Mdc1 (mediator of DNA damage checkpoint 1) - Rat Genome Database

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Gene: Mdc1 (mediator of DNA damage checkpoint 1) Rattus norvegicus
Analyze
Symbol: Mdc1
Name: mediator of DNA damage checkpoint 1
RGD ID: 1559468
Description: Predicted to enable histone reader activity. Predicted to be involved in DNA damage response; DNA replication checkpoint signaling; and protein localization to site of double-strand break. Predicted to be located in chromosome; focal adhesion; and nuclear body. Predicted to be active in site of double-strand break. Orthologous to human MDC1 (mediator of DNA damage checkpoint 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KIAA0170; mediator of DNA damage checkpoint protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,898,496 - 2,914,960 (-)NCBIGRCr8
mRatBN7.2202,893,693 - 2,912,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,895,505 - 2,910,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,946,881 - 2,961,571 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,951,854 - 2,966,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,978,021 - 2,992,929 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,405,017 - 3,419,831 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,404,711 - 3,419,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,502,120 - 5,516,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,042,953 - 3,057,607 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera20321,426 - 336,070 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
5-azacytidine  (ISO)
9-aminoacridine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
casticin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
FR900359  (ISO)
genistein  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
monocrotaline  (ISO)
n-propyl gallate  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
riddelliine  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (ISO,ISS)
focal adhesion  (ISO)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO)
site of double-strand break  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Bartkova J, etal., Oncogene. 2007 Nov 22;26(53):7414-22. Epub 2007 Jun 4.
2. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
5. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer. Yuan C, etal., Mol Cell Biochem. 2012 Jan;359(1-2):333-46. doi: 10.1007/s11010-011-1027-7. Epub 2011 Aug 19.
12. Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma. Zhang ZZ, etal., World J Gastroenterol. 2013 Mar 28;19(12):1968-74. doi: 10.3748/wjg.v19.i12.1968.
Additional References at PubMed
PMID:15060004   PMID:15489334   PMID:15604234   PMID:17577209   PMID:20008512   PMID:21293379   PMID:23039116   PMID:24217620   PMID:24550317   PMID:29656893  


Genomics

Comparative Map Data
Mdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,898,496 - 2,914,960 (-)NCBIGRCr8
mRatBN7.2202,893,693 - 2,912,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,895,505 - 2,910,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,946,881 - 2,961,571 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,951,854 - 2,966,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,978,021 - 2,992,929 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,405,017 - 3,419,831 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,404,711 - 3,419,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,502,120 - 5,516,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,042,953 - 3,057,607 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera20321,426 - 336,070 (-)NCBICelera
Cytogenetic Map20p12NCBI
MDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,699,807 - 30,717,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,699,807 - 30,717,447 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,667,584 - 30,685,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,775,563 - 30,793,437 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,775,563 - 30,790,934NCBI
Celera632,265,722 - 32,283,590 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,467,532 - 30,485,406 (-)NCBIHuRef
CHM1_1630,669,686 - 30,687,581 (-)NCBICHM1_1
T2T-CHM13v2.0630,564,011 - 30,584,416 (-)NCBIT2T-CHM13v2.0
Mdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,152,390 - 36,170,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,152,407 - 36,170,562 (+)EnsemblGRCm39 Ensembl
GRCm381735,841,495 - 35,859,670 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,841,515 - 35,859,670 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,978,443 - 35,996,615 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,449,706 - 35,467,725 (+)NCBIMGSCv36mm8
Celera1739,351,560 - 39,369,494 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
Mdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955583688,288 - 722,393 (-)NCBIChiLan1.0ChiLan1.0
MDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,260,018 - 45,278,434 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,223,716 - 41,241,276 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,444,570 - 30,462,432 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,313,898 - 31,329,246 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,314,560 - 31,329,243 (-)Ensemblpanpan1.1panPan2
MDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112496,353 - 509,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12496,878 - 507,442 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12633,666 - 647,122 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012639,486 - 652,943 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12639,486 - 652,569 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112497,479 - 510,934 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012566,333 - 579,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012634,906 - 648,361 (-)NCBIUU_Cfam_GSD_1.0
Mdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494633,998,611 - 34,015,580 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837362,928 - 378,759 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837363,870 - 379,406 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,229,510 - 23,245,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,229,508 - 23,247,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,951,468 - 26,969,675 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,735,584 - 41,754,618 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,739,419 - 41,755,141 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,396,343 - 30,414,913 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475425,007,866 - 25,020,950 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mdc1
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:62
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000046798
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 30 22 18 22 55 21 37 3
Low 1 17 27 19 1 19 8 11 19 14 4 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046798   ⟹   ENSRNOP00000049009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,895,505 - 2,910,160 (-)Ensembl
Rnor_6.0 Ensembl203,405,018 - 3,419,831 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,417,061 - 3,419,551 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,895,505 - 2,910,160 (-)Ensembl
Rnor_6.0 Ensembl203,405,017 - 3,419,831 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,895,505 - 2,910,240 (-)Ensembl
Rnor_6.0 Ensembl203,408,116 - 3,409,862 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,404,711 - 3,405,285 (-)Ensembl
RefSeq Acc Id: NM_001166275   ⟹   NP_001159747
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,900,307 - 2,914,960 (-)NCBI
mRatBN7.2202,895,504 - 2,910,160 (-)NCBI
Rnor_6.0203,405,017 - 3,419,831 (-)NCBI
Rnor_5.0205,502,120 - 5,516,934 (-)NCBI
RGSC_v3.4203,042,953 - 3,057,607 (-)RGD
Celera20321,426 - 336,070 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098643   ⟹   XP_038954571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,898,496 - 2,914,790 (-)NCBI
mRatBN7.2202,893,693 - 2,909,897 (-)NCBI
RefSeq Acc Id: XM_039098645   ⟹   XP_038954573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,898,496 - 2,914,925 (-)NCBI
mRatBN7.2202,893,693 - 2,912,394 (-)NCBI
RefSeq Acc Id: XM_039098647   ⟹   XP_038954575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,898,496 - 2,914,697 (-)NCBI
mRatBN7.2202,893,693 - 2,909,897 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001159747   ⟸   NM_001166275
- UniProtKB: Q6MG15 (UniProtKB/Swiss-Prot),   Q5U2M8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000049009   ⟸   ENSRNOT00000046798
RefSeq Acc Id: XP_038954573   ⟸   XM_039098645
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954575   ⟸   XM_039098647
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954571   ⟸   XM_039098643
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GIV7 (UniProtKB/TrEMBL)
Protein Domains
BRCT   FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2M8-F1-model_v2 AlphaFold Q5U2M8 1-1279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559468 AgrOrtholog
BioCyc Gene G2FUF-4778 BioCyc
Ensembl Genes ENSRNOG00000032813 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006814 UniProtKB/Swiss-Prot
  ENSRNOG00060003725 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046798 ENTREZGENE
  ENSRNOT00000046798.5 UniProtKB/Swiss-Prot
  ENSRNOT00000081676.2 UniProtKB/TrEMBL
  ENSRNOT00000086914.2 UniProtKB/TrEMBL
  ENSRNOT00055011175 UniProtKB/Swiss-Prot
  ENSRNOT00060006170 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134653 IMAGE-MGC_LOAD
InterPro BRCT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FHA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309595 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95298 IMAGE-MGC_LOAD
NCBI Gene 309595 ENTREZGENE
PANTHER MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRCT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTT107_BRCT_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mdc1 PhenoGen
PROSITE BRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FHA_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032813 RatGTEx
  ENSRNOG00055006814 RatGTEx
  ENSRNOG00060003725 RatGTEx
SMART BRCT UniProtKB/Swiss-Prot
  FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIV7 ENTREZGENE, UniProtKB/TrEMBL
  A6KT84_RAT UniProtKB/TrEMBL
  MDC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6MG15 ENTREZGENE
UniProt Secondary Q6MG15 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Mdc1  mediator of DNA damage checkpoint 1      Symbol and Name status set to provisional 70820 PROVISIONAL