Ano5 (anoctamin 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ano5 (anoctamin 5) Rattus norvegicus
Analyze
Symbol: Ano5
Name: anoctamin 5
RGD ID: 1564265
Description: Predicted to enable intracellular calcium activated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane and vesicle. Human ortholog(s) of this gene implicated in Miyoshi muscular dystrophy 3; autosomal recessive limb-girdle muscular dystrophy type 2L; gnathodiaphyseal dysplasia; and isolated elevated serum creatine phosphokinase levels. Orthologous to human ANO5 (anoctamin 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: anoctamin-5; LOC308637; RGD1564265; similar to integral membrane protein GDD1; Tmem16e; transmembrane protein 16E
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81110,222,411 - 110,323,505 (+)NCBIGRCr8
mRatBN7.21101,086,490 - 101,187,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1101,087,341 - 101,187,555 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01106,873,580 - 106,971,769 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1106,896,790 - 106,968,885 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01107,915,458 - 108,013,421 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41101,298,300 - 101,341,709 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera195,261,635 - 95,360,097 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,ISO)
vesicle  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies. Bolduc V, etal., Am J Hum Genet. 2010 Feb 12;86(2):213-21. doi: 10.1016/j.ajhg.2009.12.013. Epub 2010 Jan 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Frequency and characterisation of anoctamin 5 mutations in a cohort of Italian limb-girdle muscular dystrophy patients. Magri F, etal., Neuromuscul Disord. 2012 Nov;22(11):934-43. doi: 10.1016/j.nmd.2012.05.001. Epub 2012 Jun 27.
4. A novel missense mutation in ANO5/TMEM16E is causative for gnathodiaphyseal dyplasia in a large Italian pedigree. Marconi C, etal., Eur J Hum Genet. 2013 Jun;21(6):613-9. doi: 10.1038/ejhg.2012.224. Epub 2012 Oct 10.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. ANO5 gene analysis in a large cohort of patients with anoctaminopathy: confirmation of male prevalence and high occurrence of the common exon 5 gene mutation. Sarkozy A, etal., Hum Mutat. 2013 Aug;34(8):1111-8. doi: 10.1002/humu.22342. Epub 2013 Jun 12.
10. The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Tsutsumi S, etal., Am J Hum Genet. 2004 Jun;74(6):1255-61. Epub 2004 Apr 29.
11. LGMD2L with bone affection: overlapping phenotype of dominant and recessive ANO5-induced disease. Witting N, etal., Muscle Nerve. 2012 Nov;46(5):829-30. doi: 10.1002/mus.23440.
Additional References at PubMed
PMID:17418107   PMID:22075693   PMID:22946059   PMID:23532839  


Genomics

Comparative Map Data
Ano5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81110,222,411 - 110,323,505 (+)NCBIGRCr8
mRatBN7.21101,086,490 - 101,187,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1101,087,341 - 101,187,555 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01106,873,580 - 106,971,769 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1106,896,790 - 106,968,885 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01107,915,458 - 108,013,421 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41101,298,300 - 101,341,709 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera195,261,635 - 95,360,097 (+)NCBICelera
Cytogenetic Map1q22NCBI
ANO5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381122,192,473 - 22,283,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1121,782,659 - 22,283,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371122,214,631 - 22,304,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361122,171,298 - 22,257,975 (+)NCBINCBI36Build 36hg18NCBI36
Build 341122,171,297 - 22,257,975NCBI
Celera1122,346,769 - 22,437,966 (+)NCBICelera
Cytogenetic Map11p14.3NCBI
HuRef1121,897,150 - 21,988,511 (+)NCBIHuRef
CHM1_11122,214,324 - 22,304,648 (+)NCBICHM1_1
T2T-CHM13v2.01122,313,008 - 22,403,882 (+)NCBIT2T-CHM13v2.0
Ano5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39751,160,668 - 51,248,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl751,160,777 - 51,248,457 (+)EnsemblGRCm39 Ensembl
GRCm38751,510,007 - 51,598,707 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl751,511,029 - 51,598,709 (+)EnsemblGRCm38mm10GRCm38
MGSCv37758,766,399 - 58,854,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36751,379,048 - 51,466,728 (+)NCBIMGSCv36mm8
Celera748,889,506 - 48,979,118 (+)NCBICelera
Cytogenetic Map7B4NCBI
cM Map732.76NCBI
Ano5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554762,694,258 - 2,779,304 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554762,705,596 - 2,777,848 (+)NCBIChiLan1.0ChiLan1.0
ANO5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2924,478,884 - 24,572,951 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11124,438,258 - 24,532,291 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01122,201,694 - 22,295,781 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,112,466 - 22,203,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,112,482 - 22,206,637 (+)Ensemblpanpan1.1panPan2
ANO5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12143,903,422 - 43,986,778 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2143,903,537 - 43,984,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2143,389,226 - 43,459,917 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02145,009,529 - 45,104,081 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2145,009,540 - 45,102,880 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12144,030,402 - 44,101,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02144,203,022 - 44,273,728 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02144,595,596 - 44,666,444 (+)NCBIUU_Cfam_GSD_1.0
Ano5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494740,949,492 - 41,035,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366542,891,013 - 2,977,551 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366542,891,019 - 2,976,465 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANO5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl237,171,412 - 37,255,489 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1237,171,402 - 37,256,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2240,382,286 - 40,466,462 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANO5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1142,722,072 - 42,823,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl142,722,015 - 42,822,374 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038140,032,681 - 140,132,071 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ano5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476613,224,295 - 13,294,968 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476613,220,250 - 13,301,447 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ano5
1113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000021583, ENSRNOT00000042952, ENSRNOT00000064193
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 8 11 8
Low 10 11 8 3 8 60 5 18 9
Below cutoff 1 21 32 22 13 22 12 16 22 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042952   ⟹   ENSRNOP00000049894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1101,095,080 - 101,182,559 (+)Ensembl
Rnor_6.0 Ensembl1106,896,790 - 106,968,885 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000064193   ⟹   ENSRNOP00000059557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1101,087,341 - 101,187,555 (+)Ensembl
Rnor_6.0 Ensembl1106,896,790 - 106,968,885 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101249   ⟹   ENSRNOP00000093671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1101,087,341 - 101,187,555 (+)Ensembl
RefSeq Acc Id: XM_006229266   ⟹   XP_006229328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81110,222,414 - 110,323,505 (+)NCBI
mRatBN7.21101,086,491 - 101,187,547 (+)NCBI
Rnor_6.01106,873,581 - 106,971,769 (+)NCBI
Rnor_5.01107,915,458 - 108,013,421 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229268   ⟹   XP_006229330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81110,222,414 - 110,323,505 (+)NCBI
mRatBN7.21101,086,491 - 101,187,547 (+)NCBI
Rnor_6.01106,873,581 - 106,971,769 (+)NCBI
Rnor_5.01107,915,458 - 108,013,421 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590139   ⟹   XP_017445628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81110,222,413 - 110,323,505 (+)NCBI
mRatBN7.21101,086,490 - 101,187,547 (+)NCBI
Rnor_6.01106,873,580 - 106,971,769 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590140   ⟹   XP_017445629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81110,222,414 - 110,323,505 (+)NCBI
mRatBN7.21101,086,491 - 101,187,547 (+)NCBI
Rnor_6.01106,873,581 - 106,971,769 (+)NCBI
Sequence:
RefSeq Acc Id: XR_010060061
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81110,222,411 - 110,318,626 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006229328   ⟸   XM_006229266
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006229330   ⟸   XM_006229268
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017445628   ⟸   XM_017590139
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017445629   ⟸   XM_017590140
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000049894   ⟸   ENSRNOT00000042952
RefSeq Acc Id: ENSRNOP00000059557   ⟸   ENSRNOT00000064193
RefSeq Acc Id: ENSRNOP00000093671   ⟸   ENSRNOT00000101249
Protein Domains
Anoctamin dimerisation   Anoctamin transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZ77-F1-model_v2 AlphaFold F1LZ77 1-884 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564265 AgrOrtholog
BioCyc Gene G2FUF-59544 BioCyc
Ensembl Genes ENSRNOG00000015972 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042952.6 UniProtKB/TrEMBL
  ENSRNOT00000064193.3 UniProtKB/TrEMBL
  ENSRNOT00000101249.1 UniProtKB/TrEMBL
InterPro Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
  Anoctamin_TM UniProtKB/TrEMBL
NCBI Gene 308637 ENTREZGENE
PANTHER PTHR12308 UniProtKB/TrEMBL
  PTHR12308:SF23 UniProtKB/TrEMBL
Pfam Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
PhenoGen Ano5 PhenoGen
RatGTEx ENSRNOG00000015972 RatGTEx
UniProt A0A8I6AJC4_RAT UniProtKB/TrEMBL
  F1LZ77_RAT UniProtKB/TrEMBL
  F1M3M3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-25 Ano5  anoctamin 5  RGD1564265  similar to integral membrane protein GDD1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564265  similar to integral membrane protein GDD1   RGD1564265_predicted  similar to integral membrane protein GDD1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564265_predicted  similar to integral membrane protein GDD1 (predicted)  LOC308637  similar to integral membrane protein GDD1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC308637  similar to integral membrane protein GDD1      Symbol and Name status set to provisional 70820 PROVISIONAL