Cmas (cytidine monophosphate N-acetylneuraminic acid synthetase) - Rat Genome Database

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Gene: Cmas (cytidine monophosphate N-acetylneuraminic acid synthetase) Rattus norvegicus
Analyze
Symbol: Cmas
Name: cytidine monophosphate N-acetylneuraminic acid synthetase
RGD ID: 1310911
Description: Predicted to enable N-acylneuraminate cytidylyltransferase activity. Predicted to be involved in N-acetylneuraminate metabolic process. Predicted to be located in nucleus. Orthologous to human CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CMP-N-acetylneuraminic acid synthase; CMP-N-acetylneuraminic acid synthetase; CMP-NeuNAc synthase; CMP-NeuNAc synthetase; cytidine 5'-monophosphate N-acetylneuraminic acid synthetase; cytidine monophospho-N-acetylneuraminic acid synthetase; LOC312826; MGC105806; N-acylneuraminate cytidylyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,449,801 - 177,468,117 (+)NCBIGRCr8
mRatBN7.24175,718,808 - 175,737,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,718,808 - 175,737,125 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4182,013,798 - 182,032,139 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,798,073 - 177,816,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,418,640 - 176,436,981 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,994,129 - 177,012,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,994,129 - 177,012,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04241,203,361 - 241,221,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,650,927 - 180,669,243 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,896,050 - 180,914,366 (+)NCBI
Celera4164,249,097 - 164,267,377 (+)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19946888   PMID:21630459  


Genomics

Comparative Map Data
Cmas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,449,801 - 177,468,117 (+)NCBIGRCr8
mRatBN7.24175,718,808 - 175,737,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,718,808 - 175,737,125 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4182,013,798 - 182,032,139 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,798,073 - 177,816,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,418,640 - 176,436,981 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,994,129 - 177,012,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,994,129 - 177,012,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04241,203,361 - 241,221,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,650,927 - 180,669,243 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,896,050 - 180,914,366 (+)NCBI
Celera4164,249,097 - 164,267,377 (+)NCBICelera
Cytogenetic Map4q44NCBI
CMAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381222,046,218 - 22,065,668 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1222,046,218 - 22,065,674 (+)EnsemblGRCh38hg38GRCh38
GRCh371222,199,152 - 22,218,602 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361222,090,426 - 22,109,869 (+)NCBINCBI36Build 36hg18NCBI36
Build 341222,090,425 - 22,109,869NCBI
Celera1227,353,627 - 27,373,064 (+)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,972,423 - 21,991,850 (+)NCBIHuRef
CHM1_11222,164,047 - 22,183,534 (+)NCBICHM1_1
T2T-CHM13v2.01221,924,274 - 21,943,724 (+)NCBIT2T-CHM13v2.0
Cmas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,702,468 - 142,721,440 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,702,412 - 142,721,440 (+)EnsemblGRCm39 Ensembl
GRCm386142,756,686 - 142,775,714 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,756,686 - 142,775,714 (+)EnsemblGRCm38mm10GRCm38
MGSCv376142,705,206 - 142,724,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,713,995 - 142,732,930 (+)NCBIMGSCv36mm8
Celera6145,818,239 - 145,837,265 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.66NCBI
Cmas
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,575,469 - 17,599,859 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541317,575,469 - 17,596,379 (+)NCBIChiLan1.0ChiLan1.0
CMAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21074,738,425 - 74,757,537 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11274,734,823 - 74,753,931 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,234,241 - 64,253,306 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11266,838,670 - 66,857,774 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1266,838,670 - 66,857,774 (-)Ensemblpanpan1.1panPan2
CMAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,097,907 - 25,117,003 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,098,091 - 25,116,965 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2721,243,508 - 21,262,605 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02725,317,491 - 25,336,605 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,317,494 - 25,336,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,116,424 - 25,135,532 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,139,768 - 25,158,852 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02721,412,861 - 21,431,958 (+)NCBIUU_Cfam_GSD_1.0
Cmas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494586,955,025 - 86,972,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365484,877,530 - 4,895,822 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365484,877,753 - 4,895,768 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CMAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,438,020 - 51,458,615 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,438,175 - 51,458,531 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2554,719,668 - 54,740,011 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CMAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,896,607 - 21,919,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,896,630 - 21,915,657 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,226,303 - 13,245,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cmas
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475216,712,660 - 16,732,399 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475216,712,878 - 16,731,937 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cmas
71 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000018734
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH131050  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,736,819 - 175,737,039 (+)MAPPERmRatBN7.2
Rnor_6.04177,012,137 - 177,012,356NCBIRnor6.0
Rnor_5.04241,221,368 - 241,221,587UniSTSRnor5.0
RGSC_v3.44180,668,935 - 180,669,154UniSTSRGSC3.4
Celera4164,267,069 - 164,267,288UniSTS
RH 3.4 Map41044.5UniSTS
Cytogenetic Map4q44UniSTS
CMAS  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,726,158 - 175,726,550 (+)MAPPERmRatBN7.2
Rnor_6.04177,001,480 - 177,001,871NCBIRnor6.0
Rnor_5.04241,210,712 - 241,211,103UniSTSRnor5.0
RGSC_v3.44180,658,278 - 180,658,669UniSTSRGSC3.4
Celera4164,256,448 - 164,256,839UniSTS
Cytogenetic Map4q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000018734   ⟹   ENSRNOP00000018734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,718,808 - 175,737,125 (+)Ensembl
Rnor_6.0 Ensembl4176,994,129 - 177,012,444 (+)Ensembl
RefSeq Acc Id: NM_001009419   ⟹   NP_001009419
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,449,801 - 177,468,117 (+)NCBI
mRatBN7.24175,718,808 - 175,737,128 (+)NCBI
Rnor_6.04176,994,129 - 177,012,445 (+)NCBI
Rnor_5.04241,203,361 - 241,221,676 (+)NCBI
RGSC_v3.44180,650,927 - 180,669,243 (+)RGD
Celera4164,249,097 - 164,267,377 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009419 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87599 (Get FASTA)   NCBI Sequence Viewer  
  EDM01475 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018734
  ENSRNOP00000018734.3
GenBank Protein P69060 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009419   ⟸   NM_001009419
- UniProtKB: P69060 (UniProtKB/Swiss-Prot),   Q5M963 (UniProtKB/TrEMBL),   F7F0E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018734   ⟸   ENSRNOT00000018734

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P69060-F1-model_v2 AlphaFold P69060 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693492
Promoter ID:EPDNEW_R4016
Type:initiation region
Name:Cmas_1
Description:cytidine monophosphate N-acetylneuraminic acid synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,994,105 - 176,994,165EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310911 AgrOrtholog
BioCyc Gene G2FUF-42488 BioCyc
BioCyc Pathway PWY-6138 [CMP-N-acetylneuraminate biosynthesis I (eukaryotes)] BioCyc
BioCyc Pathway Image PWY-6138 BioCyc
Ensembl Genes ENSRNOG00000013816 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018734 ENTREZGENE
  ENSRNOT00000018734.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7313414 IMAGE-MGC_LOAD
InterPro Cytidylyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:312826 UniProtKB/TrEMBL
MGC_CLONE MGC:105806 IMAGE-MGC_LOAD
NCBI Gene 312826 ENTREZGENE
PANTHER HAD SUPERFAMILY MEMBERS CMAS AND KDSC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CTP_transf_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cmas PhenoGen
RatGTEx ENSRNOG00000013816 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7F0E0 ENTREZGENE, UniProtKB/TrEMBL
  NEUA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M963 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Cmas  cytidine monophosphate N-acetylneuraminic acid synthetase  Cmas  cytidine monophospho-N-acetylneuraminic acid synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cmas  cytidine monophospho-N-acetylneuraminic acid synthetase  Cmas_predicted  cytidine monophospho-N-acetylneuraminic acid synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cmas_predicted  cytidine monophospho-N-acetylneuraminic acid synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED