Zg16b (zymogen granule protein 16B) - Rat Genome Database

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Gene: Zg16b (zymogen granule protein 16B) Rattus norvegicus
Analyze
Symbol: Zg16b
Name: zymogen granule protein 16B
RGD ID: 1562673
Description: Predicted to be involved in cell migration. Predicted to be located in apicolateral plasma membrane; cytoplasm; and extracellular region. Orthologous to human ZG16B (zymogen granule protein 16B); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC363551; LOC363551; pancreatic adenocarcinoma up-regulated factor; RGD1562673; Sbpl; similar to Prostatic spermine-binding protein precursor (SBP); spermine binding protein-like; uncharacterized protein LOC363551; zymogen granule protein 16 homolog B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,484,327 - 13,488,745 (-)NCBIGRCr8
mRatBN7.21012,970,888 - 12,984,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,979,020 - 12,983,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,724,544 - 17,728,945 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,213,330 - 17,217,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,712,330 - 12,716,751 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,320,716 - 13,325,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,311,789 - 13,324,536 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,122,291 - 13,125,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,199,752 - 13,203,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1012,666,294 - 12,669,428 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16502470   PMID:19056867   PMID:19199708   PMID:22664934   PMID:23376485   PMID:23533145   PMID:23580065  


Genomics

Comparative Map Data
Zg16b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,484,327 - 13,488,745 (-)NCBIGRCr8
mRatBN7.21012,970,888 - 12,984,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,979,020 - 12,983,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,724,544 - 17,728,945 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,213,330 - 17,217,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,712,330 - 12,716,751 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,320,716 - 13,325,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,311,789 - 13,324,536 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,122,291 - 13,125,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,199,752 - 13,203,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1012,666,294 - 12,669,428 (-)NCBICelera
Cytogenetic Map10q12NCBI
ZG16B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,830,303 - 2,832,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,830,253 - 2,839,585 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,880,304 - 2,882,277 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,820,174 - 2,822,286 (+)NCBINCBI36Build 36hg18NCBI36
Celera163,080,104 - 3,082,216 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,846,843 - 2,848,955 (+)NCBIHuRef
CHM1_1162,880,206 - 2,882,318 (+)NCBICHM1_1
T2T-CHM13v2.0162,850,876 - 2,852,849 (+)NCBIT2T-CHM13v2.0
Sbpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,172,059 - 24,174,247 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,172,058 - 24,174,248 (-)EnsemblGRCm39 Ensembl
GRCm381723,953,085 - 23,955,273 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1723,953,084 - 23,955,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,090,052 - 24,092,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,090,052 - 24,092,240 (-)NCBIMGSCv36mm8
Celera1724,462,847 - 24,468,075 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.16NCBI
Zg16b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544214,569,492 - 14,572,282 (+)NCBIChiLan1.0ChiLan1.0
ZG16B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,353,067 - 3,358,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,132,115 - 7,137,059 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,735,300 - 1,737,405 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ZG16B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,353,189 - 38,355,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,352,772 - 38,355,180 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,592,472 - 39,594,373 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,663,255 - 38,665,157 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1638,348,456 - 38,350,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,321,122 - 38,323,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,797,144 - 38,799,045 (+)NCBIUU_Cfam_GSD_1.0
Zg16b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,354,113 - 105,356,001 (-)NCBIHiC_Itri_2
ZG16B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1339,334,122 - 39,336,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Zg16b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624824516,134 - 520,668 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zg16b
172 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 11 27 11 19 11 8 10 49 33 39 11 8
Below cutoff 32 30 30 30 1 25 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080810   ⟹   ENSRNOP00000074401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1012,979,917 - 12,983,572 (-)Ensembl
Rnor_6.0 Ensembl1013,320,716 - 13,323,849 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082035   ⟹   ENSRNOP00000070366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1012,979,020 - 12,983,572 (-)Ensembl
Rnor_6.0 Ensembl1013,311,789 - 13,324,536 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091772   ⟹   ENSRNOP00000070954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1013,320,877 - 13,323,796 (-)Ensembl
RefSeq Acc Id: NM_001108823   ⟹   NP_001102293
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,484,327 - 13,488,745 (-)NCBI
mRatBN7.21012,979,752 - 12,984,170 (-)NCBI
Rnor_6.01013,320,716 - 13,323,849 (-)NCBI
Rnor_5.01013,122,291 - 13,125,343 (+)NCBI
RGSC_v3.41013,199,752 - 13,203,289 (-)RGD
Celera1012,666,294 - 12,669,428 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269492   ⟹   XP_063125562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,484,332 - 13,487,459 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102293 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125562 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI67085 (Get FASTA)   NCBI Sequence Viewer  
  EDM03796 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070366.2
  ENSRNOP00000074401
  ENSRNOP00000074401.2
Reference Protein Sequences
RefSeq Acc Id: NP_001102293   ⟸   NM_001108823
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000074401   ⟸   ENSRNOT00000080810
RefSeq Acc Id: ENSRNOP00000070366   ⟸   ENSRNOT00000082035
RefSeq Acc Id: ENSRNOP00000070954   ⟸   ENSRNOT00000091772
RefSeq Acc Id: XP_063125562   ⟸   XM_063269492
- Peptide Label: isoform X1
Protein Domains
Jacalin-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K7Y9-F1-model_v2 AlphaFold A0A0G2K7Y9 1-237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562673 AgrOrtholog
BioCyc Gene G2FUF-25890 BioCyc
Ensembl Genes ENSRNOG00000057127 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080810 ENTREZGENE
  ENSRNOT00000080810.2 UniProtKB/TrEMBL
  ENSRNOT00000082035.2 UniProtKB/TrEMBL
Gene3D-CATH 2.100.10.30 UniProtKB/TrEMBL
InterPro Jacalin-like_lectin_dom_sf UniProtKB/TrEMBL
  Mannose-bd_lectin UniProtKB/TrEMBL
KEGG Report rno:363551 UniProtKB/TrEMBL
NCBI Gene 363551 ENTREZGENE
PANTHER OS11G0524900 PROTEIN UniProtKB/TrEMBL
  ZYMOGEN GRANULE PROTEIN 16 HOMOLOG B UniProtKB/TrEMBL
Pfam Jacalin UniProtKB/TrEMBL
PhenoGen Zg16b PhenoGen
PROSITE JACALIN_LECTIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057127 RatGTEx
SMART Jacalin UniProtKB/TrEMBL
Superfamily-SCOP Mannose-bd_lectin UniProtKB/TrEMBL
UniProt A0A0G2JXQ6_RAT UniProtKB/TrEMBL
  A0A0G2K7Y9_RAT UniProtKB/TrEMBL
  A6HCP1_RAT UniProtKB/TrEMBL
  B2RZA7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-19 Zg16b  zymogen granule protein 16B  Sbpl  spermine binding protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-01 Sbpl  spermine binding protein-like  RGD1562673  similar to Prostatic spermine-binding protein precursor (SBP)  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1562673  similar to Prostatic spermine-binding protein precursor (SBP)   RGD1562673_predicted  similar to Prostatic spermine-binding protein precursor (SBP) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562673_predicted  similar to Prostatic spermine-binding protein precursor (SBP) (predicted)  LOC363551  similar to Prostatic spermine-binding protein precursor (SBP)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363551  similar to Prostatic spermine-binding protein precursor (SBP)      Symbol and Name status set to provisional 70820 PROVISIONAL