Rhox8 (reproductive homeobox 8) - Rat Genome Database

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Gene: Rhox8 (reproductive homeobox 8) Rattus norvegicus
Analyze
Symbol: Rhox8
Name: reproductive homeobox 8
RGD ID: 1561047
Description: Predicted to enable DNA binding activity. Predicted to act upstream of or within regulation of gene expression and spermatogenesis. Predicted to be located in nucleus. Orthologous to human RHOXF2 (Rhox homeobox family member 2) and DPRX (divergent-paired related homeobox); INTERACTS WITH bisphenol A; genistein; all-trans-retinoic acid (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC503423; reproductive homeobox on X chromosome 8; Rhox homeobox family member 8
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,450,408 - 121,454,031 (+)NCBIGRCr8
mRatBN7.2X116,584,742 - 116,588,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,584,582 - 116,588,365 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,687,922 - 118,691,545 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,257,075 - 122,260,698 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,803,001 - 119,806,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,976,734 - 123,980,357 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,976,734 - 123,980,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,062,924 - 124,066,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,558,942 - 7,562,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,811,226 - 115,814,849 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (ISO)

Molecular Function
DNA binding  (IEA)

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Rhox8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,450,408 - 121,454,031 (+)NCBIGRCr8
mRatBN7.2X116,584,742 - 116,588,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,584,582 - 116,588,365 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,687,922 - 118,691,545 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,257,075 - 122,260,698 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,803,001 - 119,806,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,976,734 - 123,980,357 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,976,734 - 123,980,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,062,924 - 124,066,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,558,942 - 7,562,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,811,226 - 115,814,849 (+)NCBICelera
Cytogenetic MapXq35NCBI
Rhox8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X36,963,657 - 36,979,643 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX36,963,655 - 36,967,821 (-)EnsemblGRCm39 Ensembl
GRCm38X37,874,780 - 37,890,766 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX37,874,778 - 37,878,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X35,227,953 - 35,232,121 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X34,119,405 - 34,123,571 (-)NCBIMGSCv36mm8
CeleraX25,529,100 - 25,533,271 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX22.12NCBI

Variants

.
Variants in Rhox8
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:55
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000049435, ENSRNOT00000066130
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium 9
Low 10
Below cutoff 1 7 4 3 4 3 3 7 2 9 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049435   ⟹   ENSRNOP00000041820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,584,582 - 116,588,365 (+)Ensembl
Rnor_6.0 EnsemblX123,976,734 - 123,980,357 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109125   ⟹   ENSRNOP00000086118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,584,582 - 116,588,164 (+)Ensembl
RefSeq Acc Id: NM_001025776   ⟹   NP_001020947
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,450,408 - 121,454,031 (+)NCBI
mRatBN7.2X116,584,742 - 116,588,365 (+)NCBI
Rnor_6.0X123,976,734 - 123,980,357 (-)NCBI
Rnor_5.0X124,062,924 - 124,066,547 (-)NCBI
RGSC_v3.4X7,558,942 - 7,562,565 (-)RGD
CeleraX115,811,226 - 115,814,849 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020947 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAY58266 (Get FASTA)   NCBI Sequence Viewer  
  EDM10851 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041820
  ENSRNOP00000041820.5
  ENSRNOP00000086118.1
Reference Protein Sequences
RefSeq Acc Id: NP_001020947   ⟸   NM_001025776
- UniProtKB: Q4TU75 (UniProtKB/TrEMBL),   F7F1N3 (UniProtKB/TrEMBL),   A0A8I6A5E8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041820   ⟸   ENSRNOT00000049435
RefSeq Acc Id: ENSRNOP00000086118   ⟸   ENSRNOT00000109125
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4TU75-F1-model_v2 AlphaFold Q4TU75 1-178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701991
Promoter ID:EPDNEW_R12515
Type:single initiation site
Name:Rhox8_1
Description:Rhox homeobox family member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X123,980,390 - 123,980,450EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561047 AgrOrtholog
BioCyc Gene G2FUF-1283 BioCyc
Ensembl Genes ENSRNOG00000031534 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049435 ENTREZGENE
  ENSRNOT00000049435.6 UniProtKB/TrEMBL
  ENSRNOT00000109125.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:503423 UniProtKB/TrEMBL
NCBI Gene 503423 ENTREZGENE
PANTHER MCG113260-RELATED-RELATED UniProtKB/TrEMBL
  REPRODUCTIVE HOMEOBOX 8 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Rhox8 PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031534 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A8I6A5E8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XQI4_RAT UniProtKB/TrEMBL
  F7F1N3 ENTREZGENE
  Q4TU75 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7F1N3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Rhox8  reproductive homeobox 8  Rhox8  Rhox homeobox family member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-07-14 Rhox8  Rhox homeobox family member 8  Rhox8  reproductive homeobox 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Rhox8  reproductive homeobox 8  LOC503423  reproductive homeobox on X chromosome 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC503423  reproductive homeobox on X chromosome 8      Symbol and Name status set to provisional 70820 PROVISIONAL