Apc2 (APC regulator of WNT signaling pathway 2) - Rat Genome Database

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Pathways
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Gene: Apc2 (APC regulator of WNT signaling pathway 2) Rattus norvegicus
Analyze
Symbol: Apc2
Name: APC regulator of WNT signaling pathway 2
RGD ID: 1308256
Description: Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of microtubule depolymerization; and positive regulation of protein catabolic process. Is active in postsynapse. Human ortholog(s) of this gene implicated in Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2); PARTICIPATES IN basal cell carcinoma pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: adenomatosis polyposis coli 2; adenomatous polyposis coli protein 2; APC2, WNT signaling pathway regulator; LOC299611
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,043,010 - 10,065,037 (-)NCBIGRCr8
mRatBN7.279,392,336 - 9,414,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,392,336 - 9,414,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,269,150 - 12,285,377 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,144,492 - 14,160,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,011,953 - 12,028,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,258,468 - 12,280,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,258,468 - 12,275,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,428,263 - 12,450,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,903,675 - 10,920,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,906,422 - 10,920,010 (-)NCBI
Celera77,569,129 - 7,585,464 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Fu AK, etal., Nat Neurosci. 2011 Feb;14(2):181-9. doi: 10.1038/nn.2715. Epub 2010 Dec 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9823329   PMID:10021369   PMID:10644998   PMID:10646860   PMID:11691822   PMID:25635769   PMID:25753423   PMID:26393419   PMID:30018294  


Genomics

Comparative Map Data
Apc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,043,010 - 10,065,037 (-)NCBIGRCr8
mRatBN7.279,392,336 - 9,414,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,392,336 - 9,414,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,269,150 - 12,285,377 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,144,492 - 14,160,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,011,953 - 12,028,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,258,468 - 12,280,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,258,468 - 12,275,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,428,263 - 12,450,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,903,675 - 10,920,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,906,422 - 10,920,010 (-)NCBI
Celera77,569,129 - 7,585,464 (-)NCBICelera
Cytogenetic Map7q11NCBI
APC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,446,230 - 1,473,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,446,302 - 1,473,244 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,450,120 - 1,473,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,401,148 - 1,424,243 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,401,147 - 1,424,243NCBI
Celera191,384,145 - 1,407,242 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,224,572 - 1,247,128 (+)NCBIHuRef
CHM1_1191,450,140 - 1,473,245 (+)NCBICHM1_1
T2T-CHM13v2.0191,416,241 - 1,443,282 (+)NCBIT2T-CHM13v2.0
Apc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,131,790 - 80,154,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,131,811 - 80,154,097 (+)EnsemblGRCm39 Ensembl
GRCm381080,295,956 - 80,318,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,295,977 - 80,318,263 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,764,565 - 79,781,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,704,967 - 79,719,154 (+)NCBIMGSCv36mm8
Celera1081,316,697 - 81,333,128 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Apc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,467,357 - 6,489,633 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,466,434 - 6,489,612 (-)NCBIChiLan1.0ChiLan1.0
APC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,792,156 - 5,819,568 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,029,060 - 5,053,706 (+)NCBINHGRI_mPanPan1
APC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,380,472 - 57,395,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,380,460 - 57,395,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,172,171 - 57,194,303 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,111,433 - 58,133,576 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,113,852 - 58,133,525 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,167,636 - 57,189,566 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,647,109 - 57,669,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,849,121 - 57,871,249 (-)NCBIUU_Cfam_GSD_1.0
Apc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,047,462 - 217,067,723 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588767,066 - 786,951 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588767,115 - 787,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,005,706 - 77,034,561 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,005,706 - 77,034,583 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,897,990 - 77,926,867 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,218,684 - 1,244,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660817,607,781 - 7,635,123 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,223,251 - 7,247,421 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,220,768 - 7,247,395 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apc2
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1159
Count of miRNA genes:314
Interacting mature miRNAs:402
Transcripts:ENSRNOT00000049146
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
RH132628  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,392,338 - 9,392,657 (+)MAPPERmRatBN7.2
mRatBN7.279,392,338 - 9,392,785 (+)MAPPERmRatBN7.2
Rnor_6.0712,258,471 - 12,258,917NCBIRnor6.0
Rnor_6.0712,258,471 - 12,258,789NCBIRnor6.0
Rnor_5.0712,428,266 - 12,428,712UniSTSRnor5.0
Rnor_5.0712,428,266 - 12,428,584UniSTSRnor5.0
RGSC_v3.4710,903,678 - 10,904,124UniSTSRGSC3.4
RGSC_v3.4710,903,678 - 10,903,996UniSTSRGSC3.4
Celera77,569,132 - 7,569,450UniSTS
Celera77,569,132 - 7,569,578UniSTS
Cytogenetic Map7q11UniSTS
AW527321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,409,788 - 9,409,897 (+)MAPPERmRatBN7.2
Rnor_6.0712,275,920 - 12,276,028NCBIRnor6.0
Rnor_5.0712,445,715 - 12,445,823UniSTSRnor5.0
RGSC_v3.4710,921,127 - 10,921,235UniSTSRGSC3.4
Celera77,586,581 - 7,586,689UniSTS
RH 3.4 Map738.9UniSTS
Cytogenetic Map7q11UniSTS
RH139351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,392,201 - 9,392,281 (+)MAPPERmRatBN7.2
Rnor_6.0712,258,334 - 12,258,413NCBIRnor6.0
Rnor_5.0712,428,129 - 12,428,208UniSTSRnor5.0
RGSC_v3.4710,903,541 - 10,903,620UniSTSRGSC3.4
Celera77,568,995 - 7,569,074UniSTS
Cytogenetic Map7q11UniSTS
BE096640  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,406,456 - 9,406,646 (+)MAPPERmRatBN7.2
Rnor_6.0712,272,589 - 12,272,778NCBIRnor6.0
Rnor_5.0712,442,384 - 12,442,573UniSTSRnor5.0
RGSC_v3.4710,917,796 - 10,917,985UniSTSRGSC3.4
Celera77,583,250 - 7,583,439UniSTS
RH 3.4 Map739.8UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 74 1
Low 1 36 26 10 18 10 8 10 31 37 11 8
Below cutoff 2 7 31 31 1 31 1 4 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000049146   ⟹   ENSRNOP00000045757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,392,336 - 9,414,310 (-)Ensembl
Rnor_6.0 Ensembl712,258,468 - 12,274,803 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086061   ⟹   ENSRNOP00000071210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,392,336 - 9,409,975 (-)Ensembl
Rnor_6.0 Ensembl712,259,911 - 12,275,609 (-)Ensembl
RefSeq Acc Id: NM_001106769   ⟹   NP_001100239
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,010 - 10,059,345 (-)NCBI
mRatBN7.279,392,336 - 9,408,671 (-)NCBI
Rnor_6.0712,258,468 - 12,274,803 (-)NCBI
Rnor_5.0712,428,263 - 12,450,249 (-)NCBI
RGSC_v3.4710,903,675 - 10,920,010 (-)RGD
Celera77,569,129 - 7,585,464 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240878   ⟹   XP_006240940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,065,037 (-)NCBI
mRatBN7.279,392,337 - 9,414,364 (-)NCBI
Rnor_6.0712,258,470 - 12,280,459 (-)NCBI
Rnor_5.0712,428,263 - 12,450,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594716   ⟹   XP_017450205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,061,600 (-)NCBI
mRatBN7.279,392,337 - 9,410,565 (-)NCBI
Rnor_6.0712,258,470 - 12,275,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594717   ⟹   XP_017450206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,061,600 (-)NCBI
mRatBN7.279,392,337 - 9,410,565 (-)NCBI
Rnor_6.0712,258,470 - 12,275,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078647   ⟹   XP_038934575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,061,601 (-)NCBI
mRatBN7.279,392,337 - 9,410,566 (-)NCBI
RefSeq Acc Id: XM_039078648   ⟹   XP_038934576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,065,037 (-)NCBI
mRatBN7.279,392,337 - 9,414,364 (-)NCBI
RefSeq Acc Id: XM_039078649   ⟹   XP_038934577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,065,037 (-)NCBI
mRatBN7.279,392,337 - 9,414,364 (-)NCBI
RefSeq Acc Id: XM_039078650   ⟹   XP_038934578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,062,573 (-)NCBI
mRatBN7.279,392,337 - 9,411,891 (-)NCBI
RefSeq Acc Id: XM_039078651   ⟹   XP_038934579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,061,779 (-)NCBI
mRatBN7.279,392,337 - 9,411,891 (-)NCBI
RefSeq Acc Id: XM_039078652   ⟹   XP_038934580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,061,601 (-)NCBI
mRatBN7.279,392,337 - 9,410,566 (-)NCBI
RefSeq Acc Id: XM_063263171   ⟹   XP_063119241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,062,573 (-)NCBI
RefSeq Acc Id: XM_063263172   ⟹   XP_063119242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,043,011 - 10,062,572 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100239   ⟸   NM_001106769
- UniProtKB: A0A0G2JZW4 (UniProtKB/TrEMBL),   A6K8M9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240940   ⟸   XM_006240878
- Peptide Label: isoform X5
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450206   ⟸   XM_017594717
- Peptide Label: isoform X4
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450205   ⟸   XM_017594716
- Peptide Label: isoform X3
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071210   ⟸   ENSRNOT00000086061
RefSeq Acc Id: ENSRNOP00000045757   ⟸   ENSRNOT00000049146
RefSeq Acc Id: XP_038934577   ⟸   XM_039078649
- Peptide Label: isoform X6
- UniProtKB: D4A205 (UniProtKB/TrEMBL),   A6K8M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934576   ⟸   XM_039078648
- Peptide Label: isoform X2
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934578   ⟸   XM_039078650
- Peptide Label: isoform X7
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934579   ⟸   XM_039078651
- Peptide Label: isoform X7
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934580   ⟸   XM_039078652
- Peptide Label: isoform X7
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934575   ⟸   XM_039078647
- Peptide Label: isoform X1
- UniProtKB: A6K8M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119241   ⟸   XM_063263171
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JZW4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119242   ⟸   XM_063263172
- Peptide Label: isoform X9
Protein Domains
Adenomatous polyposis coli N-terminal dimerisation   Adenomatous polyposis coli protein basic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZW4-F1-model_v2 AlphaFold A0A0G2JZW4 1-2308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308256 AgrOrtholog
BioCyc Gene G2FUF-34930 BioCyc
Ensembl Genes ENSRNOG00000033791 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049146 ENTREZGENE
  ENSRNOT00000049146.5 UniProtKB/TrEMBL
  ENSRNOT00000086061 ENTREZGENE
  ENSRNOT00000086061.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.10 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro APC_basic UniProtKB/TrEMBL
  APC_crr UniProtKB/TrEMBL
  APC_dom UniProtKB/TrEMBL
  Apc_fam UniProtKB/TrEMBL
  APC_N UniProtKB/TrEMBL
  APC_N_sf UniProtKB/TrEMBL
  APC_rep UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  SAMP UniProtKB/TrEMBL
KEGG Report rno:299611 UniProtKB/TrEMBL
NCBI Gene 299611 ENTREZGENE
PANTHER PTHR12607 UniProtKB/TrEMBL
  PTHR12607:SF3 UniProtKB/TrEMBL
Pfam APC_basic UniProtKB/TrEMBL
  APC_crr UniProtKB/TrEMBL
  APC_N_CC UniProtKB/TrEMBL
  APC_rep UniProtKB/TrEMBL
  Arm UniProtKB/TrEMBL
  Arm_APC_u3 UniProtKB/TrEMBL
  SAMP UniProtKB/TrEMBL
  Suppressor_APC UniProtKB/TrEMBL
PhenoGen Apc2 PhenoGen
RatGTEx ENSRNOG00000033791 RatGTEx
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  SSF58050 UniProtKB/TrEMBL
  SSF82931 UniProtKB/TrEMBL
UniProt A0A0G2JZW4 ENTREZGENE, UniProtKB/TrEMBL
  A6K8M9 ENTREZGENE, UniProtKB/TrEMBL
  D4A205 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-26 Apc2  APC regulator of WNT signaling pathway 2  Apc2  APC2, WNT signaling pathway regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-01 Apc2  APC2, WNT signaling pathway regulator  Apc2  adenomatosis polyposis coli 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Apc2  adenomatosis polyposis coli 2   Apc2_predicted  adenomatosis polyposis coli 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Apc2_predicted  adenomatosis polyposis coli 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED