Ptges3 (prostaglandin E synthase 3)

Gene: Ptges3 (prostaglandin E synthase 3) Rattus norvegicus

Analyze

Symbol:

Ptges3

Name:

prostaglandin E synthase 3

RGD ID:

1561913

Description:

Enables several functions, including Hsp90 protein binding activity; p53 binding activity; and prostaglandin-E synthase activity. Involved in neuron apoptotic process; positive regulation of gene expression; and prostaglandin biosynthetic process. Located in actin filament; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human PTGES3 (prostaglandin E synthase 3); PARTICIPATES IN aldosterone signaling pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cPGES; cytosolic prostaglandin E2 synthase; hsp90 co-chaperone; LOC362809; MGC188278; progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); prostaglandin-E synthase 3; RGD1561913; similar to Sid3177p; telomerase-binding protein p23

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTGES3 (prostaglandin E synthase 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ptges3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ptges3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTGES3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PTGES3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ptges3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PTGES3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PTGES3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ptges3 (prostaglandin E synthase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NIPA2 (NIPA magnesium transporter 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PTGES3 (prostaglandin E synthase 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ptges3 (prostaglandin E synthase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptges3b (prostaglandin E synthase 3b (cytosolic))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Danio rerio (zebrafish):	ptges3a (prostaglandin E synthase 3a (cytosolic))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	daf-41	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SBA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	p23	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ptges3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,075,230 - 1,092,363 (+)	NCBI		GRCr8
mRatBN7.2	7	490,698 - 507,759 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	490,656 - 508,084 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,248,927 - 3,266,205 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,124,939 - 5,142,219 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,426,505 - 5,443,663 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,479,267 - 2,497,024 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,479,311 - 2,497,013 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,459,082 - 2,476,400 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,351,206 - 1,368,857 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	370,050 - 386,953 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atherosclerosis (ISO)

autism spectrum disorder (ISO)

breast cancer (ISO)

Experimental Arthritis (IEP)

genetic disease (ISO)

Hyperalgesia (IMP)

oligodendroglioma (ISO)

toxic encephalopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

albendazole (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (EXP,ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

beauvericin (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

chelerythrine (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (EXP)

cyclosporin A (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

disulfiram (ISO)

enniatin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

hexadecanoic acid (ISO)

hydrogen peroxide (ISO)

hypochlorous acid (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

mancozeb (ISO)

mercury dichloride (EXP)

methimazole (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (EXP)

nickel subsulfide (EXP)

paclitaxel (ISO)

perfluorooctane-1-sulfonic acid (ISO)

PhIP (EXP)

quercetin (ISO)

reactive oxygen species (ISO)

resveratrol (ISO)

serpentine asbestos (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium chloride (EXP)

sodium dichromate (EXP)

staurosporine (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP)

trichloroethene (ISO)

uranium atom (ISO)

valdecoxib (EXP)

vincaleukoblastine (ISO)

vorinostat (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chaperone cofactor-dependent protein refolding (ISO)

chaperone-mediated protein complex assembly (IBA,IEA,ISO)

fibroblast proliferation (IEA,ISO)

glucocorticoid receptor signaling pathway (IEA,ISO)

glycogen biosynthetic process (IEA,ISO)

lung saccule development (IEA,ISO)

neuron apoptotic process (IMP)

positive regulation of gene expression (IMP)

positive regulation of phosphorylation (ISO)

prostaglandin biosynthetic process (IBA,IDA,IEA,IMP,ISO,ISS)

prostaglandin metabolic process (IMP)

protein folding (IBA,IEA)

protein stabilization (ISO)

skin development (IEA,ISO)

telomerase holoenzyme complex assembly (IBA,IEA,ISO)

telomere maintenance via telomerase (IBA,IEA,ISO)

Cellular Component

actin filament (IDA)

cytosol (IBA,IEA)

neuronal cell body (IDA)

nucleus (IBA,IEA)

perinuclear region of cytoplasm (IDA)

protein folding chaperone complex (ISO)

protein-containing complex (IDA,ISO)

telomerase holoenzyme complex (ISO)

Molecular Function

DNA polymerase binding (IEA,ISO)

enzyme binding (IPI)

Hsp90 protein binding (IBA,IDA,IEA,ISO)

p53 binding (IDA)

prostaglandin-E synthase activity (IBA,IDA,IEA,ISO,ISS)

protein binding (ISO)

protein-folding chaperone binding (IBA,IEA)

telomerase activity (ISO)

unfolded protein binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

aldosterone signaling pathway (ISO)

cortisol signaling pathway (ISO)

estrogen signaling pathway (ISO)

prostaglandin biosynthetic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.	Chinta SJ, etal., J Mol Neurosci. 2009 Sep;39(1-2):157-68. Epub 2009 Jan 15.
2.	Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model.	Claveau D, etal., J Immunol. 2003 May 1;170(9):4738-44.
3.	Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton.	Czar MJ, etal., Eur J Cell Biol. 1996 Aug;70(4):322-30.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Prostanoids as regulators of innate and adaptive immunity.	Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
6.	Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats.	Hofacker A, etal., J Neurosci. 2005 Sep 28;25(39):9005-9.
7.	Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn.	Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
8.	Cytosolic prostaglandin E2 synthase/p23 but not apoptosis-linked gene 2 is downregulated in human atherosclerotic plaques.	Martinet W, etal., Cardiovasc Res. 2004 Feb 1;61(2):360-1.
9.	The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.	Mattila S, etal., Neuropathology. 2009 Apr;29(2):156-65.
10.	Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH.	Nakatani Y, etal., Prostaglandins Other Lipid Mediat. 2011 Apr;94(3-4):112-7. Epub 2011 Feb 17.
11.	Chaperoning of glucocorticoid receptors.	Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
12.	Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth.	Quinta HR, etal., J Neurochem. 2010 Nov;115(3):716-34. doi: 10.1111/j.1471-4159.2010.06970.x. Epub 2010 Sep 28.
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance.	Simpson NE, etal., Cancer Res. 2010 Nov 1;70(21):8446-56. Epub 2010 Sep 16.
16.	Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions.	Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
17.	Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein.	Tanioka T, etal., Biochem Biophys Res Commun. 2003 Apr 18;303(4):1018-23.
18.	Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis.	Tanioka T, etal., J Biol Chem. 2000 Oct 20;275(42):32775-82.
19.	Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain.	Vazquez-Tello A, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Nov;287(5):R1155-63. Epub 2004 Jul 29.
20.	The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.	Whitesell L, etal., Mol Cell Biol. 1998 Mar;18(3):1517-24.
21.	Interactions of the mineralocorticoid receptor--within and without.	Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.

Additional References at PubMed

PMID:10197982	PMID:10543959	PMID:10811660	PMID:12077419	PMID:12135483	PMID:12477932	PMID:12853476	PMID:17438133	PMID:19740745	PMID:19751963	PMID:21630459	PMID:22871113
PMID:23376485	PMID:29093345	PMID:29127155

Genomics

Comparative Map Data

Ptges3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,075,230 - 1,092,363 (+)	NCBI		GRCr8
mRatBN7.2	7	490,698 - 507,759 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	490,656 - 508,084 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,248,927 - 3,266,205 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,124,939 - 5,142,219 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,426,505 - 5,443,663 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,479,267 - 2,497,024 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,479,311 - 2,497,013 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,459,082 - 2,476,400 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,351,206 - 1,368,857 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	370,050 - 386,953 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

PTGES3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	56,663,349 - 56,688,284 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	56,663,341 - 56,688,408 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	57,057,133 - 57,082,068 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	55,343,649 - 55,368,156 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	56,709,596 - 56,735,126 (-)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,096,410 - 54,121,394 (-)	NCBI		HuRef
CHM1_1	12	57,024,664 - 57,049,890 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	56,631,338 - 56,658,334 (-)	NCBI		T2T-CHM13v2.0

Ptges3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,894,851 - 127,913,123 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	127,894,823 - 127,913,141 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,058,982 - 128,077,254 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,058,954 - 128,077,272 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	127,496,038 - 127,514,310 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	127,461,931 - 127,480,203 (+)	NCBI		MGSCv36	mm8
Celera	10	130,453,617 - 130,471,989 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	76.39	NCBI

Ptges3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	4,203,076 - 4,209,910 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	4,203,075 - 4,209,967 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTGES3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	37,634,948 - 37,663,906 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	37,634,392 - 37,660,421 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	32,221,908 - 32,247,228 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	32,475,989 - 32,503,181 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	32,476,835 - 32,503,181 (+)	Ensembl	panpan1.1		panPan2

PTGES3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	885,744 - 903,814 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	870,392 - 909,161 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	948,938 - 967,016 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	895,074 - 912,966 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	879,724 - 919,087 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	871,924 - 889,991 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	1,115,085 - 1,132,100 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	1,238,847 - 1,256,742 (-)	NCBI		UU_Cfam_GSD_1.0

Ptges3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	57,879,818 - 57,900,555 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936646	969,674 - 990,532 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTGES3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,000,341 - 22,021,660 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	22,000,335 - 22,022,830 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	23,674,707 - 23,696,337 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTGES3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,609,460 - 52,634,490 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	193,344,739 - 193,370,949 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptges3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	11,360,041 - 11,395,390 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	11,360,056 - 11,392,911 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ptges3
75 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	82
Interacting mature miRNAs:	92
Transcripts:	ENSRNOT00000003787
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat

Markers in Region

RH127823

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	507,474 - 507,667 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	2,496,729 - 2,496,921	NCBI	Rnor6.0
Rnor_5.0	7	2,476,116 - 2,476,308	UniSTS	Rnor5.0
RGSC_v3.4	7	1,368,573 - 1,368,765	UniSTS	RGSC3.4
Celera	7	386,669 - 386,861	UniSTS
Cytogenetic Map	X	q22	UniSTS
Cytogenetic Map	7	q11	UniSTS

UniSTS:234880

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	138,422,800 - 138,423,071 (-)	MAPPER	mRatBN7.2
mRatBN7.2	3	138,422,800 - 138,423,071 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	139,113,719 - 139,113,990 (-)	MAPPER	mRatBN7.2
mRatBN7.2	3	139,113,719 - 139,113,990 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	145,442,092 - 145,442,362	NCBI	Rnor6.0
Rnor_6.0	3	145,989,568 - 145,989,838	NCBI	Rnor6.0
Rnor_5.0	3	152,350,261 - 152,350,531	UniSTS	Rnor5.0
Rnor_5.0	3	151,809,970 - 151,810,240	UniSTS	Rnor5.0
RGSC_v3.4	3	140,062,377 - 140,062,647	UniSTS	RGSC3.4
Celera	3	137,871,890 - 137,872,160	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001130989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000003787 ⟹ ENSRNOP00000003787

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	490,656 - 507,752 (+)	Ensembl
Rnor_6.0 Ensembl	7	2,479,311 - 2,497,013 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094676 ⟹ ENSRNOP00000082352

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	490,703 - 507,571 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097034 ⟹ ENSRNOP00000080703

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	499,952 - 507,571 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097314 ⟹ ENSRNOP00000085230

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	499,595 - 508,084 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097618 ⟹ ENSRNOP00000096830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	499,609 - 508,084 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101866 ⟹ ENSRNOP00000096607

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	491,055 - 508,084 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104676 ⟹ ENSRNOP00000096677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	490,679 - 508,084 (+)	Ensembl

RefSeq Acc Id:

NM_001130989 ⟹ NP_001124461

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,075,309 - 1,092,363 (+)	NCBI
mRatBN7.2	7	490,698 - 507,759 (+)	NCBI
Rnor_6.0	7	2,479,311 - 2,497,013 (+)	NCBI
Rnor_5.0	7	2,459,082 - 2,476,400 (+)	NCBI
RGSC_v3.4	7	1,351,206 - 1,368,857 (+)	RGD
Celera	7	370,050 - 386,953 (+)	RGD

Sequence:

show sequence

CAGCCGCCGCCCGGCCTCACCACCCCTCGCGCGCACGCACGCTCCTTCTCCGTCCTCGCGCCCC
TTTTCCTACACTTTCCTCCTCTCCCGGGCTGAGGGAGCCGCTCTCCGCGCGTTGCATTCTGGGC
ATCGAGGCCGAGCCCGCCGCTGCCGCCGCCGTCGCCTAAGGGGAACGAGGAGAGGCCGCGACCG
GGTAGAGACCGCCGGAGTCGCTGCCGGAGAGGAGTCGACTCGCCAGCCGCCGCCAGCGAGGCCC
GCCCACCCGTTCGCCTGGCCCTCTGCCCCGTTCACCATGCAGCCTGCTTCTGCAAAGTGGTACG
ACCGAAGGGACTATGTATTCATTGAATTTTGTGTTGAAGACAGTAAAGATGTTAATGTAAACTT
TGAAAAATCCAAACTTACTTTCAGTTGTCTTGGAGGAAGTGATAATTTTAAGCATTTAAATGAA
ATTGATCTTTTTCATTGTATTGATCCAAATGATTCCAAGCATAAAAGAACGGACAGATCGATTT
TATGTTGTTTGCGAAAAGGAGAATCCGGCCAATCCTGGCCTAGGTTAACAAAGGAAAGGGCAAA
GCTTAATTGGCTTAGTGTGGACTTCAATAATTGGAAAGATTGGGAGGATGACTCAGATGAAGAC
ATGTCTAATTTTGACCGTTTCTCTGAGATGATGGATCACATGGGTGGTGATGAGGATGTAGATT
TACCAGAAGTAGACGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCT
GGAGTAAAGAGTGGTATCATCGCCTGGATATTGAGGGGAAAAAAATAACTTCTGCAAGATTTCA
TAATTGAGAAAATCCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTACTTGGCTCCTTTAAC
CCATTTTTCAACTTTTTTTTTTTTTAAGGCTTCACTAAGGGTTGATTATGTACCATTGTATGGG
GCAATTTAAGTCAGCTAAGGCAATATCCGTATGCATGAACATTTCCCAGAATTCCATGAAGCAG
TTGAGGTCCTAGGCAACTGCTACAGCAGCTCTGATGAATAACTGCATCTCATCTAAGTCTTCTT
TTGTCATAATACACTTAACTTCTCCATTAAGAAAGTTCTCAGCTTAGGGAAAGATAAAGGTTTT
AGATCCTAGATAATGGGCTTGAAGGAGGTGGAAACAAATTGGCTAATATCTTAAGCTGATGCCC
CGCCATTCTTCCAGGATACCTTTCAGAATTATTCCACTAAAGTTTATTTTTCAAAAAATGTACT
TTACATCATTGTTTGTGATCACTTGTCAGTGTTCAGGTGTATTTTAGCTAAGACTAGTGGATGC
CCTAACTTAGATGGTTTTTGAAGCCTATACCTTTGGTATTGTTTGGCCCTTAAGCTTTTACATC
TCTTAGCATGGAGGACAAAGAAAGCTGTACATTGTTGCTTGAGAATATGTACATTTTAGACCAG
ATTTGTACTTGCACTGTCAGTATGGCAAATGAGTGGAAAATGTTAATACACTATTGGATTTTTT
ATTTCCTGTTTTGATTTCAGCTTATGCCCTGGCTGGAAAACCTCAATTTATGTTCATGACAGTG
GGGATTTTTTTAAATGTCTACATTCTTTCTAATAAACTGTTGGAAGATTTCTTGGCAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063263697 ⟹ XP_063119767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,075,261 - 1,092,357 (+)	NCBI

RefSeq Acc Id:

XM_063263698 ⟹ XP_063119768

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,075,230 - 1,092,357 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001124461	(Get FASTA)	NCBI Sequence Viewer
	XP_063119767	(Get FASTA)	NCBI Sequence Viewer
	XP_063119768	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66579	(Get FASTA)	NCBI Sequence Viewer
	EDL84891	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003787
	ENSRNOP00000003787.8
	ENSRNOP00000080703.1
	ENSRNOP00000082352.1
	ENSRNOP00000085230.1
	ENSRNOP00000096607.1
	ENSRNOP00000096677.1
	ENSRNOP00000096830.1
	ENSRNOP00055018840
	ENSRNOP00060034480
	ENSRNOP00065016874
GenBank Protein	P83868	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001124461 ⟸ NM_001130989
- UniProtKB:	P83868 (UniProtKB/Swiss-Prot), B2GV92 (UniProtKB/TrEMBL), R9PXR7 (UniProtKB/TrEMBL), A0A8I6AQE2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDS KHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMD HMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE hide sequence

RefSeq Acc Id:

ENSRNOP00000003787 ⟸ ENSRNOT00000003787

RefSeq Acc Id:

ENSRNOP00000082352 ⟸ ENSRNOT00000094676

RefSeq Acc Id:

ENSRNOP00000096677 ⟸ ENSRNOT00000104676

RefSeq Acc Id:

ENSRNOP00000085230 ⟸ ENSRNOT00000097314

RefSeq Acc Id:

ENSRNOP00000096607 ⟸ ENSRNOT00000101866

RefSeq Acc Id:

ENSRNOP00000096830 ⟸ ENSRNOT00000097618

RefSeq Acc Id:

ENSRNOP00000080703 ⟸ ENSRNOT00000097034

RefSeq Acc Id:	XP_063119768 ⟸ XM_063263698
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063119767 ⟸ XM_063263697
- Peptide Label:	isoform X1

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P83868-F1-model_v2	AlphaFold	P83868	1-160	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694921

Promoter ID:

EPDNEW_R5446

Type:

initiation region

Name:

Ptges3_1

Description:

prostaglandin E synthase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	2,479,326 - 2,479,386	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561913	AgrOrtholog
BioCyc Gene	G2FUF-35400	BioCyc
BioCyc Pathway	PWY66-374 [C20 prostanoid biosynthesis]	BioCyc
BioCyc Pathway Image	PWY66-374	BioCyc
Ensembl Genes	ENSRNOG00000002642	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055013521	UniProtKB/Swiss-Prot
	ENSRNOG00060023883	UniProtKB/Swiss-Prot
	ENSRNOG00065013256	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003787	ENTREZGENE
	ENSRNOT00000003787.8	UniProtKB/TrEMBL
	ENSRNOT00000094676.1	UniProtKB/TrEMBL
	ENSRNOT00000097034.1	UniProtKB/TrEMBL
	ENSRNOT00000097314.1	UniProtKB/TrEMBL
	ENSRNOT00000097618.1	UniProtKB/TrEMBL
	ENSRNOT00000101866.1	UniProtKB/TrEMBL
	ENSRNOT00000104676.1	UniProtKB/TrEMBL
	ENSRNOT00055023203	UniProtKB/Swiss-Prot
	ENSRNOT00060041607	UniProtKB/Swiss-Prot
	ENSRNOT00065021795	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.790	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	CS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HSP20-like_chaperone	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	p23-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362809	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	362809	ENTREZGENE
PANTHER	PROSTAGLANDIN E SYNTHASE 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR22932	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PF04969	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ptges3	PhenoGen
PROSITE	PS51203	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002642	RatGTEx
	ENSRNOG00055013521	RatGTEx
	ENSRNOG00060023883	RatGTEx
	ENSRNOG00065013256	RatGTEx
Superfamily-SCOP	SSF49764	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZQW8_RAT	UniProtKB/TrEMBL
	A0A8I5ZTE4_RAT	UniProtKB/TrEMBL
	A0A8I5ZZQ2_RAT	UniProtKB/TrEMBL
	A0A8I6AQE2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AQZ3_RAT	UniProtKB/TrEMBL
	A0A8I6ATR8_RAT	UniProtKB/TrEMBL
	A0A8L2Q1B4_RAT	UniProtKB/TrEMBL
	B2GV92	ENTREZGENE, UniProtKB/TrEMBL
	P83868	ENTREZGENE
	R9PXR7	ENTREZGENE
	TEBP_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	R9PXR7	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-10	Ptges3	prostaglandin E synthase 3	Ptges3	prostaglandin E synthase 3 (cytosolic)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ptges3	prostaglandin E synthase 3 (cytosolic)	Ptges3_predicted	prostaglandin E synthase 3 (cytosolic) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Ptges3_predicted	prostaglandin E synthase 3 (cytosolic) (predicted)	RGD1561913_predicted	similar to Sid3177p (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1561913_predicted	similar to Sid3177p (predicted)	LOC362809	similar to Sid3177p	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC362809	similar to Sid3177p			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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