Dock1 (dedicator of cyto-kinesis 1) - Rat Genome Database

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Gene: Dock1 (dedicator of cyto-kinesis 1) Rattus norvegicus
Analyze
Symbol: Dock1
Name: dedicator of cyto-kinesis 1
RGD ID: 1566072
Description: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including myoblast fusion; positive regulation of epithelial cell migration; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human DOCK1 (dedicator of cytokinesis 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; atrazine.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: PROVISIONAL
Previously known as: dedicator of cytokinesis protein 1; dedicator of cytokinesis protein 1-like; LOC100909609; LOC309077; LOC309081; RGD1566072; similar to Dock1 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,897,021 - 199,413,636 (+)NCBIGRCr8
mRatBN7.21189,467,143 - 189,983,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1189,467,143 - 189,983,768 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1197,826,434 - 198,344,503 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01204,994,807 - 205,504,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01197,668,299 - 198,177,593 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01206,900,617 - 207,414,852 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1206,900,617 - 207,414,843 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,838,803 - 214,349,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41194,172,914 - 194,795,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1187,188,438 - 187,700,806 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12134158   PMID:15632090   PMID:15728191   PMID:17515907   PMID:19004829   PMID:21900250   PMID:23314417   PMID:23497970   PMID:24029230   PMID:27662902  


Genomics

Comparative Map Data
Dock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,897,021 - 199,413,636 (+)NCBIGRCr8
mRatBN7.21189,467,143 - 189,983,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1189,467,143 - 189,983,768 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1197,826,434 - 198,344,503 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01204,994,807 - 205,504,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01197,668,299 - 198,177,593 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01206,900,617 - 207,414,852 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1206,900,617 - 207,414,843 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,838,803 - 214,349,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41194,172,914 - 194,795,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1187,188,438 - 187,700,806 (+)NCBICelera
Cytogenetic Map1q41NCBI
DOCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810126,905,428 - 127,452,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10126,905,409 - 127,452,517 (+)EnsemblGRCh38hg38GRCh38
GRCh3710128,593,997 - 129,250,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610128,658,955 - 129,140,770 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410128,658,954 - 129,140,769NCBI
Celera10122,439,168 - 122,921,173 (+)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10122,340,788 - 122,823,487 (+)NCBIHuRef
CHM1_110129,050,827 - 129,533,068 (+)NCBICHM1_1
T2T-CHM13v2.010127,789,114 - 128,347,493 (+)NCBIT2T-CHM13v2.0
Dock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397134,272,416 - 134,775,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7134,272,383 - 134,775,368 (+)EnsemblGRCm39 Ensembl
GRCm387134,670,687 - 135,173,647 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7134,670,654 - 135,173,639 (+)EnsemblGRCm38mm10GRCm38
MGSCv377141,862,370 - 142,365,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367134,509,030 - 135,011,990 (+)NCBIMGSCv36mm8
Celera7134,477,959 - 134,991,792 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map779.14NCBI
Dock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554774,725,039 - 5,243,866 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554774,725,780 - 5,243,812 (+)NCBIChiLan1.0ChiLan1.0
DOCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28138,770,611 - 139,332,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010123,485,345 - 124,041,337 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110127,744,782 - 128,289,981 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10127,803,236 - 128,288,897 (+)Ensemblpanpan1.1panPan2
DOCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12835,862,267 - 36,397,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2835,861,523 - 36,396,883 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2835,960,163 - 36,453,573 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02836,536,271 - 37,030,199 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2836,536,316 - 37,030,230 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12836,012,508 - 36,505,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02836,009,501 - 36,504,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02836,265,344 - 36,759,122 (+)NCBIUU_Cfam_GSD_1.0
Dock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721310,451,230 - 10,887,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648614,692,532 - 15,092,307 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648614,583,042 - 15,092,164 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14136,257,807 - 136,741,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114136,199,747 - 136,745,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214148,261,860 - 148,289,427 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19119,519,230 - 120,064,767 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604880,885,791 - 81,444,814 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473719,574,948 - 20,105,265 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473719,575,012 - 20,105,406 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dock1
3569 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:87
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000054897
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat

Markers in Region
D1Rat439  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01214,281,909 - 214,282,042NCBIRnor5.0
RGSC_v3.41194,735,664 - 194,735,854RGDRGSC3.4
RGSC_v3.41194,735,665 - 194,735,854UniSTSRGSC3.4
RGSC_v3.11194,885,264 - 194,885,881RGD
Celera1187,641,456 - 187,641,645UniSTS
SHRSP x BN Map199.2499RGD
SHRSP x BN Map199.2499UniSTS
Cytogenetic Map1q41UniSTS
AI267063  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,597,179 - 189,597,261 (+)MAPPERmRatBN7.2
Rnor_6.01207,016,698 - 207,016,779NCBIRnor6.0
Rnor_5.01213,953,971 - 213,954,052UniSTSRnor5.0
RGSC_v3.41194,306,889 - 194,306,970UniSTSRGSC3.4
Celera1187,313,672 - 187,313,753UniSTS
Cytogenetic Map1q41UniSTS
RH127500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,983,221 - 189,983,431 (+)MAPPERmRatBN7.2
Rnor_6.01207,414,297 - 207,414,506NCBIRnor6.0
Rnor_5.01214,348,706 - 214,348,915UniSTSRnor5.0
RGSC_v3.41194,795,074 - 194,795,283UniSTSRGSC3.4
Celera1187,700,251 - 187,700,460UniSTS
RH 3.4 Map11441.91UniSTS
Cytogenetic Map1q41UniSTS
RH129098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,813,462 - 189,813,642 (+)MAPPERmRatBN7.2
Rnor_6.01207,236,274 - 207,236,453NCBIRnor6.0
Rnor_5.01214,170,683 - 214,170,862UniSTSRnor5.0
RGSC_v3.41194,624,675 - 194,624,854UniSTSRGSC3.4
Celera1187,530,510 - 187,530,689UniSTS
RH 3.4 Map11442.29UniSTS
Cytogenetic Map1q41UniSTS
RH133979  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,809,817 - 189,810,000 (+)MAPPERmRatBN7.2
Rnor_6.01207,232,630 - 207,232,812NCBIRnor6.0
Rnor_5.01214,167,039 - 214,167,221UniSTSRnor5.0
RGSC_v3.41194,621,031 - 194,621,213UniSTSRGSC3.4
Celera1187,526,866 - 187,527,048UniSTS
RH 3.4 Map11439.19UniSTS
Cytogenetic Map1q41UniSTS
BE112057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,806,537 - 189,806,688 (+)MAPPERmRatBN7.2
Rnor_6.01207,229,350 - 207,229,500NCBIRnor6.0
Rnor_5.01214,163,759 - 214,163,909UniSTSRnor5.0
RGSC_v3.41194,617,751 - 194,617,901UniSTSRGSC3.4
Celera1187,523,586 - 187,523,736UniSTS
RH 3.4 Map11437.99UniSTS
Cytogenetic Map1q41UniSTS
BE121032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,982,790 - 189,982,987 (+)MAPPERmRatBN7.2
Rnor_6.01207,413,866 - 207,414,062NCBIRnor6.0
Rnor_5.01214,348,275 - 214,348,471UniSTSRnor5.0
RGSC_v3.41194,794,643 - 194,794,839UniSTSRGSC3.4
Celera1187,699,803 - 187,699,999UniSTS
RH 3.4 Map11441.91UniSTS
Cytogenetic Map1q41UniSTS
BF412660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,695,162 - 189,695,272 (+)MAPPERmRatBN7.2
Rnor_6.01207,113,875 - 207,113,984NCBIRnor6.0
Rnor_5.01214,050,259 - 214,050,368UniSTSRnor5.0
RGSC_v3.41194,504,032 - 194,504,141UniSTSRGSC3.4
Celera1187,411,571 - 187,411,680UniSTS
RH 3.4 Map11442.3UniSTS
Cytogenetic Map1q41UniSTS
RH136909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,673,490 - 189,673,680 (+)MAPPERmRatBN7.2
Rnor_6.01207,092,262 - 207,092,451NCBIRnor6.0
Rnor_5.01214,028,646 - 214,028,835UniSTSRnor5.0
RGSC_v3.41194,481,579 - 194,481,768UniSTSRGSC3.4
Celera1187,389,765 - 187,389,954UniSTS
Cytogenetic Map1q41UniSTS
RH139279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,696,596 - 189,696,804 (+)MAPPERmRatBN7.2
Rnor_6.01207,115,436 - 207,115,643NCBIRnor6.0
Rnor_5.01214,051,820 - 214,052,027UniSTSRnor5.0
RGSC_v3.41194,505,719 - 194,505,926UniSTSRGSC3.4
Celera1187,413,005 - 187,413,212UniSTS
RH 3.4 Map11442.3UniSTS
Cytogenetic Map1q41UniSTS
RH140079  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,851,141 - 189,851,339 (+)MAPPERmRatBN7.2
Rnor_6.01207,273,950 - 207,274,147NCBIRnor6.0
Rnor_5.01214,208,359 - 214,208,556UniSTSRnor5.0
RGSC_v3.41194,662,353 - 194,662,550UniSTSRGSC3.4
Celera1187,568,127 - 187,568,324UniSTS
RH 3.4 Map11442.3UniSTS
Cytogenetic Map1q41UniSTS
AU048482  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01206,934,204 - 206,934,354NCBIRnor6.0
Rnor_5.01213,871,477 - 213,871,627UniSTSRnor5.0
RGSC_v3.41194,207,508 - 194,207,658UniSTSRGSC3.4
Celera1187,221,842 - 187,221,992UniSTS
Cytogenetic Map1q41UniSTS
AU048801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21189,983,866 - 189,984,074 (+)MAPPERmRatBN7.2
Rnor_6.01207,414,942 - 207,415,149NCBIRnor6.0
Rnor_5.01214,349,351 - 214,349,558UniSTSRnor5.0
RGSC_v3.41194,795,719 - 194,795,926UniSTSRGSC3.4
Celera1187,700,896 - 187,701,103UniSTS
Cytogenetic Map1q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 21 11 10 11 2 2 72 35 34 11 2
Low 1 2 36 30 9 30 6 9 2 7 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000054897   ⟹   ENSRNOP00000051781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1189,467,143 - 189,983,768 (+)Ensembl
Rnor_6.0 Ensembl1206,900,617 - 207,414,843 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1206,527,987 - 206,573,249 (+)Ensembl
RefSeq Acc Id: NM_001143858   ⟹   NP_001137330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,897,045 - 199,413,636 (+)NCBI
mRatBN7.21189,467,143 - 189,983,777 (+)NCBI
Rnor_6.01206,900,617 - 207,414,852 (+)NCBI
Rnor_5.01213,838,803 - 214,349,261 (+)NCBI
RGSC_v3.41194,172,914 - 194,795,629 (+)RGD
Celera1187,188,438 - 187,700,806 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263800   ⟹   XP_063119870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,897,021 - 199,413,635 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001137330   ⟸   NM_001143858
- UniProtKB: A6HX51 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051781   ⟸   ENSRNOT00000054897
RefSeq Acc Id: XP_063119870   ⟸   XM_063263800
- Peptide Label: isoform X1
Protein Domains
C2 DOCK-type   DOCKER   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZW1-F1-model_v2 AlphaFold D3ZZW1 1-1864 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690493
Promoter ID:EPDNEW_R1018
Type:initiation region
Name:Dock1_1
Description:dedicator of cyto-kinesis 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01206,900,637 - 206,900,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566072 AgrOrtholog
BioCyc Gene G2FUF-57166 BioCyc
Ensembl Genes ENSRNOG00000018683 Ensembl, ENTREZGENE
  ENSRNOG00000057633 Ensembl
Ensembl Transcript ENSRNOT00000054897 ENTREZGENE
Gene3D-CATH 1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  C2 domain UniProtKB/TrEMBL
  Dedicator of cytokinesis N-terminal subdomain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_DOCK-type_domain UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK1_5_SH3 UniProtKB/TrEMBL
  DOCK1_C2 UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  DOCK_N_sub1 UniProtKB/TrEMBL
  DOCKER_dom UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 309081 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS UniProtKB/TrEMBL
  DEDICATOR OF CYTOKINESIS PROTEIN 1 UniProtKB/TrEMBL
Pfam DHR-2_Lobe_A UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Dock1 PhenoGen
PROSITE C2_DOCK UniProtKB/TrEMBL
  DOCKER UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018683 RatGTEx
  ENSRNOG00000057633 RatGTEx
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP ARM repeat UniProtKB/TrEMBL
  SH3-domain UniProtKB/TrEMBL
UniProt A6HX51 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Dock1  dedicator of cyto-kinesis 1  LOC100909609  dedicator of cytokinesis protein 1-like  Data merged from RGD:6502607 737654 PROVISIONAL
2012-07-05 LOC100909609  dedicator of cytokinesis protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-06-15 Dock1  dedicator of cyto-kinesis 1  Dock1_predicted  dedicator of cyto-kinesis 1 (predicted)  Data merged from RGD:1306549 1643240 APPROVED
2008-07-08 Dock1  dedicator of cyto-kinesis 1  LOC679295  similar to Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)  Data merged from RGD:1590665 1643240 APPROVED
2008-03-07 Dock1  dedicator of cyto-kinesis 1  RGD1566072_predicted  similar to Dock1 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679295  similar to Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1566072_predicted  similar to Dock1 protein (predicted)  LOC309081  similar to Dock1 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC309081  similar to Dock1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Dock1_predicted  dedicator of cyto-kinesis 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED