Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of CALML4 mRNA | CTD | PMID:23649840 | (1->4)-beta-D-glucan | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CALML4 mRNA | CTD | PMID:36331819 | 1,2-dichloroethane | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of CALML4 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CALML4 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of CALML4 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of CALML4 mRNA | CTD | PMID:29097150 | 17beta-estradiol | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of CALML4 mRNA | CTD | PMID:20106945 | 17beta-estradiol | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Estradiol results in increased expression of CALML4 mRNA | CTD | PMID:19484750 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CALML4 mRNA] | CTD | PMID:16054899 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CALML4 mRNA | CTD | PMID:33956508 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Calml4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CALML4 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CALML4 mRNA | CTD | PMID:26159488 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CALML4 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CALML4 mRNA | CTD | PMID:20106945 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of CALML4 mRNA | CTD | PMID:26251327 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CALML4 mRNA more ... | CTD | PMID:16054899 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CALML4 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CALML4 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | bisphenol S results in increased expression of CALML4 mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Fenretinide results in increased expression of CALML4 mRNA | CTD | PMID:28973697 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of CALML4 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of CALML4 mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CALML4 mRNA | CTD | PMID:36706583 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CALML4 mRNA | CTD | PMID:30047161 | acrylamide | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | Acrylamide results in decreased expression of CALML4 mRNA | CTD | PMID:35032568 | all-trans-retinoic acid | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CALML4 mRNA | CTD | PMID:33167477 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of CALML4 mRNA | CTD | PMID:30047161 | atrazine | increases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Atrazine results in increased expression of CALML4 mRNA | CTD | PMID:22378314 | belinostat | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | belinostat results in decreased expression of CALML4 mRNA | CTD | PMID:26272509 and PMID:27188386 | belinostat | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALML4 mRNA | CTD | PMID:27188386 | benzo[a]pyrene | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CALML4 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of CALML4 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | CALML4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CALML4 exon | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | CALML4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of CALML4 3' UTR and Benzo(a)pyrene results in decreased methylation of CALML4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CALML4 mRNA | CTD | PMID:27195522 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CALML4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CALML4 mRNA | CTD | PMID:30951980 and PMID:32156529 | bisphenol A | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CALML4 mRNA | CTD | PMID:28628672 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CALML4 mRNA | CTD | PMID:29097150 and PMID:34947998 | bisphenol F | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CALML4 mRNA | CTD | PMID:28628672 | bisphenol F | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | bisphenol F results in increased expression of CALML4 mRNA | CTD | PMID:30951980 | carbon nanotube | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | carbon nanotube | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of CALML4 mRNA | CTD | PMID:25620056 | choline | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CALML4 mRNA | CTD | PMID:20938992 | ciguatoxin CTX1B | affects expression | ISO | Calml4 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of CALML4 mRNA | CTD | PMID:18353800 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of CALML4 mRNA | CTD | PMID:24386269 | copper atom | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of CALML4 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of CALML4 mRNA | CTD | PMID:20971185 | copper(II) sulfate | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of CALML4 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of CALML4 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CALML4 mRNA | CTD | PMID:20106945 more ... | dexamethasone | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CALML4 mRNA more ... | CTD | PMID:16054899 | dexamethasone | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CALML4 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CALML4 mRNA | CTD | PMID:28628672 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of CALML4 mRNA | CTD | PMID:21266533 | dicrotophos | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of CALML4 mRNA | CTD | PMID:28302478 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of CALML4 mRNA | CTD | PMID:36653537 | diiodine | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CALML4 mRNA | CTD | PMID:36706583 | diuron | decreases expression | EXP | | 6480464 | Diuron metabolite results in decreased expression of CALML4 mRNA | CTD | PMID:24172598 | dorsomorphin | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | endosulfan | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CALML4 mRNA | CTD | PMID:26159488 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CALML4 mRNA | CTD | PMID:29391264 | entinostat | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALML4 mRNA | CTD | PMID:27188386 | entinostat | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | entinostat results in decreased expression of CALML4 mRNA | CTD | PMID:26272509 | ethyl methanesulfonate | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of CALML4 mRNA | CTD | PMID:23649840 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of CALML4 mRNA | CTD | PMID:23962444 | folic acid | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of CALML4 mRNA | CTD | PMID:27387713 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of CALML4 mRNA | CTD | PMID:33387578 | glycidol | increases expression | EXP | | 6480464 | glycidol results in increased expression of CALML4 mRNA | CTD | PMID:24395379 | indometacin | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CALML4 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CALML4 mRNA | CTD | PMID:28628672 | L-methionine | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CALML4 mRNA | CTD | PMID:20938992 | lead(0) | affects expression | ISO | CALML4 (Homo sapiens) | 6480464 | Lead affects the expression of CALML4 mRNA | CTD | PMID:22313790 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of CALML4 mRNA | CTD | PMID:30047161 | methyl methanesulfonate | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of CALML4 mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | CALML4 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of CALML4 mRNA | CTD | PMID:28001369 | N(4)-hydroxycytidine | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | N(4)-hydroxycytidine results in decreased expression of CALML4 mRNA | CTD | PMID:37748715 | N-nitrosodiethylamine | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of CALML4 mRNA | CTD | PMID:24535843 | N-nitrosodiethylamine | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CALML4 mRNA | CTD | PMID:24535843 | O-methyleugenol | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of CALML4 mRNA | CTD | PMID:32234424 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of CALML4 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of CALML4 mRNA | CTD | PMID:34911549 | paracetamol | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of CALML4 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CALML4 mRNA | CTD | PMID:33387578 | perfluorononanoic acid | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of CALML4 mRNA | CTD | PMID:32588087 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CALML4 mRNA | CTD | PMID:36331819 | phenobarbital | multiple interactions | ISO | Calml4 (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CALML4 mRNA and NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CALML4 mRNA] | CTD | PMID:19482888 and PMID:24535843 | phenobarbital | affects expression | ISO | Calml4 (Mus musculus) | 6480464 | Phenobarbital affects the expression of CALML4 mRNA | CTD | PMID:23091169 | phenobarbital | affects expression | ISO | CALML4 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of CALML4 mRNA | CTD | PMID:19159669 | phenobarbital | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of CALML4 mRNA | CTD | PMID:19482888 | phenylmercury acetate | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of CALML4 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALML4 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CALML4 mRNA | CTD | PMID:19710929 | pyrogallol | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Pyrogallol results in increased expression of CALML4 mRNA | CTD | PMID:20362636 | SB 431542 | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenite | increases expression | ISO | CALML4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CALML4 mRNA | CTD | PMID:28595984 and PMID:29301061 | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of CALML4 mRNA | CTD | PMID:22110744 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of CALML4 mRNA | CTD | PMID:30047161 | tert-butyl hydroperoxide | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | tert-Butylhydroperoxide results in increased expression of CALML4 mRNA | CTD | PMID:15003993 | tetrachloroethene | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of CALML4 mRNA | CTD | PMID:28973375 | tetrachloromethane | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of CALML4 mRNA | CTD | PMID:17484886 | tetrachloromethane | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of CALML4 mRNA | CTD | PMID:27339419 and PMID:31919559 | thimerosal | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Thimerosal co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALML4 mRNA | CTD | PMID:27188386 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of CALML4 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CALML4 mRNA | CTD | PMID:23557971 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of CALML4 mRNA | CTD | PMID:25729387 | tributylstannane | increases expression | ISO | Calml4 (Mus musculus) | 6480464 | tributyltin results in increased expression of CALML4 mRNA | CTD | PMID:31939706 | troglitazone | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | troglitazone results in decreased expression of CALML4 mRNA | CTD | PMID:25572481 | urethane | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of CALML4 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | CALML4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of CALML4 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | CALML4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CALML4 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | Calml4 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of CALML4 mRNA | CTD | PMID:24896083 | valproic acid | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CALML4 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | CALML4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALML4 mRNA | CTD | PMID:27188386 | zoledronic acid | decreases expression | ISO | CALML4 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of CALML4 mRNA | CTD | PMID:20977926 | |