Odam (odontogenic, ameloblast associated) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Odam (odontogenic, ameloblast associated) Rattus norvegicus
Analyze
Symbol: Odam
Name: odontogenic, ameloblast associated
RGD ID: 1561883
Description: Involved in odontogenesis. Predicted to be located in several cellular components, including extracellular space; mitotic spindle; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human ODAM (odontogenic, ameloblast associated); INTERACTS WITH bisphenol A; cadmium dichloride; tributylstannane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Apin; APIN precursor; odontogenic ameloblast-associated protein; odontogenic, ameloblast asssociated
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,472,530 - 20,496,752 (-)NCBIGRCr8
mRatBN7.21420,193,286 - 20,202,517 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,193,302 - 20,202,517 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,123,607 - 20,132,626 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,442,493 - 21,451,512 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,173,243 - 20,182,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,842,990 - 21,852,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,842,990 - 21,852,216 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01421,753,075 - 21,767,321 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41421,714,378 - 21,724,054 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1419,595,876 - 19,605,037 (-)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell periphery  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
extracellular region  (IEA,ISO)
extracellular space  (IEA,ISO)
mitotic spindle  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
supramolecular fiber  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. Lee HK, etal., J Biol Chem. 2015 Jun 5;290(23):14740-53. doi: 10.1074/jbc.M115.648022. Epub 2015 Apr 24.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14647039   PMID:15234340   PMID:16674676   PMID:17647262   PMID:21092812   PMID:21154245   PMID:22387195  


Genomics

Comparative Map Data
Odam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,472,530 - 20,496,752 (-)NCBIGRCr8
mRatBN7.21420,193,286 - 20,202,517 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,193,302 - 20,202,517 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,123,607 - 20,132,626 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,442,493 - 21,451,512 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,173,243 - 20,182,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,842,990 - 21,852,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,842,990 - 21,852,216 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01421,753,075 - 21,767,321 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41421,714,378 - 21,724,054 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1419,595,876 - 19,605,037 (-)NCBICelera
Cytogenetic Map14p21NCBI
ODAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,195,725 - 70,204,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,195,725 - 70,204,576 (+)EnsemblGRCh38hg38GRCh38
GRCh37471,061,442 - 71,070,293 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,096,833 - 71,104,882 (+)NCBINCBI36Build 36hg18NCBI36
Celera468,420,214 - 68,428,263 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef466,864,474 - 66,872,522 (+)NCBIHuRef
CHM1_1471,098,652 - 71,106,701 (+)NCBICHM1_1
T2T-CHM13v2.0473,535,038 - 73,543,889 (+)NCBIT2T-CHM13v2.0
Odam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,032,869 - 88,042,668 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,032,888 - 88,042,033 (+)EnsemblGRCm39 Ensembl
GRCm38587,885,010 - 87,894,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl587,885,029 - 87,894,174 (+)EnsemblGRCm38mm10GRCm38
MGSCv37588,314,720 - 88,321,770 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36588,962,048 - 88,968,733 (+)NCBIMGSCv36mm8
MGSCv36587,491,886 - 87,498,571 (+)NCBIMGSCv36mm8
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
Odam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554472,653,815 - 2,661,043 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554472,653,815 - 2,661,043 (-)NCBIChiLan1.0ChiLan1.0
ODAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,878,118 - 59,887,218 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1460,074,401 - 60,083,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0454,019,039 - 54,028,085 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,362,655 - 60,370,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl460,362,655 - 60,370,747 (-)Ensemblpanpan1.1panPan2
ODAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11359,588,642 - 59,597,873 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1359,588,647 - 59,597,873 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1359,315,664 - 59,324,921 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01360,383,221 - 60,392,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1360,383,221 - 60,392,488 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11359,997,363 - 60,006,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01359,501,814 - 59,511,051 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01360,648,776 - 60,658,033 (+)NCBIUU_Cfam_GSD_1.0
Odam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528515,986,195 - 15,993,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365984,438,258 - 4,445,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365984,438,258 - 4,445,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ODAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl867,058,472 - 67,066,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1867,059,284 - 67,068,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28148,456,188 - 148,465,034 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ODAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1718,676,794 - 18,687,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl718,678,422 - 18,685,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660844,236,479 - 4,251,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Odam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248901,623,562 - 1,629,960 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248901,622,846 - 1,631,114 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Odam
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000037003
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 10
Below cutoff 1 8 5 1 12 1 1 1 5 8 16 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000037003   ⟹   ENSRNOP00000035991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,193,302 - 20,202,517 (-)Ensembl
Rnor_6.0 Ensembl1421,842,990 - 21,852,216 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103950   ⟹   ENSRNOP00000097228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,194,697 - 20,202,517 (-)Ensembl
RefSeq Acc Id: NM_001044274   ⟹   NP_001037739
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,472,530 - 20,481,760 (-)NCBI
mRatBN7.21420,193,286 - 20,202,517 (-)NCBI
Rnor_6.01421,842,990 - 21,852,216 (-)NCBI
Rnor_5.01421,753,075 - 21,767,321 (-)NCBI
RGSC_v3.41421,714,378 - 21,724,054 (-)RGD
Celera1419,595,876 - 19,605,037 (-)RGD
Sequence:
RefSeq Acc Id: XM_063273575   ⟹   XP_063129645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,472,530 - 20,496,752 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001037739 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABA54404 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035991
  ENSRNOP00000035991.3
  ENSRNOP00000097228.1
GenBank Protein Q3HS83 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001037739   ⟸   NM_001044274
- Peptide Label: precursor
- UniProtKB: Q3HS83 (UniProtKB/Swiss-Prot),   A0A8I6AW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035991   ⟸   ENSRNOT00000037003
RefSeq Acc Id: ENSRNOP00000097228   ⟸   ENSRNOT00000103950
RefSeq Acc Id: XP_063129645   ⟸   XM_063273575
- Peptide Label: isoform X1
- UniProtKB: F1LR01 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3HS83-F1-model_v2 AlphaFold Q3HS83 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561883 AgrOrtholog
BioCyc Gene G2FUF-16139 BioCyc
Ensembl Genes ENSRNOG00000023372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037003 ENTREZGENE
  ENSRNOT00000037003.5 UniProtKB/TrEMBL
  ENSRNOT00000103950.1 UniProtKB/TrEMBL
InterPro Odam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:641555 UniProtKB/Swiss-Prot
NCBI Gene 641555 ENTREZGENE
PANTHER ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16237 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ODAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Odam PhenoGen
RatGTEx ENSRNOG00000023372 RatGTEx
UniProt A0A8I6AW47 ENTREZGENE, UniProtKB/TrEMBL
  F1LR01 ENTREZGENE, UniProtKB/TrEMBL
  ODAM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Odam  odontogenic, ameloblast associated  Odam  odontogenic, ameloblast asssociated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Odam  odontogenic, ameloblast asssociated  Apin  APIN precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Apin  APIN precursor      Symbol and Name status set to provisional 70820 PROVISIONAL