Prepl (prolyl endopeptidase-like) - Rat Genome Database

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Gene: Prepl (prolyl endopeptidase-like) Rattus norvegicus
Analyze
Symbol: Prepl
Name: prolyl endopeptidase-like
RGD ID: 1310143
Description: Predicted to enable peptidase activity. Predicted to be involved in Golgi to plasma membrane protein transport; regulation of synaptic vesicle exocytosis; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and nucleus. Predicted to be active in Golgi apparatus and cytoskeleton. Predicted to colocalize with trans-Golgi network. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC298771; MGC105586; RGD1310143; similar to RIKEN cDNA D030028O16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,333,107 - 15,362,825 (+)NCBIGRCr8
mRatBN7.269,580,367 - 9,609,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx69,869,516 - 9,898,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,178,893 - 10,208,191 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,700,429 - 9,729,763 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,316,861 - 8,346,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,318,979 - 8,346,197 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,249,345 - 8,278,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,419,874 - 8,447,739 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,419,873 - 8,447,739 (-)NCBI
Celera69,304,799 - 9,331,994 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoskeleton  (IBA,IEA,ISO)
cytosol  (IEA)
Golgi apparatus  (IBA,IEA,ISO)
nucleus  (IEA)
trans-Golgi network  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21692504   PMID:22871113   PMID:23321636   PMID:23485813   PMID:24610330   PMID:28726805  


Genomics

Comparative Map Data
Prepl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,333,107 - 15,362,825 (+)NCBIGRCr8
mRatBN7.269,580,367 - 9,609,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx69,869,516 - 9,898,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,178,893 - 10,208,191 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,700,429 - 9,729,763 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,316,861 - 8,346,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,318,979 - 8,346,197 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,249,345 - 8,278,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,419,874 - 8,447,739 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,419,873 - 8,447,739 (-)NCBI
Celera69,304,799 - 9,331,994 (+)NCBICelera
Cytogenetic Map6q12NCBI
PREPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,317,607 - 44,361,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl244,316,281 - 44,361,862 (-)EnsemblGRCh38hg38GRCh38
GRCh37244,544,746 - 44,589,001 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,399,406 - 44,440,393 (-)NCBINCBI36Build 36hg18NCBI36
Celera244,383,700 - 44,427,951 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef244,281,407 - 44,325,655 (-)NCBIHuRef
CHM1_1244,472,451 - 44,516,684 (-)NCBICHM1_1
T2T-CHM13v2.0244,322,928 - 44,367,164 (-)NCBIT2T-CHM13v2.0
Prepl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,370,122 - 85,397,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,370,898 - 85,397,669 (-)EnsemblGRCm39 Ensembl
GRCm381785,062,511 - 85,090,504 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1785,063,470 - 85,090,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv371785,462,817 - 85,489,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361784,971,812 - 84,998,534 (-)NCBIMGSCv36mm8
Celera1789,425,166 - 89,451,900 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.19NCBI
Prepl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,418,299 - 11,453,218 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544111,418,299 - 11,453,889 (-)NCBIChiLan1.0ChiLan1.0
PREPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,044,665 - 82,090,876 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,048,635 - 82,094,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A44,417,735 - 44,463,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,353,326 - 45,398,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A45,353,326 - 45,397,903 (-)Ensemblpanpan1.1panPan2
PREPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,733,769 - 46,792,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,726,676 - 46,792,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,595,349 - 46,654,047 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01047,613,473 - 47,672,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,613,473 - 47,672,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11047,320,610 - 47,379,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,611,662 - 47,670,468 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,794,300 - 47,853,142 (-)NCBIUU_Cfam_GSD_1.0
Prepl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,209,248 - 36,243,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365087,637,882 - 7,674,877 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365087,637,844 - 7,674,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,092,314 - 96,159,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,248,639 - 102,314,853 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PREPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11462,879,616 - 62,925,265 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1462,875,133 - 62,924,746 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604548,954,858 - 49,006,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prepl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,802,793 - 25,834,762 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473825,802,156 - 25,835,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prepl
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:121
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000009660, ENSRNOT00000061826
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 29 13 11 13 8 11 74 35 40 11 8
Low 1 28 28 8 28 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001010951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009660   ⟹   ENSRNOP00000009660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,582,169 - 9,607,772 (+)Ensembl
Rnor_6.0 Ensembl68,319,175 - 8,344,574 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000061826   ⟹   ENSRNOP00000058540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)Ensembl
Rnor_6.0 Ensembl68,319,058 - 8,346,197 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082353   ⟹   ENSRNOP00000070154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,580,549 - 9,607,772 (+)Ensembl
Rnor_6.0 Ensembl68,318,979 - 8,344,897 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117547   ⟹   ENSRNOP00000076580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,580,245 - 9,607,758 (+)Ensembl
RefSeq Acc Id: NM_001010951   ⟹   NP_001010951
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,395 - 15,362,825 (+)NCBI
mRatBN7.269,580,527 - 9,609,957 (+)NCBI
Rnor_6.068,319,058 - 8,346,197 (-)NCBI
Rnor_5.068,249,345 - 8,278,750 (-)NCBI
RGSC_v3.468,419,874 - 8,447,739 (-)RGD
Celera69,304,799 - 9,331,994 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239697   ⟹   XP_006239759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,371 - 15,362,825 (+)NCBI
mRatBN7.269,580,516 - 9,609,957 (+)NCBI
Rnor_6.068,316,861 - 8,346,220 (-)NCBI
Rnor_5.068,249,345 - 8,278,750 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764456   ⟹   XP_008762678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,367 - 15,362,825 (+)NCBI
mRatBN7.269,580,517 - 9,609,957 (+)NCBI
Rnor_6.068,316,861 - 8,346,220 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764458   ⟹   XP_008762680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,351 - 15,362,825 (+)NCBI
mRatBN7.269,580,489 - 9,609,957 (+)NCBI
Rnor_6.068,316,861 - 8,346,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111895   ⟹   XP_038967823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,117 - 15,362,825 (+)NCBI
mRatBN7.269,580,367 - 9,609,957 (+)NCBI
RefSeq Acc Id: XM_063261601   ⟹   XP_063117671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,367 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261602   ⟹   XP_063117672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,371 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261603   ⟹   XP_063117673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,352 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261604   ⟹   XP_063117674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,396 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261605   ⟹   XP_063117675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,384 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261606   ⟹   XP_063117676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,107 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261607   ⟹   XP_063117677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,385 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261608   ⟹   XP_063117678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,357 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261609   ⟹   XP_063117679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,385 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261610   ⟹   XP_063117680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,354 - 15,362,825 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001010951   ⟸   NM_001010951
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A6H9H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239759   ⟸   XM_006239697
- Peptide Label: isoform X2
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A0A0G2JX67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762680   ⟸   XM_008764458
- Peptide Label: isoform X8
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A6H9H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762678   ⟸   XM_008764456
- Peptide Label: isoform X5
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070154   ⟸   ENSRNOT00000082353
RefSeq Acc Id: ENSRNOP00000058540   ⟸   ENSRNOT00000061826
RefSeq Acc Id: ENSRNOP00000009660   ⟸   ENSRNOT00000009660
RefSeq Acc Id: XP_038967823   ⟸   XM_039111895
- Peptide Label: isoform X6
- UniProtKB: A0A8L2UN13 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000076580   ⟸   ENSRNOT00000117547
RefSeq Acc Id: XP_063117676   ⟸   XM_063261606
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063117673   ⟸   XM_063261603
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JX67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117680   ⟸   XM_063261610
- Peptide Label: isoform X8
- UniProtKB: A6H9H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117678   ⟸   XM_063261608
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063117671   ⟸   XM_063261601
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117672   ⟸   XM_063261602
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117675   ⟸   XM_063261605
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063117679   ⟸   XM_063261609
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063117677   ⟸   XM_063261607
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063117674   ⟸   XM_063261604
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JX67 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S9 prolyl oligopeptidase catalytic   Peptidase S9A N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5HZA6-F1-model_v2 AlphaFold Q5HZA6 1-726 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694380
Promoter ID:EPDNEW_R4905
Type:initiation region
Name:Prepl_1
Description:prolyl endopeptidase-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,346,216 - 8,346,276EPDNEW
RGD ID:13694383
Promoter ID:EPDNEW_R4906
Type:multiple initiation site
Name:AC111831_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,346,637 - 8,346,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310143 AgrOrtholog
BioCyc Gene G2FUF-38656 BioCyc
Ensembl Genes ENSRNOG00000007326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009660.7 UniProtKB/TrEMBL
  ENSRNOT00000061826.4 UniProtKB/TrEMBL
  ENSRNOT00000082353 UniProtKB/TrEMBL
  ENSRNOT00000082353.2 UniProtKB/Swiss-Prot
  ENSRNOT00000117547.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prolyl oligopeptidase, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312962 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S9A_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:298771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105586 IMAGE-MGC_LOAD
NCBI Gene 298771 ENTREZGENE
PANTHER PROLYL ENDOPEPTIDASE-LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASE FAMILY S9A OLIGOPEPTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prepl PhenoGen
PRINTS PROLIGOPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007326 RatGTEx
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UN13 ENTREZGENE, UniProtKB/TrEMBL
  A6H9H3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZ32_RAT UniProtKB/TrEMBL
  PPCEL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Prepl  prolyl endopeptidase-like  RGD1310143  similar to RIKEN cDNA D030028O16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310143  similar to RIKEN cDNA D030028O16  RGD1310143_predicted  similar to RIKEN cDNA D030028O16 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310143_predicted  similar to RIKEN cDNA D030028O16 (predicted)  LOC298771_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC298771_predicted  similar to RIKEN cDNA D030028O16 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL