Ces1a (carboxylesterase 1A) - Rat Genome Database

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Gene: Ces1a (carboxylesterase 1A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces1a
Name: carboxylesterase 1A
RGD ID: 1583671
Description: Predicted to enable carboxylic ester hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxylesterase 1-like; LOC679817; similar to carboxylesterase 1 isoform c precursor
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,132,678 - 30,159,368 (+)NCBIGRCr8
mRatBN7.21913,959,529 - 13,986,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,959,482 - 13,986,370 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,655,005 - 15,681,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,849,776 - 20,876,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,795,353 - 23,822,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,339,152 - 15,366,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,339,152 - 15,366,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,436,075 - 26,462,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,025,350 - 15,051,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1913,884,007 - 13,910,659 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:36174736  


Genomics

Variants

.
Variants in Ces1a
253 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000060929
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat

Markers in Region
RH135420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,970,158 - 13,970,346 (+)MAPPERmRatBN7.2
Rnor_6.01915,349,758 - 15,349,945NCBIRnor6.0
Rnor_5.01926,446,062 - 26,446,249UniSTSRnor5.0
RGSC_v3.41915,035,522 - 15,035,709UniSTSRGSC3.4
Celera1913,894,448 - 13,894,635UniSTS
Cytogenetic Map19p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 27 19 8 19 11 2 6
Below cutoff 2 4 20 12 3 12 8 11 14 10 18 5 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060929   ⟹   ENSRNOP00000057649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,959,482 - 13,986,370 (+)Ensembl
Rnor_6.0 Ensembl1915,339,152 - 15,366,079 (+)Ensembl
RefSeq Acc Id: NM_001190375   ⟹   NP_001177304
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,132,678 - 30,159,368 (+)NCBI
mRatBN7.21913,959,676 - 13,986,370 (+)NCBI
Rnor_6.01915,339,152 - 15,366,079 (+)NCBI
Rnor_5.01926,436,075 - 26,462,383 (+)NCBI
Celera1913,884,007 - 13,910,659 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097977   ⟹   XP_038953905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,139,178 - 30,159,368 (+)NCBI
mRatBN7.21913,966,195 - 13,986,364 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001177304 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953905 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87576 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057649
  ENSRNOP00000057649.2
Reference Protein Sequences
RefSeq Acc Id: NP_001177304   ⟸   NM_001190375
- Peptide Label: precursor
- UniProtKB: A6KD50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057649   ⟸   ENSRNOT00000060929
RefSeq Acc Id: XP_038953905   ⟸   XM_039097977
- Peptide Label: isoform X1
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA05-F1-model_v2 AlphaFold D4AA05 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700968
Promoter ID:EPDNEW_R11490
Type:single initiation site
Name:Ces1a_1
Description:carboxylesterase 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,339,134 - 15,339,194EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583671 AgrOrtholog
BioCyc Gene G2FUF-6404 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6857 BioCyc
Ensembl Genes ENSRNOG00000039725 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060929 ENTREZGENE
  ENSRNOT00000060929.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
NCBI Gene 679817 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/TrEMBL
  CARBOXYLIC ESTER HYDROLASE UniProtKB/TrEMBL
Pfam COesterase UniProtKB/TrEMBL
PhenoGen Ces1a PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039725 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A6KD50 ENTREZGENE, UniProtKB/TrEMBL
  D4AA05_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces1a  carboxylesterase 1a  LOC679817  similar to carboxylesterase 1 isoform c precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-18 Ces1a  carboxylesterase 1A  Ces1a  carboxylesterase 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679817  similar to carboxylesterase 1 isoform c precursor  LOC683132  similar to carboxylesterase 1 isoform c precursor  Data merged from RGD:1590434 1643240 APPROVED
2006-11-20 LOC683132  similar to carboxylesterase 1 isoform c precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679817  similar to carboxylesterase 1 isoform c precursor      Symbol and Name status set to provisional 70820 PROVISIONAL