Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Col16a1 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of COL16A1 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of COL16A1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of COL16A1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | COL16A1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of COL16A1 mRNA and [Progesterone co-treated with Estradiol] results in decreased expression of COL16A1 mRNA | CTD | PMID:20226447 and PMID:30165855 | 17beta-estradiol | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Estradiol results in increased expression of COL16A1 mRNA | CTD | PMID:19484750 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of COL16A1 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of COL16A1 mRNA | CTD | PMID:33387578 | 4,4'-sulfonyldiphenol | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of COL16A1 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Col16a1 (Mus musculus) | 6480464 | bisphenol S affects the methylation of COL16A1 gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Col16a1 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of COL16A1 exon | CTD | PMID:33297965 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of COL16A1 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of COL16A1 mRNA | CTD | PMID:30047161 | acrylamide | decreases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of COL16A1 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of COL16A1 5' UTR and Aflatoxin B1 results in increased methylation of COL16A1 gene | CTD | PMID:27153756 and PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of COL16A1 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of COL16A1 mRNA | CTD | PMID:23724009 and PMID:23830798 | all-trans-retinoic acid | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of COL16A1 mRNA | CTD | PMID:30951980 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of COL16A1 mRNA | CTD | PMID:30047161 | antimycin A | decreases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Antimycin A results in decreased expression of COL16A1 mRNA | CTD | PMID:19304788 | antimycin A | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Antimycin A results in increased expression of COL16A1 mRNA | CTD | PMID:33512557 | antirheumatic drug | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of COL16A1 mRNA | CTD | PMID:24449571 | arsenous acid | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of COL16A1 mRNA | CTD | PMID:20458559 | arsenous acid | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Arsenic Trioxide results in increased expression of COL16A1 mRNA | CTD | PMID:35676786 | benzo[a]pyrene | increases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of COL16A1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of COL16A1 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of COL16A1 5' UTR | CTD | PMID:30157460 | benzo[e]pyrene | increases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of COL16A1 5' UTR | CTD | PMID:30157460 | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL16A1 mRNA | CTD | PMID:18164116 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of COL16A1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of COL16A1 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of COL16A1 mRNA | CTD | PMID:30816183 more ... | bisphenol A | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of COL16A1 mRNA | CTD | PMID:30951980 more ... | bisphenol A | affects expression | ISO | COL16A1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of COL16A1 mRNA | CTD | PMID:30903817 | bisphenol F | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of COL16A1 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | bisphenol F results in increased expression of COL16A1 mRNA | CTD | PMID:30951980 | butanal | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of COL16A1 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of COL16A1 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of COL16A1 mRNA | CTD | PMID:37325564 | calcitriol | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of COL16A1 mRNA | CTD | PMID:16002434 and PMID:26485663 | carbamazepine | affects expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of COL16A1 mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | COL16A1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to COL16A1 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL16A1 mRNA | CTD | PMID:20548288 and PMID:20938992 | chromium(6+) | affects expression | ISO | Col16a1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of COL16A1 mRNA | CTD | PMID:24374135 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of COL16A1 mRNA | CTD | PMID:24386269 | copper(II) sulfate | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of COL16A1 mRNA | CTD | PMID:16283523 | cyclosporin A | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of COL16A1 mRNA | CTD | PMID:25562108 | dextran sulfate | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Dextran Sulfate results in increased expression of COL16A1 mRNA | CTD | PMID:35093514 | diarsenic trioxide | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of COL16A1 mRNA | CTD | PMID:20458559 | diarsenic trioxide | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Arsenic Trioxide results in increased expression of COL16A1 mRNA | CTD | PMID:35676786 | entinostat | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | entinostat results in increased expression of COL16A1 mRNA | CTD | PMID:27188386 | ethanol | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Ethanol results in increased expression of COL16A1 mRNA | CTD | PMID:30319688 | fenpyroximate | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | fenpyroximate results in increased expression of COL16A1 mRNA | CTD | PMID:33512557 | folic acid | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20548288 more ... | fulvestrant | increases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of COL16A1 gene | CTD | PMID:31601247 | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of COL16A1 gene | CTD | PMID:27387713 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of COL16A1 mRNA | CTD | PMID:27387713 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of COL16A1 mRNA | CTD | PMID:33387578 | graphite | increases expression | EXP | | 6480464 | Graphite results in increased expression of COL16A1 mRNA | CTD | PMID:29933104 | GW 4064 | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | GW 4064 results in increased expression of COL16A1 mRNA | CTD | PMID:26655953 | hydrogen peroxide | affects expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of COL16A1 mRNA | CTD | PMID:20044591 | L-methionine | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL16A1 mRNA | CTD | PMID:20548288 and PMID:20938992 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of COL16A1 mRNA | CTD | PMID:11578147 | methapyrilene | increases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of COL16A1 5' UTR | CTD | PMID:30157460 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of COL16A1 mRNA | CTD | PMID:30047161 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of COL16A1 mRNA | CTD | PMID:31378766 | methylseleninic acid | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | methylselenic acid results in increased expression of COL16A1 mRNA | CTD | PMID:18548127 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL16A1 mRNA | CTD | PMID:18164116 | nickel atom | decreases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Nickel results in decreased expression of COL16A1 mRNA | CTD | PMID:24768652 | nickel sulfate | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of COL16A1 mRNA | CTD | PMID:18651567 | ozone | multiple interactions | ISO | Col16a1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of COL16A1 mRNA | CTD | PMID:27106289 | paracetamol | affects expression | ISO | Col16a1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of COL16A1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of COL16A1 mRNA | CTD | PMID:33387578 | pentanal | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | pentanal results in increased expression of COL16A1 mRNA | CTD | PMID:26079696 | pirinixic acid | multiple interactions | ISO | COL16A1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of COL16A1 mRNA | CTD | PMID:19710929 | progesterone | decreases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Progesterone results in decreased expression of COL16A1 mRNA | CTD | PMID:18070364 | progesterone | multiple interactions | ISO | COL16A1 (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of COL16A1 mRNA | CTD | PMID:20226447 | propanal | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of COL16A1 mRNA | CTD | PMID:26079696 | rotenone | decreases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Rotenone results in decreased expression of COL16A1 mRNA | CTD | PMID:19304788 | silicon dioxide | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of COL16A1 mRNA | CTD | PMID:25895662 | silver atom | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Silver results in increased expression of COL16A1 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Silver results in increased expression of COL16A1 mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of COL16A1 mRNA | CTD | PMID:29301061 and PMID:32844245 | sodium arsenite | decreases methylation | ISO | COL16A1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased methylation of COL16A1 intron | CTD | PMID:32844245 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of COL16A1 mRNA | CTD | PMID:19281266 | tamoxifen | increases expression | ISO | Col16a1 (Mus musculus) | 6480464 | Tamoxifen results in increased expression of COL16A1 mRNA | CTD | PMID:25123088 | temozolomide | decreases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of COL16A1 mRNA | CTD | PMID:31758290 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of COL16A1 mRNA | CTD | PMID:34492290 | triptonide | decreases expression | ISO | Col16a1 (Mus musculus) | 6480464 | triptonide results in decreased expression of COL16A1 mRNA | CTD | PMID:33045310 | valproic acid | decreases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of COL16A1 mRNA | CTD | PMID:29154799 | zoledronic acid | increases expression | ISO | COL16A1 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of COL16A1 mRNA | CTD | PMID:24714768 | |