Tsen2 (tRNA splicing endonuclease subunit 2) - Rat Genome Database

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Gene: Tsen2 (tRNA splicing endonuclease subunit 2) Rattus norvegicus
Analyze
Symbol: Tsen2
Name: tRNA splicing endonuclease subunit 2
RGD ID: 1309946
Description: Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2); PARTICIPATES IN tRNA maturation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC312649; RGD1309946; similar to hypothetical protein MGC2776; tRNA splicing endonuclease 2 homolog (S. cerevisiae); tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae); tRNA-intron endonuclease Sen2; tRNA-intron nuclease 2; tRNA-splicing endonuclease subunit Sen2; TSEN2 tRNA splicing endonuclease subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,275,389 - 150,310,846 (+)NCBIGRCr8
mRatBN7.24148,602,805 - 148,638,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,602,863 - 148,638,215 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,827,001 - 154,862,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,610,088 - 150,645,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,233,907 - 149,269,200 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,455,506 - 147,490,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,455,533 - 147,490,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,742,791 - 210,778,839 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,672,953 - 151,708,835 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,917,793 - 151,953,680 (+)NCBI
Celera4137,494,385 - 137,528,921 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IEA,ISO)
cytosol  (IEA,ISO)
nucleolus  (IEA)
nucleoplasm  (IEA,ISO)
tRNA-intron endonuclease complex  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Handling tRNA introns, archaeal way and eukaryotic way. Yoshihisa T Front Genet. 2014 Jul 10;5:213. doi: 10.3389/fgene.2014.00213. eCollection 2014.
Additional References at PubMed
PMID:15489334   PMID:17495927  


Genomics

Comparative Map Data
Tsen2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,275,389 - 150,310,846 (+)NCBIGRCr8
mRatBN7.24148,602,805 - 148,638,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,602,863 - 148,638,215 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,827,001 - 154,862,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,610,088 - 150,645,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,233,907 - 149,269,200 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,455,506 - 147,490,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,455,533 - 147,490,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,742,791 - 210,778,839 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,672,953 - 151,708,835 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,917,793 - 151,953,680 (+)NCBI
Celera4137,494,385 - 137,528,921 (+)NCBICelera
Cytogenetic Map4q42NCBI
TSEN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,480,231 - 12,539,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,484,421 - 12,541,549 (+)EnsemblGRCh38hg38GRCh38
GRCh37312,525,979 - 12,581,123 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,501,028 - 12,549,812 (+)NCBINCBI36Build 36hg18NCBI36
Celera312,463,261 - 12,512,159 (+)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,458,994 - 12,507,895 (+)NCBIHuRef
CHM1_1312,476,015 - 12,524,909 (+)NCBICHM1_1
T2T-CHM13v2.0312,478,037 - 12,537,426 (+)NCBIT2T-CHM13v2.0
Tsen2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,521,652 - 115,555,297 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,521,625 - 115,555,589 (+)EnsemblGRCm39 Ensembl
GRCm386115,544,659 - 115,578,350 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,544,664 - 115,578,628 (+)EnsemblGRCm38mm10GRCm38
MGSCv376115,494,722 - 115,528,354 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,510,323 - 115,543,955 (+)NCBIMGSCv36mm8
Celera6117,384,279 - 117,417,834 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.58NCBI
Tsen2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,969,289 - 14,997,220 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,970,105 - 14,997,459 (+)NCBIChiLan1.0ChiLan1.0
TSEN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,471,154 - 12,524,257 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,475,973 - 12,529,018 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0312,410,885 - 12,463,932 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,754,106 - 12,800,801 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,759,375 - 12,800,201 (+)Ensemblpanpan1.1panPan2
TSEN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,031,295 - 6,090,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,050,357 - 6,207,981 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,067,927 - 6,127,172 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0206,060,280 - 6,119,929 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,078,684 - 6,119,841 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1205,775,670 - 5,835,307 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,129,564 - 6,189,194 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,106,273 - 6,164,648 (-)NCBIUU_Cfam_GSD_1.0
Tsen2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,714,525 - 17,745,833 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,164,227 - 1,195,221 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,163,927 - 1,195,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSEN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,467,860 - 68,520,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,480,708 - 68,520,726 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,697,087 - 75,737,589 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSEN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,458,404 - 48,510,420 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,463,693 - 48,510,123 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041117,993,783 - 118,042,002 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tsen2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462495622,035 - 46,874 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462495621,284 - 51,588 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tsen2
223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:43
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000056429
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat

Markers in Region
AU047745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,611,979 - 148,612,164 (+)MAPPERmRatBN7.2
Rnor_6.04147,464,631 - 147,464,815NCBIRnor6.0
Rnor_5.04210,752,182 - 210,752,366UniSTSRnor5.0
RGSC_v3.44151,682,574 - 151,682,758UniSTSRGSC3.4
Celera4137,503,507 - 137,503,681UniSTS
Cytogenetic Map4q42UniSTS
RH137709  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,638,026 - 148,638,182 (+)MAPPERmRatBN7.2
Rnor_6.04147,490,677 - 147,490,832NCBIRnor6.0
Rnor_5.04210,778,647 - 210,778,802UniSTSRnor5.0
RGSC_v3.44151,708,643 - 151,708,798UniSTSRGSC3.4
Celera4137,528,729 - 137,528,884UniSTS
RH 3.4 Map4949.21UniSTS
Cytogenetic Map4q42UniSTS
BF417781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,621,699 - 148,621,837 (+)MAPPERmRatBN7.2
Rnor_6.04147,474,350 - 147,474,487NCBIRnor6.0
Rnor_5.04210,761,902 - 210,762,039UniSTSRnor5.0
RGSC_v3.44151,692,294 - 151,692,431UniSTSRGSC3.4
Celera4137,513,217 - 137,513,354UniSTS
RH 3.4 Map4949.91UniSTS
Cytogenetic Map4q42UniSTS
AI229772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,619,650 - 148,619,772 (+)MAPPERmRatBN7.2
Rnor_6.04147,472,301 - 147,472,422NCBIRnor6.0
Rnor_5.04210,759,853 - 210,759,974UniSTSRnor5.0
RGSC_v3.44151,690,245 - 151,690,366UniSTSRGSC3.4
Celera4137,511,168 - 137,511,289UniSTS
RH 3.4 Map4952.0UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 66 10 18
Low 3 43 55 39 19 39 8 11 8 25 23 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000081957   ⟹   ENSRNOP00000073692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,602,871 - 148,638,215 (+)Ensembl
Rnor_6.0 Ensembl4147,455,533 - 147,490,733 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094843   ⟹   ENSRNOP00000079451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,602,863 - 148,609,111 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119184   ⟹   ENSRNOP00000086444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,602,863 - 148,613,532 (+)Ensembl
RefSeq Acc Id: NM_001014057   ⟹   NP_001014079
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,275,482 - 150,310,846 (+)NCBI
mRatBN7.24148,602,853 - 148,638,219 (+)NCBI
Rnor_6.04147,455,518 - 147,490,869 (+)NCBI
Rnor_5.04210,742,791 - 210,778,839 (+)NCBI
RGSC_v3.44151,672,953 - 151,708,835 (+)RGD
Celera4137,494,385 - 137,528,921 (+)RGD
Sequence:
RefSeq Acc Id: XM_008763240   ⟹   XP_008761462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,275,497 - 150,310,822 (+)NCBI
mRatBN7.24148,602,895 - 148,638,219 (+)NCBI
Rnor_6.04147,455,614 - 147,490,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763242   ⟹   XP_008761464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,275,472 - 150,310,822 (+)NCBI
mRatBN7.24148,602,861 - 148,638,219 (+)NCBI
Rnor_6.04147,455,506 - 147,490,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107638   ⟹   XP_038963566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,278,988 - 150,310,822 (+)NCBI
mRatBN7.24148,606,346 - 148,638,219 (+)NCBI
RefSeq Acc Id: XM_039107639   ⟹   XP_038963567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,278,991 - 150,310,822 (+)NCBI
mRatBN7.24148,606,356 - 148,638,219 (+)NCBI
RefSeq Acc Id: XM_063286090   ⟹   XP_063142160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,278,991 - 150,310,822 (+)NCBI
RefSeq Acc Id: XM_063286091   ⟹   XP_063142161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,275,389 - 150,301,865 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001014079   ⟸   NM_001014057
- UniProtKB: Q5M954 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761464   ⟸   XM_008763242
- Peptide Label: isoform X1
- UniProtKB: Q5M954 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761462   ⟸   XM_008763240
- Peptide Label: isoform X1
- UniProtKB: Q5M954 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073692   ⟸   ENSRNOT00000081957
RefSeq Acc Id: XP_038963566   ⟸   XM_039107638
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963567   ⟸   XM_039107639
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000079451   ⟸   ENSRNOT00000094843
RefSeq Acc Id: ENSRNOP00000086444   ⟸   ENSRNOT00000119184
RefSeq Acc Id: XP_063142161   ⟸   XM_063286091
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142160   ⟸   XM_063286090
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M954-F1-model_v2 AlphaFold Q5M954 1-463 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693322
Promoter ID:EPDNEW_R3847
Type:multiple initiation site
Name:Tsen2_1
Description:tRNA splicing endonuclease subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,455,505 - 147,455,565EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309946 AgrOrtholog
BioCyc Gene G2FUF-43321 BioCyc
Ensembl Genes ENSRNOG00000060175 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009167 UniProtKB/Swiss-Prot
  ENSRNOG00060025995 UniProtKB/Swiss-Prot
  ENSRNOG00065029073 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081957 ENTREZGENE
  ENSRNOT00000081957.2 UniProtKB/Swiss-Prot
  ENSRNOT00000094843.1 UniProtKB/TrEMBL
  ENSRNOT00000119184.1 UniProtKB/TrEMBL
  ENSRNOT00055015518 UniProtKB/Swiss-Prot
  ENSRNOT00060045077 UniProtKB/Swiss-Prot
  ENSRNOT00065050259 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1350.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319546 IMAGE-MGC_LOAD
InterPro tRNA_endonuc-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_intron_Endo_cat-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_intron_Endonuc_cat-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_intron_Endonuc_N UniProtKB/Swiss-Prot
  tRNA_splic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_splic_SEN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:312649 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105632 IMAGE-MGC_LOAD
NCBI Gene 312649 ENTREZGENE
PANTHER PTHR21227 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam tRNA_int_endo UniProtKB/Swiss-Prot
  tRNA_int_endo_N UniProtKB/Swiss-Prot
PhenoGen Tsen2 PhenoGen
PIRSF tRNA_splic_SEN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060175 RatGTEx
  ENSRNOG00055009167 RatGTEx
  ENSRNOG00060025995 RatGTEx
  ENSRNOG00065029073 RatGTEx
Superfamily-SCOP SSF53032 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A3T4_RAT UniProtKB/TrEMBL
  A0A8I6G3B7_RAT UniProtKB/TrEMBL
  A6IKY7_RAT UniProtKB/TrEMBL
  Q5M954 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Tsen2  tRNA splicing endonuclease subunit 2  Tsen2  TSEN2 tRNA splicing endonuclease subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-09-17 Tsen2  TSEN2 tRNA splicing endonuclease subunit  Tsen2  tRNA splicing endonuclease 2 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Tsen2  tRNA splicing endonuclease 2 homolog (S. cerevisiae)  Tsen2  tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Tsen2  tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae)  Tsen2  tRNA splicing endonuclease 2 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tsen2  tRNA splicing endonuclease 2 homolog (S. cerevisiae)  RGD1309946  similar to hypothetical protein MGC2776  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1309946  similar to hypothetical protein MGC2776  RGD1309946_predicted  similar to hypothetical protein MGC2776 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309946_predicted  similar to hypothetical protein MGC2776 (predicted)  LOC312649_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC312649_predicted  similar to hypothetical protein MGC2776 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL