Zbtb33 (zinc finger and BTB domain containing 33) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Zbtb33 (zinc finger and BTB domain containing 33) Rattus norvegicus
Analyze
Symbol: Zbtb33
Name: zinc finger and BTB domain containing 33
RGD ID: 1566309
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in nucleoplasm. Orthologous to human ZBTB33 (zinc finger and BTB domain containing 33); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100910807; LOC501506; RGD1566309; similar to kaiso protein; transcriptional regulator Kaiso; transcriptional regulator Kaiso-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,828,960 - 121,836,193 (+)NCBIGRCr8
mRatBN7.2X116,963,337 - 116,970,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,963,347 - 116,971,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX119,061,678 - 119,066,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,630,827 - 122,635,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X120,176,705 - 120,181,374 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X124,319,299 - 124,326,506 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,393,332 - 124,398,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,321,551 - 124,323,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,405,073 - 124,412,271 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,166,136 - 7,170,805 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX116,181,032 - 116,185,701 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
nucleolus  (ISO)
nucleoplasm  (IBA,ISO)
nucleus  (ISO)
plasma membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10207085   PMID:16354688   PMID:20403812   PMID:23251453  


Genomics

Comparative Map Data
Zbtb33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,828,960 - 121,836,193 (+)NCBIGRCr8
mRatBN7.2X116,963,337 - 116,970,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,963,347 - 116,971,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX119,061,678 - 119,066,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,630,827 - 122,635,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X120,176,705 - 120,181,374 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X124,319,299 - 124,326,506 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,393,332 - 124,398,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,321,551 - 124,323,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,405,073 - 124,412,271 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,166,136 - 7,170,805 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX116,181,032 - 116,185,701 (+)NCBICelera
Cytogenetic MapXq35NCBI
ZBTB33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X120,250,812 - 120,258,398 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX120,250,752 - 120,258,398 (+)EnsemblGRCh38hg38GRCh38
GRCh37X119,384,667 - 119,392,253 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X119,268,635 - 119,276,279 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X119,166,488 - 119,174,133NCBI
CeleraX119,850,192 - 119,857,836 (+)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX108,837,055 - 108,844,699 (+)NCBIHuRef
CHM1_1X119,295,897 - 119,303,542 (+)NCBICHM1_1
T2T-CHM13v2.0X118,625,869 - 118,633,458 (+)NCBIT2T-CHM13v2.0
Zbtb33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X37,278,670 - 37,285,923 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX37,278,670 - 37,285,923 (+)EnsemblGRCm39 Ensembl
GRCm38X38,189,793 - 38,197,046 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX38,189,793 - 38,197,046 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X35,542,970 - 35,550,223 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X34,423,425 - 34,439,167 (+)NCBIMGSCv36mm8
CeleraX25,835,372 - 25,842,625 (+)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX22.45NCBI
Zbtb33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555721,628,263 - 1,635,828 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555721,628,263 - 1,636,299 (-)NCBIChiLan1.0ChiLan1.0
ZBTB33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X119,796,471 - 119,805,624 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X119,800,074 - 119,809,229 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X109,521,333 - 109,530,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X119,710,140 - 119,717,795 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX119,712,818 - 119,714,836 (+)Ensemblpanpan1.1panPan2
ZBTB33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X92,243,159 - 92,250,940 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX92,245,000 - 92,247,984 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX78,272,158 - 78,280,057 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X93,981,166 - 93,989,061 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX93,976,404 - 93,989,041 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X91,436,152 - 91,444,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X93,193,021 - 93,200,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X92,974,050 - 92,981,947 (+)NCBIUU_Cfam_GSD_1.0
Zbtb33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X91,196,712 - 91,205,572 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364799,781,952 - 9,790,821 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364799,781,923 - 9,791,000 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZBTB33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX98,405,319 - 98,414,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,370,137 - 98,413,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X113,104,986 - 113,132,862 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZBTB33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606532,973,319 - 32,981,015 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zbtb33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462493161,132 - 67,339 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462493161,085 - 69,372 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zbtb33
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:163
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000049424, ENSRNOT00000074486
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 30 44 28 19 28 7 7 74 34 36 11 7
Below cutoff 12 28 17 16 17 1 4 8 6 17 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049424   ⟹   ENSRNOP00000050403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,963,347 - 116,971,023 (+)Ensembl
Rnor_6.0 EnsemblX124,393,332 - 124,398,001 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074486   ⟹   ENSRNOP00000066134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX124,321,551 - 124,323,960 (+)Ensembl
RefSeq Acc Id: NM_001109314   ⟹   NP_001102784
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,829,085 - 121,833,754 (+)NCBI
mRatBN7.2X116,963,439 - 116,968,108 (+)NCBI
Rnor_6.0X124,319,398 - 124,324,067 (+)NCBI
Rnor_5.0X124,405,073 - 124,412,271 (+)NCBI
RGSC_v3.4X7,166,136 - 7,170,805 (-)RGD
CeleraX116,181,032 - 116,185,701 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257485   ⟹   XP_006257547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,828,960 - 121,836,193 (+)NCBI
mRatBN7.2X116,963,337 - 116,970,547 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102784 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257547 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10857 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050403
  ENSRNOP00000050403.3
Reference Protein Sequences
RefSeq Acc Id: NP_001102784   ⟸   NM_001109314
- UniProtKB: D3ZAN8 (UniProtKB/TrEMBL),   A6JMJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066134   ⟸   ENSRNOT00000074486
RefSeq Acc Id: XP_006257547   ⟸   XM_006257485
- Peptide Label: isoform X1
- UniProtKB: D3ZAN8 (UniProtKB/TrEMBL),   A6JMJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050403   ⟸   ENSRNOT00000049424
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAN8-F1-model_v2 AlphaFold D3ZAN8 1-670 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566309 AgrOrtholog
BioCyc Gene G2FUF-1262 BioCyc
Ensembl Genes ENSRNOG00000028899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046156 Ensembl
Ensembl Transcript ENSRNOT00000049424 ENTREZGENE
  ENSRNOT00000049424.4 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:501506 UniProtKB/TrEMBL
NCBI Gene 501506 ENTREZGENE
PANTHER AGAP004733-PA UniProtKB/TrEMBL
  ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7C UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
PhenoGen Zbtb33 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028899 RatGTEx
  ENSRNOG00000046156 RatGTEx
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A6JMJ5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAN8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zbtb33  zinc finger and BTB domain containing 33  LOC100910807  transcriptional regulator Kaiso-like  Data merged from RGD:6496755 737654 PROVISIONAL
2012-07-05 LOC100910807  transcriptional regulator Kaiso-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-07 Zbtb33  zinc finger and BTB domain containing 33  RGD1566309_predicted  similar to kaiso protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566309_predicted  similar to kaiso protein (predicted)  LOC501506  similar to kaiso protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501506  similar to kaiso protein      Symbol and Name status set to provisional 70820 PROVISIONAL