Ndufb11 (NADH:ubiquinone oxidoreductase subunit B11) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ndufb11 (NADH:ubiquinone oxidoreductase subunit B11) Rattus norvegicus
Analyze
Symbol: Ndufb11
Name: NADH:ubiquinone oxidoreductase subunit B11
RGD ID: 1563698
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299310; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; RGD1563698; similar to neuronal protein 15.6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,126,317 - 4,128,575 (+)NCBIGRCr8
mRatBN7.2X1,572,805 - 1,575,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,572,785 - 1,575,062 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,606,809 - 1,609,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,082,507 - 5,084,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,397,809 - 1,400,067 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,787,266 - 1,789,524 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,787,266 - 1,789,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,580,319 - 2,582,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,989,912 - 12,992,170 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,136,744 - 2,139,002 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12611891   PMID:14651853   PMID:18614015   PMID:21700703   PMID:27626371   PMID:28844695  


Genomics

Comparative Map Data
Ndufb11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,126,317 - 4,128,575 (+)NCBIGRCr8
mRatBN7.2X1,572,805 - 1,575,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,572,785 - 1,575,062 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,606,809 - 1,609,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,082,507 - 5,084,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,397,809 - 1,400,067 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,787,266 - 1,789,524 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,787,266 - 1,789,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,580,319 - 2,582,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,989,912 - 12,992,170 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,136,744 - 2,139,002 (+)NCBICelera
Cytogenetic MapXq11NCBI
NDUFB11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,142,216 - 47,145,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,142,071 - 47,145,466 (-)EnsemblGRCh38hg38GRCh38
GRCh37X47,001,615 - 47,004,890 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,886,563 - 46,889,381 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X46,757,872 - 46,760,691NCBI
CeleraX51,196,935 - 51,199,928 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,714,096 - 44,714,626 (-)NCBIHuRef
CHM1_1X47,033,379 - 47,036,366 (-)NCBICHM1_1
T2T-CHM13v2.0X46,551,936 - 46,555,216 (-)NCBIT2T-CHM13v2.0
Ndufb11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,481,565 - 20,483,858 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,481,565 - 20,483,858 (-)EnsemblGRCm39 Ensembl
GRCm38X20,615,326 - 20,617,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,615,326 - 20,617,619 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X20,192,452 - 20,194,690 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,772,285 - 19,774,513 (-)NCBIMGSCv36mm8
CeleraX18,746,089 - 18,748,327 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.11NCBI
Ndufb11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516934,740 - 937,207 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955516934,740 - 937,207 (+)NCBIChiLan1.0ChiLan1.0
NDUFB11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,770,012 - 48,772,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,773,388 - 48,775,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,579,460 - 39,582,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,437,573 - 47,440,578 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,437,573 - 47,440,578 (-)Ensemblpanpan1.1panPan2
NDUFB11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,744,408 - 40,746,831 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,744,408 - 40,746,837 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,119,865 - 15,122,300 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,878,921 - 40,881,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,878,921 - 40,881,350 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,866,623 - 40,869,058 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,854,280 - 40,856,715 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,947,370 - 40,949,805 (-)NCBIUU_Cfam_GSD_1.0
Ndufb11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,068,679 - 33,082,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,921,370 - 12,923,683 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,921,371 - 12,923,702 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFB11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,770,941 - 41,774,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,770,929 - 41,773,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,878,471 - 46,881,284 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFB11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,336,626 - 44,339,635 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,336,285 - 44,340,109 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,594,336 - 9,597,626 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufb11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,918,432 - 3,921,348 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,919,109 - 3,921,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufb11
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000011183
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000011183   ⟹   ENSRNOP00000011183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,572,785 - 1,575,062 (+)Ensembl
Rnor_6.0 EnsemblX1,787,266 - 1,789,524 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102219   ⟹   ENSRNOP00000096047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,572,785 - 1,574,964 (+)Ensembl
RefSeq Acc Id: NM_001106756   ⟹   NP_001100226
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,126,317 - 4,128,575 (+)NCBI
mRatBN7.2X1,572,805 - 1,575,063 (+)NCBI
Rnor_6.0X1,787,266 - 1,789,524 (+)NCBI
Rnor_5.0X2,580,319 - 2,582,577 (+)NCBI
RGSC_v3.4X12,989,912 - 12,992,170 (+)RGD
CeleraX2,136,744 - 2,139,002 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97698 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011183
  ENSRNOP00000011183.4
  ENSRNOP00000096047.1
RefSeq Acc Id: NP_001100226   ⟸   NM_001106756
- UniProtKB: D4A7L4 (UniProtKB/TrEMBL),   A6JZT7 (UniProtKB/TrEMBL),   A0A8I6AUJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011183   ⟸   ENSRNOT00000011183
RefSeq Acc Id: ENSRNOP00000096047   ⟸   ENSRNOT00000102219

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7L4-F1-model_v2 AlphaFold D4A7L4 1-151 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701697
Promoter ID:EPDNEW_R12221
Type:multiple initiation site
Name:Ndufb11_1
Description:NADH:ubiquinone oxidoreductase subunit B11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X1,787,253 - 1,787,313EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563698 AgrOrtholog
BioCyc Gene G2FUF-3186 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
Ensembl Genes ENSRNOG00000008329 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011183 ENTREZGENE
  ENSRNOT00000011183.5 UniProtKB/TrEMBL
  ENSRNOT00000102219.1 UniProtKB/TrEMBL
InterPro NADH_UbQ_OxRdtase_ESSS_su UniProtKB/TrEMBL
KEGG Report rno:299310 UniProtKB/TrEMBL
NCBI Gene 299310 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR13327 UniProtKB/TrEMBL
Pfam ESSS UniProtKB/TrEMBL
PhenoGen Ndufb11 PhenoGen
RatGTEx ENSRNOG00000008329 RatGTEx
UniProt A0A8I6AUJ7 ENTREZGENE, UniProtKB/TrEMBL
  A6JZT7 ENTREZGENE, UniProtKB/TrEMBL
  D4A7L4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Ndufb11  NADH:ubiquinone oxidoreductase subunit B11  Ndufb11  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ndufb11  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11   Ndufb11_predicted  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ndufb11_predicted  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 (predicted)  RGD1563698_predicted  similar to neuronal protein 15.6 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563698_predicted  similar to neuronal protein 15.6 (predicted)  LOC299310  similar to neuronal protein 15.6  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299310  similar to neuronal protein 15.6      Symbol and Name status set to provisional 70820 PROVISIONAL