Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of LAD1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAD1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of LAD1 mRNA | CTD | PMID:23019147 and PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAD1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Lad1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LAD1 mRNA | CTD | PMID:26377647 and PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Lad1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LAD1 mRNA | CTD | PMID:19770486 | 3-Nitrobenzanthrone | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | 3-nitrobenzanthrone results in increased expression of LAD1 mRNA | CTD | PMID:34036453 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Lad1 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of LAD1 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of LAD1 mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of LAD1 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | Decitabine inhibits the reaction [Smoke results in decreased expression of LAD1 mRNA] | CTD | PMID:21095227 | 5-aza-2'-deoxycytidine | affects expression | ISO | LAD1 (Homo sapiens) | 6480464 | Decitabine affects the expression of LAD1 mRNA | CTD | PMID:23300844 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LAD1 mRNA | CTD | PMID:30047161 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of LAD1 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of LAD1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of LAD1 mRNA | CTD | PMID:32699268 | aflatoxin B1 | decreases expression | ISO | Lad1 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of LAD1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases mutagenesis | EXP | | 6480464 | Aflatoxin B1 results in increased mutagenesis of LAD1 gene | CTD | PMID:36908029 | all-trans-retinoic acid | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of LAD1 mRNA | CTD | PMID:23830798 | all-trans-retinoic acid | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of LAD1 mRNA | CTD | PMID:30951980 | alpha-pinene | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of LAD1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of LAD1 mRNA | CTD | PMID:32699268 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of LAD1 mRNA | CTD | PMID:30047161 | antirheumatic drug | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of LAD1 mRNA | CTD | PMID:24449571 | benzo[a]pyrene | decreases methylation | ISO | LAD1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of LAD1 exon and Benzo(a)pyrene results in decreased methylation of LAD1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of LAD1 mRNA | CTD | PMID:32234424 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of LAD1 mRNA | CTD | PMID:25181051 and PMID:34947998 | bisphenol A | decreases methylation | ISO | LAD1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of LAD1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of LAD1 mRNA | CTD | PMID:32156529 and PMID:34585602 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LAD1 mRNA | CTD | PMID:30816183 and PMID:32528016 | bisphenol F | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of LAD1 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | bisphenol F results in increased expression of LAD1 mRNA | CTD | PMID:30951980 | bromobenzene | increases expression | EXP | | 6480464 | bromobenzene results in increased expression of LAD1 mRNA | CTD | PMID:32479839 | butan-1-ol | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of LAD1 mRNA | CTD | PMID:29432896 | cadmium atom | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LAD1 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LAD1 mRNA | CTD | PMID:37325564 | caffeine | affects phosphorylation | ISO | LAD1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of LAD1 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Lad1 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of LAD1 mRNA | CTD | PMID:25620056 | carbon nanotube | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of LAD1 mRNA | CTD | PMID:25620056 | carmustine | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Carmustine results in decreased expression of LAD1 mRNA | CTD | PMID:15980968 | CGP 52608 | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to LAD1 gene] | CTD | PMID:28238834 | chlorpyrifos | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of LAD1 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LAD1 gene | CTD | PMID:20938992 | cisplatin | affects expression | ISO | LAD1 (Homo sapiens) | 6480464 | Cisplatin affects the expression of LAD1 mRNA | CTD | PMID:23300844 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of LAD1 mRNA | CTD | PMID:30556269 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of LAD1 mRNA | CTD | PMID:30556269 | copper(II) sulfate | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of LAD1 mRNA | CTD | PMID:19549813 | coumarin | increases expression | EXP | | 6480464 | coumarin results in increased expression of LAD1 mRNA | CTD | PMID:18480146 | cyclosporin A | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of LAD1 mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [Dexamethasone results in increased phosphorylation of and results in increased activity of NR3C1 protein] which results in increased expression of LAD1 mRNA | CTD | PMID:18483179 | dimethylarsinic acid | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of LAD1 mRNA | CTD | PMID:34876320 | ethylparaben | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | ethyl-p-hydroxybenzoate results in increased expression of LAD1 mRNA | CTD | PMID:37690743 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of LAD1 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LAD1 gene | CTD | PMID:20938992 | folic acid | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of LAD1 mRNA | CTD | PMID:21867686 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of LAD1 mRNA | CTD | PMID:27387713 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of LAD1 mRNA | CTD | PMID:33387578 | ivermectin | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of LAD1 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LAD1 gene | CTD | PMID:20938992 | lipopolysaccharide | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | lipopolysaccharide | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of LAD1 mRNA | CTD | PMID:35811015 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of LAD1 mRNA | CTD | PMID:30047161 | methylarsonic acid | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of LAD1 mRNA | CTD | PMID:34876320 | methylphenidate | decreases expression | ISO | Lad1 (Mus musculus) | 6480464 | Methylphenidate results in decreased expression of LAD1 mRNA | CTD | PMID:22470460 | nickel atom | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Nickel results in increased expression of LAD1 mRNA | CTD | PMID:25583101 | nickel sulfate | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of LAD1 mRNA | CTD | PMID:16780908 | ozone | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of LAD1 mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of LAD1 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | Lad1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of LAD1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LAD1 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of LAD1 mRNA | CTD | PMID:21420995 more ... | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of LAD1 mRNA | CTD | PMID:32680482 | pentachlorophenol | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of LAD1 mRNA | CTD | PMID:23892564 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Lad1 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of LAD1 mRNA | CTD | PMID:28903501 | propanal | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of LAD1 mRNA | CTD | PMID:26079696 | quercetin | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Quercetin results in increased expression of LAD1 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of LAD1 mRNA | CTD | PMID:23557933 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | sodium arsenate | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of LAD1 mRNA | CTD | PMID:34876320 | sodium arsenite | affects expression | ISO | LAD1 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of LAD1 mRNA | CTD | PMID:34032870 | sodium arsenite | multiple interactions | ISO | Lad1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of LAD1 mRNA | CTD | PMID:34876320 | sotorasib | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAD1 mRNA | CTD | PMID:36139627 | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of LAD1 mRNA | CTD | PMID:30047161 | sulindac | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Sulindac results in increased expression of LAD1 mRNA | CTD | PMID:11507085 | sunitinib | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of LAD1 mRNA | CTD | PMID:31533062 | tetrachloromethane | decreases expression | ISO | Lad1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of LAD1 mRNA | CTD | PMID:31919559 | trametinib | multiple interactions | ISO | LAD1 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAD1 mRNA | CTD | PMID:36139627 | triptonide | increases expression | ISO | Lad1 (Mus musculus) | 6480464 | triptonide results in increased expression of LAD1 mRNA | CTD | PMID:33045310 | uranium atom | affects expression | ISO | LAD1 (Homo sapiens) | 6480464 | Uranium affects the expression of LAD1 mRNA | CTD | PMID:15672453 | urethane | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of LAD1 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of LAD1 mRNA | CTD | PMID:29154799 | valproic acid | increases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of LAD1 mRNA | CTD | PMID:23527032 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of LAD1 mRNA | CTD | PMID:23034163 | vitamin E | decreases expression | ISO | LAD1 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of LAD1 mRNA | CTD | PMID:19244175 | |