Kifc1 (kinesin family member C1) - Rat Genome Database

Name: Kifc1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Kifc1 (kinesin family member C1) Rattus norvegicus

Analyze

Symbol:

Kifc1

Name:

kinesin family member C1

RGD ID:

1359118

Description:

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and minus-end-directed microtubule motor activity. Involved in spermatogenesis. Predicted to be located in endocytic vesicle and spindle pole centrosome. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton and nucleus. Orthologous to human KIFC1 (kinesin family member C1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

kinesin-like protein KIFC1; kinesin-related protein 1; kinesin-related protein KRP1; MGC94918

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KIFC1 (kinesin family member C1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KIFC1 (kinesin family member C1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kifc1 (kinesin family member C1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kifc5b (kinesin family member C5B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kifc1 (kinesin family member C1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	KAR3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	klp-16	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	ncd	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dcun1d5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kifc1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,000,929 - 5,018,967 (+)	NCBI		GRCr8
mRatBN7.2	20	4,998,832 - 5,017,107 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,999,047 - 5,017,105 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,722,546 - 5,742,381 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,084,291 - 5,104,118 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	5,564,478 - 5,582,550 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,509,059 - 5,526,175 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,509,059 - 5,526,175 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,567,671 - 7,585,188 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	5,150,810 - 5,169,264 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	5,151,036 - 5,169,489 (+)	NCBI
Celera	20	6,581,869 - 6,599,528 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autosomal dominant intellectual developmental disorder 5 (ISO)

COVID-19 (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Triple Negative Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbamazepine (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cocaine (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

corticosterone (EXP)

coumestrol (ISO)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

Cuprizon (EXP)

cyclosporin A (EXP,ISO)

diallyl trisulfide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

diethyl maleate (EXP)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

fenofibrate (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (ISO)

lidocaine (EXP)

linezolid (EXP)

lithium atom (EXP)

lithium hydride (EXP)

lucanthone (ISO)

MeIQx (ISO)

mercury dichloride (EXP)

methamphetamine (ISO)

methapyrilene (EXP)

methotrexate (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

niclosamide (ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenanthridone (ISO)

pirinixic acid (EXP)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

quercetin (EXP)

silicon dioxide (ISO)

sirolimus (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

tacrolimus hydrate (EXP)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (EXP)

topotecan (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

microtubule-based movement (IBA,IEA)

minus-end-directed vesicle transport along microtubule (ISO)

mitotic metaphase chromosome alignment (IEA,ISO,ISS)

mitotic spindle assembly (IBA,IEA,ISO,ISS)

negative regulation of centrosome duplication (ISO)

spermatogenesis (IEP)

vesicle transport along microtubule (ISO)

Cellular Component

cytoplasm (IEA)

early endosome (IEA)

endocytic vesicle (ISO)

kinesin complex (IBA)

microtubule (IBA,IEA)

microtubule organizing center (IBA)

mitotic spindle (IBA,ISO)

nucleus (IBA,ISO)

spindle pole centrosome (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA)

microtubule binding (IBA,IEA)

microtubule motor activity (IBA,IEA)

minus-end-directed microtubule motor activity (ISO)

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6.	C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport.	Yang WX and Sperry AO, Biol Reprod 2003 Nov;69(5):1719-29. Epub 2003 Jun 25.
7.	The molecular motor KIFC1 associates with a complex containing nucleoporin NUP62 that is regulated during development and by the small GTPase RAN.	Yang WX, etal., Biol Reprod. 2006 Apr;74(4):684-90. Epub 2005 Dec 21.

Additional References at PubMed

PMID:8688559	PMID:15843429	PMID:19946888	PMID:30804089

Genomics

Comparative Map Data

Kifc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,000,929 - 5,018,967 (+)	NCBI		GRCr8
mRatBN7.2	20	4,998,832 - 5,017,107 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,999,047 - 5,017,105 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,722,546 - 5,742,381 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,084,291 - 5,104,118 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	5,564,478 - 5,582,550 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,509,059 - 5,526,175 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,509,059 - 5,526,175 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,567,671 - 7,585,188 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	5,150,810 - 5,169,264 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	5,151,036 - 5,169,489 (+)	NCBI
Celera	20	6,581,869 - 6,599,528 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

KIFC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	33,391,461 - 33,409,896 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	33,391,823 - 33,409,896 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	33,359,600 - 33,377,673 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	33,467,583 - 33,485,625 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	34,913,703 - 34,932,095 (+)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	33,101,381 - 33,119,773 (+)	NCBI		HuRef
CHM1_1	6	33,361,187 - 33,379,567 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,212,742 - 33,231,258 (+)	NCBI		T2T-CHM13v2.0

Kifc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,094,640 - 34,109,607 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,094,633 - 34,109,635 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	33,875,664 - 33,890,633 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	33,875,659 - 33,890,661 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,012,611 - 34,027,600 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	27,054,036 - 27,069,524 (+)	NCBI		MGSCv36	mm8
Celera	17	36,628,582 - 36,643,546 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.98	NCBI

Kifc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	1,923,506 - 1,940,970 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	1,923,136 - 1,941,094 (+)	NCBI	ChiLan1.0	ChiLan1.0

KIFC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	47,876,580 - 47,894,889 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	43,743,866 - 43,761,938 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	32,971,033 - 32,989,129 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	34,081,586 - 34,100,591 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	34,078,842 - 34,100,373 (+)	Ensembl	panpan1.1		panPan2

KIFC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,808,374 - 2,821,203 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	2,808,705 - 2,821,217 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	2,889,201 - 2,901,948 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	3,140,027 - 3,152,781 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	3,140,220 - 3,152,876 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	2,807,166 - 2,819,907 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,888,268 - 2,901,012 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,986,376 - 2,999,127 (+)	NCBI		UU_Cfam_GSD_1.0

Kifc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,457,125 - 38,472,793 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	25,487,503 - 25,546,359 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	25,488,426 - 25,503,135 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KIFC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	29,694,778 - 29,713,712 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	29,692,775 - 29,713,716 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	34,198,547 - 34,212,734 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KIFC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,656,517 - 38,675,056 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,656,246 - 38,674,470 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	33,240,536 - 33,258,617 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kifc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,410,007 - 23,413,902 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	23,405,951 - 23,421,696 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kifc1
162 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	47
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000065349
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1527959	5304575	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	4606607	6691706	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
7175096	Tcs1	T cell selection QTL 1			T cell selection	expression	20	4727078	5024580	Rat

Markers in Region

UniSTS:236125

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	5,011,213 - 5,011,477 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	5,520,294 - 5,520,557	NCBI	Rnor6.0
Rnor_5.0	20	7,579,303 - 7,579,566	UniSTS	Rnor5.0
RGSC_v3.4	20	5,163,379 - 5,163,642	UniSTS	RGSC3.4
Celera	20	6,593,643 - 6,593,906	UniSTS
Cytogenetic Map	20	p12	UniSTS

UniSTS:463415

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	5,009,883 - 5,011,077 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	5,518,964 - 5,520,157	NCBI	Rnor6.0
Rnor_5.0	20	7,577,973 - 7,579,166	UniSTS	Rnor5.0
RGSC_v3.4	20	5,162,049 - 5,163,242	UniSTS	RGSC3.4
Celera	20	6,592,313 - 6,593,506	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	29	22	17	22			39	26	36
Low		16	24	15	2	15	6	9	33	9	5	11	6
Below cutoff		1	4	4		4	2	2	2				2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF035951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX883042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000065349 ⟹ ENSRNOP00000061875

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,047 - 5,017,102 (+)	Ensembl
Rnor_6.0 Ensembl	20	5,509,059 - 5,526,175 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092584

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	5,519,216 - 5,519,923 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095546 ⟹ ENSRNOP00000087209

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,367 - 5,017,105 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103176 ⟹ ENSRNOP00000087122

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,060 - 5,017,105 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114906 ⟹ ENSRNOP00000092623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,047 - 5,012,147 (+)	Ensembl

RefSeq Acc Id:

NM_001005878 ⟹ NP_001005878

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,000,929 - 5,018,967 (+)	NCBI
mRatBN7.2	20	4,999,060 - 5,017,107 (+)	NCBI
Rnor_6.0	20	5,509,059 - 5,526,175 (+)	NCBI
Rnor_5.0	20	7,567,671 - 7,585,188 (+)	NCBI
RGSC_v3.4	20	5,150,810 - 5,169,264 (+)	RGD
Celera	20	6,581,869 - 6,599,528 (+)	RGD

Sequence:

show sequence

GGTGGTCTGGCTCCTGGGCCGTCTGGCTCGGGTGTTGCGTGGCGCGAGCCCATGAGAGGACGCG
GGTCTCGGGACACCGGCACCCAGTCTGCTGCCTTTGCATCCCGTCCTGTGCGGACCACCGTGGA
CATGCAGGCACAGAGGGCCCCTTTGATGGAAGTGAAGAGGAACTTGGAGCTGAGCACAACCCTG
GTCAAGTCCTCCTCCCGGCTGCCCCTACCAGGAAGCAGGCTCAAGAGGGGTCCTGACCAGATGG
AGGATGGCCTGGAGCCTGCAAAGAAACGAACACGAGGCATGGGCACAGTGACCAAAGTTGACAC
ATCCCGCCCGAGAGGGCCACCCCTCAGCGCAGTGTCCACTGCAGCTCAGAAAGGCCCTAGGAAG
ACTGGACCTCGAGGGTGCTCTGCTGTCGGTCCAGTGCTGAGGAACCAGAAGCCAGCTCCCGCTG
CTCCTGCCCAGAAGCCAGGCACATCCACTGCTCCTGCGGTGGCAGGAAAGAAACCTGGCAAGCG
TCCTGCCTGGGACTTGAAGGGCCAGTTGTGTGACCTCCATGAAGAGTTGAAACAGTATCGGGAG
AAGACTCAGACACTGGACCGTGAGAACCAGGGGCTCCGAGAGCAACTCAGAGAGGTTCAGGAGC
AGGCCACGACCCTGGGGACAGAGCGGAACACCCTGGAGGAGGAGCTGGCCAGTGTACGCAGGCG
AGCTGAGCAGAGCCAGCAGAAGCTGGAGACTCTGGGTGCCCGCGTCTTGGAGCTGGAGGAATGT
CTGGGTACCAAGGAAAGGCTGGTTCAGGAGCTTCAGACAGAGCGGCTGCAATTGCAGGAGGAAC
GCAGTACACTGAGCACCCAGCTGGAGGAGCGGGAGAGGGAGTTTCAGGCCTCAGAAGCAGCTCT
GTCAAGCAGCCGAGCAGAGGTACTGTGTCTTCGGCAGAAGACTGCAGCCCAGGTGACCTTACTG
GCCGAGCAGGGAGACCGGCTCTATGGGCTAGAGATGGAGCGCCGTCGACTCCACAACCAGCTGC
AGGAACTGAAGGGCAACATCCGGGTCTTCTGCCGGGTGCGCCCTGTCCTTGAGGGGGAGTCCAC
TCCATCTCCTGGCTTCCTTGTATTCCCTCCTGGCCCTGCTGGACCCTCTGACCCCCCAACTCGC
CTTTGCCTCTCTCGGTCTGATGACCGGCGCTCCACCCTGACAAGGGCACCAGCAGCTGCTACCC
GCCATGACTTCTCCTTTGATCGGGTGTTCCCACCAGGAAGCAAGCAGGAGGAGGTGTTTGAGGA
GATCTCCATGCTTGTCCAGTCAGCACTGGATGGCTACCCTGTGTGCATCTTTGCCTATGGACAG
ACAGGCAGCGGCAAGACCTTCACCATGGAGGGCGGGCCTCGGGGAGACCCCCAGTTGGAGGGGC
TGATCCCCCGGGCCATGCGGCATCTGTTCTCTGTGGCCCAGGAGATGAGTGGCCAGGGCTGGAC
TTACAGTTTTGTGGCCAGTTACGTAGAGATCTACAATGAGACCGTCCGAGACCTGCTAGCTACA
GGGACCCGCAAGGGACAAGGGGGCGACTGTGAGATTCGTCGGGCAGGCCCAGGGAGTGAGGAAC
TTACTGTCACCAATGCACGATATGTCCCTGTTTCCTGTGAGAAAGAGGTGGAGGCTCTGCTCCA
TTTGGCCCAGCAGAATCGGGCTGTGGCCCGCACTGCCCAGAATGAGAGATCATCACGCAGCCAC
AGTGTGTTCCAGCTACAGATCTCTGGAGAGCATGCTGCCCGGGGCCTGCAGTGTGGTGCTCCCC
TCAACCTGGTGGACCTGGCTGGGAGTGAGCGGCTTGACCCTGGCTTAACCCTAGGCCCTGGAGA
GCGGGATCGTCTTCGGGAAACACAAGCCATTAACAGCAGTCTGTCTACACTGGGACTGGTCATA
ATGGCCCTGAGCAATAAGGAGTCCCACGTGCCTTACCGAAATAGCAAGCTTACCTACCTGCTGC
AGAACTCTCTGGGTGGCAGTGCCAAGATGCTCATGTTCGTGAACATTTCTCCTCTGGAAGAGAA
TGTCTCCGAGTCTCTGAATTCACTCCGCTTTGCTTCCAAGGTGAACCAGTGCGTGATCGGCACT
GCTCAGGCTAATAAGAAATGAAGATGGATGCAGAGCCTGGCTCCTGTGCAAGCGGGTGTGCGTG
TCTGTTTTGTGTATATGTATAACACGGGGGTGGGGCGGGGCTGAGACATGATTTTATTGGGTGG
ACAACATTATGTACCCAACTATCAAATAAAGAAAATTTGGTGTAGGTTAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001005878	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB88699	(Get FASTA)	NCBI Sequence Viewer
	AAH83827	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061875
	ENSRNOP00000061875.3
	ENSRNOP00000087122.1
	ENSRNOP00000087209.1
	ENSRNOP00000092623.1
	ENSRNOP00055010636
	ENSRNOP00060006359
	ENSRNOP00065046499
GenBank Protein	Q5XI63	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001005878 ⟸ NM_001005878

- UniProtKB:

O54719 (UniProtKB/Swiss-Prot), Q5XI63 (UniProtKB/Swiss-Prot), A0A8L2QUA0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRGRGSRDTGTQSAAFASRPVRTTVDMQAQRAPLMEVKRNLELSTTLVKSSSRLPLPGSRLKRG
PDQMEDGLEPAKKRTRGMGTVTKVDTSRPRGPPLSAVSTAAQKGPRKTGPRGCSAVGPVLRNQK
PAPAAPAQKPGTSTAPAVAGKKPGKRPAWDLKGQLCDLHEELKQYREKTQTLDRENQGLREQLR
EVQEQATTLGTERNTLEEELASVRRRAEQSQQKLETLGARVLELEECLGTKERLVQELQTERLQ
LQEERSTLSTQLEEREREFQASEAALSSSRAEVLCLRQKTAAQVTLLAEQGDRLYGLEMERRRL
HNQLQELKGNIRVFCRVRPVLEGESTPSPGFLVFPPGPAGPSDPPTRLCLSRSDDRRSTLTRAP
AAATRHDFSFDRVFPPGSKQEEVFEEISMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDP
QLEGLIPRAMRHLFSVAQEMSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGDCEIRRAGP
GSEELTVTNARYVPVSCEKEVEALLHLAQQNRAVARTAQNERSSRSHSVFQLQISGEHAARGLQ
CGAPLNLVDLAGSERLDPGLTLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKL
TYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK

hide sequence

RefSeq Acc Id:

ENSRNOP00000061875 ⟸ ENSRNOT00000065349

RefSeq Acc Id:

ENSRNOP00000087122 ⟸ ENSRNOT00000103176

RefSeq Acc Id:

ENSRNOP00000087209 ⟸ ENSRNOT00000095546

RefSeq Acc Id:

ENSRNOP00000092623 ⟸ ENSRNOT00000114906

Protein Domains

Kinesin motor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XI63-F1-model_v2	AlphaFold	Q5XI63	1-693	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701417

Promoter ID:

EPDNEW_R11941

Type:

initiation region

Name:

Kifc1_1

Description:

kinesin family member C1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	5,509,066 - 5,509,126	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359118	AgrOrtholog
BioCyc Gene	G2FUF-4506	BioCyc
Ensembl Genes	ENSRNOG00000000479	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055007878	UniProtKB/Swiss-Prot
	ENSRNOG00060005088	UniProtKB/Swiss-Prot
	ENSRNOG00065032873	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000065349	ENTREZGENE
	ENSRNOT00000065349.4	UniProtKB/TrEMBL
	ENSRNOT00000095546.1	UniProtKB/TrEMBL
	ENSRNOT00000103176.1	UniProtKB/TrEMBL
	ENSRNOT00000114906.1	UniProtKB/TrEMBL
	ENSRNOT00055013260	UniProtKB/Swiss-Prot
	ENSRNOT00060008482	UniProtKB/Swiss-Prot
	ENSRNOT00065056520	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.1490	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.850.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7112250	IMAGE-MGC_LOAD
InterPro	Kinesin-like_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinesin_motor_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinesin_motor_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinesin_motor_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:294286	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94918	IMAGE-MGC_LOAD
NCBI Gene	294286	ENTREZGENE
PANTHER	KINESIN-LIKE PROTEIN KLP-3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN CLARET SEGREGATIONAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Kinesin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Kifc1	PhenoGen
PRINTS	KINESINHEAVY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	KINESIN_MOTOR_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KINESIN_MOTOR_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000479	RatGTEx
	ENSRNOG00055007878	RatGTEx
	ENSRNOG00060005088	RatGTEx
	ENSRNOG00065032873	RatGTEx
SMART	KISc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tropomyosin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AVX0_RAT	UniProtKB/TrEMBL
	A0A8I6GEU0_RAT	UniProtKB/TrEMBL
	A0A8I6GEW9_RAT	UniProtKB/TrEMBL
	A0A8L2QUA0	ENTREZGENE, UniProtKB/TrEMBL
	KIFC1_RAT	UniProtKB/Swiss-Prot
	O54719	ENTREZGENE
	Q5XI63	ENTREZGENE
UniProt Secondary	O54719	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Kifc1	kinesin family member C1			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Kifc1	kinesin family member C1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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