Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | Cpne4 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of CPNE4 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | affects expression | ISO | Cpne4 (Mus musculus) | 6480464 | ethylene dichloride affects the expression of CPNE4 mRNA | CTD | PMID:28960355 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:21394737 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cpne4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CPNE4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CPNE4 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | decreases methylation | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased methylation of CPNE4 gene | CTD | PMID:26431795 | 4,4'-sulfonyldiphenol | increases methylation | ISO | Cpne4 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of CPNE4 exon | CTD | PMID:33297965 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of CPNE4 mRNA | CTD | PMID:24780913 and PMID:25825206 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of CPNE4 mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases methylation | ISO | CPNE4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of CPNE4 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of CPNE4 mRNA | CTD | PMID:32234424 | all-trans-retinoic acid | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CPNE4 mRNA | CTD | PMID:21934132 and PMID:23724009 | amitriptyline | decreases expression | EXP | | 6480464 | Amitriptyline results in decreased expression of CPNE4 mRNA | CTD | PMID:22341215 | arsane | affects methylation | ISO | CPNE4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of CPNE4 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | CPNE4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of CPNE4 gene | CTD | PMID:25304211 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of CPNE4 gene | CTD | PMID:35440735 | belinostat | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | belinostat results in increased expression of CPNE4 mRNA | CTD | PMID:26272509 | belinostat | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA | CTD | PMID:27188386 | benzo[a]pyrene | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of CPNE4 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | increases methylation | ISO | CPNE4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CPNE4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | CPNE4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CPNE4 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Cpne4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA | CTD | PMID:27858113 | benzo[b]fluoranthene | multiple interactions | ISO | Cpne4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA | CTD | PMID:27858113 | bisphenol A | decreases expression | ISO | Cpne4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of CPNE4 mRNA | CTD | PMID:26063408 and PMID:32156529 | bisphenol A | increases methylation | ISO | CPNE4 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of CPNE4 gene | CTD | PMID:31601247 | bisphenol A | increases methylation | ISO | Cpne4 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of CPNE4 promoter | CTD | PMID:27312807 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CPNE4 mRNA | CTD | PMID:25181051 more ... | cadmium atom | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CPNE4 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CPNE4 mRNA | CTD | PMID:35301059 | CGP 52608 | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CPNE4 gene] | CTD | PMID:28238834 | chrysene | multiple interactions | ISO | Cpne4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA | CTD | PMID:27858113 | cisplatin | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CPNE4 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of CPNE4 mRNA | CTD | PMID:27392435 | clothianidin | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | clothianidin results in increased expression of CPNE4 mRNA | CTD | PMID:31626844 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of CPNE4 mRNA | CTD | PMID:26577399 | cyclosporin A | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CPNE4 mRNA | CTD | PMID:20106945 | dorsomorphin | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA | CTD | PMID:27188386 | entinostat | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | entinostat results in increased expression of CPNE4 mRNA | CTD | PMID:26272509 | ethanol | affects splicing | ISO | Cpne4 (Mus musculus) | 6480464 | Ethanol affects the splicing of CPNE4 mRNA | CTD | PMID:30319688 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of CPNE4 mRNA | CTD | PMID:23962444 | folic acid | decreases expression | ISO | Cpne4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of CPNE4 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of CPNE4 mRNA | CTD | PMID:23649840 | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of CPNE4 gene | CTD | PMID:35440735 | maneb | multiple interactions | ISO | Cpne4 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of CPNE4 mRNA | CTD | PMID:36117858 | methapyrilene | increases methylation | EXP | | 6480464 | Methapyrilene results in increased methylation of CPNE4 gene | CTD | PMID:26431795 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of CPNE4 gene | CTD | PMID:35440735 | methyl methanesulfonate | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of CPNE4 mRNA | CTD | PMID:23649840 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of CPNE4 gene | CTD | PMID:33148267 | nickel atom | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Nickel results in decreased expression of CPNE4 mRNA | CTD | PMID:25583101 | O-methyleugenol | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of CPNE4 mRNA | CTD | PMID:32234424 | ochratoxin A | decreases methylation | EXP | | 6480464 | ochratoxin A results in decreased methylation of CPNE4 gene | CTD | PMID:26431795 | ozone | multiple interactions | ISO | Cpne4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of CPNE4 mRNA | CTD | PMID:27106289 | panobinostat | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | panobinostat results in increased expression of CPNE4 mRNA | CTD | PMID:26272509 | panobinostat | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA | CTD | PMID:27188386 | paracetamol | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of CPNE4 mRNA | CTD | PMID:29067470 | paraquat | multiple interactions | ISO | Cpne4 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of CPNE4 mRNA | CTD | PMID:36117858 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of CPNE4 gene | CTD | PMID:33148267 | pirinixic acid | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CPNE4 mRNA | CTD | PMID:19710929 | SB 431542 | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of CPNE4 mRNA | CTD | PMID:25895662 | sodium fluoride | decreases expression | ISO | Cpne4 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of CPNE4 mRNA | CTD | PMID:27862939 | sunitinib | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of CPNE4 mRNA | CTD | PMID:31533062 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CPNE4 mRNA | CTD | PMID:30723492 and PMID:31150632 | tetraphene | multiple interactions | ISO | Cpne4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA | CTD | PMID:27858113 | tributylstannane | decreases expression | EXP | | 6480464 | tributyltin results in decreased expression of CPNE4 mRNA | CTD | PMID:31129395 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of CPNE4 mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of CPNE4 mRNA | CTD | PMID:24935251 | triclosan | decreases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of CPNE4 mRNA | CTD | PMID:30510588 | valproic acid | affects expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CPNE4 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | CPNE4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CPNE4 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | CPNE4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA | CTD | PMID:27188386 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of CPNE4 gene | CTD | PMID:31079544 and PMID:31682807 | |