Rab11fip2 (RAB11 family interacting protein 2)

Gene: Rab11fip2 (RAB11 family interacting protein 2) Rattus norvegicus

Analyze

Symbol:

Rab11fip2

Name:

RAB11 family interacting protein 2

RGD ID:

1308538

Description:

Predicted to enable protein homodimerization activity and protein kinase binding activity. Involved in positive regulation of protein localization to plasma membrane. Predicted to be located in nucleoplasm. Predicted to be active in endosome and phagocytic cup. Orthologous to human RAB11FIP2 (RAB11 family interacting protein 2); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC108349712; LOC308003; RAB11 family interacting protein 2 (class I); rab11 family-interacting protein 2; rab11-family interacting protein 2; Rab11-FIP2; RGD1308538; similar to KIAA0941 protein; uncharacterized LOC108349712

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAB11FIP2 (RAB11 family interacting protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rab11fip2 (RAB11 family interacting protein 2 (class I))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rab11fip2 (RAB11 family interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAB11FIP2 (RAB11 family interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAB11FIP2 (RAB11 family interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rab11fip2 (RAB11 family interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAB11FIP2 (RAB11 family interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAB11FIP2 (RAB11 family interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rab11fip2 (RAB11 family interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CCNG1 (cyclin G1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RAB11FIP2 (RAB11 family interacting protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rab11fip2 (RAB11 family interacting protein 2 (class I))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y39F10B.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Rip11	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rab11fip2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	268,908,825 - 269,080,691 (-)	NCBI		GRCr8
mRatBN7.2	1	258,950,535 - 259,094,555 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	258,923,873 - 259,093,752 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	267,264,170 - 267,299,888 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	273,970,206 - 274,005,924 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	266,616,423 - 266,652,133 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	281,065,346 - 281,101,163 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	281,065,168 - 281,101,438 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	288,422,015 - 288,457,832 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	266,461,752 - 266,497,576 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	266,672,789 - 266,713,588 (-)	NCBI
Celera	1	254,705,763 - 254,741,674 (-)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

lead diacetate (ISO)

lead(0) (ISO)

methimazole (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

toluene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of cell polarity (ISO)

insulin secretion involved in cellular response to glucose stimulus (ISO)

phagocytosis (ISO)

positive regulation of protein localization to plasma membrane (IMP)

regulated exocytosis (IBA,ISO)

TRAM-dependent toll-like receptor 4 signaling pathway (ISO)

Cellular Component

endosome (IBA,ISO)

intracellular membrane-bounded organelle (ISO)

nucleoplasm (IEA,ISO)

phagocytic cup (IBA,ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

protein kinase binding (ISO)

small GTPase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

vasopressin signaling pathway (ISO)

vasopressin signaling pathway via receptor type 2 (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.	Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
2.	Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface.	Chu BB, etal., J Biol Chem. 2009 Aug 14;284(33):22481-90. doi: 10.1074/jbc.M109.034355. Epub 2009 Jun 19.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.	Nedvetsky PI, etal., Traffic. 2007 Feb;8(2):110-23. Epub 2006 Dec 6.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:16775013	PMID:16905101	PMID:17728463	PMID:19335615	PMID:20534835	PMID:23554492	PMID:25931508	PMID:30883606	PMID:31757887

Genomics

Comparative Map Data

Rab11fip2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	268,908,825 - 269,080,691 (-)	NCBI		GRCr8
mRatBN7.2	1	258,950,535 - 259,094,555 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	258,923,873 - 259,093,752 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	267,264,170 - 267,299,888 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	273,970,206 - 274,005,924 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	266,616,423 - 266,652,133 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	281,065,346 - 281,101,163 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	281,065,168 - 281,101,438 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	288,422,015 - 288,457,832 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	266,461,752 - 266,497,576 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	266,672,789 - 266,713,588 (-)	NCBI
Celera	1	254,705,763 - 254,741,674 (-)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

RAB11FIP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	118,004,916 - 118,046,941 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	118,004,916 - 118,046,941 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	119,764,427 - 119,806,452 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	119,754,419 - 119,796,104 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	119,754,418 - 119,796,104	NCBI
Celera	10	113,494,224 - 113,535,915 (-)	NCBI		Celera
Cytogenetic Map	10	q26.11	NCBI
HuRef	10	113,392,863 - 113,434,552 (-)	NCBI		HuRef
CHM1_1	10	120,048,435 - 120,090,122 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	118,898,958 - 118,940,990 (-)	NCBI		T2T-CHM13v2.0

Rab11fip2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	59,881,934 - 59,933,086 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	59,891,316 - 59,932,086 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	59,893,502 - 59,943,656 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	59,902,884 - 59,943,654 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	59,978,787 - 60,019,557 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	59,958,359 - 59,998,027 (-)	NCBI		MGSCv36	mm8
Celera	19	62,094,408 - 62,135,218 (-)	NCBI		Celera
Cytogenetic Map	19	D3	NCBI
cM Map	19	56.28	NCBI

Rab11fip2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	22,634,103 - 22,674,107 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	22,637,605 - 22,674,107 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAB11FIP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	129,865,455 - 129,907,443 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	129,870,793 - 129,912,003 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	114,577,851 - 114,619,808 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	118,003,025 - 118,044,607 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	117,970,693 - 118,044,607 (-)	Ensembl	panpan1.1		panPan2

RAB11FIP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	28,415,139 - 28,457,215 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	28,415,639 - 28,457,286 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	28,531,739 - 28,600,617 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	28,917,842 - 28,986,521 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	28,944,943 - 28,986,369 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	28,478,894 - 28,547,486 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	28,493,741 - 28,562,416 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	28,688,873 - 28,757,762 (-)	NCBI		UU_Cfam_GSD_1.0

Rab11fip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	17,831,562 - 17,868,725 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	7,691,752 - 7,729,742 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	7,692,577 - 7,729,736 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB11FIP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	128,068,959 - 128,110,512 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	128,068,085 - 128,110,949 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	139,582,795 - 139,625,498 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAB11FIP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	110,805,236 - 110,846,691 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	110,805,022 - 110,846,830 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	72,061,961 - 72,103,670 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rab11fip2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	28,634,079 - 28,686,886 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	28,633,815 - 28,675,773 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rab11fip2
767 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	22
Interacting mature miRNAs:	24
Transcripts:	ENSRNOT00000012734
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221264111	259647894	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	221414816	260522016	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	222363780	260522016	Rat
1600392	Bw123	Body weight QTL 123		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	223201027	260522016	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	224054293	260122809	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	224054293	260122809	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	224569538	260122809	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	225126575	260522016	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	228581588	259647894	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	232156370	259647894	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	233948574	260522016	Rat
631690	Scl5	Serum cholesterol level QTL 5	2.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	236125214	260522016	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	0.00000487	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	237147813	260522016	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	238699859	259647894	Rat
737975	Bw122	Body weight QTL 122	9.11	0.005	body mass (VT:0001259)	body weight (CMO:0000012)	1	258843780	260122809	Rat

Markers in Region

AW558126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	259,054,309 - 259,054,394 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	281,061,879 - 281,061,963	NCBI	Rnor6.0
Rnor_5.0	1	288,418,548 - 288,418,632	UniSTS	Rnor5.0
RGSC_v3.4	1	266,458,285 - 266,458,369	UniSTS	RGSC3.4
Celera	1	254,702,296 - 254,702,380	UniSTS
Cytogenetic Map	1	q55	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			17	1	16	1			74	31	41	11
Low	3	43	40	40	3	40	8	11		4			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012734 ⟹ ENSRNOP00000012734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	259,057,078 - 259,093,752 (-)	Ensembl
Rnor_6.0 Ensembl	1	281,065,168 - 281,101,438 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081218 ⟹ ENSRNOP00000087232

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	258,935,647 - 259,093,752 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097684 ⟹ ENSRNOP00000088001

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	258,923,873 - 259,093,752 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102047 ⟹ ENSRNOP00000087438

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	258,998,616 - 259,093,752 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108108 ⟹ ENSRNOP00000095948

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	258,935,647 - 259,093,752 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115594 ⟹ ENSRNOP00000091347

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	259,053,812 - 259,093,752 (-)	Ensembl

RefSeq Acc Id:

NM_001107447 ⟹ NP_001100917

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	269,043,836 - 269,079,661 (-)	NCBI
mRatBN7.2	1	259,057,777 - 259,093,608 (-)	NCBI
Rnor_6.0	1	281,065,346 - 281,101,163 (-)	NCBI
Rnor_5.0	1	288,422,015 - 288,457,832 (-)	NCBI
RGSC_v3.4	1	266,461,752 - 266,497,576 (-)	RGD
Celera	1	254,705,763 - 254,741,674 (-)	RGD

Sequence:

show sequence

CAGAATGATGCTGTCTGAGCAAGCCCAAAAGTGGTTTCCAACCCACGTGCAGGTCACAGTGCTC
CAAGCTAAAGATCTGAAGCCAAAAGGCAAAAGTGGCACCAATGACACATACACCATAATTCAGT
TGGGCAAAGAGAAGTATTCTACATCTGTAGCGGAGAAAACCCTGGAGCCGGTCTGGAAGGAGGA
GGCCTCTTTTGAGCTGCCTGGGTTGCTCATGCAGGGTAATCCGGAGAAATACATTCTTTTTCTT
ATAGTGATGCACAGGTCCCTGGTGGGACTGGATAAGTTTTTAGGGCAGGTGGCAATCAATCTCA
ATGACATCTTTGAGGACAAACAAAGAAGGAAAACAGAGTGGTTTAGATTAGAATCAAAACAAGG
AAAAAGAATAAAAAACAGGGGTGAGATAAAGGTCAATATTCAATTTATGAGGAACAACATGACA
GCAAGCATGTTTGACTTGTCAATGAAGGACAAGACGAGATCACCTTTTGCAAAATTAAAAGATA
AGATGAAAGGCAGGAAAAGCGACGGGGTGTTTTCTGATACGTCCTCTGCCATCGTTCCGAGCAC
TCACATGCCTGATGCCAATCCTGAGTTTTCAAGTGGTGAAATGCAGATGAAATCCAAACCAAAA
AAGCCTTTTCTTCTGGGTCCTCAGCGGCTCTCTTCTGCCCATTCGATGTCTGATTTAACTGGGT
CCCACTTATCTTCTGAGAAGCTGAAGTCTAGCACTGTAGGCCCAACACATCTTCTCAGTCACCA
GATAAATTCCTTTGGAGTTGTTCCAGAAAGTGGAAGTCTCAAGTCTCCACACAGACGAACACTA
AGCTTTGATACTTCTAAATTGAACCAACCTGGCAGCATTGTGGATGAAGGTGAACACTGTTTTG
GAAGACAGAGTGACCCATTTACAAATGTGACTGCTTCATTACCCCAAAAATTTGCAACACTGCC
AAGGAAGAAGAATCCATTTGAAGAAAGCAGTGAGCCATGGGACAGCAGCACGAATTTATTTTCA
AAACCAATTGAAGTCAGGAAAGAAAGTAAGAGAGAGAAAAGGGAGAAGGTGAGCCTCTTTGAAA
GAGTGACTGGGAAGAGAGATAGCAGGAGATCTGACAAGCTGAACAATGGGGGATCTGATAGCCC
ATGTGACTTGAAATCACCTAGTGCTTTTAATGAAAACCGGCAGGACTATTTTGAATATGAGTCA
ACCAACCCGTTTACAGCAAAATTCAGGGCTTCAACTATAATGCCATCTTCAAGTTTTCATATGA
ATCCAACAAGCAGTGATGACCTCAGGAAAATCCCGGATAGCAATCCCTTCGATGCCACGGCTGG
GTACCGGAGTCTGACCTACGAAGAGGTGCTGCAGGAGCTGGTGAAGCACAAAGAACTCCTTCGG
AGGAAGGACACCCACATCCGGGAGCTAGAGGACTACATCGACAACCTCCTTGTCAGGGTGATGG
AAGAGACACCCAGCATCCTGCGAGTGCCCTATGAGCCATCCAGGAAAGCTGGCAAGTTTACCAA
TAGCTAGTGGGAGTCAAGAGGACTGTTT

hide sequence

RefSeq Acc Id:

XM_039110359 ⟹ XP_038966287

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	268,921,760 - 269,080,691 (-)	NCBI
mRatBN7.2	1	258,950,535 - 259,094,555 (-)	NCBI

RefSeq Acc Id:

XM_063288292 ⟹ XP_063144362

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	268,921,761 - 269,080,691 (-)	NCBI

RefSeq Acc Id:

XM_063288295 ⟹ XP_063144365

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	268,908,825 - 269,080,691 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100917	(Get FASTA)	NCBI Sequence Viewer
	XP_038966287	(Get FASTA)	NCBI Sequence Viewer
	XP_063144362	(Get FASTA)	NCBI Sequence Viewer
	XP_063144365	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94565	(Get FASTA)	NCBI Sequence Viewer
	EDL94566	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012734.7
	ENSRNOP00000087232
	ENSRNOP00000087232.1
	ENSRNOP00000087438.1
	ENSRNOP00000088001.1
	ENSRNOP00000091347
	ENSRNOP00000091347.1
	ENSRNOP00000095948.1

RefSeq Acc Id:

NP_001100917 ⟸ NM_001107447

- UniProtKB:

A0A8I6AF99 (UniProtKB/TrEMBL), A6JI91 (UniProtKB/TrEMBL), A0A8I6ASH5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEA
SFELPGLLMQGNPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGK
RIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKSDGVFSDTSSAIVPSTH
MPDANPEFSSGEMQMKSKPKKPFLLGPQRLSSAHSMSDLTGSHLSSEKLKSSTVGPTHLLSHQI
NSFGVVPESGSLKSPHRRTLSFDTSKLNQPGSIVDEGEHCFGRQSDPFTNVTASLPQKFATLPR
KKNPFEESSEPWDSSTNLFSKPIEVRKESKREKREKVSLFERVTGKRDSRRSDKLNNGGSDSPC
DLKSPSAFNENRQDYFEYESTNPFTAKFRASTIMPSSSFHMNPTSSDDLRKIPDSNPFDATAGY
RSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKFTNS

hide sequence

RefSeq Acc Id:

ENSRNOP00000012734 ⟸ ENSRNOT00000012734

RefSeq Acc Id:	XP_038966287 ⟸ XM_039110359
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A6W2 (UniProtKB/TrEMBL), A0A8I6ASH5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000088001 ⟸ ENSRNOT00000097684

RefSeq Acc Id:

ENSRNOP00000087438 ⟸ ENSRNOT00000102047

RefSeq Acc Id:

ENSRNOP00000087232 ⟸ ENSRNOT00000081218

RefSeq Acc Id:

ENSRNOP00000095948 ⟸ ENSRNOT00000108108

RefSeq Acc Id:

ENSRNOP00000091347 ⟸ ENSRNOT00000115594

RefSeq Acc Id:	XP_063144365 ⟸ XM_063288295
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A6W2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063144362 ⟸ XM_063288292
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A6W2 (UniProtKB/TrEMBL)

Protein Domains

C2 FIP-RBD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZD48-F1-model_v2	AlphaFold	D3ZD48	1-512	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308538	AgrOrtholog
BioCyc Gene	G2FUF-55237	BioCyc
Ensembl Genes	ENSRNOG00000009523	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012734.8	UniProtKB/TrEMBL
	ENSRNOT00000081218.2	UniProtKB/TrEMBL
	ENSRNOT00000097684.1	UniProtKB/TrEMBL
	ENSRNOT00000102047.1	UniProtKB/TrEMBL
	ENSRNOT00000108108.1	UniProtKB/TrEMBL
	ENSRNOT00000115594	ENTREZGENE
	ENSRNOT00000115594.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.2440	UniProtKB/TrEMBL
	2.60.40.150	UniProtKB/TrEMBL
InterPro	C2_Ca-dep	UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/TrEMBL
	FIP-RBD_C_sf	UniProtKB/TrEMBL
	FIP_classI	UniProtKB/TrEMBL
	Rab11-bd_FIP_dom_C	UniProtKB/TrEMBL
KEGG Report	rno:308003	UniProtKB/TrEMBL
NCBI Gene	308003	ENTREZGENE
PANTHER	PTHR15746	UniProtKB/TrEMBL
	RAB11 FAMILY-INTERACTING PROTEIN 2	UniProtKB/TrEMBL
Pfam	PF00168	UniProtKB/TrEMBL
	RBD-FIP	UniProtKB/TrEMBL
PhenoGen	Rab11fip2	PhenoGen
PROSITE	FIP_RBD	UniProtKB/TrEMBL
	PS50004	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009523	RatGTEx
SMART	SM00239	UniProtKB/TrEMBL
Superfamily-SCOP	SSF144270	UniProtKB/TrEMBL
	SSF49562	UniProtKB/TrEMBL
UniProt	A0A8I6A5U7_RAT	UniProtKB/TrEMBL
	A0A8I6A6W2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A8W0_RAT	UniProtKB/TrEMBL
	A0A8I6AF99	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ASH5	ENTREZGENE, UniProtKB/TrEMBL
	A6JI91	ENTREZGENE, UniProtKB/TrEMBL
	D3ZD48_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Rab11fip2	RAB11 family interacting protein 2	LOC108349712	uncharacterized LOC108349712	Data merged from RGD:11369632	737654	PROVISIONAL
2016-08-02	LOC108349712	uncharacterized LOC108349712			Symbol and Name status set to provisional	70820	PROVISIONAL
2016-05-04	Rab11fip2	RAB11 family interacting protein 2	Rab11fip2	RAB11 family interacting protein 2 (class I)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Rab11fip2	RAB11 family interacting protein 2 (class I)	Rab11fip2_predicted	RAB11 family interacting protein 2 (class I) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Rab11fip2_predicted	RAB11 family interacting protein 2 (class I) (predicted)	RGD1308538_predicted	similar to KIAA0941 protein; rab11-family interacting protein 2 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1308538_predicted	similar to KIAA0941 protein; rab11-family interacting protein 2 (predicted)	LOC308003_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC308003_predicted	similar to KIAA0941 protein; rab11-family interacting protein 2 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)