Adgrf1 (adhesion G protein-coupled receptor F1) - Rat Genome Database

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Gene: Adgrf1 (adhesion G protein-coupled receptor F1) Rattus norvegicus
Analyze
Symbol: Adgrf1
Name: adhesion G protein-coupled receptor F1
RGD ID: 1310285
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cannabinoid signaling pathway and cell surface receptor signaling pathway. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; memory; and nervous system development. Predicted to be located in plasma membrane. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1); INTERACTS WITH amphetamine; cocaine; Monobutylphthalate.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adhesion G-protein coupled receptor F1; G protein-coupled receptor 110; Gpr110; LOC301266
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,158,198 - 25,210,744 (-)NCBIGRCr8
mRatBN7.2917,661,258 - 17,696,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,660,930 - 17,711,704 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0920,343,730 - 20,378,686 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0919,202,510 - 19,318,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,359,998 - 13,419,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,358,106 - 13,416,371 (-)NCBI
Celera915,370,906 - 15,421,796 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27759003  


Genomics

Comparative Map Data
Adgrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,158,198 - 25,210,744 (-)NCBIGRCr8
mRatBN7.2917,661,258 - 17,696,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,660,930 - 17,711,704 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0920,343,730 - 20,378,686 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0919,202,510 - 19,318,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,359,998 - 13,419,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,358,106 - 13,416,371 (-)NCBI
Celera915,370,906 - 15,421,796 (-)NCBICelera
Cytogenetic Map9q13NCBI
ADGRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,997,708 - 47,042,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,997,708 - 47,042,350 (-)EnsemblGRCh38hg38GRCh38
GRCh37646,965,445 - 47,010,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,075,772 - 47,118,041 (-)NCBINCBI36Build 36hg18NCBI36
Build 34647,075,917 - 47,094,194NCBI
Celera648,520,157 - 48,562,426 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,690,703 - 46,732,981 (-)NCBIHuRef
CHM1_1646,971,042 - 47,013,305 (-)NCBICHM1_1
T2T-CHM13v2.0646,835,188 - 46,879,812 (-)NCBIT2T-CHM13v2.0
Adgrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,581,174 - 43,636,767 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,581,220 - 43,635,628 (+)EnsemblGRCm39 Ensembl
GRCm381743,270,283 - 43,325,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,270,329 - 43,324,737 (+)EnsemblGRCm38mm10GRCm38
MGSCv371743,407,296 - 43,461,355 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,735,601 - 42,789,388 (+)NCBIMGSCv36mm8
Celera1746,686,960 - 46,746,176 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.71NCBI
Adgrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,744,342 - 11,772,305 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,744,387 - 11,772,260 (-)NCBIChiLan1.0ChiLan1.0
ADGRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2561,495,623 - 61,540,289 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1657,361,859 - 57,406,528 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0646,583,013 - 46,627,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,848,040 - 47,892,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,848,040 - 47,892,912 (-)Ensemblpanpan1.1panPan2
ADGRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,149,254 - 15,283,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,150,543 - 15,204,300 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1215,181,601 - 15,315,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01215,646,559 - 15,741,910 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,648,211 - 15,702,592 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,161,203 - 15,256,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,254,178 - 15,349,786 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,400,749 - 15,534,732 (-)NCBIUU_Cfam_GSD_1.0
Adgrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,586,577 - 50,612,890 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647613,358,096 - 13,374,819 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647613,339,985 - 13,373,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl741,806,393 - 41,853,657 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1741,806,385 - 41,853,829 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,466,209 - 48,497,395 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,236,855 - 25,279,589 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,237,852 - 25,273,087 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604447,017,749 - 47,049,257 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,722,457 - 13,751,378 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,722,528 - 13,749,892 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrf1
410 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat

Markers in Region
D9Got21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,664,358 - 17,664,536 (+)MAPPERmRatBN7.2
Rnor_6.0920,333,114 - 20,333,291NCBIRnor6.0
Rnor_5.0919,205,763 - 19,205,940UniSTSRnor5.0
RGSC_v3.4913,363,882 - 13,364,060RGDRGSC3.4
RGSC_v3.4913,363,883 - 13,364,060UniSTSRGSC3.4
RGSC_v3.1913,361,205 - 13,361,382RGD
Celera915,374,007 - 15,374,184UniSTS
RH 3.4 Map9135.3UniSTS
RH 3.4 Map9135.3RGD
RH 2.0 Map9115.9RGD
Cytogenetic Map9q12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000115168   ⟹   ENSRNOP00000093180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl917,660,930 - 17,711,704 (-)Ensembl
RefSeq Acc Id: XM_039084502   ⟹   XP_038940430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,191,230 (-)NCBI
mRatBN7.2917,661,258 - 17,693,969 (-)NCBI
RefSeq Acc Id: XM_039084503   ⟹   XP_038940431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,208,948 (-)NCBI
mRatBN7.2917,661,258 - 17,696,359 (-)NCBI
RefSeq Acc Id: XM_039084504   ⟹   XP_038940432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,191,221 (-)NCBI
mRatBN7.2917,661,258 - 17,693,933 (-)NCBI
RefSeq Acc Id: XM_063267885   ⟹   XP_063123955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,210,744 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038940430 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940431 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940432 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123955 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18690 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093180
  ENSRNOP00000093180.1
Reference Protein Sequences
RefSeq Acc Id: XP_038940431   ⟸   XM_039084503
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AIR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940430   ⟸   XM_039084502
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940432   ⟸   XM_039084504
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000093180   ⟸   ENSRNOT00000115168
RefSeq Acc Id: XP_063123955   ⟸   XM_063267885
- Peptide Label: isoform X3
Protein Domains
G-protein coupled receptors family 2 profile   SEA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310285 AgrOrtholog
BioCyc Gene G2FUF-28103 BioCyc
Ensembl Genes ENSRNOG00000062544 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000115168.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.610 UniProtKB/TrEMBL
  2.60.220.50 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_Ig-hepta-like_rcpt UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  SEA_dom UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
NCBI Gene 301266 ENTREZGENE
PANTHER ADHESION G-PROTEIN COUPLED RECEPTOR F1 UniProtKB/TrEMBL
  PTHR45813 UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
PhenoGen Adgrf1 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/TrEMBL
  IGHEPTARCPTR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062544 RatGTEx
SMART GPS UniProtKB/TrEMBL
Superfamily-SCOP SSF82671 UniProtKB/TrEMBL
UniProt A0A8I6AIR1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Adgrf1  adhesion G protein-coupled receptor F1  Adgrf1  adhesion G protein-coupled receptor F1  Data merged from RGD:149736219 737654 PROVISIONAL
2021-08-09 Adgrf1  adhesion G protein-coupled receptor F1      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-03-16 Adgrf1  adhesion G protein-coupled receptor F1  Gpr110  G protein-coupled receptor 110  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gpr110  G protein-coupled receptor 110   Gpr110_predicted  G protein-coupled receptor 110 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpr110_predicted  G protein-coupled receptor 110 (predicted)      Symbol and Name status set to approved 70820 APPROVED