Stat2 (signal transducer and activator of transcription 2)

Gene: Stat2 (signal transducer and activator of transcription 2) Rattus norvegicus

Analyze

Symbol:

Stat2

Name:

signal transducer and activator of transcription 2

RGD ID:

1311649

Description:

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including defense response to symbiont; negative regulation of type I interferon-mediated signaling pathway; and receptor signaling pathway via JAK-STAT. Predicted to be located in cytosol and plasma membrane. Predicted to be part of ISGF3 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2); PARTICIPATES IN interleukin-27 signaling pathway; Jak-Stat signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC288774

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,287,025 - 1,302,858 (+)	NCBI		GRCr8
mRatBN7.2	7	702,565 - 718,349 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	702,495 - 718,967 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,458,867 - 3,474,660 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,334,848 - 5,350,643 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,637,673 - 5,653,273 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,691,064 - 2,707,530 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,691,369 - 2,707,741 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,669,952 - 2,685,673 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,564,385 - 1,580,652 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	1,564,384 - 1,580,651 (+)	NCBI
Celera	7	578,845 - 593,799 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Arenaviridae infectious disease (ISO)

Bunyaviridae Infections (ISO)

Chronic Hepatitis B (ISO)

Cytomegalovirus Infections (ISO)

dengue disease (ISO)

gastric adenocarcinoma (ISO)

genetic disease (ISO)

hepatitis C (ISO)

immunodeficiency 44 (ISO)

influenza A (ISO)

lymphocytic choriomeningitis (ISO)

neutropenia (ISO)

Pseudo-TORCH Syndrome 3 (ISO)

Reperfusion Injury (IEP)

severe COVID-19 (ISO)

Staphylococcal Infections (ISO)

Vesicular Stomatitis (ISO)

yellow fever (ISO)

Zika fever (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-naphthylamine (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (EXP)

4-tert-Octylphenol (ISO)

aconitine (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

amiodarone (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

busulfan (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

cerium (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clopidogrel (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

dibutyl phthalate (EXP)

dieldrin (EXP)

diethylstilbestrol (EXP)

dioxygen (EXP)

doxorubicin (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

geraniol (ISO)

GW 4064 (ISO)

hydroxytyrosol (ISO)

inulin (ISO)

ivermectin (ISO)

kaempferol (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nickel atom (ISO)

nicotine (ISO)

oxaliplatin (EXP)

p-tert-Amylphenol (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP,ISO)

poly(I:C) (ISO)

poly(vinylpyrrolidone) (EXP)

potassium chromate (ISO)

potassium dichromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

ruxolitinib (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

silver atom (EXP,ISO)

silver(0) (EXP,ISO)

sodium fluoride (ISO)

succimer (ISO)

sunitinib (ISO)

T-2 toxin (EXP,ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tofacitinib (ISO)

topotecan (EXP)

trichostatin A (ISO)

trimellitic anhydride (EXP)

triphenyl phosphate (EXP)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

zidovudine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell surface receptor signaling pathway via JAK-STAT (IBA,ISO)

defense response (IBA)

defense response to virus (ISO)

negative regulation of type I interferon-mediated signaling pathway (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of cell population proliferation (IBA)

regulation of mitochondrial fission (ISO)

regulation of protein phosphorylation (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

response to peptide hormone (IBA)

type I interferon-mediated signaling pathway (IBA,ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

ISGF3 complex (IBA,ISO)

nucleus (IBA,ISO)

plasma membrane (IEA,ISO)

Molecular Function

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

identical protein binding (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

ubiquitin-like protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

hepatitis C pathway (IEA)

influenza A pathway (IEA)

interleukin-27 signaling pathway (ISO)

Jak-Stat signaling pathway (IEA,ISO)

measles pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Mouse STAT2 restricts early dengue virus replication.	Ashour J, etal., Cell Host Microbe. 2010 Nov 18;8(5):410-21. doi: 10.1016/j.chom.2010.10.007.
2.	Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection.	Elsaesser HJ, etal., Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5420-5429. doi: 10.1073/pnas.1913776117. Epub 2020 Feb 24.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection.	Gopal R, etal., Front Immunol. 2018 Sep 25;9:2151. doi: 10.3389/fimmu.2018.02151. eCollection 2018.
6.	An Immunocompetent Mouse Model of Zika Virus Infection.	Gorman MJ, etal., Cell Host Microbe. 2018 May 9;23(5):672-685.e6. doi: 10.1016/j.chom.2018.04.003.
7.	Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling.	Hahm B, etal., Immunity. 2005 Feb;22(2):247-57. doi: 10.1016/j.immuni.2005.01.005.
8.	Signaling through the JAK/STAT pathway, recent advances and future challenges.	Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
9.	STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist.	Le-Trilling VTK, etal., J Virol. 2018 Jun 29;92(14). pii: JVI.00296-18. doi: 10.1128/JVI.00296-18. Print 2018 Jul 15.
10.	IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.	Li W, etal., J Virol. 2014 Jul;88(13):7578-88. doi: 10.1128/JVI.03117-13. Epub 2014 Apr 23.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.	Miorin L, etal., J Virol. 2019 Jun 28;93(14). pii: JVI.00151-19. doi: 10.1128/JVI.00151-19. Print 2019 Jul 15.
13.	The JAK-STAT signaling pathway: input and output integration.	Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
14.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
15.	STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.	Perry ST, etal., PLoS Pathog. 2011 Feb;7(2):e1001297. doi: 10.1371/journal.ppat.1001297. Epub 2011 Feb 17.
16.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
17.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18.	GOA pipeline	RGD automated data pipeline
19.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
21.	Comprehensive gene review and curation	RGD comprehensive gene curation
22.	Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.	Song H, etal., J Immunol. 2019 Apr 15;202(8):2266-2275. doi: 10.4049/jimmunol.1800848. Epub 2019 Mar 6.
23.	Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion.	Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
24.	Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness.	Sung PS, etal., Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10443-8. doi: 10.1073/pnas.1513341112. Epub 2015 Jul 27.
25.	A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses.	Tripathi S, etal., PLoS Pathog. 2017 Mar 9;13(3):e1006258. doi: 10.1371/journal.ppat.1006258. eCollection 2017 Mar.
26.	Association of genetic polymorphisms with interferon-induced haematologic adverse effects in chronic hepatitis C patients.	Wada M, etal., J Viral Hepat. 2009 Jun;16(6):388-96. doi: 10.1111/j.1365-2893.2009.01095.x. Epub 2009 Feb 5.
27.	A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses.	Wang Y, etal., Cell Res. 2021 Feb;31(2):206-218. doi: 10.1038/s41422-020-0386-6. Epub 2020 Aug 5.
28.	Species-Specific Pathogenicity of Severe Fever with Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2 Activity of NSs.	Yoshikawa R, etal., J Virol. 2019 May 1;93(10). pii: JVI.02226-18. doi: 10.1128/JVI.02226-18. Print 2019 May 15.

Additional References at PubMed

PMID:8605877	PMID:12477932	PMID:12634107	PMID:19609277	PMID:23391734	PMID:24598055	PMID:26122121	PMID:27782195	PMID:31505169	PMID:36762436

Genomics

Comparative Map Data

Stat2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,287,025 - 1,302,858 (+)	NCBI		GRCr8
mRatBN7.2	7	702,565 - 718,349 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	702,495 - 718,967 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,458,867 - 3,474,660 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,334,848 - 5,350,643 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,637,673 - 5,653,273 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,691,064 - 2,707,530 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,691,369 - 2,707,741 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,669,952 - 2,685,673 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,564,385 - 1,580,652 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	1,564,384 - 1,580,651 (+)	NCBI
Celera	7	578,845 - 593,799 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

STAT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	56,341,597 - 56,360,107 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	56,341,597 - 56,360,203 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,735,381 - 56,753,891 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	55,021,648 - 55,040,176 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	55,021,650 - 55,040,176	NCBI
Celera	12	56,388,733 - 56,407,397 (-)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	53,774,045 - 53,793,077 (-)	NCBI		HuRef
CHM1_1	12	56,702,765 - 56,721,407 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	56,309,243 - 56,327,794 (-)	NCBI		T2T-CHM13v2.0

Stat2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,106,367 - 128,128,722 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,106,428 - 128,128,718 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,270,498 - 128,292,853 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,270,559 - 128,292,849 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	127,707,632 - 127,729,905 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	127,673,525 - 127,695,798 (+)	NCBI		MGSCv36	mm8
Celera	10	130,656,386 - 130,681,169 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	76.5	NCBI

Stat2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,952,738 - 3,970,668 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,953,019 - 3,973,151 (-)	NCBI	ChiLan1.0	ChiLan1.0

STAT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	37,972,152 - 37,994,084 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	37,968,913 - 37,990,850 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	32,555,523 - 32,574,137 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	32,808,586 - 32,827,732 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	32,808,586 - 32,827,732 (+)	Ensembl	panpan1.1		panPan2

STAT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	641,543 - 660,882 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	642,718 - 658,546 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	704,962 - 724,101 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	650,365 - 669,707 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	649,947 - 669,646 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	627,617 - 646,943 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	870,771 - 890,099 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	994,493 - 1,013,823 (-)	NCBI		UU_Cfam_GSD_1.0

Stat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,106,734 - 58,122,062 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	748,727 - 761,287 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	747,178 - 763,449 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STAT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,733,035 - 21,751,354 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,733,030 - 21,748,960 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	23,280,591 - 23,294,360 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STAT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,297,890 - 52,316,089 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	52,297,543 - 52,316,105 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	193,669,493 - 193,688,727 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stat2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	11,648,020 - 11,660,216 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	11,645,851 - 11,662,812 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Stat2
110 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	270
Count of miRNA genes:	156
Interacting mature miRNAs:	182
Transcripts:	ENSRNOT00000049536
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat

Markers in Region

RH131097

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	718,069 - 718,253 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	2,706,872 - 2,707,055	NCBI	Rnor6.0
Rnor_5.0	7	2,685,392 - 2,685,575	UniSTS	Rnor5.0
RGSC_v3.4	7	1,580,373 - 1,580,556	UniSTS	RGSC3.4
Celera	7	593,520 - 593,703	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	28	57	41	19	41		1	72	35	34	11
Low		15					8	10	2		7		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000049536 ⟹ ENSRNOP00000046028

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	702,495 - 718,967 (+)	Ensembl
Rnor_6.0 Ensembl	7	2,691,369 - 2,707,150 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088201 ⟹ ENSRNOP00000075125

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	702,525 - 718,967 (+)	Ensembl
Rnor_6.0 Ensembl	7	2,694,440 - 2,707,741 (+)	Ensembl

RefSeq Acc Id:

NM_001011905 ⟹ NP_001011905

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,287,090 - 1,302,858 (+)	NCBI
mRatBN7.2	7	702,565 - 718,349 (+)	NCBI
Rnor_6.0	7	2,691,369 - 2,707,151 (+)	NCBI
Rnor_5.0	7	2,669,952 - 2,685,673 (+)	NCBI
RGSC_v3.4	7	1,564,385 - 1,580,652 (+)	RGD
Celera	7	578,845 - 593,799 (+)	RGD

Sequence:

show sequence

CCGCCGCTCACGGTCTGGGTCCGCCAGAGTCGGGAGTGGGTGGGAAACGGGTCCTTGAGCCACT
TGAAGGATTGGAAGTTGAAACGGGAGCACTGGAAGGAGCGGCACTTTACCCTCAGAAGAGTCCA
AATGGCGCAGTGGGAGATGTTGCAGAACCTTGACAGTCCATTTCTGGACCAGTTGCATGAGCTC
TACTCACAAAGCCTCCTGCCAATGGACGTCCGACAGCACTTGGCTGCCTGGATTGAAGACCAGA
ACTGGAGGGAAGCTGTACTAGGCAGTGATCATTCCAAGGCCAACATGCTATACTTCAACATCCT
GGACCAGCTGAACCAGTGGGACCACTACAGCTTGGACTCCGACTACCTTTTATTACAGCATAAC
TTGCGAAAATTCAATCGGGACATTCAGATGTTTCCCAATGGCCCTACCCAGTTGGCTGAGATGA
TCTTCAATCTTCTCCTGGAAGAGAAAAGGATTCTGAATCAGGCCCAAAGAGCTCAAGAGATGCA
GCCCAGGCCAGCCCCTGAAGCGGCAGGGGAGAGCCAGCAGCAGCTTGAGATTGAAACAAGAATC
CTGGATTTACAGACTGCTGTGGAGGCGCTGGTGAGATCCATCAGGCAGCTGAAGGATGTGCAGG
ATGTCTTCAGCTTCAGATACACAGTTCTCAATCACAAGAAGACATCGTCTTTGGACCCCCATCA
GAGCCAACAGCGGCAGCTTGTGCAGACAACAGCCAATGAACTGGACAGAATGAGAAAGGAGGTG
CTGGACATCTCCAAAGCCCTGGTTGGACGATTAACCACCCTGGTCGACCTGTTGCTGCCAAAGC
TGGATGAGTGGAAGGCTCAGCAGCAGAAGTCCTGCATTGGAGCCCCAGCACCCGAGCTGCAGCT
GGATCAGCTGGAACAGTGGTTGACAGCTGGAGCAAAGGTCTTGTTCCACCTTCGGCAGCTACTG
AAGCAACTGAAGGATATGAGTCTTATGCTTCGTTATGAGGGTGACATGTTTGGCCAAGGGGTGG
ACCTGCAGAATGCCCAAGTCACGGAGTTACTTCAGCGTCTGCTCCAAAGGTCCTTTGTAGTGGA
AACCCAGCCCTGCATGCCCCAGACTCTCCATCGACCCCTCATCCTGAAGACTGGGAGCAAGTTC
ACTGTCCGAACAAGACTGCTGGTGAGACTCCAGGAAGGCAATGAATCACTCAAAGCAGAAGTCT
CCATTGACAGGAATTCAGAGTTGCCAGGCTTCCGGAAGTTCAACATTCTGACCTCAAACCAGAA
GTCCTTGACCCCTGAGGAAGGCCAGAGACAAGGCTTAATTTGGGACTTCGGCTTCTTGACGCTG
GTGGAGCAGCGCTCAGTGGGCGCAGGAAAGGGCAGCAACAAGGGGCCGCTGCCTGTGACAGAGG
AGCTACACATCATCAGCGCCATGGTGGAGTACGTTTACCAGGGTCTGAAGATGAAGCTGCAGAC
GGACACTCTCCCTGTGGTGATTATCTCTAACATGAACCAACTCTCCATTGCCTGGGCCTCCATT
CTCTGGTTCAACATGCTCAGCTCAACTCCCAAGGACCAGCAGTTCTTCTGCAAAGTTCCGAAAG
CTCCGTGGAGTTTGCTGGGGCCTGCACTCAGTTGGCAGTTCTCCTCCTACATCGGCCGAGGCCT
CGATCCTGAGCAGCTGGGCATGCTGAGAAACAAGCTGTTCGGAAAGAACTGCAAGACAGAGGAT
GCACTGTTGTCCTGGGCAGACTTCAGCAAGCGAGAGAGCCCCCCTGGCAAGATCCCTTTCTGGA
CCTGGCTGGACAAAATTCTGGAGCTGGTACATGACCACCTGAAGGATCTCTGGAATGATGGGCG
CATCATGGGCTTTGTGAGCCGGAGCGAGGAACGCCGACTACTGAAGAAGATGGTGTCGGGCACC
TTCCTGCTGCGCTTCAGTGAGACTTCTGAAGGGGGCATTACCTGCTCTTGGGTGGAGCACCAGG
ATGATGATAAAGTCCTCATCTACTCTGTGCAGCCCTACACCAAGGAAGTGCTACAGTCACTCCC
ACTGACAGAAATCATCCGCCACTACCAGGTTCTCGCCGAAGAGAATGCTCCTGAGAACCCACTC
CGCTTCCTCTATCCCCGCGTCCCTCGGGACGAAGCCTTTGGGTGTTACTACCAGGAAAAAGTTA
ACTTGGAAGAACGGAGGAAATACCTGAAACATAGACTCATCGTGATCTCTAACAGACAGGCGGA
CGAGCTGCAGCAGCCTCTGGAGCTTAAACAGGATCCAGAGTCCTTAGAGCTGGATGCAGAGCTC
ATGTCAGTGATGGAGTTGGCACGAGACCTGGAGCTGCAGTCAATGCTGCAGGTGGGGCTGGACC
TGGGCGTAGAGCCGAAACCAGATCCCACACTGAGTCCAGCCCCACAAATCCTGCTGGAGCCAGA
CCCAGCACGTGCATTGAATCAGCTGTTGCCAGAGCCGGATTTGCCTCAGGACCTGCAGCAGCTG
AACACAGGGGAGATGGAAATCTTCAGAAACAACATAAATATTGATGACGTCATGCCCTACGGTG
ACCCAGTGTTGGCTGGCCAGAGCATCATAGAGGAGGCTTACAGGTCCTGCCCCAGCCATTTTGA
CGTGGATGGACCCTTGATTCCTTCTGAAGACTAAGAGCTTTGTTTCTGTTTTGTCCCTTCTAAC
TCCCAAATCAGGATGTTGCTTCCAGCAGTGGGAAAAGAGGCCTTGTGAGCAGGGTTAGCATAGG
CTCTGGAGTAAGAGGTAGAAGCATAGCATGCTTTCTAAGGTACACCACAGGGTCAGAACAGACA
CTGGCCATAGCCCTTCTAGGACCCTGAGGCTGCCTGCCATGCTGGGAGACACAGGGGTCTTAAG
GGCAGGTCAGGACATTTGGGAGGTCCTTAGAGGGTCTGAGGCAGTGGTGTCTTTCCAGTATGGA
ACGATTTTAATGTTTTGATAATTGGCTAAGTTGGTATGAAGCAACATTGGGCCTTGGTGGGGAG
CTCATGGATGGAATTCTGTCCTTCCTTCATCGCTATCCTGGGACCTGTCAAACCCAGAACCTTG
CCCATGGTAGGCAACCACAGTGGCACTGAGCCATACCCAACTGAGTTCTTCAGTTCTCTCTTCC
GGTTATCTCAGGTCTCCTCCCTTCACTCCTGACTCCAGTTCTAAATCCTTCTCTTCCTGTAGAG
ACTGAGGGCTATCTGCTTCAGTTGGCCATGTGAAGCAGACTACTGCTAGCAGCCCCTTGCCATG
CTCAACCCCCACAAAGTGACCCTGACACTCTAGTGAAGGCGTGACGCTTTGCTGCCTTAGACTG
TCCCGTCTCTACCTCCCCCAGCGCCTGAGAGAATCACTCCTGGAGCTTTGAACGGTTTCTGAGC
CCTTGGGCATTGCTTCTCATAATAAATATTTGATAGAGCTGAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063263089 ⟹ XP_063119159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,287,031 - 1,302,858 (+)	NCBI

RefSeq Acc Id:

XM_063263090 ⟹ XP_063119160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,287,031 - 1,302,858 (+)	NCBI

RefSeq Acc Id:

XM_063263091 ⟹ XP_063119161

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,287,025 - 1,302,858 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011905	(Get FASTA)	NCBI Sequence Viewer
	XP_063119159	(Get FASTA)	NCBI Sequence Viewer
	XP_063119160	(Get FASTA)	NCBI Sequence Viewer
	XP_063119161	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83867	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000046028.4
	ENSRNOP00000075125
	ENSRNOP00000075125.2

RefSeq Acc Id:

NP_001011905 ⟸ NM_001011905

- UniProtKB:

Q5XI26 (UniProtKB/TrEMBL), F7EYG9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQWEMLQNLDSPFLDQLHELYSQSLLPMDVRQHLAAWIEDQNWREAVLGSDHSKANMLYFNIL
DQLNQWDHYSLDSDYLLLQHNLRKFNRDIQMFPNGPTQLAEMIFNLLLEEKRILNQAQRAQEMQ
PRPAPEAAGESQQQLEIETRILDLQTAVEALVRSIRQLKDVQDVFSFRYTVLNHKKTSSLDPHQ
SQQRQLVQTTANELDRMRKEVLDISKALVGRLTTLVDLLLPKLDEWKAQQQKSCIGAPAPELQL
DQLEQWLTAGAKVLFHLRQLLKQLKDMSLMLRYEGDMFGQGVDLQNAQVTELLQRLLQRSFVVE
TQPCMPQTLHRPLILKTGSKFTVRTRLLVRLQEGNESLKAEVSIDRNSELPGFRKFNILTSNQK
SLTPEEGQRQGLIWDFGFLTLVEQRSVGAGKGSNKGPLPVTEELHIISAMVEYVYQGLKMKLQT
DTLPVVIISNMNQLSIAWASILWFNMLSSTPKDQQFFCKVPKAPWSLLGPALSWQFSSYIGRGL
DPEQLGMLRNKLFGKNCKTEDALLSWADFSKRESPPGKIPFWTWLDKILELVHDHLKDLWNDGR
IMGFVSRSEERRLLKKMVSGTFLLRFSETSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLP
LTEIIRHYQVLAEENAPENPLRFLYPRVPRDEAFGCYYQEKVNLEERRKYLKHRLIVISNRQAD
ELQQPLELKQDPESLELDAELMSVMELARDLELQSMLQVGLDLGVEPKPDPTLSPAPQILLEPD
PARALNQLLPEPDLPQDLQQLNTGEMEIFRNNINIDDVMPYGDPVLAGQSIIEEAYRSCPSHFD
VDGPLIPSED

hide sequence

RefSeq Acc Id:

ENSRNOP00000046028 ⟸ ENSRNOT00000049536

RefSeq Acc Id:

ENSRNOP00000075125 ⟸ ENSRNOT00000088201

RefSeq Acc Id:	XP_063119161 ⟸ XM_063263091
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063119159 ⟸ XM_063263089
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063119160 ⟸ XM_063263090
- Peptide Label:	isoform X2

Protein Domains

SH2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XI26-F1-model_v2	AlphaFold	Q5XI26	1-842	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694931

Promoter ID:

EPDNEW_R5456

Type:

initiation region

Name:

Stat2_1

Description:

signal transducer and activator of transcription 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	2,691,351 - 2,691,411	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311649	AgrOrtholog
BioCyc Gene	G2FUF-35380	BioCyc
Ensembl Genes	ENSRNOG00000031081	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000049536.5	UniProtKB/TrEMBL
	ENSRNOT00000088201	ENTREZGENE
	ENSRNOT00000088201.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.532.10	UniProtKB/TrEMBL
	2.60.40.630	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
	STAT transcription factor, all-alpha domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7127907	IMAGE-MGC_LOAD
InterPro	p53-like_TF_DNA-bd	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	STAT2_C	UniProtKB/TrEMBL
	STAT2_SH2	UniProtKB/TrEMBL
	STAT_linker	UniProtKB/TrEMBL
	STAT_N_sf	UniProtKB/TrEMBL
	STAT_TF_alpha	UniProtKB/TrEMBL
	STAT_TF_coiled-coil	UniProtKB/TrEMBL
	STAT_TF_core	UniProtKB/TrEMBL
	STAT_TF_DNA-bd	UniProtKB/TrEMBL
	STAT_TF_DNA-bd_sub	UniProtKB/TrEMBL
	STAT_TF_prot_interaction	UniProtKB/TrEMBL
KEGG Report	rno:288774	UniProtKB/TrEMBL
MGC_CLONE	MGC:95122	IMAGE-MGC_LOAD
NCBI Gene	288774	ENTREZGENE
PANTHER	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2	UniProtKB/TrEMBL
	STAT	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
	STAT2_C	UniProtKB/TrEMBL
	STAT_alpha	UniProtKB/TrEMBL
	STAT_bind	UniProtKB/TrEMBL
	STAT_int	UniProtKB/TrEMBL
	STAT_linker	UniProtKB/TrEMBL
PhenoGen	Stat2	PhenoGen
PROSITE	SH2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000031081	RatGTEx
SMART	SH2	UniProtKB/TrEMBL
	STAT_int	UniProtKB/TrEMBL
Superfamily-SCOP	P53_like_DNA_bnd	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	STAT	UniProtKB/TrEMBL
	STAT	UniProtKB/TrEMBL
UniProt	A0A0G2K9T9_RAT	UniProtKB/TrEMBL
	F7EYG9	ENTREZGENE, UniProtKB/TrEMBL
	Q5XI26	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Stat2	signal transducer and activator of transcription 2	Stat2_predicted	signal transducer and activator of transcription 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Stat2_predicted	signal transducer and activator of transcription 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)