Fam149a (family with sequence similarity 149, member A) - Rat Genome Database

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Gene: Fam149a (family with sequence similarity 149, member A) Rattus norvegicus
Analyze
Symbol: Fam149a
Name: family with sequence similarity 149, member A
RGD ID: 1586153
Description: Orthologous to human FAM149A (family with sequence similarity 149 member A); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC361153; LOC361153
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,587,841 - 53,647,072 (+)NCBIGRCr8
mRatBN7.21646,855,377 - 46,914,553 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,854,635 - 46,912,066 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01650,049,816 - 50,105,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,049,828 - 50,107,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,772,867 - 49,828,919 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,146,296 - 50,202,278 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1644,846,237 - 44,905,097 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
isotretinoin  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fam149a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,587,841 - 53,647,072 (+)NCBIGRCr8
mRatBN7.21646,855,377 - 46,914,553 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,854,635 - 46,912,066 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01650,049,816 - 50,105,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,049,828 - 50,107,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,772,867 - 49,828,919 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,146,296 - 50,202,278 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1644,846,237 - 44,905,097 (+)NCBICelera
Cytogenetic Map16q11NCBI
FAM149A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384186,104,704 - 186,175,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4186,104,419 - 186,175,337 (+)EnsemblGRCh38hg38GRCh38
GRCh374187,025,858 - 187,096,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,302,989 - 187,330,811 (+)NCBINCBI36Build 36hg18NCBI36
Celera4184,388,532 - 184,416,266 (+)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4182,817,905 - 182,845,396 (+)NCBIHuRef
CHM1_14187,042,492 - 187,070,022 (+)NCBICHM1_1
T2T-CHM13v2.04189,445,101 - 189,515,714 (+)NCBIT2T-CHM13v2.0
Fam149a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,789,752 - 45,835,328 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,789,754 - 45,835,328 (-)EnsemblGRCm39 Ensembl
GRCm38845,336,715 - 45,382,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,336,717 - 45,382,291 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,422,069 - 46,467,645 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36846,837,897 - 46,880,990 (-)NCBIMGSCv36mm8
Celera848,024,168 - 48,069,370 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.25NCBI
Fam149a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,928,995 - 22,970,897 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,926,429 - 22,970,916 (-)NCBIChiLan1.0ChiLan1.0
FAM149A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23183,845,933 - 183,913,819 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14184,195,316 - 184,263,213 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04178,274,672 - 178,342,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14190,483,371 - 190,549,952 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,482,894 - 190,549,952 (+)Ensemblpanpan1.1panPan2
FAM149A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,550,726 - 44,603,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,550,846 - 44,653,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,037,390 - 45,090,114 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01646,764,597 - 46,817,330 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11644,732,733 - 44,785,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01645,345,580 - 45,398,325 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01645,476,837 - 45,529,850 (-)NCBIUU_Cfam_GSD_1.0
Fam149a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,754,168 - 34,808,738 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,299,134 - 3,355,293 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,301,244 - 3,358,304 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM149A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,995,180 - 47,038,190 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,995,350 - 47,037,934 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,779,426 - 53,800,250 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM149A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17132,073,318 - 132,096,409 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7132,076,754 - 132,099,843 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037112,353,908 - 112,417,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam149a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476916,954,423 - 17,013,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476916,954,366 - 17,015,705 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam149a
507 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:70
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000034448
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

Markers in Region
RH129178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,911,794 - 46,911,988 (+)MAPPERmRatBN7.2
Rnor_6.01650,105,139 - 50,105,332NCBIRnor6.0
Rnor_5.01649,828,096 - 49,828,289UniSTSRnor5.0
RGSC_v3.41650,202,022 - 50,202,215UniSTSRGSC3.4
Celera1644,902,339 - 44,902,532UniSTS
RH 3.4 Map16460.9UniSTS
Cytogenetic Map16q11UniSTS
RH144010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,897,094 - 46,897,309 (+)MAPPERmRatBN7.2
Rnor_6.01650,090,440 - 50,090,654NCBIRnor6.0
Rnor_5.01649,813,397 - 49,813,611UniSTSRnor5.0
RGSC_v3.41650,187,442 - 50,187,656UniSTSRGSC3.4
Celera1644,887,640 - 44,887,854UniSTS
RH 3.4 Map16462.1UniSTS
Cytogenetic Map16q11UniSTS
AW530202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,894,136 - 46,894,316 (+)MAPPERmRatBN7.2
Rnor_6.01650,087,482 - 50,087,661NCBIRnor6.0
Rnor_5.01649,810,439 - 49,810,618UniSTSRnor5.0
RGSC_v3.41650,184,484 - 50,184,663UniSTSRGSC3.4
Celera1644,884,682 - 44,884,861UniSTS
RH 3.4 Map16460.69UniSTS
Cytogenetic Map16q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 39 36 36 29 35 32 11
Low 3 39 18 5 19 5 8 11 45 6 8
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034448   ⟹   ENSRNOP00000029147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,854,635 - 46,912,066 (+)Ensembl
Rnor_6.0 Ensembl1650,049,828 - 50,107,856 (+)Ensembl
RefSeq Acc Id: NM_001427705   ⟹   NP_001414634
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,587,841 - 53,647,072 (+)NCBI
RefSeq Acc Id: XM_063275519   ⟹   XP_063131589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,587,895 - 53,638,643 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414634 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131589 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78857 (Get FASTA)   NCBI Sequence Viewer  
  EDL78858 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029147.5
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000029147   ⟸   ENSRNOT00000034448
RefSeq Acc Id: NP_001414634   ⟸   NM_001427705
- UniProtKB: F1LUX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131589   ⟸   XM_063275519
- Peptide Label: isoform X1
Protein Domains
DUF3719

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LUX5-F1-model_v2 AlphaFold F1LUX5 1-790 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586153 AgrOrtholog
BioCyc Gene G2FUF-11314 BioCyc
Ensembl Genes ENSRNOG00000021693 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034448.6 UniProtKB/TrEMBL
InterPro DUF3719 UniProtKB/TrEMBL
  FAM149 UniProtKB/TrEMBL
KEGG Report rno:361153 UniProtKB/TrEMBL
NCBI Gene 361153 ENTREZGENE
PANTHER PROTEIN FAM149A UniProtKB/TrEMBL
  PTHR31997 UniProtKB/TrEMBL
Pfam DUF3719 UniProtKB/TrEMBL
PhenoGen Fam149a PhenoGen
RatGTEx ENSRNOG00000021693 RatGTEx
UniProt F1LUX5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-19 Fam149a  family with sequence similarity 149, member A  LOC361153  hypothetical LOC361153  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC361153  hypothetical LOC361153      Symbol and Name status set to provisional 70820 PROVISIONAL