Uba1 (ubiquitin-like modifier activating enzyme 1) - Rat Genome Database

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Gene: Uba1 (ubiquitin-like modifier activating enzyme 1) Rattus norvegicus
Analyze
Symbol: Uba1
Name: ubiquitin-like modifier activating enzyme 1
RGD ID: 1359327
Description: Predicted to enable ubiquitin activating enzyme activity. Predicted to be involved in DNA damage response; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of heterochromatin. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with bounding membrane of organelle and desmosome. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1); PARTICIPATES IN Parkinson's disease pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,5-hexanedione; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314432; similar to ubiquitin-protein ligase (EC 6.3.2.19) E1 - mouse; Ube1x; ubiquitin-activating enzyme E1, Chr X; ubiquitin-like modifier-activating enzyme 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,062,216 - 4,084,192 (-)NCBIGRCr8
mRatBN7.2X1,508,700 - 1,530,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,508,666 - 1,530,636 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,542,708 - 1,561,181 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,018,410 - 5,036,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,333,715 - 1,352,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,723,135 - 1,745,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,723,174 - 1,741,701 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,516,602 - 2,538,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,926,049 - 12,944,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,931,605 - 12,950,078 (-)NCBI
CeleraX2,072,832 - 2,091,181 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-hexanedione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benomyl  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethyldithiocarbamic acid  (EXP,ISO)
dimethyldithiocarbamate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
FR900359  (ISO)
furan  (EXP)
glafenine  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
metam  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
molinate  (ISO)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (EXP)
potassium dichromate  (ISO)
propiconazole  (EXP)
prostaglandin A1  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
SKF 38393  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
desmosome  (IEA,ISO)
endosome membrane  (IEA,ISO)
heterochromatin  (IEA,ISO)
lysosomal membrane  (IEA,ISO)
mitochondrion  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
rough endoplasmic reticulum membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. Allen E, etal., Nature. 2005 Nov 10;438(7065):224-8. doi: 10.1038/nature04256. Epub 2005 Oct 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1376922   PMID:1511901   PMID:12629039   PMID:18818210   PMID:19056867   PMID:19199708   PMID:20448150   PMID:20458337   PMID:21630459   PMID:21685362   PMID:22082260   PMID:22456334  
PMID:22658674   PMID:22681889   PMID:22871113   PMID:23376485   PMID:23533145   PMID:26919560   PMID:33450132  


Genomics

Comparative Map Data
Uba1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,062,216 - 4,084,192 (-)NCBIGRCr8
mRatBN7.2X1,508,700 - 1,530,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,508,666 - 1,530,636 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,542,708 - 1,561,181 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,018,410 - 5,036,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,333,715 - 1,352,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,723,135 - 1,745,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,723,174 - 1,741,701 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,516,602 - 2,538,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,926,049 - 12,944,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,931,605 - 12,950,078 (-)NCBI
CeleraX2,072,832 - 2,091,181 (-)NCBICelera
Cytogenetic MapXq11NCBI
UBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,190,847 - 47,215,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,190,861 - 47,215,128 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,050,246 - 47,074,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,935,204 - 46,959,471 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX51,245,489 - 51,269,819 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,761,319 - 44,784,789 (+)NCBIHuRef
CHM1_1X47,081,686 - 47,106,022 (+)NCBICHM1_1
T2T-CHM13v2.0X46,600,543 - 46,624,827 (+)NCBIT2T-CHM13v2.0
Uba1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,524,660 - 20,549,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,524,565 - 20,549,418 (+)EnsemblGRCm39 Ensembl
GRCm38X20,658,302 - 20,683,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,658,326 - 20,683,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,235,547 - 20,260,305 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,815,380 - 19,840,138 (+)NCBIMGSCv36mm8
CeleraX18,792,750 - 18,813,110 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.15NCBI
Uba1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516876,354 - 891,206 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516876,542 - 898,763 (-)NCBIChiLan1.0ChiLan1.0
UBA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,818,274 - 48,842,554 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,821,657 - 48,845,930 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,627,753 - 39,652,023 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,485,374 - 47,509,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,493,331 - 47,509,654 (+)Ensemblpanpan1.1panPan2
UBA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,784,240 - 40,807,072 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,783,809 - 40,807,069 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,159,372 - 15,182,235 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,918,209 - 40,941,099 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,918,225 - 40,941,097 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,905,897 - 40,928,783 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,893,780 - 40,916,640 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,986,880 - 41,009,744 (+)NCBIUU_Cfam_GSD_1.0
Uba1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,120,490 - 33,143,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,969,145 - 12,984,238 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,961,236 - 12,984,235 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,814,101 - 41,832,812 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,810,726 - 41,832,818 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,779,768 - 46,793,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,377,765 - 44,402,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,385,940 - 44,405,051 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,636,110 - 9,660,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uba1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,963,871 - 3,984,243 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,961,699 - 3,983,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uba1
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:108
Interacting mature miRNAs:111
Transcripts:ENSRNOT00000031115
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat

Markers in Region
RH129666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,508,722 - 1,508,912 (+)MAPPERmRatBN7.2
Rnor_6.0X1,723,194 - 1,723,383NCBIRnor6.0
Rnor_5.0X2,516,625 - 2,516,814UniSTSRnor5.0
RGSC_v3.4X12,926,072 - 12,926,261UniSTSRGSC3.4
CeleraX2,072,855 - 2,073,044UniSTS
Cytogenetic MapXq12UniSTS
AA989744  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,508,832 - 1,508,932 (+)MAPPERmRatBN7.2
Rnor_6.0X1,723,304 - 1,723,403NCBIRnor6.0
Rnor_5.0X2,516,735 - 2,516,834UniSTSRnor5.0
RGSC_v3.4X12,926,182 - 12,926,281UniSTSRGSC3.4
CeleraX2,072,965 - 2,073,064UniSTS
Cytogenetic MapXq12UniSTS
Ube1x  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,512,821 - 1,512,893 (+)MAPPERmRatBN7.2
Rnor_6.0X1,727,293 - 1,727,364NCBIRnor6.0
Rnor_5.0X2,520,724 - 2,520,795UniSTSRnor5.0
RGSC_v3.4X12,930,171 - 12,930,242UniSTSRGSC3.4
CeleraX2,076,954 - 2,077,025UniSTS
Cytogenetic MapXq12UniSTS
UniSTS:256410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,508,928 - 1,509,874 (+)MAPPERmRatBN7.2
Rnor_6.0X1,723,400 - 1,724,345NCBIRnor6.0
Rnor_5.0X2,516,831 - 2,517,776UniSTSRnor5.0
RGSC_v3.4X12,926,278 - 12,927,223UniSTSRGSC3.4
CeleraX2,073,061 - 2,074,006UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000031115   ⟹   ENSRNOP00000033950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,508,666 - 1,522,637 (-)Ensembl
Rnor_6.0 EnsemblX1,723,174 - 1,741,701 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085338   ⟹   ENSRNOP00000084488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,508,702 - 1,530,636 (-)Ensembl
RefSeq Acc Id: NM_001014080   ⟹   NP_001014102
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,062,216 - 4,080,689 (-)NCBI
mRatBN7.2X1,508,700 - 1,527,174 (-)NCBI
Rnor_6.0X1,723,171 - 1,741,644 (-)NCBI
Rnor_5.0X2,516,602 - 2,538,602 (-)NCBI
RGSC_v3.4X12,926,049 - 12,944,522 (-)RGD
CeleraX2,072,832 - 2,091,181 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256612   ⟹   XP_006256674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,062,216 - 4,084,161 (-)NCBI
mRatBN7.2X1,508,700 - 1,530,634 (-)NCBI
Rnor_6.0X1,723,135 - 1,745,070 (-)NCBI
Rnor_5.0X2,516,602 - 2,538,602 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256613   ⟹   XP_006256675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,062,216 - 4,084,192 (-)NCBI
mRatBN7.2X1,508,700 - 1,530,677 (-)NCBI
Rnor_6.0X1,723,135 - 1,745,147 (-)NCBI
Rnor_5.0X2,516,602 - 2,538,602 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063280005   ⟹   XP_063136075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,062,216 - 4,084,036 (-)NCBI
RefSeq Acc Id: NP_001014102   ⟸   NM_001014080
- UniProtKB: Q5U300 (UniProtKB/Swiss-Prot),   A0A8L2QII5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256675   ⟸   XM_006256613
- Peptide Label: isoform X1
- UniProtKB: Q5U300 (UniProtKB/Swiss-Prot),   A0A8L2QII5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256674   ⟸   XM_006256612
- Peptide Label: isoform X1
- UniProtKB: Q5U300 (UniProtKB/Swiss-Prot),   A0A8L2QII5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033950   ⟸   ENSRNOT00000031115
RefSeq Acc Id: ENSRNOP00000084488   ⟸   ENSRNOT00000085338
RefSeq Acc Id: XP_063136075   ⟸   XM_063280005
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U300-F1-model_v2 AlphaFold Q5U300 1-1058 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701695
Promoter ID:EPDNEW_R12219
Type:multiple initiation site
Name:Uba1_1
Description:ubiquitin-like modifier activating enzyme 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X1,741,665 - 1,741,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359327 AgrOrtholog
BioCyc Gene G2FUF-3188 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000019164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055016495 UniProtKB/Swiss-Prot
  ENSRNOG00060021167 UniProtKB/Swiss-Prot
  ENSRNOG00065020374 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031115.5 UniProtKB/TrEMBL
  ENSRNOT00000085338.3 UniProtKB/TrEMBL
  ENSRNOT00055028048 UniProtKB/Swiss-Prot
  ENSRNOT00060037267 UniProtKB/Swiss-Prot
  ENSRNOT00065034509 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.2660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.30.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.290.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109118 IMAGE-MGC_LOAD
InterPro E1_4HB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_FCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_FCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ub-activating_enz_E1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ub-E1_IAD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_E1_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_E1_Cys UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubi_acti_E1_SCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1_Cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ/SUMO-activ_enz_E1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314432 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93773 IMAGE-MGC_LOAD
NCBI Gene 314432 ENTREZGENE
PANTHER PTHR10953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1_4HB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_FCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_UFD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_e1_thiolCys UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uba1 PhenoGen
PRINTS UBIQUITINACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE UBIQUITIN_ACTIVAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN_ACTIVAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019164 RatGTEx
  ENSRNOG00055016495 RatGTEx
  ENSRNOG00060021167 RatGTEx
  ENSRNOG00065020374 RatGTEx
SMART UBA_e1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZY80_RAT UniProtKB/TrEMBL
  A0A8L2QII5 ENTREZGENE, UniProtKB/TrEMBL
  Q5U300 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27     Uba1  ubiquitin-like modifier activating enzyme 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Uba1  ubiquitin-like modifier activating enzyme 1  Ube1x  ubiquitin-activating enzyme E1, Chr X  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-11 Ube1x  ubiquitin-activating enzyme E1, Chr X  LOC314432  similar to ubiquitin-protein ligase (EC 6.3.2.19) E1 - mouse  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-07-29 LOC314432  similar to ubiquitin-protein ligase (EC 6.3.2.19) E1 - mouse      Symbol and Name status set to provisional 70820 PROVISIONAL