Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Demecolcine results in increased expression of UBR4 mRNA | CTD | PMID:23649840 | 1,2-dimethylhydrazine | affects expression | ISO | Ubr4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of UBR4 mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | UBR4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ubr4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UBR4 mRNA | CTD | PMID:23238561 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UBR4 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of UBR4 mRNA | CTD | PMID:21215274 more ... | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of UBR4 mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of UBR4 mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of UBR4 mRNA | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | [bisphenol S co-treated with LIF protein] results in decreased expression of UBR4 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | UBR4 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of UBR4 gene | CTD | PMID:31601247 | aflatoxin B1 | increases expression | ISO | Ubr4 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of UBR4 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | UBR4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of UBR4 exon | CTD | PMID:30157460 | aflatoxin B1 | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of UBR4 mRNA | CTD | PMID:27153756 | aflatoxin B1 | decreases methylation | ISO | UBR4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of UBR4 gene | CTD | PMID:27153756 | arsenite(3-) | multiple interactions | ISO | UBR4 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to UBR4 mRNA] | CTD | PMID:32406909 | atrazine | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Atrazine results in increased expression of UBR4 mRNA | CTD | PMID:22378314 | bazedoxifene | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | bazedoxifene results in increased expression of UBR4 mRNA | CTD | PMID:19914376 | benzo[a]pyrene | increases mutagenesis | ISO | UBR4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of UBR4 gene | CTD | PMID:25435355 | benzo[a]pyrene | decreases methylation | ISO | UBR4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of UBR4 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | Ubr4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of UBR4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of UBR4 mRNA | CTD | PMID:21632981 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of UBR4 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | UBR4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of UBR4 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of UBR4 mRNA | CTD | PMID:32145629 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of UBR4 mRNA | CTD | PMID:30816183 | bisphenol A | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | [bisphenol A co-treated with LIF protein] results in decreased expression of UBR4 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of UBR4 protein | CTD | PMID:34186270 | cadmium atom | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of UBR4 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of UBR4 mRNA | CTD | PMID:37325564 | caffeine | affects phosphorylation | ISO | UBR4 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of UBR4 protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | UBR4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to UBR4 gene] | CTD | PMID:28238834 | cisplatin | decreases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of UBR4 mRNA | CTD | PMID:27594783 | clobetasol | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of UBR4 mRNA | CTD | PMID:27462272 | clofibrate | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of UBR4 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBR4 mRNA] | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of UBR4 mRNA | CTD | PMID:17585979 | cobalt dichloride | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of UBR4 mRNA | CTD | PMID:19320972 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of UBR4 mRNA | CTD | PMID:20187946 | copper atom | multiple interactions | ISO | UBR4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of UBR4 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | UBR4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of UBR4 mRNA | CTD | PMID:20971185 | copper(II) sulfate | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of UBR4 mRNA | CTD | PMID:19549813 | coumarin | affects phosphorylation | ISO | UBR4 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of UBR4 protein | CTD | PMID:35688186 | cyclosporin A | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of UBR4 mRNA | CTD | PMID:20106945 and PMID:25562108 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of UBR4 mRNA | CTD | PMID:23914054 | dicrotophos | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of UBR4 mRNA | CTD | PMID:28302478 | endosulfan | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Endosulfan results in increased expression of UBR4 mRNA | CTD | PMID:26615145 | ethanol | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | Ethanol results in decreased expression of UBR4 mRNA | CTD | PMID:29018328 | ethanol | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of UBR4 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of UBR4 mRNA | CTD | PMID:30307764 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of UBR4 mRNA | CTD | PMID:34044035 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of UBR4 mRNA | CTD | PMID:24136188 | formaldehyde | decreases expression | EXP | | 6480464 | Formaldehyde results in decreased expression of UBR4 mRNA | CTD | PMID:24304932 | FR900359 | affects phosphorylation | ISO | UBR4 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of UBR4 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | UBR4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of UBR4 gene | CTD | PMID:31601247 | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of UBR4 gene | CTD | PMID:35440735 | hexadecanoic acid | decreases phosphorylation | ISO | UBR4 (Homo sapiens) | 6480464 | Palmitic Acid results in decreased phosphorylation of UBR4 protein | CTD | PMID:28073184 | hydrogen peroxide | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | [Hydrogen Peroxide co-treated with N-(oxo-5 more ... | CTD | PMID:31494107 | ivermectin | decreases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of UBR4 protein | CTD | PMID:32959892 | lead(0) | affects methylation | ISO | UBR4 (Homo sapiens) | 6480464 | Lead affects the methylation of UBR4 gene | CTD | PMID:31636367 | menadione | affects expression | ISO | UBR4 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of UBR4 mRNA | CTD | PMID:20044591 | mercury dichloride | increases expression | EXP | | 6480464 | Mercuric Chloride results in increased expression of UBR4 mRNA | CTD | PMID:16507785 | Mesaconitine | increases expression | EXP | | 6480464 | mesaconitine results in increased expression of UBR4 protein | CTD | PMID:37182599 | methamphetamine | increases expression | ISO | Ubr4 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of UBR4 mRNA | CTD | PMID:26307267 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of UBR4 gene | CTD | PMID:35440735 | methyl methanesulfonate | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of UBR4 mRNA | CTD | PMID:23649840 | miconazole | affects expression | ISO | Ubr4 (Mus musculus) | 6480464 | Miconazole affects the expression of UBR4 mRNA | CTD | PMID:27462272 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of UBR4 mRNA | CTD | PMID:24136188 | paracetamol | affects expression | ISO | Ubr4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of UBR4 mRNA | CTD | PMID:17562736 | paracetamol | multiple interactions | ISO | Ubr4 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of UBR4 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBR4 mRNA] | CTD | PMID:17585979 | perfluorohexanesulfonic acid | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of UBR4 mRNA | CTD | PMID:37995155 | pirinixic acid | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of UBR4 mRNA | CTD | PMID:17426115 | quercetin | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Quercetin results in increased expression of UBR4 mRNA | CTD | PMID:21632981 | rac-lactic acid | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of UBR4 mRNA | CTD | PMID:30851411 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of UBR4 protein | CTD | PMID:35544339 | SB 431542 | multiple interactions | ISO | UBR4 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of UBR4 protein | CTD | PMID:37664457 | sodium arsenite | decreases expression | ISO | UBR4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of UBR4 mRNA | CTD | PMID:29301061 | sunitinib | decreases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of UBR4 mRNA | CTD | PMID:31533062 | tebuconazole | decreases expression | ISO | UBR4 (Homo sapiens) | 6480464 | tebuconazole results in decreased expression of UBR4 mRNA | CTD | PMID:30458266 | triptonide | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | triptonide results in decreased expression of UBR4 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | troglitazone results in decreased expression of UBR4 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Ubr4 (Mus musculus) | 6480464 | Tungsten results in decreased expression of UBR4 mRNA | CTD | PMID:30912803 | tunicamycin | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of UBR4 mRNA | CTD | PMID:22378314 and PMID:29453283 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of UBR4 mRNA | CTD | PMID:29427782 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of UBR4 mRNA | CTD | PMID:19015723 | vincristine | increases expression | ISO | UBR4 (Homo sapiens) | 6480464 | Vincristine results in increased expression of UBR4 mRNA | CTD | PMID:23649840 | |