Nsd3 (nuclear receptor binding SET domain protein 3) - Rat Genome Database

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Gene: Nsd3 (nuclear receptor binding SET domain protein 3) Rattus norvegicus
Analyze
Symbol: Nsd3
Name: nuclear receptor binding SET domain protein 3
RGD ID: 1308980
Description: Predicted to enable histone H3 methyltransferase activity and transcription regulator activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-lysine N-methyltransferase NSD3; LOC290831; Whsc1l1; Wolf-Hirschhorn syndrome candidate 1-like 1; Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,056,748 - 73,170,082 (-)NCBIGRCr8
mRatBN7.21666,354,030 - 66,466,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,358,973 - 66,465,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,637,714 - 71,744,185 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,044,021 - 75,150,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,283,886 - 70,390,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,126,276 - 71,237,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,130,668 - 71,237,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,786,828 - 70,897,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,733,902 - 70,839,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,734,444 - 70,806,495 (-)NCBI
Celera1664,268,667 - 64,374,056 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Rosati R, etal., Blood. 2002 May 15;99(10):3857-60.
Additional References at PubMed
PMID:12477932   PMID:16682010   PMID:21555454  


Genomics

Comparative Map Data
Nsd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,056,748 - 73,170,082 (-)NCBIGRCr8
mRatBN7.21666,354,030 - 66,466,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,358,973 - 66,465,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,637,714 - 71,744,185 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,044,021 - 75,150,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,283,886 - 70,390,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,126,276 - 71,237,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,130,668 - 71,237,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,786,828 - 70,897,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,733,902 - 70,839,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,734,444 - 70,806,495 (-)NCBI
Celera1664,268,667 - 64,374,056 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
NSD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,269,704 - 38,382,271 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,269,704 - 38,382,272 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,127,222 - 38,239,789 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,251,717 - 38,358,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 34838,251,716 - 38,358,947NCBI
Celera837,085,612 - 37,192,859 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,666,622 - 36,774,003 (-)NCBIHuRef
CHM1_1838,334,565 - 38,441,681 (-)NCBICHM1_1
T2T-CHM13v2.0838,546,659 - 38,659,240 (-)NCBIT2T-CHM13v2.0
Nsd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,091,617 - 26,209,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,091,617 - 26,209,694 (+)EnsemblGRCm39 Ensembl
GRCm38825,601,601 - 25,719,667 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,601,601 - 25,719,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,712,778 - 26,830,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,067,146 - 27,185,212 (+)NCBIMGSCv36mm8
Celera827,070,741 - 27,187,953 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Nsd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,869,610 - 13,946,830 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,864,294 - 13,985,995 (-)NCBIChiLan1.0ChiLan1.0
NSD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,833,190 - 56,946,563 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,550,256 - 32,662,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,571,831 - 37,684,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,748,409 - 34,860,766 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,754,353 - 34,860,766 (-)Ensemblpanpan1.1panPan2
NSD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,106,348 - 27,225,049 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,151,222 - 27,219,907 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,619,192 - 27,742,909 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,000,367 - 29,124,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,004,852 - 29,120,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,223,565 - 27,347,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,800,625 - 27,924,334 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,839,601 - 27,963,573 (+)NCBIUU_Cfam_GSD_1.0
Nsd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,728,386 - 49,835,860 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,631,234 - 1,732,827 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,629,178 - 1,732,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,136,363 - 48,241,815 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,119,132 - 48,245,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,298,067 - 55,405,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,288,997 - 36,398,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,291,104 - 36,398,246 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,590,913 - 5,700,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,241,537 - 5,363,325 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,241,556 - 5,367,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nsd3
261 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:186
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000066974
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH133969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,462,655 - 66,462,861 (+)MAPPERmRatBN7.2
Rnor_6.01671,234,352 - 71,234,557NCBIRnor6.0
Rnor_5.01670,894,885 - 70,895,090UniSTSRnor5.0
RGSC_v3.41670,837,036 - 70,837,241UniSTSRGSC3.4
Celera1664,371,290 - 64,371,495UniSTS
RH 3.4 Map16622.6UniSTS
Cytogenetic Map16q12.4UniSTS
BF396304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,406,353 - 66,406,525 (+)MAPPERmRatBN7.2
Rnor_6.01671,178,062 - 71,178,233NCBIRnor6.0
Rnor_5.01670,838,584 - 70,838,755UniSTSRnor5.0
RGSC_v3.41670,780,812 - 70,780,983UniSTSRGSC3.4
Celera1664,316,090 - 64,316,261UniSTS
RH 3.4 Map16631.2UniSTS
Cytogenetic Map16q12.4UniSTS
BM391134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,404,274 - 66,404,454 (+)MAPPERmRatBN7.2
Rnor_6.01671,175,983 - 71,176,162NCBIRnor6.0
Rnor_5.01670,836,505 - 70,836,684UniSTSRnor5.0
RGSC_v3.41670,778,733 - 70,778,912UniSTSRGSC3.4
Celera1664,314,011 - 64,314,190UniSTS
RH 3.4 Map16623.2UniSTS
Cytogenetic Map16q12.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 39 23 19 23 1 1 74 35 38 11 1
Low 16 18 18 18 7 10 3 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC100146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000066974   ⟹   ENSRNOP00000060879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,358,973 - 66,465,423 (-)Ensembl
Rnor_6.0 Ensembl1671,130,668 - 71,237,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088458   ⟹   ENSRNOP00000071250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,358,973 - 66,431,788 (-)Ensembl
Rnor_6.0 Ensembl1671,130,748 - 71,203,609 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097772   ⟹   ENSRNOP00000078775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,358,973 - 66,432,710 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111004   ⟹   ENSRNOP00000078885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,358,973 - 66,464,797 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119483   ⟹   ENSRNOP00000076954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,392,448 - 66,431,788 (-)Ensembl
RefSeq Acc Id: NM_001106090   ⟹   NP_001099560
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,061,694 - 73,168,130 (-)NCBI
mRatBN7.21666,358,973 - 66,465,423 (-)NCBI
Rnor_6.01671,130,668 - 71,237,118 (-)NCBI
Rnor_5.01670,786,828 - 70,897,651 (-)NCBI
RGSC_v3.41670,733,902 - 70,839,802 (-)RGD
Celera1664,268,667 - 64,374,056 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253307   ⟹   XP_006253369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
mRatBN7.21666,354,030 - 66,464,377 (-)NCBI
Rnor_6.01671,126,276 - 71,236,413 (-)NCBI
Rnor_5.01670,786,828 - 70,897,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253309   ⟹   XP_006253371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
mRatBN7.21666,354,030 - 66,464,377 (-)NCBI
Rnor_6.01671,126,276 - 71,236,413 (-)NCBI
Rnor_5.01670,786,828 - 70,897,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253311   ⟹   XP_006253373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
mRatBN7.21666,354,030 - 66,464,377 (-)NCBI
Rnor_6.01671,126,276 - 71,236,412 (-)NCBI
Rnor_5.01670,786,828 - 70,897,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771350   ⟹   XP_008769572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,094,782 - 73,167,115 (-)NCBI
mRatBN7.21666,392,066 - 66,431,796 (-)NCBI
Rnor_6.01671,163,783 - 71,236,410 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094396   ⟹   XP_038950324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
mRatBN7.21666,354,030 - 66,464,377 (-)NCBI
RefSeq Acc Id: XM_039094399   ⟹   XP_038950327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,170,082 (-)NCBI
mRatBN7.21666,354,030 - 66,466,202 (-)NCBI
RefSeq Acc Id: XM_039094400   ⟹   XP_038950328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,162,748 (-)NCBI
mRatBN7.21666,354,030 - 66,449,691 (-)NCBI
RefSeq Acc Id: XM_039094401   ⟹   XP_038950329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
mRatBN7.21666,354,030 - 66,464,377 (-)NCBI
RefSeq Acc Id: XM_039094402   ⟹   XP_038950330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
mRatBN7.21666,354,030 - 66,464,377 (-)NCBI
RefSeq Acc Id: XM_063275244   ⟹   XP_063131314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,111 (-)NCBI
RefSeq Acc Id: XM_063275245   ⟹   XP_063131315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
RefSeq Acc Id: XM_063275246   ⟹   XP_063131316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,167,115 (-)NCBI
RefSeq Acc Id: XM_063275247   ⟹   XP_063131317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,056,748 - 73,123,907 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001099560   ⟸   NM_001106090
- UniProtKB: D3ZK47 (UniProtKB/TrEMBL),   A6IW11 (UniProtKB/TrEMBL),   A0A8I5ZLN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253373   ⟸   XM_006253311
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZLN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253371   ⟸   XM_006253309
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZLN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253369   ⟸   XM_006253307
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K001 (UniProtKB/TrEMBL),   A0A8I5ZLN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769572   ⟸   XM_008771350
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZK70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060879   ⟸   ENSRNOT00000066974
RefSeq Acc Id: ENSRNOP00000071250   ⟸   ENSRNOT00000088458
RefSeq Acc Id: XP_038950327   ⟸   XM_039094399
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950330   ⟸   XM_039094402
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZLN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950329   ⟸   XM_039094401
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950324   ⟸   XM_039094396
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950328   ⟸   XM_039094400
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000076954   ⟸   ENSRNOT00000119483
RefSeq Acc Id: ENSRNOP00000078775   ⟸   ENSRNOT00000097772
RefSeq Acc Id: ENSRNOP00000078885   ⟸   ENSRNOT00000111004
RefSeq Acc Id: XP_063131316   ⟸   XM_063275246
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063131315   ⟸   XM_063275245
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063131314   ⟸   XM_063275244
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131317   ⟸   XM_063275247
- Peptide Label: isoform X9
Protein Domains
AWS   PHD-type   Post-SET   PWWP   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K001-F1-model_v2 AlphaFold A0A0G2K001 1-1443 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308980 AgrOrtholog
BioCyc Gene G2FUF-10969 BioCyc
Ensembl Genes ENSRNOG00000015621 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066974 ENTREZGENE
  ENSRNOT00000066974.3 UniProtKB/TrEMBL
  ENSRNOT00000088458.2 UniProtKB/TrEMBL
  ENSRNOT00000097772.1 UniProtKB/TrEMBL
  ENSRNOT00000111004.1 UniProtKB/TrEMBL
  ENSRNOT00000119483.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  PHD2_NSD3 UniProtKB/TrEMBL
  PHD4_NSD3 UniProtKB/TrEMBL
  PHD5_NSD3 UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  PWWP_NSD3_rpt1 UniProtKB/TrEMBL
  PWWP_NSD3_rpt2 UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SET_NSD3 UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:290831 UniProtKB/TrEMBL
NCBI Gene 290831 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE NSD3 UniProtKB/TrEMBL
  SET DOMAIN PROTEINS UniProtKB/TrEMBL
Pfam AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Nsd3 PhenoGen
PROSITE AWS UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015621 RatGTEx
SMART AWS UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A0G2K001 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZK70 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPM8_RAT UniProtKB/TrEMBL
  A6IW11 ENTREZGENE, UniProtKB/TrEMBL
  D3ZK47 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-29 Nsd3  nuclear receptor binding SET domain protein 3  Whsc1l1  Wolf-Hirschhorn syndrome candidate 1-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-04 Whsc1l1  Wolf-Hirschhorn syndrome candidate 1-like 1  Whsc1l1  Wolf-Hirschhorn syndrome candidate 1-like 1 (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Whsc1l1  Wolf-Hirschhorn syndrome candidate 1-like 1 (human)  Whsc1l1_predicted  Wolf-Hirschhorn syndrome candidate 1-like 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Whsc1l1_predicted  Wolf-Hirschhorn syndrome candidate 1-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED