Myo6 (myosin VI) - Rat Genome Database

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Gene: Myo6 (myosin VI) Rattus norvegicus
Analyze
Symbol: Myo6
Name: myosin VI
RGD ID: 1560646
Description: Predicted to enable several functions, including ADP binding activity; actin filament binding activity; and calmodulin binding activity. Involved in response to xenobiotic stimulus. Located in several cellular components, including endocytic vesicle; microvillus; and ruffle membrane. Part of protein-containing complex. Used to study hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI); PARTICIPATES IN auditory mechanotransduction pathway; E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC315840; RGD1560646; similar to Myosin VI; unconventional myosin-VI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8889,967,351 - 90,122,219 (+)NCBIGRCr8
mRatBN7.2881,087,157 - 81,242,022 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0887,583,649 - 87,731,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl887,630,916 - 87,731,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0887,121,910 - 87,268,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4885,203,987 - 85,368,026 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera880,810,746 - 80,962,891 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (EXP)
hexaconazole  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of myosin VI within the early endocytic pathway in adult and developing proximal tubules. Biemesderfer D, etal., Am J Physiol Renal Physiol. 2002 May;282(5):F785-94.
2. The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. Buss F, etal., J Cell Biol. 1998 Dec 14;143(6):1535-45.
3. Regulation of myosin-VI targeting to endocytic compartments. Dance AL, etal., Traffic. 2004 Oct;5(10):798-813.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins. Majewski L, etal., Nucleus. 2018 Jan 1;9(1):125-141. doi: 10.1080/19491034.2017.1421881.
6. MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss. Melchionda S, etal., Am J Hum Genet. 2001 Sep;69(3):635-40. Epub 2001 Jul 20.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. The auditory hair cell ribbon synapse: from assembly to function. Safieddine S, etal., Annu Rev Neurosci. 2012;35:509-28. doi: 10.1146/annurev-neuro-061010-113705.
14. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. Sahlender DA, etal., J Cell Biol. 2005 Apr 25;169(2):285-95. Epub 2005 Apr 18.
15. Review series: The cell biology of hearing. Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
16. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
17. GOLPH2 and MYO6: putative prostate cancer markers localized to the Golgi apparatus. Wei S, etal., Prostate. 2008 Sep 15;68(13):1387-95.
18. Interaction of SAP97 with Minus-end-directed Actin Motor Myosin VI. IMPLICATIONS FOR AMPA RECEPTOR TRAFFICKING. Wu H, etal., J Biol Chem 2002 Aug 23;277(34):30928-34.
19. Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance. Yang LE, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1197-208. Epub 2007 Jul 25.
20. Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Yang LE, etal., Am J Physiol Renal Physiol. 2008 Oct;295(4):F1003-16. Epub 2008 Jul 23.
21. Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension. Yang LE, etal., J Am Soc Nephrol. 2005 Oct;16(10):2890-6. Epub 2005 Aug 17.
22. Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer. Yoshida H, etal., Proc Natl Acad Sci U S A. 2004 May 25;101(21):8144-9. Epub 2004 May 14.
Additional References at PubMed
PMID:5980120   PMID:7493015   PMID:10519557   PMID:10525338   PMID:11447109   PMID:12857860   PMID:15037754   PMID:15247260   PMID:15657400   PMID:15975910   PMID:16025302   PMID:16507995  
PMID:16819522   PMID:16949370   PMID:16962269   PMID:17329413   PMID:18511944   PMID:19056867   PMID:19744958   PMID:19946888   PMID:20016102   PMID:20198214   PMID:20351096   PMID:21052544  
PMID:21300049   PMID:22105175   PMID:22105702   PMID:22114352   PMID:22475431   PMID:23275125   PMID:23376485   PMID:24625528   PMID:25468996   PMID:25896210   PMID:28096472   PMID:35352799  


Genomics

Comparative Map Data
Myo6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8889,967,351 - 90,122,219 (+)NCBIGRCr8
mRatBN7.2881,087,157 - 81,242,022 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0887,583,649 - 87,731,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl887,630,916 - 87,731,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0887,121,910 - 87,268,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4885,203,987 - 85,368,026 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera880,810,746 - 80,962,891 (+)NCBICelera
Cytogenetic Map8q31NCBI
MYO6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38675,749,239 - 75,919,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl675,749,201 - 75,919,537 (+)EnsemblGRCh38hg38GRCh38
GRCh37676,458,956 - 76,629,254 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36676,515,629 - 76,685,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 34676,515,702 - 76,682,665NCBI
Celera676,852,216 - 77,022,585 (+)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef673,657,457 - 73,828,024 (+)NCBIHuRef
CHM1_1676,625,146 - 76,795,504 (+)NCBICHM1_1
T2T-CHM13v2.0676,926,117 - 77,096,418 (+)NCBIT2T-CHM13v2.0
Myo6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39980,072,262 - 80,219,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl980,072,313 - 80,219,011 (+)EnsemblGRCm39 Ensembl
GRCm38980,164,976 - 80,311,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl980,165,031 - 80,311,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv37980,012,841 - 80,159,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36979,950,724 - 80,097,413 (+)NCBIMGSCv36mm8
Celera977,304,677 - 77,455,393 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.98NCBI
Myo6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555024,218,885 - 4,356,988 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555024,219,067 - 4,356,988 (+)NCBIChiLan1.0ChiLan1.0
MYO6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2595,797,543 - 95,965,239 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1693,675,327 - 93,845,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0673,593,794 - 73,764,352 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1676,882,994 - 77,050,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl676,951,634 - 77,048,796 (+)Ensemblpanpan1.1panPan2
MYO6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11237,359,200 - 37,502,342 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1237,413,570 - 37,500,724 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1237,238,751 - 37,384,310 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01238,063,158 - 38,289,614 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1238,063,189 - 38,287,255 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11237,466,515 - 37,612,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01237,455,898 - 37,602,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01237,586,007 - 37,731,589 (+)NCBIUU_Cfam_GSD_1.0
Myo6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494672,743,121 - 72,882,178 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367881,174,544 - 1,262,746 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367881,125,332 - 1,264,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl189,992,866 - 90,137,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1189,992,860 - 90,137,767 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21100,972,527 - 101,143,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYO6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.113527,361 - 620,418 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl13457,495 - 618,858 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040176,761,726 - 176,924,982 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248192,896,374 - 2,999,819 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248192,835,783 - 2,999,819 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo6
1057 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000016428, ENSRNOT00000064856
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat

Markers in Region
RH133282  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,239,463 - 81,239,648 (+)MAPPERmRatBN7.2
Rnor_6.0887,728,711 - 87,728,895NCBIRnor6.0
Rnor_5.0887,266,340 - 87,266,524UniSTSRnor5.0
RGSC_v3.4885,367,836 - 85,368,020UniSTSRGSC3.4
Celera880,960,331 - 80,960,515UniSTS
RH 3.4 Map8930.3UniSTS
Cytogenetic Map8q31UniSTS
U49739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,238,156 - 81,238,344 (+)MAPPERmRatBN7.2
Rnor_6.0887,727,404 - 87,727,591NCBIRnor6.0
Rnor_5.0887,265,033 - 87,265,220UniSTSRnor5.0
RGSC_v3.4885,366,529 - 85,366,716UniSTSRGSC3.4
Celera880,959,024 - 80,959,211UniSTS
Cytogenetic Map8q31UniSTS
BF399451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,093,922 - 81,094,110 (+)MAPPERmRatBN7.2
Rnor_6.0887,590,409 - 87,590,596NCBIRnor6.0
Rnor_5.0887,128,666 - 87,128,853UniSTSRnor5.0
RGSC_v3.4885,210,706 - 85,210,893UniSTSRGSC3.4
Celera880,817,378 - 80,817,565UniSTS
RH 3.4 Map8933.5UniSTS
Cytogenetic Map8q31UniSTS
AU048109  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera880,871,294 - 80,871,470UniSTS
Cytogenetic Map8q31UniSTS
PMC124268P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,237,301 - 81,238,188 (+)MAPPERmRatBN7.2
Rnor_6.0887,726,549 - 87,727,435NCBIRnor6.0
Rnor_5.0887,264,178 - 87,265,064UniSTSRnor5.0
RGSC_v3.4885,365,674 - 85,366,560UniSTSRGSC3.4
Celera880,958,169 - 80,959,055UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 13 6 7 6 60 35 37 11
Low 11 44 35 12 35 8 11 14 4 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001061392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016428   ⟹   ENSRNOP00000016428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
Rnor_6.0 Ensembl887,630,916 - 87,731,269 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103299   ⟹   ENSRNOP00000091730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108142   ⟹   ENSRNOP00000091239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112254   ⟹   ENSRNOP00000077341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119730   ⟹   ENSRNOP00000083145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120263   ⟹   ENSRNOP00000083134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
RefSeq Acc Id: NM_001427259   ⟹   NP_001414188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,397 - 90,122,219 (+)NCBI
RefSeq Acc Id: XM_008766423   ⟹   XP_008764645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,122,219 (+)NCBI
mRatBN7.2881,087,158 - 81,242,022 (+)NCBI
Rnor_6.0887,583,649 - 87,731,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766425   ⟹   XP_008764647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,122,219 (+)NCBI
mRatBN7.2881,087,160 - 81,242,022 (+)NCBI
Rnor_6.0887,583,650 - 87,731,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082536   ⟹   XP_038938464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,122,219 (+)NCBI
mRatBN7.2881,087,158 - 81,242,022 (+)NCBI
RefSeq Acc Id: XM_063265552   ⟹   XP_063121622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8890,053,437 - 90,122,219 (+)NCBI
RefSeq Acc Id: XM_063265553   ⟹   XP_063121623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8890,053,437 - 90,122,219 (+)NCBI
RefSeq Acc Id: XR_005488326
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,084,056 (+)NCBI
mRatBN7.2881,087,157 - 81,203,859 (+)NCBI
RefSeq Acc Id: XR_005488327
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,084,056 (+)NCBI
mRatBN7.2881,087,158 - 81,203,859 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008764645   ⟸   XM_008766423
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACM8 (UniProtKB/TrEMBL),   A0A8I5ZYN7 (UniProtKB/TrEMBL),   A0A8I6AEW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764647   ⟸   XM_008766425
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AEW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016428   ⟸   ENSRNOT00000016428
RefSeq Acc Id: XP_038938464   ⟸   XM_039082536
- Peptide Label: isoform X2
- UniProtKB: D4A5I9 (UniProtKB/TrEMBL),   A0A8I5ZYN7 (UniProtKB/TrEMBL),   A0A8I6AEW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091239   ⟸   ENSRNOT00000108142
RefSeq Acc Id: ENSRNOP00000091730   ⟸   ENSRNOT00000103299
RefSeq Acc Id: ENSRNOP00000083134   ⟸   ENSRNOT00000120263
RefSeq Acc Id: ENSRNOP00000077341   ⟸   ENSRNOT00000112254
RefSeq Acc Id: ENSRNOP00000083145   ⟸   ENSRNOT00000119730
RefSeq Acc Id: NP_001414188   ⟸   NM_001427259
- UniProtKB: A0A8I5Y7N7 (UniProtKB/TrEMBL),   A0A8I5ZWC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121622   ⟸   XM_063265552
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063121623   ⟸   XM_063265553
- Peptide Label: isoform X5
Protein Domains
Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5I9-F1-model_v2 AlphaFold D4A5I9 1-1285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560646 AgrOrtholog
BioCyc Gene G2FUF-29733 BioCyc
Ensembl Genes ENSRNOG00000011852 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016428.9 UniProtKB/TrEMBL
  ENSRNOT00000103299.1 UniProtKB/TrEMBL
  ENSRNOT00000108142.1 UniProtKB/TrEMBL
  ENSRNOT00000112254.1 UniProtKB/TrEMBL
  ENSRNOT00000119730.1 UniProtKB/TrEMBL
  ENSRNOT00000120263.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/TrEMBL
  3.30.70.1590 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.10.220.10 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
InterPro Kinesin_motor_dom_sf UniProtKB/TrEMBL
  MYO6_lever UniProtKB/TrEMBL
  Myosin-VI_CBD UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  MYSc_Myo6 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:315840 UniProtKB/TrEMBL
NCBI Gene 315840 ENTREZGENE
PANTHER MYOSIN UniProtKB/TrEMBL
  UNCONVENTIONAL MYOSIN-VI UniProtKB/TrEMBL
Pfam MYO6_lever UniProtKB/TrEMBL
  Myosin-VI_CBD UniProtKB/TrEMBL
  Myosin_head UniProtKB/TrEMBL
PhenoGen Myo6 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011852 RatGTEx
SMART MYSc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5Y7N7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEW8 ENTREZGENE, UniProtKB/TrEMBL
  D4A5I9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Myo6  myosin VI  RGD1560646  similar to Myosin VI  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-03-14 RGD1560646  similar to Myosin VI  RGD1560646_predicted  similar to Myosin VI (predicted)  Symbol and Name updated 1299863 PROVISIONAL
2006-03-07 RGD1560646_predicted  similar to Myosin VI (predicted)  LOC315840  similar to Myosin VI  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC315840  similar to Myosin VI      Symbol and Name status set to provisional 70820 PROVISIONAL