Rptor (regulatory associated protein of MTOR, complex 1) - Rat Genome Database

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Gene: Rptor (regulatory associated protein of MTOR, complex 1) Rattus norvegicus
Analyze
Symbol: Rptor
Name: regulatory associated protein of MTOR, complex 1
RGD ID: 1311784
Description: Enables protein kinase binding activity. Involved in positive regulation of endothelial cell proliferation and regulation of phosphorylation. Colocalizes with dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1); PARTICIPATES IN mTOR signaling pathway; insulin signaling pathway; INTERACTS WITH bisphenol A; carbon disulfide; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC287871; raptor; regulatory-associated protein of mTOR; RGD1311784; similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,376,943 - 105,675,416 (+)NCBIGRCr8
mRatBN7.210104,878,487 - 105,176,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,981,892 - 110,280,534 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,444,928 - 109,743,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,799,071 - 105,097,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,750,620 - 109,058,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,353,697 - 108,658,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,000,666 - 109,302,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,015,970 - 109,317,386 (+)NCBI
Celera10103,425,303 - 103,722,658 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,4-phenylenediamine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,4,6-tribromophenol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
amino acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon disulfide  (EXP)
cholesterol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dimercaprol  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (ISO)
glycerol 2-phosphate  (ISO)
glyphosate  (EXP,ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
linuron  (EXP)
mechlorethamine  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
orotic acid  (ISO)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
pevonedistat  (ISO)
phenylarsine oxide  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tetrathiomolybdate(2-)  (ISO)
torin 1  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. mTOR signaling in growth control and disease. Laplante M and Sabatini DM, Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
3. Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Li W, etal., Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.
4. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
5. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. Takei N, etal., J Neurosci. 2004 Nov 3;24(44):9760-9.
12. mTORC1 and mTORC2 differentially promote natural killer cell development. Yang C, etal., Elife. 2018 May 29;7. pii: 35619. doi: 10.7554/eLife.35619.
Additional References at PubMed
PMID:12150925   PMID:12150926   PMID:12718876   PMID:15467718   PMID:17897319   PMID:18426977   PMID:18439900   PMID:19211835   PMID:20233713   PMID:20381137   PMID:20543138   PMID:21613227  
PMID:21779001   PMID:22424946   PMID:23092880   PMID:24036451   PMID:25940091   PMID:27006450  


Genomics

Comparative Map Data
Rptor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,376,943 - 105,675,416 (+)NCBIGRCr8
mRatBN7.210104,878,487 - 105,176,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,981,892 - 110,280,534 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,444,928 - 109,743,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,799,071 - 105,097,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,750,620 - 109,058,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,353,697 - 108,658,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,000,666 - 109,302,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,015,970 - 109,317,386 (+)NCBI
Celera10103,425,303 - 103,722,658 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
RPTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,544,838 - 80,966,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,544,819 - 80,966,371 (+)EnsemblGRCh38hg38GRCh38
GRCh371778,518,638 - 78,940,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,133,220 - 76,554,768 (+)NCBINCBI36Build 36hg18NCBI36
Celera1775,147,295 - 75,567,674 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,954,508 - 74,378,467 (+)NCBIHuRef
CHM1_11778,604,958 - 79,026,514 (+)NCBICHM1_1
T2T-CHM13v2.01781,446,296 - 81,873,303 (+)NCBIT2T-CHM13v2.0
Rptor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,493,731 - 119,790,417 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,493,731 - 119,790,402 (+)EnsemblGRCm39 Ensembl
GRCm3811119,602,905 - 119,899,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,602,905 - 119,899,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711119,464,309 - 119,760,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,419,900 - 119,713,572 (+)NCBIMGSCv36mm8
Celera11131,343,545 - 131,633,430 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.96NCBI
Rptor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,008,044 - 2,401,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBIChiLan1.0ChiLan1.0
RPTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,125,522 - 97,543,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,025,309 - 102,442,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,973,420 - 75,389,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,705,544 - 81,118,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1780,705,544 - 81,118,708 (+)Ensemblpanpan1.1panPan2
RPTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,012,512 - 1,345,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,013,603 - 1,344,148 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,630,245 - 1,963,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,621,864 - 1,955,230 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,621,871 - 1,953,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,645,842 - 1,978,909 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,771,374 - 2,104,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,852,046 - 2,185,237 (-)NCBIUU_Cfam_GSD_1.0
Rptor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,653,875 - 1,984,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,427,169 - 4,760,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,427,225 - 4,758,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,709,128 - 1,991,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,709,121 - 1,991,844 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,614,075 - 1,710,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,513,593 - 72,916,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,513,619 - 72,918,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607743,826,714 - 44,287,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rptor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,677,307 - 10,048,719 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248019,676,965 - 10,053,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rptor
964 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:256
Count of miRNA genes:163
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000005337
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat

Markers in Region
D10Rat108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,926,165 - 104,926,367 (+)MAPPERmRatBN7.2
Rnor_6.010108,798,298 - 108,798,497NCBIRnor6.0
Rnor_5.010108,401,375 - 108,401,574UniSTSRnor5.0
RGSC_v3.410109,048,343 - 109,048,543RGDRGSC3.4
RGSC_v3.410109,048,344 - 109,048,543UniSTSRGSC3.4
RGSC_v3.110109,062,847 - 109,063,047RGD
Celera10103,472,978 - 103,473,177UniSTS
SHRSP x BN Map1092.75RGD
SHRSP x BN Map1092.75UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 27 26 10 17 10 1 2 74 26 34 11 1
Low 2 16 31 31 2 31 7 9 9 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000005337   ⟹   ENSRNOP00000005337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)Ensembl
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101121   ⟹   ENSRNOP00000098000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111480   ⟹   ENSRNOP00000092487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)Ensembl
RefSeq Acc Id: NM_001134499   ⟹   NP_001127971
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,376,943 - 105,675,413 (+)NCBI
mRatBN7.210104,878,487 - 105,176,983 (+)NCBI
Rnor_6.010108,750,620 - 109,058,691 (+)NCBI
Rnor_5.010108,353,697 - 108,658,916 (+)NCBI
RGSC_v3.410109,000,666 - 109,302,700 (+)RGD
Celera10103,425,303 - 103,722,658 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085689   ⟹   XP_038941617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,377,824 - 105,675,416 (+)NCBI
mRatBN7.210104,879,344 - 105,176,986 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001127971 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941617 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06799 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005337
  ENSRNOP00000005337.5
  ENSRNOP00000092487.1
  ENSRNOP00000098000
  ENSRNOP00000098000.1
RefSeq Acc Id: NP_001127971   ⟸   NM_001134499
- UniProtKB: D3ZDU2 (UniProtKB/TrEMBL),   A6HL94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005337   ⟸   ENSRNOT00000005337
RefSeq Acc Id: XP_038941617   ⟸   XM_039085689
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANV2 (UniProtKB/TrEMBL),   A6HL94 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000098000   ⟸   ENSRNOT00000101121
RefSeq Acc Id: ENSRNOP00000092487   ⟸   ENSRNOT00000111480
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDU2-F1-model_v2 AlphaFold D3ZDU2 1-1335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697946
Promoter ID:EPDNEW_R8471
Type:initiation region
Name:Rptor_1
Description:regulatory associated protein of MTOR, complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010108,750,703 - 108,750,763EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311784 AgrOrtholog
BioCyc Gene G2FUF-22475 BioCyc
Ensembl Genes ENSRNOG00000003821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005337 ENTREZGENE
  ENSRNOT00000005337.7 UniProtKB/TrEMBL
  ENSRNOT00000101121.1 UniProtKB/TrEMBL
  ENSRNOT00000111480.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  Raptor UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:287871 UniProtKB/TrEMBL
NCBI Gene 287871 ENTREZGENE
PANTHER Raptor UniProtKB/TrEMBL
  REGULATORY-ASSOCIATED PROTEIN OF MTOR UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Rptor PhenoGen
PRINTS YEAST176DUF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003821 RatGTEx
SMART Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A8I6AHQ2_RAT UniProtKB/TrEMBL
  A0A8I6ANV2 ENTREZGENE, UniProtKB/TrEMBL
  A6HL94 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDU2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Rptor  regulatory associated protein of MTOR, complex 1  RGD1311784  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1311784  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats   RGD1311784_predicted  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1311784_predicted  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats (predicted)  LOC287871_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287871_predicted  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL