Serpinb3 (serpin family B member 3) - Rat Genome Database

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Gene: Serpinb3 (serpin family B member 3) Rattus norvegicus
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Symbol: Serpinb3
Name: serpin family B member 3
RGD ID: 1549766
Description: Predicted to enable endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Predicted to be involved in several processes, including autocrine signaling; paracrine signaling; and positive regulation of epithelial to mesenchymal transition. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytosol; and extracellular exosome. Predicted to be active in extracellular space. Orthologous to human SERPINB3 (serpin family B member 3); INTERACTS WITH bisphenol A; fenvalerate; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: serine protease inhibitor B3; serpin peptidase inhibitor, clade B (ovalbumin), member 3
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,788,758 - 23,795,298 (-)NCBIGRCr8
mRatBN7.21323,274,120 - 23,280,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,274,484 - 23,313,682 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,637,345 - 23,643,886 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01324,921,816 - 24,928,357 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01323,607,534 - 23,614,075 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01327,186,701 - 27,193,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,187,130 - 27,192,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01332,336,215 - 32,341,680 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41313,339,447 - 13,344,912 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1323,119,963 - 23,125,428 (-)NCBICelera
Cytogenetic Map13p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10956412   PMID:12949073   PMID:12975381   PMID:19056867   PMID:19190083   PMID:20527027   PMID:21383048   PMID:21557262   PMID:21630459   PMID:23376485  


Genomics

Comparative Map Data
Serpinb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,788,758 - 23,795,298 (-)NCBIGRCr8
mRatBN7.21323,274,120 - 23,280,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,274,484 - 23,313,682 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,637,345 - 23,643,886 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01324,921,816 - 24,928,357 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01323,607,534 - 23,614,075 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01327,186,701 - 27,193,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,187,130 - 27,192,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01332,336,215 - 32,341,680 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41313,339,447 - 13,344,912 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1323,119,963 - 23,125,428 (-)NCBICelera
Cytogenetic Map13p11NCBI
SERPINB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,655,197 - 63,661,893 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1863,655,197 - 63,661,893 (-)EnsemblGRCh38hg38GRCh38
GRCh371861,322,431 - 61,329,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361859,473,411 - 59,480,094 (-)NCBINCBI36Build 36hg18NCBI36
Build 341859,473,410 - 59,480,094NCBI
Celera1858,042,926 - 58,049,692 (-)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1858,022,262 - 58,029,029 (-)NCBIHuRef
CHM1_11861,318,618 - 61,325,385 (-)NCBICHM1_1
T2T-CHM13v2.01863,860,279 - 63,866,975 (-)NCBIT2T-CHM13v2.0
Serpinb3d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391107,005,893 - 107,011,210 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1107,005,897 - 107,011,236 (-)EnsemblGRCm39 Ensembl
GRCm381107,078,163 - 107,083,480 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1107,078,167 - 107,083,506 (-)EnsemblGRCm38mm10GRCm38
MGSCv371108,974,770 - 108,980,057 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361108,905,740 - 108,911,027 (-)NCBIMGSCv36mm8
Celera1109,926,247 - 109,931,536 (-)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map150.34NCBI

Variants

.
Variants in Serpinb3
88 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:60
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000040021
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 8
Below cutoff 4 5 1 1 13 3 9 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003475   ⟹   ENSRNOP00000003475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1323,274,484 - 23,313,682 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000040021   ⟹   ENSRNOP00000046632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1323,274,484 - 23,280,011 (-)Ensembl
Rnor_6.0 Ensembl1327,187,130 - 27,192,592 (-)Ensembl
RefSeq Acc Id: NM_001395733   ⟹   NP_001382662
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,788,758 - 23,795,298 (-)NCBI
mRatBN7.21323,274,120 - 23,280,660 (-)NCBI
RefSeq Acc Id: XM_006249631   ⟹   XP_006249693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,788,758 - 23,794,720 (-)NCBI
mRatBN7.21323,274,120 - 23,280,082 (-)NCBI
Rnor_6.01327,186,701 - 27,193,211 (-)NCBI
Rnor_5.01332,336,215 - 32,341,680 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001382662 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249693 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51401 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003475
  ENSRNOP00000003475.3
  ENSRNOP00000046632.3
Reference Protein Sequences
RefSeq Acc Id: XP_006249693   ⟸   XM_006249631
- Peptide Label: isoform X1
- UniProtKB: F1MAA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000046632   ⟸   ENSRNOT00000040021
RefSeq Acc Id: ENSRNOP00000003475   ⟸   ENSRNOT00000003475
RefSeq Acc Id: NP_001382662   ⟸   NM_001395733
- UniProtKB: F1MAA9 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAA9-F1-model_v2 AlphaFold F1MAA9 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549766 AgrOrtholog
BioCyc Gene G2FUF-18595 BioCyc
Ensembl Genes ENSRNOG00000031134 Ensembl
  ENSRNOG00000070387 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003475 ENTREZGENE
  ENSRNOT00000003475.5 UniProtKB/TrEMBL
  ENSRNOT00000040021.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:304688 UniProtKB/TrEMBL
NCBI Gene 304688 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  SERPIN B4 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb3 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031134 RatGTEx
  ENSRNOG00000070387 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt D3ZJK2_RAT UniProtKB/TrEMBL
  F1MAA9 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE44_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpinb3  serpin family B member 3  Serpinb3  serpin peptidase inhibitor, clade B (ovalbumin), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-07 Serpinb3  serpin peptidase inhibitor, clade B (ovalbumin), member 3  Serpinb3  serine protease inhibitor B3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 Serpinb3  serine protease inhibitor B3      Symbol and Name status set to provisional 70820 PROVISIONAL