Ak7 (adenylate kinase 7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ak7 (adenylate kinase 7) Rattus norvegicus
Analyze
Symbol: Ak7
Name: adenylate kinase 7
RGD ID: 1309600
Description: Predicted to enable adenylate kinase activity; cytidylate kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation and phosphorylation. Predicted to act upstream of or within several processes, including axoneme assembly; epithelial cilium movement involved in extracellular fluid movement; and inflammatory response to antigenic stimulus. Human ortholog(s) of this gene implicated in spermatogenic failure 27. Orthologous to human AK7 (adenylate kinase 7); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314416; putative adenylate kinase 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,376,499 - 130,444,674 (+)NCBIGRCr8
mRatBN7.26124,611,789 - 124,679,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,734,223 - 124,803,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06125,029,490 - 125,098,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,389,700 - 124,457,780 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,538,648 - 129,606,960 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,538,982 - 129,606,932 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,732,026 - 138,805,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,861,499 - 129,933,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,865,370 - 129,939,804 (+)NCBI
Celera6122,178,930 - 122,246,130 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10215863   PMID:18776131   PMID:21080915   PMID:21746835   PMID:23416111  


Genomics

Comparative Map Data
Ak7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,376,499 - 130,444,674 (+)NCBIGRCr8
mRatBN7.26124,611,789 - 124,679,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,734,223 - 124,803,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06125,029,490 - 125,098,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,389,700 - 124,457,780 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,538,648 - 129,606,960 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,538,982 - 129,606,932 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,732,026 - 138,805,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,861,499 - 129,933,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,865,370 - 129,939,804 (+)NCBI
Celera6122,178,930 - 122,246,130 (+)NCBICelera
Cytogenetic Map6q32NCBI
AK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,392,128 - 96,489,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,392,128 - 96,489,427 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,858,465 - 96,955,764 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,928,201 - 96,024,865 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,928,200 - 96,024,866NCBI
Celera1476,914,175 - 77,010,845 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1477,043,535 - 77,140,413 (+)NCBIHuRef
CHM1_11496,797,289 - 96,894,524 (+)NCBICHM1_1
T2T-CHM13v2.01490,623,724 - 90,721,030 (+)NCBIT2T-CHM13v2.0
Ak7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,670,115 - 105,748,706 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,672,235 - 105,748,706 (+)EnsemblGRCm39 Ensembl
GRCm3812105,703,858 - 105,782,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,705,976 - 105,782,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,944,192 - 107,020,657 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612106,107,032 - 106,183,497 (+)NCBIMGSCv36mm8
Celera12106,940,507 - 107,017,130 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.95NCBI
Ak7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543818,178,822 - 18,233,051 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543818,178,822 - 18,233,051 (+)NCBIChiLan1.0ChiLan1.0
AK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,552,083 - 97,651,326 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,768,587 - 96,867,830 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01477,021,880 - 77,119,037 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,344,219 - 96,440,415 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,344,240 - 96,440,384 (+)Ensemblpanpan1.1panPan2
AK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1865,136,750 - 65,213,589 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl865,136,705 - 65,213,555 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,653,322 - 64,730,381 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0865,409,508 - 65,486,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,409,456 - 65,486,388 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1865,082,340 - 65,159,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0865,143,563 - 65,220,637 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,467,259 - 65,544,215 (+)NCBIUU_Cfam_GSD_1.0
Ak7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,339,422 - 9,402,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936604680,329 - 742,284 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936604680,237 - 742,580 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,609,840 - 117,667,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,609,791 - 117,667,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,867,883 - 124,925,586 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,275,451 - 74,376,032 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,275,637 - 74,377,562 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605361,426,946 - 61,526,079 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247346,942,374 - 7,001,212 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247346,942,786 - 7,000,453 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ak7
452 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:107
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000050752
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 5
Low 3 6 34 28 2 28 56 11 25 6
Below cutoff 15 22 13 16 13 5 7 18 24 6 5

Sequence


RefSeq Acc Id: ENSRNOT00000082522   ⟹   ENSRNOP00000073263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)Ensembl
Rnor_6.0 Ensembl6129,539,075 - 129,606,930 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083626   ⟹   ENSRNOP00000070935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)Ensembl
Rnor_6.0 Ensembl6129,538,982 - 129,606,932 (+)Ensembl
RefSeq Acc Id: NM_001108055   ⟹   NP_001101525
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,604 - 130,444,666 (+)NCBI
mRatBN7.26124,611,902 - 124,679,970 (+)NCBI
Rnor_6.06129,539,075 - 129,606,939 (+)NCBI
Rnor_5.06138,732,026 - 138,805,327 (+)NCBI
RGSC_v3.46129,861,499 - 129,933,903 (+)RGD
Celera6122,178,930 - 122,246,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594182   ⟹   XP_017449671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,499 - 130,444,674 (+)NCBI
mRatBN7.26124,611,795 - 124,679,978 (+)NCBI
Rnor_6.06129,538,649 - 129,606,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063262001   ⟹   XP_063118071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,502 - 130,444,674 (+)NCBI
RefSeq Acc Id: XM_063262002   ⟹   XP_063118072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,502 - 130,444,674 (+)NCBI
RefSeq Acc Id: XM_063262003   ⟹   XP_063118073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,503 - 130,444,674 (+)NCBI
RefSeq Acc Id: NP_001101525   ⟸   NM_001108055
- UniProtKB: A0A0G2K524 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449671   ⟸   XM_017594182
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K524 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073263   ⟸   ENSRNOT00000082522
RefSeq Acc Id: ENSRNOP00000070935   ⟸   ENSRNOT00000083626
RefSeq Acc Id: XP_063118071   ⟸   XM_063262001
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118072   ⟸   XM_063262002
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118073   ⟸   XM_063262003
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ71-F1-model_v2 AlphaFold A0A0G2JZ71 1-724 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309600 AgrOrtholog
BioCyc Gene G2FUF-36329 BioCyc
BioCyc Pathway PWY-7219 [adenosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7219 BioCyc
Ensembl Genes ENSRNOG00000055714 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082522 ENTREZGENE
  ENSRNOT00000082522.2 UniProtKB/TrEMBL
  ENSRNOT00000083626.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Adenylate_kin UniProtKB/TrEMBL
  DD_AK7 UniProtKB/TrEMBL
  Dpy-30_motif UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:314416 UniProtKB/TrEMBL
NCBI Gene 314416 ENTREZGENE
PANTHER Adenylate_kin UniProtKB/TrEMBL
  PTHR23359:SF105 UniProtKB/TrEMBL
Pfam ADK UniProtKB/TrEMBL
  Dpy-30 UniProtKB/TrEMBL
PhenoGen Ak7 PhenoGen
RatGTEx ENSRNOG00000055714 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JZ71_RAT UniProtKB/TrEMBL
  A0A0G2K524 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ak7  adenylate kinase 7   Ak7_predicted  adenylate kinase 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ak7_predicted  adenylate kinase 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED