Pm20d1 (peptidase M20 domain containing 1)

Gene: Pm20d1 (peptidase M20 domain containing 1) Rattus norvegicus

Analyze

Symbol:

Pm20d1

Name:

peptidase M20 domain containing 1

RGD ID:

1564063

Description:

Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in several processes, including adaptive thermogenesis; amide catabolic process; and energy homeostasis. Predicted to be located in extracellular space. Orthologous to human PM20D1 (peptidase M20 domain containing 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC498226; N-fatty-acyl-amino acid synthase/hydrolase PM20D1; probable carboxypeptidase PM20D1; RGD1564063; similar to hypothetical protein FLJ32569

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PM20D1 (peptidase M20 domain containing 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pm20d1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pm20d1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PM20D1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PM20D1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pm20d1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PM20D1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PM20D1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pm20d1 (peptidase M20 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pm20d1 (peptidase M20 domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PM20D1 (peptidase M20 domain containing 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pm20d1.1 (peptidase M20 domain containing 1, tandem duplicate 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pm20d1.2 (peptidase M20 domain containing 1, tandem duplicate 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CPS1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pm20d1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	45,790,161 - 45,812,206 (+)	NCBI		GRCr8
mRatBN7.2	13	43,237,954 - 43,259,999 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	43,237,971 - 43,259,999 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	45,841,357 - 45,863,527 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	47,129,507 - 47,151,675 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	44,394,184 - 44,416,388 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	48,575,094 - 48,596,515 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	48,575,091 - 48,596,515 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	53,650,960 - 53,670,855 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	44,735,202 - 44,755,913 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	43,576,159 - 43,597,847 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrabromodibenzodioxine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-chloropropane-1,2-diol (EXP)

aflatoxin B1 (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cyclosporin A (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

etoposide (ISO)

furan (EXP)

methapyrilene (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive thermogenesis (ISO)

amide biosynthetic process (IBA,ISO)

amide catabolic process (IBA,ISO)

amino acid metabolic process (IBA,ISO)

cellular lipid metabolic process (IBA,ISO)

energy homeostasis (ISO)

proteolysis involved in protein catabolic process (IEA)

Cellular Component

extracellular space (ISO)

Molecular Function

carboxypeptidase activity (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IBA,ISO)

metal ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19056867	PMID:21840748	PMID:27374330

Genomics

Comparative Map Data

Pm20d1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	45,790,161 - 45,812,206 (+)	NCBI		GRCr8
mRatBN7.2	13	43,237,954 - 43,259,999 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	43,237,971 - 43,259,999 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	45,841,357 - 45,863,527 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	47,129,507 - 47,151,675 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	44,394,184 - 44,416,388 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	48,575,094 - 48,596,515 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	48,575,091 - 48,596,515 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	53,650,960 - 53,670,855 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	44,735,202 - 44,755,913 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	43,576,159 - 43,597,847 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

PM20D1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	205,828,025 - 205,850,132 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	205,828,025 - 205,850,132 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	205,797,153 - 205,819,260 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	204,063,776 - 204,085,868 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	178,933,498 - 178,955,670 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	176,961,776 - 176,983,237 (-)	NCBI		HuRef
CHM1_1	1	207,220,641 - 207,242,775 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	205,092,679 - 205,114,789 (-)	NCBI		T2T-CHM13v2.0

Pm20d1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	131,725,122 - 131,749,210 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	131,725,119 - 131,749,211 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	131,797,385 - 131,821,472 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	131,797,381 - 131,821,473 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	133,693,972 - 133,714,692 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	133,624,944 - 133,649,018 (+)	NCBI		MGSCv36	mm8
Celera	1	134,401,882 - 134,422,608 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	57.19	NCBI

Pm20d1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	41,518,526 - 41,544,348 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	41,522,800 - 41,544,332 (-)	NCBI	ChiLan1.0	ChiLan1.0

PM20D1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	43,519,454 - 43,541,640 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	43,484,967 - 43,508,103 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	181,437,045 - 181,459,103 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	185,720,642 - 185,742,757 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	185,720,642 - 185,742,757 (-)	Ensembl	panpan1.1		panPan2

PM20D1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	2,247,645 - 2,270,286 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	2,250,272 - 2,270,653 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	2,343,134 - 2,362,931 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	2,247,675 - 2,267,472 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	2,247,684 - 2,267,765 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	2,241,768 - 2,261,562 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	2,633,458 - 2,653,227 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	2,834,108 - 2,854,142 (-)	NCBI		UU_Cfam_GSD_1.0

Pm20d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	69,370,573 - 69,390,938 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	6,610,834 - 6,631,331 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	6,610,862 - 6,631,220 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PM20D1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	9	66,522,015 - 66,550,511 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	72,788,453 - 72,816,829 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PM20D1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	23,498,460 - 23,521,233 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	23,498,845 - 23,520,637 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	24,196,498 - 24,216,762 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pm20d1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	5,408,689 - 5,432,131 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	5,406,363 - 5,428,392 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pm20d1
66 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	264
Count of miRNA genes:	159
Interacting mature miRNAs:	199
Transcripts:	ENSRNOT00000009838
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
2303032	Bp328	Blood pressure QTL 328			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	41184022	45417941	Rat

Markers in Region

RH135125

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	43,257,721 - 43,257,924 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	48,594,238 - 48,594,440	NCBI	Rnor6.0
Rnor_5.0	13	53,668,578 - 53,668,780	UniSTS	Rnor5.0
RGSC_v3.4	13	44,753,636 - 44,753,838	UniSTS	RGSC3.4
Celera	13	43,595,570 - 43,595,772	UniSTS
RH 3.4 Map	13	111.9	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		16	16		16				23
Low	2	43	41	25	19	25	8	11	49	12	36	11	8
Below cutoff									25		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000009838 ⟹ ENSRNOP00000009838

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	43,237,971 - 43,259,999 (+)	Ensembl
Rnor_6.0 Ensembl	13	48,575,091 - 48,596,515 (+)	Ensembl

RefSeq Acc Id:

NM_001109068 ⟹ NP_001102538

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,790,179 - 45,812,206 (+)	NCBI
mRatBN7.2	13	43,237,971 - 43,259,999 (+)	NCBI
Rnor_6.0	13	48,575,094 - 48,596,515 (+)	NCBI
Rnor_5.0	13	53,650,960 - 53,670,855 (+)	NCBI
RGSC_v3.4	13	44,735,202 - 44,755,913 (+)	RGD
Celera	13	43,576,159 - 43,597,847 (+)	RGD

Sequence:

show sequence

TAAACTCCAGCCTGACTGGCGGCGCGCCATCGGAGAGACATGGCTGAGCTACTTGTTATCTTGC
CCACCCGGGCAGCTGTGCTCCTTCTCTTTTTCGCTACCGTCTCAGGATCCACGGGCCCTGGCAG
CAGGGAAAGTCGAGGATCGTCGCGGATCCCTTCCCAGTTCAGCGAGGAGGAGCGCGTCGCTATG
AAAGAGGCGCTGAAAGGTGCCATCCGGATTCCCACAGTGTCTTTCAGCCACGAGGAATCCAACA
CCACAGCCCTTGCTGAGTTTGGAGAATATATCCGAAAAGCCTTTCCTACAGTGTTCCACAGCAA
CCTTATCCAACACGAAGTCGTGGGGAAGTATAGCCACCTGCTCACCGTCCGAGGCTCGGACCCC
AGTTTGCAGCCCTACATGCTGATGGCTCACTTCGACGTGGTTCCTGCCTCTGAAGAAGGATGGG
AGGTGCCCCCGTTCTCAGGCCTGGAGCAAAATGGCTTCATCCATGGCCGGGGTGCGCTGGACAA
CAAAAACTCTGTGATGGCAGTCCTGCAGGCTTTGGAGCTCCTGTTGATCAGAAAATACAGCCCC
AAAAGACCTTTCTTCATTGCTTTGGGCCATGATGAGGAGGTGTCTGGGACAAAGGGGGCTCAGC
AGATCTCAGCACTCTTACAGACGAGGGGTGTCCAGCTAGCTTTTCTTGTGGATGAAGGGAGCTT
TATCTTGGAAGACTTCATTCCGAACCTCAAGAAGCCGTTTGCCATGATTTCAGTCACCGAGAAG
GGTGCCCTTGACCTCATGCTGCAAGTAAACATGACTCCAGGCCACTCTTCAGCTCCCCCAAAGG
AGACAAGCATTGGAATCCTTTCTGCCGCTGTCAGCCGACTGGAGCAGACACCAATGCCAAACAT
GTTTGGAAACGGGCCATTGAAGAAGACATTGAAGCTACTGGCAAATGAGTTTTCCTTCCCTACC
AATATAATCTTGGGGAACCTGTGGCTATTCCGTCCCATTGTAAGCAGGGTAATGGAGAGGAATC
CCATAACGAATGCATTGGTCAGAACTACCACAGCCCTCACCATGTTCAATGCAGGAATCAAGGT
GAATGTCATCCCCCCATTGGCTCAGGCGACAGTCAACTTCCGAATTCACCCTTCGCAGACAGTA
CACGAGGTCGTAGAACTCGTCCAGAACATTGTGGCTGATGACCGAGTCCAGTTGCATGTGTTGA
GATCCTTTGAACCACTGCCCGTCAGCCCCTCTGATGACCAGGCCATGGGCTACCAGCTGCTTCA
ACAGACCATACAGTCTGTCTTCCCGGAAGTCAAGATCATTGTCCCCGGTATTTGTATTGGCAAC
ACGGACACCCGACACTATGTCAACCTGACCAATGGCTTGTACCGGTTCAACCCCGTTTTCCTGA
AGCCTCAGGACTTCAGTAGTGTCCATGGAATCAATGAGAAAATCTCCGTTGAGAGCTACCAGAA
CCAGGTGAAGTTCATCTTTGAGTTGATCCAAAATGCTGACACCTACAGCAAGCCAGTTCCTCAT
CAGCATGAACTATGAGACAAGGACCCAGCTGGGTGAGGGGCGCCCAGCACTGAGCCAGGACTCA
CCTAAGGGGAGAGGAGCTGGTATTAAGGAAAGGTTTGGTGGAAACCATCCTGTCATGCAGGGTT
CACCTGCCTGGCTCCCTCCTTCACTCACCGAGGAGGAAAGGGAGATGAACATAATCTCACCTGT
CATCCTCCTGACACCTGTGTTCTTCCCATGAGTGGCATCTGCTGCCTGTCCTGCCTGTTGGCCT
GTCTCATGCCGGTGGTTACTAACTATTCCACTTTCCCAGCCTGTCTTAACAAATACAGATTTTG
GGAACACCTCAAGCAGGGTTTAATCTAGAGTATTGACTTCGGATACTTGAGCCGGACTGTCTTC
TAGAATTTCCTTTCTCCTGTCTTCTCTCCAACTTGGGAGCTGCCCCTTGGCCTCTTTCTTCCTG
CCTCTGCTTCCTTCCTCCAATCTCCGGTTCGTTTCCATATCTGCAGTTAGGACTCAAACTGAGA
AGCTCCCGTGATCACAGTCAAATAAAGGGGTCCGTGTAGTGACTGTCAAGCTGGCCTCCGTCAA
GTGAGTGGGAGGTGGAGACTTTGCAAGAAACCCAGAACTCCTAGTTCCAGAGGCTTGGGCTCTT
GGGATTGTTGTTCCCCTCCCCTGCCCTGTTCCTGCCACCTGCTGTTGCTGCCCCACCTCAGGAA
GCTCTAATCTGTGAAAGCATTTCCCTGGCACAGTTTATGGGCTGAGCTCCCAAGAGAGGAACAC
TCAAGATCCAGCTTCTCAGTGGCTCCCTGGCCCTGGCTTGTCCTGTTTCAGAATGACCAAGGGG
AAGTGGAGGGCAAGGAAGGGGATGGTTAGAGGGGCTCTTCCCTGGACAAAAGAAGCAAGCGTCC
ATTAGCGTATATTGGAGCTCTTGTCTTCTCTCTGGACTCCAACCCTACGCATATTTGGATGCAC
TTAGTAGCTGCCAGGTGGGGAGCATTGGAAAGCCACATTTCTTGGCTCAAGGCCACCATCTCTG
CTTTGTGGATGACAAGGGGAGTCAAGGTCACACAGGGAGACACAGAAACGGAGCTTGAAAAGCT
CCCTCTTTTCCCCTCTCCAGACTAGCACCTTCTGTGTCTCCCAGCAGTTTGACAGTTCTAGGTT
TGCTTGCCCCCCACCTCCTTGGAAATCCCCATTCTCCCTCCTCCCAAGTACTTACCTTCCCCCC
AGGATGTGAACTGTTCCTTGAAGCTCTGACTTAATTGTTATCATTAGAAACAGTGTGGGGATTA
TTCGAGCTTTTTAGCTACTCCTGCTAAGATTCACATTCCTTCCTCACTCTGGCTTTTTGGCCAA
CTCAGTACTTATTCAGCCTTAGTTGGAGGGCAAGCTTAAGAACAAAGATAATCCTTTACTTTCG
TGCAGAGCTCTGTGAGATCGTCTTATGCGTGCCTTATCTCAGCCCTCTGAGCATGCTGTCATTA
CCCCTTCCTACAGAGACTGGCTACACATCTTGCTGGAAACAGTTGTCAAACCTTCATTACCTTG
CCATCGGGACCATTCTCTGATCCTGAATCACCTACTCCCCACTGATTTCTTATTTAATTCTCAT
AACTACTGTGGCATGAGTACCCCCACTGTTGTTATGTTGTAAACAAAGTCATACGAGGAAAAGT
ATTCACAGGGAGGGAACATGGCCGACTGGGGCTTGCCTTTGTAGGGTCATTAGGATTAGGCCCT
GGGTCTGAGCTCCATCCTTGACTTATTAATGGACTTTTTAAGAAGAGAGTTTGGGCAAATAGAC
ACATTTAATCTGATTCGGACAAGGCACCATGAATACCTGTGTCAAAACATCACAGTACTCCATC
CACTAAATCAGAGAAAGAGAGGGGGAAAGAGAGCAGAAGACAGACAGGTTCATACATGTACGTC
ATGTGAGGGCCTATACCATCTCTTGCACAAGGAGACCTCTATCCATCAGGGGGCAAACCAGTGC
TCCCCACATGATTTTAACACTCCCGAGCTGTGAGCCGAAATAAACGTCTTTTTTTTTATAACTC
GACCCGGTTTGTGGTGTCATGTTCTTGGAAACAGAAAACAAGAGTAGCACAATTTGAATGCACT
ATCACTCCATTTTGTAAAAAGGAAGTGCCAGGTTTAAAAATCCCAAGGCTGCACAAGACCATGC
CAGTGTTAAGAACAGGGTCTCTCTGAATTCAAAGTCTATGCTACTAGTCCTGAAGAGAAAACAG
ACTCCCAAAAGCCC

hide sequence

RefSeq Acc Id:

XR_005492268

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,790,161 - 45,797,372 (+)	NCBI
mRatBN7.2	13	43,237,954 - 43,245,164 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102538	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09816	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009838
	ENSRNOP00000009838.6

RefSeq Acc Id:	NP_001102538 ⟸ NM_001109068
- Peptide Label:	precursor
- UniProtKB:	F1M0Q9 (UniProtKB/TrEMBL), A6IC31 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAELLVILPTRAAVLLLFFATVSGSTGPGSRESRGSSRIPSQFSEEERVAMKEALKGAIRIPTV SFSHEESNTTALAEFGEYIRKAFPTVFHSNLIQHEVVGKYSHLLTVRGSDPSLQPYMLMAHFDV VPASEEGWEVPPFSGLEQNGFIHGRGALDNKNSVMAVLQALELLLIRKYSPKRPFFIALGHDEE VSGTKGAQQISALLQTRGVQLAFLVDEGSFILEDFIPNLKKPFAMISVTEKGALDLMLQVNMTP GHSSAPPKETSIGILSAAVSRLEQTPMPNMFGNGPLKKTLKLLANEFSFPTNIILGNLWLFRPI VSRVMERNPITNALVRTTTALTMFNAGIKVNVIPPLAQATVNFRIHPSQTVHEVVELVQNIVAD DRVQLHVLRSFEPLPVSPSDDQAMGYQLLQQTIQSVFPEVKIIVPGICIGNTDTRHYVNLTNGL YRFNPVFLKPQDFSSVHGINEKISVESYQNQVKFIFELIQNADTYSKPVPHQHEL hide sequence

RefSeq Acc Id:

ENSRNOP00000009838 ⟸ ENSRNOT00000009838

Protein Domains

Peptidase M20 dimerisation

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M0Q9-F1-model_v2	AlphaFold	F1M0Q9	1-472	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564063	AgrOrtholog
BioCyc Gene	G2FUF-18338	BioCyc
Ensembl Genes	ENSRNOG00000039745	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009838	ENTREZGENE
	ENSRNOT00000009838.6	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.900	UniProtKB/TrEMBL
	3.30.70.360	UniProtKB/TrEMBL
	Zn peptidases	UniProtKB/TrEMBL
InterPro	Bact_exopeptidase_dim_dom	UniProtKB/TrEMBL
	Pept_M20A	UniProtKB/TrEMBL
	Peptidase_M20	UniProtKB/TrEMBL
	Peptidase_M20_dimer	UniProtKB/TrEMBL
KEGG Report	rno:498226	UniProtKB/TrEMBL
NCBI Gene	498226	ENTREZGENE
PANTHER	N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1	UniProtKB/TrEMBL
	N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1	UniProtKB/TrEMBL
Pfam	M20_dimer	UniProtKB/TrEMBL
	Peptidase_M20	UniProtKB/TrEMBL
PhenoGen	Pm20d1	PhenoGen
RatGTEx	ENSRNOG00000039745	RatGTEx
Superfamily-SCOP	Peptidase_M20_dimer	UniProtKB/TrEMBL
	Zn-dependent exopeptidases	UniProtKB/TrEMBL
UniProt	A6IC31	ENTREZGENE, UniProtKB/TrEMBL
	F1M0Q9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-02	Pm20d1	peptidase M20 domain containing 1	RGD1564063	similar to hypothetical protein FLJ32569	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1564063	similar to hypothetical protein FLJ32569	RGD1564063_predicted	similar to hypothetical protein FLJ32569 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1564063_predicted	similar to hypothetical protein FLJ32569 (predicted)	LOC498226	similar to hypothetical protein FLJ32569	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498226	similar to hypothetical protein FLJ32569			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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