Vash1 (vasohibin 1) - Rat Genome Database

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Gene: Vash1 (vasohibin 1) Rattus norvegicus
Analyze
Symbol: Vash1
Name: vasohibin 1
RGD ID: 1564082
Description: Predicted to enable actin binding activity and metallocarboxypeptidase activity. Predicted to be involved in negative regulation of blood vessel endothelial cell migration; proteolysis; and regulation of angiogenesis. Predicted to act upstream of or within several processes, including blood vessel development; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Predicted to be located in apical part of cell; endoplasmic reticulum; and extracellular space. Predicted to be active in cytoplasm. Biomarker of portal hypertension. Human ortholog(s) of this gene implicated in liver cirrhosis and portal hypertension. Orthologous to human VASH1 (vasohibin 1); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC503052; RGD1564082; similar to RIKEN cDNA G630009D10 gene; tubulinyl-Tyr carboxypeptidase 1; vasohibin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,060,086 - 112,076,689 (+)NCBIGRCr8
mRatBN7.26106,330,374 - 106,345,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,329,123 - 106,345,726 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.06110,624,377 - 110,640,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6110,624,856 - 110,637,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06119,921,674 - 119,938,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46110,806,294 - 110,818,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6104,151,889 - 104,168,420 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats. Coch L, etal., Hepatology. 2014 Aug;60(2):633-47. doi: 10.1002/hep.26995. Epub 2014 Jun 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15467828   PMID:16707096   PMID:19204325   PMID:20133819   PMID:20659423   PMID:20736312   PMID:23056314   PMID:25184477   PMID:29146868   PMID:29146869   PMID:31171830   PMID:31235911  


Genomics

Comparative Map Data
Vash1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,060,086 - 112,076,689 (+)NCBIGRCr8
mRatBN7.26106,330,374 - 106,345,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,329,123 - 106,345,726 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.06110,624,377 - 110,640,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6110,624,856 - 110,637,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06119,921,674 - 119,938,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46110,806,294 - 110,818,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6104,151,889 - 104,168,420 (+)NCBICelera
Cytogenetic Map6q31NCBI
VASH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381476,761,468 - 76,783,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1476,761,468 - 76,783,015 (+)EnsemblGRCh38hg38GRCh38
GRCh371477,227,811 - 77,249,358 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361476,298,285 - 76,319,111 (+)NCBINCBI36Build 36hg18NCBI36
Build 341476,298,284 - 76,319,109NCBI
Celera1457,266,828 - 57,287,976 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1457,396,835 - 57,417,983 (+)NCBIHuRef
CHM1_11477,166,049 - 77,187,187 (+)NCBICHM1_1
T2T-CHM13v2.01470,970,762 - 70,992,327 (+)NCBIT2T-CHM13v2.0
Vash1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391286,725,474 - 86,742,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1286,725,474 - 86,738,865 (+)EnsemblGRCm39 Ensembl
GRCm381286,678,700 - 86,695,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1286,678,700 - 86,692,091 (+)EnsemblGRCm38mm10GRCm38
MGSCv371288,019,650 - 88,036,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361287,567,803 - 87,581,194 (+)NCBIMGSCv36mm8
Celera1288,140,378 - 88,157,636 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1240.84NCBI
Vash1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955438752,554 - 772,937 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955438753,392 - 772,937 (+)NCBIChiLan1.0ChiLan1.0
VASH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21577,846,765 - 77,868,086 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,063,264 - 77,084,593 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01457,315,866 - 57,337,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11476,522,881 - 76,544,254 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1476,522,881 - 76,544,251 (+)Ensemblpanpan1.1panPan2
VASH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1849,631,029 - 49,651,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl849,631,910 - 49,648,168 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,314,932 - 49,335,554 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0849,857,895 - 49,878,478 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl849,858,702 - 49,881,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1849,528,855 - 49,548,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0849,551,007 - 49,571,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0849,949,126 - 49,969,713 (+)NCBIUU_Cfam_GSD_1.0
Vash1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864026,372,770 - 26,393,180 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364885,675,782 - 5,696,222 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364885,675,788 - 5,696,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VASH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl799,910,497 - 99,929,770 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1799,910,644 - 99,933,633 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27105,958,917 - 105,978,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VASH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,025,548 - 54,047,122 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2454,026,617 - 54,047,135 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605342,224,646 - 42,246,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vash1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473425,034,266 - 25,053,398 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473425,034,266 - 25,053,409 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vash1
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:69
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000014017
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat

Markers in Region
D6Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.46110,804,020 - 110,804,147UniSTSRGSC3.4
RGSC_v3.46110,804,019 - 110,804,147RGDRGSC3.4
RGSC_v3.16110,807,550 - 110,807,678RGD
Celera6104,150,854 - 104,150,981UniSTS
RH 3.4 Map6742.29RGD
RH 2.0 Map6988.6RGD
D6Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26106,328,135 - 106,328,263 (+)MAPPERmRatBN7.2
Rnor_6.06110,623,342 - 110,623,469NCBIRnor6.0
Rnor_5.06119,920,604 - 119,920,731UniSTSRnor5.0
RGSC_v3.46110,804,020 - 110,804,147UniSTSRGSC3.4
Celera6104,150,854 - 104,150,981UniSTS
RH 3.4 Map6742.29UniSTS
Cytogenetic Map6q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 6 6 6 73 20 30 6
Low 2 15 50 34 19 34 8 11 1 15 11 5 8
Below cutoff 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014017   ⟹   ENSRNOP00000014017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,329,123 - 106,345,726 (+)Ensembl
Rnor_6.0 Ensembl6110,624,856 - 110,637,382 (+)Ensembl
RefSeq Acc Id: NM_001427235   ⟹   NP_001414164
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,060,086 - 112,076,689 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414164 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81606 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014017.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000014017   ⟸   ENSRNOT00000014017
RefSeq Acc Id: NP_001414164   ⟸   NM_001427235
- UniProtKB: A6JE62 (UniProtKB/TrEMBL),   D4AE85 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE85-F1-model_v2 AlphaFold D4AE85 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564082 AgrOrtholog
BioCyc Gene G2FUF-36755 BioCyc
Ensembl Genes ENSRNOG00000010457 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014017.7 UniProtKB/TrEMBL
InterPro Vasohibin UniProtKB/TrEMBL
KEGG Report rno:503052 UniProtKB/TrEMBL
NCBI Gene 503052 ENTREZGENE
PANTHER PTHR15750 UniProtKB/TrEMBL
  PTHR15750:SF5 UniProtKB/TrEMBL
Pfam Vasohibin UniProtKB/TrEMBL
PhenoGen Vash1 PhenoGen
RatGTEx ENSRNOG00000010457 RatGTEx
UniProt A6JE62 ENTREZGENE, UniProtKB/TrEMBL
  D4AE85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Vash1  vasohibin 1  RGD1564082_predicted  similar to RIKEN cDNA G630009D10 gene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564082_predicted  similar to RIKEN cDNA G630009D10 gene (predicted)  LOC503052  similar to RIKEN cDNA G630009D10 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503052  similar to RIKEN cDNA G630009D10 gene      Symbol and Name status set to provisional 70820 PROVISIONAL