Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TSPAN6 mRNA] | CTD | PMID:31150632 | (-)-epigallocatechin 3-gallate | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | epigallocatechin gallate results in decreased expression of TSPAN6 mRNA | CTD | PMID:16084531 | 1,2-dimethylhydrazine | multiple interactions | ISO | Tspan6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TSPAN6 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | Tspan6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TSPAN6 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tspan6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TSPAN6 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TSPAN6 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TSPAN6 mRNA | CTD | PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2-hydroxypropanoic acid | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of TSPAN6 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | TSPAN6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TSPAN6 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | TSPAN6 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of TSPAN6 gene | CTD | PMID:31601247 | 4-hydroxyphenyl retinamide | increases expression | ISO | Tspan6 (Mus musculus) | 6480464 | Fenretinide results in increased expression of TSPAN6 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of TSPAN6 mRNA | CTD | PMID:24780913 | all-trans-retinoic acid | increases expression | ISO | Tspan6 (Mus musculus) | 6480464 | Tretinoin results in increased expression of TSPAN6 mRNA | CTD | PMID:16604517 | antirheumatic drug | increases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of TSPAN6 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of TSPAN6 mRNA | CTD | PMID:33212167 | atrazine | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of TSPAN6 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | ISO | Tspan6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of TSPAN6 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | TSPAN6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TSPAN6 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | TSPAN6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of TSPAN6 5' UTR | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | Tspan6 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of TSPAN6 mRNA | CTD | PMID:26063408 | bisphenol A | decreases methylation | ISO | TSPAN6 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of TSPAN6 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TSPAN6 mRNA | CTD | PMID:34947998 | bisphenol A | affects expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | bisphenol A affects the expression of TSPAN6 mRNA | CTD | PMID:30903817 | bisphenol A | multiple interactions | ISO | TSPAN6 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TSPAN6 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TSPAN6 mRNA | CTD | PMID:28628672 and PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TSPAN6 mRNA | CTD | PMID:25181051 | Bisphenol B | increases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of TSPAN6 protein | CTD | PMID:34186270 | carbon nanotube | decreases expression | ISO | Tspan6 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of TSPAN6 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | TSPAN6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TSPAN6 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Tspan6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TSPAN6 mRNA | CTD | PMID:20938992 | copper(II) sulfate | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of TSPAN6 mRNA | CTD | PMID:19549813 | crocidolite asbestos | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased expression of TSPAN6 mRNA | CTD | PMID:29523930 | cyclosporin A | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TSPAN6 mRNA | CTD | PMID:20106945 more ... | dexamethasone | multiple interactions | ISO | TSPAN6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TSPAN6 mRNA | CTD | PMID:28628672 | dibutyl phthalate | decreases expression | ISO | Tspan6 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of TSPAN6 mRNA | CTD | PMID:17361019 and PMID:21266533 | dicrotophos | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of TSPAN6 mRNA | CTD | PMID:28302478 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of TSPAN6 mRNA | CTD | PMID:21551480 | folic acid | multiple interactions | ISO | Tspan6 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | folpet | decreases expression | ISO | Tspan6 (Mus musculus) | 6480464 | folpet results in decreased expression of TSPAN6 mRNA | CTD | PMID:31558096 | fulvestrant | multiple interactions | ISO | TSPAN6 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TSPAN6 gene | CTD | PMID:31601247 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of TSPAN6 mRNA | CTD | PMID:24136188 | indometacin | multiple interactions | ISO | TSPAN6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TSPAN6 mRNA | CTD | PMID:28628672 | isotretinoin | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Isotretinoin results in decreased expression of TSPAN6 mRNA | CTD | PMID:20436886 | L-methionine | multiple interactions | ISO | Tspan6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TSPAN6 mRNA | CTD | PMID:20938992 | menadione | affects expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of TSPAN6 mRNA | CTD | PMID:20044591 | mono(2-ethylhexyl) phthalate | affects response to substance | ISO | TSPAN6 (Homo sapiens) | 6480464 | TSPAN6 gene SNP affects the susceptibility to mono-(2-ethylhexyl)phthalate | CTD | PMID:25622337 | monosodium L-glutamate | multiple interactions | ISO | Tspan6 (Mus musculus) | 6480464 | [Trans Fatty Acids co-treated with Sodium Glutamate] results in increased expression of TSPAN6 mRNA | CTD | PMID:22078008 | N-acetyl-L-cysteine | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Acetylcysteine results in decreased expression of TSPAN6 mRNA | CTD | PMID:16084531 | nickel atom | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Nickel results in decreased expression of TSPAN6 mRNA | CTD | PMID:24768652 and PMID:25583101 | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of TSPAN6 mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TSPAN6 mRNA | CTD | PMID:25729387 | paracetamol | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TSPAN6 mRNA | CTD | PMID:29067470 | perfluorohexanesulfonic acid | increases expression | ISO | Tspan6 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of TSPAN6 mRNA | CTD | PMID:37995155 | perfluorooctanoic acid | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of TSPAN6 protein | CTD | PMID:26879310 | piroxicam | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of TSPAN6 mRNA | CTD | PMID:21858171 | rac-lactic acid | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of TSPAN6 mRNA | CTD | PMID:30851411 | temozolomide | increases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of TSPAN6 mRNA | CTD | PMID:31758290 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TSPAN6 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TSPAN6 mRNA] | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of TSPAN6 mRNA | CTD | PMID:23411599 | tolcapone | decreases expression | EXP | | 6480464 | tolcapone results in decreased expression of TSPAN6 mRNA | CTD | PMID:24136188 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of TSPAN6 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TSPAN6 mRNA | CTD | PMID:25729387 | valproic acid | decreases expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TSPAN6 mRNA | CTD | PMID:29154799 | valproic acid | affects expression | ISO | TSPAN6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TSPAN6 mRNA | CTD | PMID:25979313 | vancomycin | decreases expression | ISO | Tspan6 (Mus musculus) | 6480464 | Vancomycin results in decreased expression of TSPAN6 mRNA | CTD | PMID:18930951 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of TSPAN6 mRNA | CTD | PMID:23034163 | |