Dipk2b (divergent protein kinase domain 2B) - Rat Genome Database

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Gene: Dipk2b (divergent protein kinase domain 2B) Rattus norvegicus
Analyze
Symbol: Dipk2b
Name: divergent protein kinase domain 2B
RGD ID: 1559731
Description: Predicted to be located in extracellular region. Orthologous to human DIPK2B (divergent protein kinase domain 2B); INTERACTS WITH bisphenol A; 4,4'-sulfonyldiphenol (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: deleted in autism-related protein 1; LOC501512; RGD1559731; similar to RIKEN cDNA 4930578C19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,788,387 - 6,857,845 (+)NCBIGRCr8
mRatBN7.2X4,205,486 - 4,274,939 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX4,205,490 - 4,271,574 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X4,691,406 - 4,743,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX4,691,172 - 4,739,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X5,476,606 - 5,529,420 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X15,776,105 - 15,843,788 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX4,765,167 - 4,789,281 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Dipk2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,788,387 - 6,857,845 (+)NCBIGRCr8
mRatBN7.2X4,205,486 - 4,274,939 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX4,205,490 - 4,271,574 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X4,691,406 - 4,743,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX4,691,172 - 4,739,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X5,476,606 - 5,529,420 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X15,776,105 - 15,843,788 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX4,765,167 - 4,789,281 (+)NCBICelera
Cytogenetic MapXq11NCBI
DIPK2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X45,148,373 - 45,200,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX45,148,373 - 45,200,901 (-)EnsemblGRCh38hg38GRCh38
GRCh37X45,007,618 - 45,060,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X44,906,511 - 44,945,090 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X44,777,820 - 44,816,400NCBI
CeleraX49,199,429 - 49,252,310 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX42,724,751 - 42,777,060 (-)NCBIHuRef
CHM1_1X45,040,306 - 45,092,809 (-)NCBICHM1_1
T2T-CHM13v2.0X44,557,298 - 44,609,794 (-)NCBIT2T-CHM13v2.0
Dipk2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X18,280,406 - 18,327,657 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX18,281,120 - 18,327,636 (-)EnsemblGRCm39 Ensembl
GRCm38X18,414,167 - 18,461,419 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX18,414,881 - 18,461,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X17,995,553 - 18,038,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X17,575,386 - 17,618,233 (-)NCBIMGSCv36mm8
CeleraX15,993,172 - 16,036,005 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX13.73NCBI
Dipk2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555163,041,092 - 3,083,491 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555163,041,112 - 3,081,740 (+)NCBIChiLan1.0ChiLan1.0
DIPK2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X46,782,827 - 46,835,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X46,786,202 - 46,838,884 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X37,587,189 - 37,639,862 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X45,398,721 - 45,451,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX45,398,721 - 45,451,579 (-)Ensemblpanpan1.1panPan2
DIPK2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X38,996,003 - 39,039,589 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX38,999,379 - 39,039,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX26,224,101 - 26,266,358 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X39,085,983 - 39,128,904 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX39,083,920 - 39,128,684 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X39,119,051 - 39,161,927 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X39,105,631 - 39,148,732 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X39,198,217 - 39,241,140 (-)NCBIUU_Cfam_GSD_1.0
Dipk2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X31,402,417 - 31,443,545 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650211,247,775 - 11,284,186 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650211,243,167 - 11,284,186 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIPK2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX40,178,969 - 40,222,542 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X40,179,289 - 40,223,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X44,761,659 - 44,802,800 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DIPK2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X42,336,140 - 42,382,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660767,526,418 - 7,586,768 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dipk2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248871,326,336 - 1,361,124 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248871,321,247 - 1,361,036 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dipk2b
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:89
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000005659
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 28 15 12 8 11 63 2 27 11 8
Below cutoff 2 5 24 23 6 23 11 29 13

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005659   ⟹   ENSRNOP00000005659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,205,490 - 4,271,574 (+)Ensembl
Rnor_6.0 EnsemblX4,691,172 - 4,739,890 (+)Ensembl
RefSeq Acc Id: XM_039100232   ⟹   XP_038956160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,788,387 - 6,857,845 (+)NCBI
mRatBN7.2X4,205,488 - 4,274,939 (+)NCBI
RefSeq Acc Id: XM_039100233   ⟹   XP_038956161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,788,396 - 6,853,523 (+)NCBI
mRatBN7.2X4,205,486 - 4,270,618 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038956160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956161 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97684 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005659
  ENSRNOP00000005659.7
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000005659   ⟸   ENSRNOT00000005659
RefSeq Acc Id: XP_038956161   ⟸   XM_039100233
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038956160   ⟸   XM_039100232
- Peptide Label: isoform X1
- UniProtKB: D3ZCG1 (UniProtKB/TrEMBL)
Protein Domains
FAM69 protein-kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCG1-F1-model_v2 AlphaFold D3ZCG1 1-235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559731 AgrOrtholog
BioCyc Gene G2FUF-3136 BioCyc
Ensembl Genes ENSRNOG00000004265 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005659.7 UniProtKB/TrEMBL
InterPro DIPK2A/B UniProtKB/TrEMBL
  FAM69_kinase_dom UniProtKB/TrEMBL
NCBI Gene 501512 ENTREZGENE
PANTHER DIVERGENT PROTEIN KINASE DOMAIN 2B UniProtKB/TrEMBL
  PTHR32073 UniProtKB/TrEMBL
Pfam PIP49_C UniProtKB/TrEMBL
PhenoGen Dipk2b PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004265 RatGTEx
UniProt D3ZCG1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-18 Dipk2b  divergent protein kinase domain 2B  RGD1559731  similar to RIKEN cDNA 4930578C19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559731  similar to RIKEN cDNA 4930578C19   RGD1559731_predicted  similar to RIKEN cDNA 4930578C19 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559731_predicted  similar to RIKEN cDNA 4930578C19 (predicted)  LOC501512  similar to RIKEN cDNA 4930578C19  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501512  similar to RIKEN cDNA 4930578C19      Symbol and Name status set to provisional 70820 PROVISIONAL