C19h4orf51 (similar to human chromosome 4 open reading frame 51) - Rat Genome Database

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Gene: C19h4orf51 (similar to human chromosome 4 open reading frame 51) Rattus norvegicus
Analyze
Symbol: C19h4orf51 (Ensembl: LOC498933)
Name: similar to human chromosome 4 open reading frame 51 (Ensembl:LOC498933)
RGD ID: 1561806
Description: Orthologous to human C4orf51 (chromosome 4 open reading frame 51); INTERACTS WITH benzo[a]pyrene (ortholog); rifampicin (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498933; LOC498933; LOC498933; MGC116194; uncharacterized protein C4orf51 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81945,573,267 - 45,608,796 (+)NCBIGRCr8
mRatBN7.21928,669,044 - 28,704,512 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1928,669,059 - 28,704,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1935,523,847 - 35,559,276 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,177,925 - 36,213,366 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01938,413,579 - 38,449,166 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01932,344,078 - 32,380,029 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1932,344,078 - 32,380,025 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01943,240,203 - 43,275,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41930,505,305 - 30,540,608 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1928,177,863 - 28,212,691 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
C19h4orf51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81945,573,267 - 45,608,796 (+)NCBIGRCr8
mRatBN7.21928,669,044 - 28,704,512 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1928,669,059 - 28,704,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1935,523,847 - 35,559,276 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,177,925 - 36,213,366 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01938,413,579 - 38,449,166 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01932,344,078 - 32,380,029 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1932,344,078 - 32,380,025 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01943,240,203 - 43,275,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41930,505,305 - 30,540,608 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1928,177,863 - 28,212,691 (+)NCBICelera
Cytogenetic Map19q11NCBI
C4orf51
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384145,680,146 - 145,792,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4145,680,146 - 145,771,032 (+)EnsemblGRCh38hg38GRCh38
GRCh374146,601,298 - 146,653,949 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,820,806 - 146,873,399 (+)NCBINCBI36Build 36hg18NCBI36
Celera4143,928,891 - 143,981,824 (+)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4142,331,319 - 142,382,942 (+)NCBIHuRef
CHM1_14146,577,928 - 146,631,252 (+)NCBICHM1_1
T2T-CHM13v2.04148,995,961 - 149,108,468 (+)NCBIT2T-CHM13v2.0
1700011L22Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39879,937,059 - 79,975,212 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl879,937,060 - 79,975,199 (-)EnsemblGRCm39 Ensembl
GRCm38879,210,430 - 79,248,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,210,431 - 79,248,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv37881,734,329 - 81,772,482 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36882,106,502 - 82,144,642 (-)NCBIMGSCv36mm8
Celera883,487,532 - 83,525,636 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.48NCBI
LOC102007039
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,500,090 - 1,529,078 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554281,503,025 - 1,543,635 (+)NCBIChiLan1.0ChiLan1.0
C3H4orf51
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23143,555,555 - 143,628,303 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14143,920,547 - 143,993,278 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04138,022,499 - 138,094,804 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14149,681,583 - 149,732,163 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4149,681,583 - 149,753,557 (+)Ensemblpanpan1.1panPan2
C15H4orf51
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11544,255,853 - 44,282,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1544,646,899 - 44,748,294 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01544,933,923 - 45,023,000 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11544,196,384 - 44,296,371 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.01544,548,031 - 44,648,475 (+)NCBIUU_Cfam_GSD_1.0
CUNH4orf51
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530146,027,012 - 46,055,081 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365353,464,407 - 3,467,764 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUNH4orf51
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1792,241,869 - 92,313,423 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl792,242,439 - 92,283,850 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603771,892,258 - 71,966,137 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH4orf51
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248534,589,551 - 4,627,607 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C19h4orf51
218 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:73
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000015541
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low 1 1
Below cutoff 1 12 21 8 9 8 8 9 6 8 9 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015541   ⟹   ENSRNOP00000015541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1928,669,059 - 28,704,508 (+)Ensembl
Rnor_6.0 Ensembl1932,344,078 - 32,380,025 (+)Ensembl
RefSeq Acc Id: NM_001025764   ⟹   NP_001020935
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,573,330 - 45,608,796 (+)NCBI
mRatBN7.21928,669,044 - 28,704,512 (+)NCBI
Rnor_6.01932,344,078 - 32,380,029 (+)NCBI
Rnor_5.01943,240,203 - 43,275,432 (+)NCBI
RGSC_v3.41930,505,305 - 30,540,608 (+)RGD
Celera1928,177,863 - 28,212,691 (+)RGD
Sequence:
RefSeq Acc Id: XM_063278188   ⟹   XP_063134258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,573,267 - 45,605,186 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001020935 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134258 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98038 (Get FASTA)   NCBI Sequence Viewer  
  EDL92315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015541
  ENSRNOP00000015541.4
  ENSRNOP00055010314
  ENSRNOP00060018429
  ENSRNOP00065012246
GenBank Protein Q4V7B2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001020935   ⟸   NM_001025764
- UniProtKB: Q4V7B2 (UniProtKB/Swiss-Prot),   A6IYI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015541   ⟸   ENSRNOT00000015541
RefSeq Acc Id: XP_063134258   ⟸   XM_063278188
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7B2-F1-model_v2 AlphaFold Q4V7B2 1-208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701053
Promoter ID:EPDNEW_R11576
Type:initiation region
Name:LOC498933_1
Description:LOC498933
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01932,344,063 - 32,344,123EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561806 AgrOrtholog
BioCyc Gene G2FUF-5944 BioCyc
Ensembl Genes ENSRNOG00000011671 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055007726 UniProtKB/Swiss-Prot
  ENSRNOG00060013610 UniProtKB/Swiss-Prot
  ENSRNOG00065010048 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015541 ENTREZGENE
  ENSRNOT00000015541.5 UniProtKB/Swiss-Prot
  ENSRNOT00055012930 UniProtKB/Swiss-Prot
  ENSRNOT00060023230 UniProtKB/Swiss-Prot
  ENSRNOT00065016170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7456623 IMAGE-MGC_LOAD
InterPro DUF4722 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:498933 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116194 IMAGE-MGC_LOAD
NCBI Gene 498933 ENTREZGENE
Pfam DUF4722 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C19h4orf51 PhenoGen
RatGTEx ENSRNOG00000011671 RatGTEx
  ENSRNOG00055007726 RatGTEx
  ENSRNOG00060013610 RatGTEx
  ENSRNOG00065010048 RatGTEx
UniProt A6IYI7 ENTREZGENE, UniProtKB/TrEMBL
  CD051_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C19h4orf51  similar to human chromosome 4 open reading frame 51  LOC498933  LOC498933  Symbol and Name Changed 1299863 APPROVED
2006-02-09 LOC498933  LOC498933      Symbol and Name status set to provisional 70820 PROVISIONAL