Asxl1 (ASXL transcriptional regulator 1) - Rat Genome Database

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Gene: Asxl1 (ASXL transcriptional regulator 1) Rattus norvegicus
Analyze
Symbol: Asxl1
Name: ASXL transcriptional regulator 1
RGD ID: 1561878
Description: Predicted to enable nuclear retinoic acid receptor binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator activity. Involved in negative regulation of lipid storage. Predicted to be located in nucleus. Predicted to be part of PR-DUB complex. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: additional sex combs like 1; additional sex combs like 1, transcriptional regulator; additional sex combs like transcriptional regulator 1; LOC311553; polycomb group protein ASXL1; putative Polycomb group protein ASXL1; RGD1561878; similar to mKIAA0978 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,273,828 - 162,341,742 (+)NCBIGRCr8
mRatBN7.23141,814,012 - 141,881,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,813,433 - 141,881,538 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03148,832,231 - 148,902,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,837,814 - 148,900,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,202,740 - 155,267,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,703,295 - 143,767,523 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3140,560,551 - 140,627,551 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (ISO)
PR-DUB complex  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. Chou WC, etal., Blood. 2010 Nov 18;116(20):4086-94. doi: 10.1182/blood-2010-05-283291. Epub 2010 Aug 6.
2. ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases. Damaj G, etal., PLoS One. 2014 Jan 21;9(1):e85362. doi: 10.1371/journal.pone.0085362. eCollection 2014.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. Gelsi-Boyer V, etal., Br J Haematol. 2010 Nov;151(4):365-75. doi: 10.1111/j.1365-2141.2010.08381.x. Epub 2010 Sep 29.
5. Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. Inoue D, etal., J Clin Invest. 2013 Nov;123(11):4627-40.
6. Loss of ASXL1 expression is associated with lymph node metastasis in colorectal cancer. Lee JH, etal., Indian J Pathol Microbiol. 2020 Apr-Jun;63(2):221-225. doi: 10.4103/IJPM.IJPM_822_19.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis. Park UH, etal., Biochem Biophys Res Commun. 2014 Jan 10;443(2):489-94. doi: 10.1016/j.bbrc.2013.11.124. Epub 2013 Dec 7.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. Stein BL, etal., Haematologica. 2011 Oct;96(10):1462-9. doi: 10.3324/haematol.2011.045591. Epub 2011 Jun 28.
13. Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes. Thol F, etal., J Clin Oncol. 2011 Jun 20;29(18):2499-506. doi: 10.1200/JCO.2010.33.4938. Epub 2011 May 16.
14. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms. Traina F, etal., Leukemia. 2014 Jan;28(1):78-87. doi: 10.1038/leu.2013.269. Epub 2013 Sep 18.
15. Mutations and prognosis in primary myelofibrosis. Vannucchi AM, etal., Leukemia. 2013 Sep;27(9):1861-9. doi: 10.1038/leu.2013.119. Epub 2013 Apr 26.
16. TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
Additional References at PubMed
PMID:16606617   PMID:19861679   PMID:20436459   PMID:21047783   PMID:22876197   PMID:23376485   PMID:24860998   PMID:26385183  


Genomics

Comparative Map Data
Asxl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,273,828 - 162,341,742 (+)NCBIGRCr8
mRatBN7.23141,814,012 - 141,881,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,813,433 - 141,881,538 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03148,832,231 - 148,902,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,837,814 - 148,900,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,202,740 - 155,267,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,703,295 - 143,767,523 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3140,560,551 - 140,627,551 (+)NCBICelera
Cytogenetic Map3q41NCBI
ASXL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382032,358,331 - 32,439,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2032,358,330 - 32,439,319 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,946,134 - 31,027,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,409,814 - 30,490,783 (+)NCBINCBI36Build 36hg18NCBI36
Build 342030,409,820 - 30,490,783NCBI
Celera2027,702,183 - 27,783,146 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,742,560 - 27,816,603 (+)NCBIHuRef
CHM1_12030,850,605 - 30,932,052 (+)NCBICHM1_1
T2T-CHM13v2.02034,083,215 - 34,164,178 (+)NCBIT2T-CHM13v2.0
Asxl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392153,187,750 - 153,245,927 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,187,749 - 153,245,927 (+)EnsemblGRCm39 Ensembl
GRCm382153,345,830 - 153,404,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,345,829 - 153,404,007 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,171,875 - 153,229,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362153,037,493 - 153,095,448 (+)NCBIMGSCv36mm8
MGSCv362154,151,679 - 154,209,986 (+)NCBIMGSCv36mm8
Celera2159,188,615 - 159,246,403 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Asxl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542228,664,282 - 28,721,896 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542228,662,392 - 28,721,896 (-)NCBIChiLan1.0ChiLan1.0
ASXL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22138,038,565 - 38,130,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12038,043,027 - 38,123,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02028,647,004 - 28,727,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,773,836 - 29,852,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,774,582 - 29,850,453 (+)Ensemblpanpan1.1panPan2
ASXL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,725,126 - 21,804,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,661,059 - 21,802,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,372,658 - 21,451,415 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02422,413,734 - 22,492,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2422,414,540 - 22,493,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,690,505 - 21,768,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,797,741 - 21,876,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,228,633 - 22,307,459 (+)NCBIUU_Cfam_GSD_1.0
Asxl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,792,007 - 170,865,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648519,227,400 - 19,298,912 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648519,218,494 - 19,297,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASXL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,985,535 - 36,067,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,985,978 - 36,067,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,908,208 - 40,984,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASXL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,735,449 - 36,810,447 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,735,830 - 36,812,387 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,099,728 - 90,176,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asxl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741188,745 - 250,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741188,985 - 258,065 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asxl1
155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:77
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000045241
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat

Markers in Region
RH134019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,877,418 - 141,877,627 (+)MAPPERmRatBN7.2
Rnor_6.03148,898,252 - 148,898,460NCBIRnor6.0
Rnor_5.03155,206,636 - 155,206,844UniSTSRnor5.0
RGSC_v3.43143,763,418 - 143,763,626UniSTSRGSC3.4
Celera3140,623,447 - 140,623,655UniSTS
RH 3.4 Map31268.3UniSTS
Cytogenetic Map3q41UniSTS
AW525550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,881,398 - 141,881,493 (+)MAPPERmRatBN7.2
Rnor_6.03148,902,232 - 148,902,326NCBIRnor6.0
Rnor_5.03155,202,770 - 155,202,864UniSTSRnor5.0
RGSC_v3.43143,767,398 - 143,767,492UniSTSRGSC3.4
Celera3140,627,427 - 140,627,521UniSTS
RH 3.4 Map31277.9UniSTS
Cytogenetic Map3q41UniSTS
BE107504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,814,727 - 141,814,911 (+)MAPPERmRatBN7.2
Rnor_6.03148,832,640 - 148,832,823NCBIRnor6.0
Rnor_5.03155,268,207 - 155,268,390UniSTSRnor5.0
RGSC_v3.43143,698,178 - 143,698,361UniSTSRGSC3.4
Celera3140,560,933 - 140,561,116UniSTS
RH 3.4 Map31275.6UniSTS
Cytogenetic Map3q41UniSTS
RH138075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,838,001 - 141,838,240 (+)MAPPERmRatBN7.2
Rnor_6.03148,855,287 - 148,855,525NCBIRnor6.0
Rnor_5.03155,245,505 - 155,245,743UniSTSRnor5.0
RGSC_v3.43143,721,543 - 143,721,781UniSTSRGSC3.4
Celera3140,584,134 - 140,584,372UniSTS
RH 3.4 Map31277.8UniSTS
Cytogenetic Map3q41UniSTS
AI136740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,880,883 - 141,881,067 (+)MAPPERmRatBN7.2
Rnor_6.03148,901,717 - 148,901,900NCBIRnor6.0
Rnor_5.03155,203,196 - 155,203,379UniSTSRnor5.0
RGSC_v3.43143,766,883 - 143,767,066UniSTSRGSC3.4
Celera3140,626,912 - 140,627,095UniSTS
RH 3.4 Map31280.4UniSTS
Cytogenetic Map3q41UniSTS
RH92532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,879,491 - 141,879,643 (+)MAPPERmRatBN7.2
Rnor_6.03148,900,325 - 148,900,476NCBIRnor6.0
Rnor_5.03155,204,620 - 155,204,771UniSTSRnor5.0
RGSC_v3.43143,765,491 - 143,765,642UniSTSRGSC3.4
Celera3140,625,520 - 140,625,671UniSTS
Cytogenetic Map3q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 41 25 19 25 1 68 34 41 11
Low 10 16 16 16 8 10 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000091808   ⟹   ENSRNOP00000068945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,824,295 - 141,881,538 (+)Ensembl
Rnor_6.0 Ensembl3148,837,814 - 148,900,452 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103739   ⟹   ENSRNOP00000094902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,813,433 - 141,881,538 (+)Ensembl
RefSeq Acc Id: NM_001427647   ⟹   NP_001414576
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83162,273,828 - 162,341,742 (+)NCBI
RefSeq Acc Id: XM_063283837   ⟹   XP_063139907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83162,282,336 - 162,341,740 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414576 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139907 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068945.2
  ENSRNOP00000094902.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000068945   ⟸   ENSRNOT00000091808
RefSeq Acc Id: ENSRNOP00000094902   ⟸   ENSRNOT00000103739
RefSeq Acc Id: NP_001414576   ⟸   NM_001427647
RefSeq Acc Id: XP_063139907   ⟸   XM_063283837
- Peptide Label: isoform X1
Protein Domains
DEUBAD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JU33-F1-model_v2 AlphaFold A0A0G2JU33 1-1493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561878 AgrOrtholog
BioCyc Gene G2FUF-47219 BioCyc
Ensembl Genes ENSRNOG00000061603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091808.2 UniProtKB/TrEMBL
  ENSRNOT00000103739.1 UniProtKB/TrEMBL
InterPro ASX-like_PHD UniProtKB/TrEMBL
  ASX/ASX-like UniProtKB/TrEMBL
  ASXH UniProtKB/TrEMBL
  DEUBAD_dom UniProtKB/TrEMBL
NCBI Gene 311553 ENTREZGENE
PANTHER PTHR13578 UniProtKB/TrEMBL
  PTHR13578:SF19 UniProtKB/TrEMBL
Pfam ASXH UniProtKB/TrEMBL
  PHD_3 UniProtKB/TrEMBL
PhenoGen Asxl1 PhenoGen
PROSITE DEUBAD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061603 RatGTEx
UniProt A0A0G2JU33_RAT UniProtKB/TrEMBL
  A0A8I6GKY0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-18 Asxl1  ASXL transcriptional regulator 1  Asxl1  additional sex combs like 1, transcriptional regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Asxl1  additional sex combs like 1, transcriptional regulator  Asxl1  additional sex combs like transcriptional regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-25 Asxl1  additional sex combs like transcriptional regulator 1  Asxl1  additional sex combs like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-11 Asxl1  additional sex combs like 1  RGD1561878  similar to mKIAA0978 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561878  similar to mKIAA0978 protein   RGD1561878_predicted  similar to mKIAA0978 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561878_predicted  similar to mKIAA0978 protein (predicted)  LOC311553  similar to mKIAA0978 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC311553  similar to mKIAA0978 protein      Symbol and Name status set to provisional 70820 PROVISIONAL