROVISIONAL