Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of IRAG2 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of IRAG2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Irag2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of IRAG2 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of IRAG2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Irag2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRAG2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | IRAG2 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of IRAG2 mRNA | CTD | PMID:30165855 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IRAG2 mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IRAG2 mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Irag2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of IRAG2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IRAG2 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Irag2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRAG2 mRNA | CTD | PMID:17942748 | 2-butoxyethanol | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | n-butoxyethanol results in decreased expression of IRAG2 mRNA | CTD | PMID:19812364 | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of IRAG2 mRNA | CTD | PMID:21061450 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Irag2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of IRAG2 promoter | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of IRAG2 mRNA | CTD | PMID:26251327 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of IRAG2 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of IRAG2 protein | CTD | PMID:34186270 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of IRAG2 mRNA | CTD | PMID:28973697 | aflatoxin B1 | affects expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of IRAG2 protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of IRAG2 mRNA | CTD | PMID:22100608 and PMID:27153756 | arsenite(3-) | increases methylation | ISO | IRAG2 (Homo sapiens) | 6480464 | arsenite results in increased methylation of IRAG2 promoter | CTD | PMID:23974009 | benzo[a]pyrene | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of IRAG2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | IRAG2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of IRAG2 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Irag2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of IRAG2 mRNA | CTD | PMID:27858113 | benzo[a]pyrene | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of IRAG2 mRNA | CTD | PMID:22228805 and PMID:27195522 | benzo[a]pyrene | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of IRAG2 mRNA | CTD | PMID:21569818 | benzo[b]fluoranthene | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of IRAG2 mRNA | CTD | PMID:26377693 | benzo[b]fluoranthene | multiple interactions | ISO | Irag2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of IRAG2 mRNA | CTD | PMID:27858113 | bis(2-chloroethyl) sulfide | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of IRAG2 mRNA | CTD | PMID:15674844 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of IRAG2 mRNA | CTD | PMID:25181051 | bisphenol A | affects expression | ISO | IRAG2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of IRAG2 protein | CTD | PMID:34186270 | bisphenol A | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of IRAG2 mRNA | CTD | PMID:32156529 | Bisphenol B | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of IRAG2 protein | CTD | PMID:34186270 | bisphenol F | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of IRAG2 protein | CTD | PMID:34186270 | buta-1,3-diene | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of IRAG2 mRNA | CTD | PMID:29038090 | cadmium atom | multiple interactions | ISO | IRAG2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IRAG2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | IRAG2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IRAG2 mRNA | CTD | PMID:35301059 | carbon nanotube | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of IRAG2 mRNA | CTD | PMID:25554681 | carmustine | decreases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Carmustine results in decreased expression of IRAG2 mRNA | CTD | PMID:15980968 | chloroprene | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of IRAG2 mRNA | CTD | PMID:23125180 | chlorpyrifos | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of IRAG2 mRNA | CTD | PMID:32715474 | chrysene | multiple interactions | ISO | Irag2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of IRAG2 mRNA | CTD | PMID:27858113 | cisplatin | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of IRAG2 mRNA | CTD | PMID:27594783 | curcumin | decreases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Curcumin results in decreased expression of IRAG2 mRNA | CTD | PMID:17198877 | cyclophosphamide | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | Cyclophosphamide results in decreased expression of IRAG2 mRNA | CTD | PMID:21041162 | dexamethasone | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of IRAG2 mRNA | CTD | PMID:21041162 | diethylstilbestrol | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | Diethylstilbestrol results in decreased expression of IRAG2 mRNA | CTD | PMID:21041162 | epoxiconazole | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of IRAG2 mRNA | CTD | PMID:35436446 | ethyl methanesulfonate | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of IRAG2 mRNA | CTD | PMID:23649840 | formaldehyde | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of IRAG2 mRNA | CTD | PMID:23649840 | lead diacetate | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | lead acetate results in decreased expression of IRAG2 mRNA | CTD | PMID:21829687 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of IRAG2 gene | CTD | PMID:35440735 | methyl methanesulfonate | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of IRAG2 mRNA | CTD | PMID:23649840 | nickel atom | increases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Nickel results in increased expression of IRAG2 mRNA | CTD | PMID:25583101 | ozone | multiple interactions | ISO | Irag2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of IRAG2 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of IRAG2 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | Irag2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of IRAG2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of IRAG2 mRNA | CTD | PMID:17585979 | pirinixic acid | decreases expression | ISO | Irag2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of IRAG2 mRNA | CTD | PMID:17426115 | quercetin | decreases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of IRAG2 protein | CTD | PMID:19207037 | resveratrol | multiple interactions | ISO | IRAG2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of IRAG2 mRNA | CTD | PMID:23557933 | silicon dioxide | decreases expression | ISO | IRAG2 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of IRAG2 mRNA | CTD | PMID:25351596 | tamoxifen | affects expression | ISO | Irag2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of IRAG2 mRNA | CTD | PMID:17555576 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IRAG2 mRNA | CTD | PMID:32741896 | tetraphene | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of IRAG2 mRNA | CTD | PMID:26377693 | tetraphene | multiple interactions | ISO | Irag2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of IRAG2 mRNA | CTD | PMID:27858113 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of IRAG2 mRNA | CTD | PMID:23411599 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of IRAG2 mRNA | CTD | PMID:34492290 | triptonide | increases expression | ISO | Irag2 (Mus musculus) | 6480464 | triptonide results in increased expression of IRAG2 mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | Irag2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of IRAG2 mRNA | CTD | PMID:17292431 | |