(-)-cotinine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Cotinine CTD PMID:14570768 and PMID:16141602 (5Z,8Z,11Z,13E)-15-HETE increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of 15-hydroxy-5 more ... CTD PMID:15231852 (S)-nicotine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 and PMID:16141602 (S)-nicotine decreases expression ISO Ugt1a5 (Mus musculus) 6480464 Nicotine results in decreased expression of UGT1A5 mRNA CTD PMID:21955143 1-Hydroxypyrene increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO UGT1A4 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of UGT1A4 mRNA and Tetrachlorodibenzodioxin results in increased expression of UGT1A4 protein CTD PMID:16155002 and PMID:18433817 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Ugt1a5 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of UGT1A5 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Ugt1a5 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of UGT1A5 mRNA CTD PMID:19474220 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in decreased expression of UGT1A5 mRNA and NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A5 mRNA] CTD PMID:19474220 and PMID:22496397 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO UGT1A4 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased activity of UGT1A4 protein CTD PMID:16155002 2,3,7,8-tetrachlorodibenzodioxine affects response to substance ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 promoter SNP affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:18433817 20-HETE increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of 20-hydroxy-5 more ... CTD PMID:15231852 3-methylcholanthrene increases expression ISO UGT1A4 (Homo sapiens) 6480464 Methylcholanthrene results in increased expression of UGT1A4 mRNA CTD PMID:19118567 4,4'-sulfonyldiphenol affects methylation ISO Ugt1a5 (Mus musculus) 6480464 bisphenol S affects the methylation of UGT1A5 gene CTD PMID:31683443 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 gene polymorphism results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and UGT1A4 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:14871856 and PMID:31307193 4-hydroxyphenytoin multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole increases expression ISO UGT1A4 (Homo sapiens) 6480464 Omeprazole results in increased expression of UGT1A4 mRNA CTD PMID:19118567 Afloqualone increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of afloqualone CTD PMID:15475412 Afloqualone multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone] CTD PMID:15475412 amentoflavone decreases activity ISO UGT1A4 (Homo sapiens) 6480464 amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 amphibole asbestos decreases expression ISO UGT1A4 (Homo sapiens) 6480464 Asbestos and Amphibole results in decreased expression of UGT1A4 protein CTD PMID:20855422 androsterone increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein SNP results in increased glucuronidation of Androsterone analog CTD PMID:15708967 arachidonic acid increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 Aroclor 1254 increases expression ISO UGT1A4 (Homo sapiens) 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A4 mRNA CTD PMID:17851650 benzo[a]pyrene increases activity ISO UGT1A4 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased activity of UGT1A4 protein CTD PMID:17065433 benzo[a]pyrene decreases expression ISO UGT1A4 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of UGT1A4 mRNA CTD PMID:32234424 benzo[a]pyrene increases expression ISO Ugt1a5 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of UGT1A5 mRNA CTD PMID:20127859 and PMID:32417428 benzo[a]pyrene multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of UGT1A4 mRNA] CTD PMID:30439556 benzo[a]pyrene increases expression ISO UGT1A4 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of UGT1A4 mRNA CTD PMID:30439556 beta-naphthoflavone increases expression ISO UGT1A4 (Homo sapiens) 6480464 beta-Naphthoflavone results in increased expression of UGT1A4 mRNA CTD PMID:19118567 beta-naphthoflavone increases expression ISO Ugt1a5 (Mus musculus) 6480464 beta-Naphthoflavone results in increased expression of UGT1A5 mRNA CTD PMID:19144771 betulin increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of betulin CTD PMID:30776358 biphenyl-4-amine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of 4-biphenylamine CTD PMID:15840509 biphenyl-4-amine multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine more ... CTD PMID:17080401 bisphenol A decreases expression ISO UGT1A4 (Homo sapiens) 6480464 bisphenol A results in decreased expression of UGT1A4 mRNA CTD PMID:24214726 buta-1,3-diene increases expression ISO Ugt1a5 (Mus musculus) 6480464 1 and 3-butadiene results in increased expression of UGT1A5 mRNA CTD PMID:29038090 butyric acid increases expression ISO UGT1A4 (Homo sapiens) 6480464 Butyric Acid results in increased expression of UGT1A4 mRNA CTD PMID:30439556 butyric acid multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of UGT1A4 mRNA] CTD PMID:30439556 captan increases expression ISO Ugt1a5 (Mus musculus) 6480464 Captan results in increased expression of UGT1A5 mRNA CTD PMID:31558096 clofibrate increases expression ISO Ugt1a5 (Mus musculus) 6480464 Clofibrate results in increased expression of UGT1A5 mRNA CTD PMID:22496397 clozapine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein SNP results in increased glucuronidation of Clozapine CTD PMID:15708967 dibenzo[a,l]pyrene increases glycosylation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glycosylation of dibenzo(a and l)pyrene CTD PMID:21780761 dichloroacetic acid increases expression ISO Ugt1a5 (Mus musculus) 6480464 Dichloroacetic Acid results in increased expression of UGT1A5 mRNA CTD PMID:28962523 diclofenac increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Diclofenac CTD PMID:15843492 dimethylarsinic acid multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 ethanol increases expression ISO Ugt1a5 (Mus musculus) 6480464 Ethanol results in increased expression of UGT1A5 mRNA CTD PMID:21955143 ethoxyquin increases expression ISO Ugt1a5 (Mus musculus) 6480464 Ethoxyquin results in increased expression of UGT1A5 mRNA CTD PMID:19144771 farnesol increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 fenthion increases expression ISO Ugt1a5 (Mus musculus) 6480464 Fenthion results in increased expression of UGT1A5 mRNA CTD PMID:34813904 finasteride multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine] and Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine] CTD PMID:25448279 flurbiprofen increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 folpet increases expression ISO Ugt1a5 (Mus musculus) 6480464 folpet results in increased expression of UGT1A5 mRNA CTD PMID:31558096 Hecogenin multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine more ... CTD PMID:17080401 more ... imipramine affects metabolic processing ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein affects the metabolism of Imipramine CTD PMID:15286053 imipramine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Imipramine and UGT1A4 protein SNP results in increased glucuronidation of Imipramine CTD PMID:14570768 more ... imipramine multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine] CTD PMID:25448279 indometacin increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Indomethacin CTD PMID:15843492 inulin multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of UGT1A5 mRNA CTD PMID:36331819 ketoprofen increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Ketoprofen CTD PMID:15843492 lamotrigine multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine more ... CTD PMID:19845433 lamotrigine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of lamotrigine CTD PMID:17151188 and PMID:19845433 Licochalcone A multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein] CTD PMID:26875642 lipopolysaccharide multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA CTD PMID:22777745 methotrexate increases expression ISO UGT1A4 (Homo sapiens) 6480464 Methotrexate results in increased expression of UGT1A4 mRNA CTD PMID:20854796 methylarsonic acid multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 morphine increases expression ISO Ugt1a5 (Mus musculus) 6480464 Morphine results in increased expression of UGT1A5 mRNA CTD PMID:21955143 N'-Nitrosoanabasine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of N'-nitrosoanabasine CTD PMID:18238858 N'-Nitrosoanatabine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of N'-nitrosoanatabine CTD PMID:18238858 N'-Nitrosonornicotine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of N'-nitrosonornicotine CTD PMID:18238858 N-hydroxy-PhIP multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine binds to Glucuronides] CTD PMID:15986396 N-hydroxy-PhIP increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine CTD PMID:15310245 N-hydroxy-PhIP increases metabolic processing ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine CTD PMID:15986396 N-Nitrosopyrrolidine decreases expression ISO UGT1A4 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of UGT1A4 mRNA CTD PMID:32234424 nicotine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 and PMID:16141602 nicotine decreases expression ISO Ugt1a5 (Mus musculus) 6480464 Nicotine results in decreased expression of UGT1A5 mRNA CTD PMID:21955143 Nor-9-carboxy-delta9-THC multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of UGT1A4 gene CTD PMID:30521419 obeticholic acid decreases expression ISO UGT1A4 (Homo sapiens) 6480464 obeticholic acid results in decreased expression of UGT1A4 mRNA CTD PMID:27939613 obeticholic acid increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of obeticholic acid CTD PMID:31299240 oltipraz increases expression ISO Ugt1a5 (Mus musculus) 6480464 oltipraz results in increased expression of UGT1A5 mRNA CTD PMID:19144771 omeprazole increases expression ISO UGT1A4 (Homo sapiens) 6480464 Omeprazole results in increased expression of UGT1A4 mRNA CTD PMID:19118567 perfluorodecanoic acid multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA] CTD PMID:27344344 perfluorodecanoic acid increases expression ISO Ugt1a5 (Mus musculus) 6480464 perfluorodecanoic acid results in increased expression of UGT1A5 mRNA CTD PMID:27344344 perfluorooctane-1-sulfonic acid multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of UGT1A5 mRNA CTD PMID:36331819 phenobarbital multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine CTD PMID:19845433 phenobarbital increases activity ISO UGT1A4 (Homo sapiens) 6480464 Phenobarbital results in increased activity of UGT1A4 protein CTD PMID:19845433 pirinixic acid increases activity ISO UGT1A4 (Homo sapiens) 6480464 pirinixic acid results in increased activity of UGT1A4 protein CTD PMID:19845433 pirinixic acid increases expression ISO UGT1A4 (Homo sapiens) 6480464 pirinixic acid results in increased expression of UGT1A4 mRNA and pirinixic acid results in increased expression of UGT1A4 protein CTD PMID:17151188 pirinixic acid multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine CTD PMID:19845433 pregnenolone 16alpha-carbonitrile multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine CTD PMID:19845433 pregnenolone 16alpha-carbonitrile increases expression ISO Ugt1a5 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in increased expression of UGT1A5 mRNA CTD PMID:22496397 pregnenolone 16alpha-carbonitrile multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A5 mRNA CTD PMID:22496397 pregnenolone 16alpha-carbonitrile increases expression ISO UGT1A4 (Homo sapiens) 6480464 Pregnenolone Carbonitrile results in increased expression of UGT1A4 mRNA and Pregnenolone Carbonitrile results in increased expression of UGT1A4 protein CTD PMID:16155002 pregnenolone 16alpha-carbonitrile increases activity ISO UGT1A4 (Homo sapiens) 6480464 Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein CTD PMID:16155002 and PMID:19845433 sarpogrelate increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 senecionine multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine CTD PMID:20092275 senecionine increases glycosylation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glycosylation of senecionine CTD PMID:20092275 sodium arsenate multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 sodium arsenite multiple interactions ISO Ugt1a5 (Mus musculus) 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 spironolactone increases expression ISO Ugt1a5 (Mus musculus) 6480464 Spironolactone results in increased expression of UGT1A5 mRNA CTD PMID:19144771 sulindac increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 sulindac sulfone increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 tamoxifen increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Tamoxifen CTD PMID:15135306 triclocarban multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA] CTD PMID:22761658 triclocarban increases expression ISO UGT1A4 (Homo sapiens) 6480464 triclocarban results in increased expression of UGT1A4 mRNA CTD PMID:22761658 triclosan increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Triclosan CTD PMID:30776358 trifluoperazine increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Trifluoperazine CTD PMID:15135306 more ... trifluoperazine multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine] more ... CTD PMID:15475412 more ... trifluoperazine increases activity ISO UGT1A4 (Homo sapiens) 6480464 Trifluoperazine results in increased activity of UGT1A4 protein CTD PMID:26875642 Triptolide decreases expression ISO Ugt1a5 (Mus musculus) 6480464 triptolide results in decreased expression of UGT1A5 mRNA CTD PMID:32835833 troglitazone decreases expression ISO UGT1A4 (Homo sapiens) 6480464 troglitazone results in decreased expression of UGT1A4 mRNA CTD PMID:19631733 troglitazone increases expression ISO UGT1A4 (Homo sapiens) 6480464 troglitazone results in increased expression of UGT1A4 mRNA CTD PMID:19631733 ursodeoxycholic acid increases glucuronidation ISO UGT1A4 (Homo sapiens) 6480464 UGT1A4 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 usnic acid increases expression ISO UGT1A4 (Homo sapiens) 6480464 usnic acid results in increased expression of UGT1A4 mRNA CTD PMID:21953288 and PMID:22777745 usnic acid multiple interactions ISO UGT1A4 (Homo sapiens) 6480464 [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA CTD PMID:22777745 valproic acid decreases methylation ISO UGT1A4 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of UGT1A4 gene CTD PMID:29154799 valproic acid decreases expression ISO UGT1A4 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of UGT1A4 mRNA CTD PMID:29501571 zinc molecular entity decreases expression ISO UGT1A4 (Homo sapiens) 6480464 Zinc Compounds results in decreased expression of UGT1A4 mRNA CTD PMID:24035972