Kmt2e (lysine methyltransferase 2E) - Rat Genome Database

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Gene: Kmt2e (lysine methyltransferase 2E) Rattus norvegicus
Analyze
Symbol: Kmt2e
Name: lysine methyltransferase 2E
RGD ID: 1309641
Description: Predicted to enable enzyme binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including erythrocyte differentiation; neutrophil activation; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nuclear body. Predicted to be part of Rpd3L-Expanded complex; Set3 complex; and euchromatin. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E (inactive)); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; inactive histone-lysine N-methyltransferase 2E; LOC311968; lysine (K)-specific methyltransferase 2E; Mll5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8412,550,570 - 12,655,329 (-)NCBIGRCr8
mRatBN7.2411,658,218 - 11,727,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl411,658,979 - 11,727,373 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx416,808,572 - 16,877,641 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0412,631,657 - 12,700,618 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,980,564 - 11,049,632 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.048,187,751 - 8,255,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl48,187,751 - 8,255,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.048,193,464 - 8,261,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.447,042,012 - 7,111,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.147,042,856 - 7,111,933 (-)NCBI
Celera47,269,290 - 7,338,691 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. Dong S, etal., Cell Rep. 2014 Oct 9;9(1):16-23. doi: 10.1016/j.celrep.2014.08.068. Epub 2014 Oct 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study. Lucena-Araujo AR, etal., Br J Haematol. 2014 Aug;166(4):540-9. doi: 10.1111/bjh.12921. Epub 2014 May 3.
5. Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Madan V, etal., Blood. 2009 Feb 12;113(7):1444-54. doi: 10.1182/blood-2008-02-142638. Epub 2008 Oct 24.
6. Targeted Silencing of MLL5beta Inhibits Tumor Growth and Promotes Gamma-Irradiation Sensitization in HPV16/18-Associated Cervical Cancers. Nin DS, etal., Mol Cancer Ther. 2014 Aug 29.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Altered expression of MLL methyltransferase family genes in breast cancer. Rabello Ddo A, etal., Int J Oncol. 2013 Aug;43(2):653-60. doi: 10.3892/ijo.2013.1981. Epub 2013 Jun 10.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand. Vieillard V, etal., Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10981-6. Epub 2005 Jul 26.
14. Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. Vieira FQ, etal., Endocr Relat Cancer. 2013 Dec 16;21(1):51-61. doi: 10.1530/ERC-13-0375. Print 2014 Feb.
Additional References at PubMed
PMID:12477932   PMID:18854576   PMID:23629655   PMID:23798402   PMID:24130829   PMID:26678539   PMID:27812132  


Genomics

Comparative Map Data
Kmt2e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8412,550,570 - 12,655,329 (-)NCBIGRCr8
mRatBN7.2411,658,218 - 11,727,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl411,658,979 - 11,727,373 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx416,808,572 - 16,877,641 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0412,631,657 - 12,700,618 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,980,564 - 11,049,632 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.048,187,751 - 8,255,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl48,187,751 - 8,255,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.048,193,464 - 8,261,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.447,042,012 - 7,111,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.147,042,856 - 7,111,933 (-)NCBI
Celera47,269,290 - 7,338,691 (-)NCBICelera
Cytogenetic Map4q11NCBI
KMT2E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387105,014,205 - 105,115,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7104,940,943 - 105,115,019 (+)EnsemblGRCh38hg38GRCh38
GRCh377104,654,652 - 104,755,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367104,441,873 - 104,541,768 (+)NCBINCBI36Build 36hg18NCBI36
Build 347104,248,587 - 104,348,759NCBI
Celera799,460,293 - 99,560,171 (+)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef799,014,817 - 99,114,834 (+)NCBIHuRef
CHM1_17104,587,944 - 104,687,855 (+)NCBICHM1_1
T2T-CHM13v2.07106,328,912 - 106,429,704 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27104,015,330 - 104,115,205 (+)NCBI
Kmt2e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39523,638,034 - 23,709,233 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl523,639,439 - 23,709,233 (+)EnsemblGRCm39 Ensembl
GRCm38523,433,036 - 23,504,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl523,434,441 - 23,504,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv37522,940,247 - 23,010,047 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36522,474,922 - 22,544,722 (+)NCBIMGSCv36mm8
Celera520,371,485 - 20,442,294 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.33NCBI
Kmt2e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554109,714,587 - 9,808,021 (+)NCBIChiLan1.0ChiLan1.0
KMT2E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26141,860,491 - 141,960,609 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17190,130,785 - 190,230,583 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0797,001,250 - 97,099,956 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17109,734,825 - 109,832,851 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7109,734,808 - 109,832,851 (+)Ensemblpanpan1.1panPan2
KMT2E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11815,240,631 - 15,332,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1815,239,994 - 15,332,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1814,884,734 - 14,977,530 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01815,541,852 - 15,634,905 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1815,542,495 - 15,634,849 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11815,323,554 - 15,416,396 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01815,247,117 - 15,339,914 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01815,526,846 - 15,619,856 (-)NCBIUU_Cfam_GSD_1.0
Kmt2e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511857,550,888 - 57,640,427 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647918,675,413 - 18,738,983 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647918,674,657 - 18,764,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT2E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9104,911,821 - 105,007,084 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19104,876,301 - 105,007,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29115,681,075 - 115,726,865 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KMT2E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12173,930,957 - 74,030,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2173,930,932 - 74,029,673 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604229,947,885 - 30,048,854 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt2e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473924,372,237 - 24,476,137 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473924,371,415 - 24,476,245 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kmt2e
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:68
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000068276
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

Markers in Region
D4Got254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,698,565 - 11,698,740 (+)MAPPERmRatBN7.2
Rnor_6.048,226,497 - 8,226,673NCBIRnor6.0
Rnor_5.048,232,210 - 8,232,386UniSTSRnor5.0
RGSC_v3.447,083,137 - 7,083,313UniSTSRGSC3.4
Celera47,309,923 - 7,310,099UniSTS
Cytogenetic Map4q11UniSTS
BI282943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,723,153 - 11,723,309 (+)MAPPERmRatBN7.2
Rnor_6.048,251,359 - 8,251,514NCBIRnor6.0
Rnor_5.048,257,072 - 8,257,227UniSTSRnor5.0
RGSC_v3.447,107,741 - 7,107,896UniSTSRGSC3.4
Celera47,334,472 - 7,334,627UniSTS
RH 3.4 Map414.0UniSTS
Cytogenetic Map4q11UniSTS
RH128390  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,658,304 - 11,658,524 (+)MAPPERmRatBN7.2
Rnor_6.048,188,245 - 8,188,464NCBIRnor6.0
Rnor_5.048,193,958 - 8,194,177UniSTSRnor5.0
RGSC_v3.447,042,183 - 7,042,402UniSTSRGSC3.4
Celera47,269,784 - 7,270,003UniSTS
RH 3.4 Map42.4UniSTS
Cytogenetic Map4q11UniSTS
RH139600  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,658,261 - 11,658,411 (+)MAPPERmRatBN7.2
Rnor_6.048,188,202 - 8,188,351NCBIRnor6.0
Rnor_5.048,193,915 - 8,194,064UniSTSRnor5.0
RGSC_v3.447,042,140 - 7,042,289UniSTSRGSC3.4
Celera47,269,741 - 7,269,890UniSTS
RH 3.4 Map42.4UniSTS
Cytogenetic Map4q11UniSTS
RH140458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,658,300 - 11,658,409 (+)MAPPERmRatBN7.2
Rnor_6.048,188,241 - 8,188,349NCBIRnor6.0
Rnor_5.048,193,954 - 8,194,062UniSTSRnor5.0
RGSC_v3.447,042,179 - 7,042,287UniSTSRGSC3.4
Celera47,269,780 - 7,269,888UniSTS
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 52 36 19 36 1 2 74 35 41 11 1
Low 6 5 5 5 7 9 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC091279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK367010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000068276   ⟹   ENSRNOP00000061252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,212,289 - 8,239,289 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl411,658,979 - 11,727,373 (-)Ensembl
Rnor_6.0 Ensembl48,188,153 - 8,212,576 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,188,153 - 8,212,576 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076583   ⟹   ENSRNOP00000068072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,217,556 - 8,255,379 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076633   ⟹   ENSRNOP00000068460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,217,556 - 8,255,514 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076642   ⟹   ENSRNOP00000068148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,212,203 - 8,214,555 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076950   ⟹   ENSRNOP00000068110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,217,556 - 8,255,379 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084050   ⟹   ENSRNOP00000069854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl411,658,979 - 11,688,000 (-)Ensembl
Rnor_6.0 Ensembl48,187,751 - 8,214,555 (-)Ensembl
RefSeq Acc Id: NM_001100851   ⟹   NP_001094321
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,619,721 (-)NCBI
mRatBN7.2411,658,218 - 11,727,373 (-)NCBI
Rnor_6.048,187,751 - 8,255,578 (-)NCBI
Rnor_5.048,193,464 - 8,261,291 (-)NCBI
Celera47,269,290 - 7,338,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285947   ⟹   XP_063142017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,655,329 (-)NCBI
RefSeq Acc Id: XM_063285948   ⟹   XP_063142018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,619,722 (-)NCBI
RefSeq Acc Id: XM_063285949   ⟹   XP_063142019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,619,781 (-)NCBI
RefSeq Acc Id: XM_063285950   ⟹   XP_063142020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,619,707 (-)NCBI
RefSeq Acc Id: XM_063285951   ⟹   XP_063142021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,619,748 (-)NCBI
RefSeq Acc Id: XM_063285952   ⟹   XP_063142022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,655,329 (-)NCBI
RefSeq Acc Id: XM_063285953   ⟹   XP_063142023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,655,329 (-)NCBI
RefSeq Acc Id: XM_063285954   ⟹   XP_063142024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,603,483 (-)NCBI
RefSeq Acc Id: XM_063285955   ⟹   XP_063142025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,550,570 - 12,563,079 (-)NCBI
RefSeq Acc Id: XR_010065633
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,554,938 - 12,655,329 (-)NCBI
RefSeq Acc Id: XR_010065634
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,554,949 - 12,655,329 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001094321   ⟸   NM_001100851
- UniProtKB: A0A8I6ASP1 (UniProtKB/TrEMBL),   A0A0G2JWF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061252   ⟸   ENSRNOT00000068276
RefSeq Acc Id: ENSRNOP00000068110   ⟸   ENSRNOT00000076950
RefSeq Acc Id: ENSRNOP00000069854   ⟸   ENSRNOT00000084050
RefSeq Acc Id: ENSRNOP00000068460   ⟸   ENSRNOT00000076633
RefSeq Acc Id: ENSRNOP00000068148   ⟸   ENSRNOT00000076642
RefSeq Acc Id: ENSRNOP00000068072   ⟸   ENSRNOT00000076583
RefSeq Acc Id: XP_063142023   ⟸   XM_063285953
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142022   ⟸   XM_063285952
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142017   ⟸   XM_063285947
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142019   ⟸   XM_063285949
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142021   ⟸   XM_063285951
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142018   ⟸   XM_063285948
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142020   ⟸   XM_063285950
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142024   ⟸   XM_063285954
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063142025   ⟸   XM_063285955
- Peptide Label: isoform X5
Protein Domains
PHD-type   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWF0-F1-model_v2 AlphaFold A0A0G2JWF0 1-1613 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692802
Promoter ID:EPDNEW_R3325
Type:initiation region
Name:Kmt2e_1
Description:lysine methyltransferase 2E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.048,255,543 - 8,255,603EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309641 AgrOrtholog
BioCyc Gene G2FUF-46009 BioCyc
Ensembl Genes ENSRNOG00000021614 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075902 ENTREZGENE
  ENSRNOT00000075902.3 UniProtKB/TrEMBL
  ENSRNOT00000084050.2 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7382007 IMAGE-MGC_LOAD
  IMAGE:9029914 IMAGE-MGC_LOAD
InterPro KMT2E_SET UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
MGC_CLONE MGC:109160 IMAGE-MGC_LOAD
  MGC:187390 IMAGE-MGC_LOAD
NCBI Gene 311968 ENTREZGENE
PANTHER PTHR46462:SF2 UniProtKB/TrEMBL
  UPSET, ISOFORM A UniProtKB/TrEMBL
Pfam PHD_5 UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Kmt2e PhenoGen
PROSITE SET UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021614 RatGTEx
SMART PHD UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP SSF57903 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A0G2JWF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASP1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kmt2e  lysine methyltransferase 2E  Kmt2e  lysine (K)-specific methyltransferase 2E  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-15 Kmt2e  lysine (K)-specific methyltransferase 2E  Mll5  myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mll5  myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)  Mll5_predicted  myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mll5_predicted  myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED