Opa3 (outer mitochondrial membrane lipid metabolism regulator OPA3) - Rat Genome Database

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Gene: Opa3 (outer mitochondrial membrane lipid metabolism regulator OPA3) Rattus norvegicus
Analyze
Symbol: Opa3
Name: outer mitochondrial membrane lipid metabolism regulator OPA3
RGD ID: 1309147
Description: Predicted to be involved in visual perception. Predicted to act upstream of or within several processes, including bone development; fat cell differentiation; and neuromuscular process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308409; NEWGENE_1309147; OPA3, outer mitochondrial membrane lipid metabolism regulator; optic atrophy 3; optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); optic atrophy 3 (human); optic atrophy 3 protein; optic atrophy 3 protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Opa3-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,007,707 - 88,037,639 (+)NCBIGRCr8
mRatBN7.2178,879,612 - 78,910,453 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,880,862 - 78,913,056 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl178,880,114 - 78,901,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,270,502 - 84,289,703 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,828,026 - 92,847,264 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,025,584 - 86,044,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,141,630 - 80,160,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,141,630 - 80,160,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,408,113 - 81,426,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,592,874 - 78,611,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,670,662 - 78,687,666 (+)NCBI
Celera173,343,904 - 73,362,059 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:15342707   PMID:18222992   PMID:18614015   PMID:21613372   PMID:22869679  


Genomics

Comparative Map Data
Opa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,007,707 - 88,037,639 (+)NCBIGRCr8
mRatBN7.2178,879,612 - 78,910,453 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,880,862 - 78,913,056 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl178,880,114 - 78,901,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,270,502 - 84,289,703 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,828,026 - 92,847,264 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,025,584 - 86,044,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,141,630 - 80,160,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,141,630 - 80,160,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,408,113 - 81,426,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,592,874 - 78,611,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,670,662 - 78,687,666 (+)NCBI
Celera173,343,904 - 73,362,059 (+)NCBICelera
Cytogenetic Map1q21NCBI
OPA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,527,427 - 45,584,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,527,767 - 45,602,212 (-)EnsemblGRCh38hg38GRCh38
GRCh371946,030,685 - 46,088,060 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,722,865 - 50,779,962 (-)NCBINCBI36Build 36hg18NCBI36
Build 341950,747,641 - 50,779,917NCBI
Celera1942,837,136 - 42,894,236 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,460,247 - 42,517,324 (-)NCBIHuRef
CHM1_11946,034,268 - 46,091,400 (-)NCBICHM1_1
T2T-CHM13v2.01948,354,701 - 48,412,074 (-)NCBIT2T-CHM13v2.0
Opa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,962,314 - 18,980,742 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,962,259 - 18,990,468 (+)EnsemblGRCm39 Ensembl
GRCm38719,228,389 - 19,246,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,228,334 - 19,256,543 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,813,738 - 19,832,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,386,905 - 18,405,158 (+)NCBIMGSCv36mm8
Celera716,641,243 - 16,659,819 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.48NCBI
Opa3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495557460,652 - 82,343 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495557460,652 - 82,343 (-)NCBIChiLan1.0ChiLan1.0
OPA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,689,574 - 51,750,652 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,560,990 - 53,622,129 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,477,467 - 42,546,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,073,322 - 51,130,555 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,073,322 - 51,130,555 (-)Ensemblpanpan1.1panPan2
Opa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,598,813 - 17,647,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,964,237 - 1,995,175 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,961,571 - 1,996,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,917,379 - 51,964,488 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,917,956 - 51,967,624 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
OPA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,974,455 - 39,032,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,001,467 - 39,032,347 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,595,898 - 18,655,810 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,580,823 - 7,605,443 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248327,580,402 - 7,619,122 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Opa3
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:170
Interacting mature miRNAs:207
Transcripts:ENSRNOT00000029552
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat

Markers in Region
D4Mit141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,898,725 - 78,898,843 (+)MAPPERmRatBN7.2
Rnor_6.0180,159,322 - 80,159,439NCBIRnor6.0
Rnor_5.0181,425,805 - 81,425,922UniSTSRnor5.0
RGSC_v3.4178,610,206 - 78,610,323UniSTSRGSC3.4
Celera173,361,236 - 73,361,353UniSTS
Cytogenetic Map1q21UniSTS
BE102432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,890,314 - 78,890,464 (+)MAPPERmRatBN7.2
Rnor_6.0180,150,553 - 80,150,702NCBIRnor6.0
Rnor_5.0181,417,036 - 81,417,185UniSTSRnor5.0
RGSC_v3.4178,601,797 - 78,601,946UniSTSRGSC3.4
Celera173,352,827 - 73,352,976UniSTS
RH 3.4 Map1768.6UniSTS
Cytogenetic Map1q21UniSTS
RH134672  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,900,206 - 78,900,413 (+)MAPPERmRatBN7.2
Rnor_6.0180,160,803 - 80,161,009NCBIRnor6.0
Rnor_5.0181,427,286 - 81,427,492UniSTSRnor5.0
RGSC_v3.4178,611,687 - 78,611,893UniSTSRGSC3.4
Celera173,362,717 - 73,362,923UniSTS
RH 3.4 Map1768.5UniSTS
Cytogenetic Map1q21UniSTS
RH135203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,899,322 - 78,899,511 (+)MAPPERmRatBN7.2
Rnor_6.0180,159,919 - 80,160,107NCBIRnor6.0
Rnor_5.0181,426,402 - 81,426,590UniSTSRnor5.0
RGSC_v3.4178,610,803 - 78,610,991UniSTSRGSC3.4
Celera173,361,833 - 73,362,021UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 31 22 11 22 8 11 74 35 31 11 8
Low 26 19 8 19 10
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029552   ⟹   ENSRNOP00000030360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,880,114 - 78,901,469 (+)Ensembl
Rnor_6.0 Ensembl180,141,630 - 80,160,145 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096607   ⟹   ENSRNOP00000095404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,880,862 - 78,913,056 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099247   ⟹   ENSRNOP00000097116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,881,437 - 78,910,175 (+)Ensembl
RefSeq Acc Id: NM_001399653   ⟹   NP_001386582
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,009,412 - 88,028,659 (+)NCBI
mRatBN7.2178,881,392 - 78,900,641 (+)NCBI
RefSeq Acc Id: XM_017589999   ⟹   XP_017445488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,007,707 - 88,037,639 (+)NCBI
mRatBN7.2178,879,612 - 78,910,453 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386582 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445488 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68945 (Get FASTA)   NCBI Sequence Viewer  
  EDM08221 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030360.5
  ENSRNOP00000095404.1
  ENSRNOP00000097116
  ENSRNOP00000097116.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000030360   ⟸   ENSRNOT00000029552
RefSeq Acc Id: XP_017445488   ⟸   XM_017589999
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQX4 (UniProtKB/TrEMBL),   A0A8I6AQB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001386582   ⟸   NM_001399653
RefSeq Acc Id: ENSRNOP00000097116   ⟸   ENSRNOT00000099247
RefSeq Acc Id: ENSRNOP00000095404   ⟸   ENSRNOT00000096607

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF67-F1-model_v2 AlphaFold B5DF67 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689764
Promoter ID:EPDNEW_R289
Type:multiple initiation site
Name:Opa3_1
Description:OPA3, outer mitochondrial membrane lipid metabolism regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,141,653 - 80,141,713EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309147 AgrOrtholog
BioCyc Gene G2FUF-60520 BioCyc
Ensembl Genes ENSRNOG00000025890 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000064373 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029552.7 UniProtKB/TrEMBL
  ENSRNOT00000096607.1 UniProtKB/TrEMBL
  ENSRNOT00000099247.1 UniProtKB/TrEMBL
InterPro OPA3-like UniProtKB/TrEMBL
KEGG Report rno:308409 UniProtKB/TrEMBL
NCBI Gene 308409 ENTREZGENE
PANTHER OPTIC ATROPHY 3 PROTEIN UniProtKB/TrEMBL
  PTHR12499 UniProtKB/TrEMBL
Pfam OPA3 UniProtKB/TrEMBL
PhenoGen Opa3 PhenoGen
RatGTEx ENSRNOG00000025890 RatGTEx
  ENSRNOG00000064373 RatGTEx
UniProt A0A8I6AQB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQX4 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y7T5_RAT UniProtKB/TrEMBL
  B5DF67_RAT UniProtKB/TrEMBL
UniProt Secondary D4A4M6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Opa3  outer mitochondrial membrane lipid metabolism regulator OPA3  NEWGENE_1309147  optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)  Data merged from RGD:149736447 737654 PROVISIONAL
2021-08-09 NEWGENE_1309147  optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)      Symbol and Name status set to provisional 45752 PROVISIONAL
2020-08-13 Opa3  outer mitochondrial membrane lipid metabolism regulator OPA3  Opa3  OPA3, outer mitochondrial membrane lipid metabolism regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-09-06 Opa3  OPA3, outer mitochondrial membrane lipid metabolism regulator  Opa3  optic atrophy 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Opa3  optic atrophy 3  Opa3  optic atrophy 3 (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-27 Opa3  optic atrophy 3 (human)  Opa3  optic atrophy 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Opa3  optic atrophy 3   Opa3_predicted  optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Opa3_predicted  optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) (predicted)      Symbol and Name status set to approved 70820 APPROVED