Ppp1r7 (protein phosphatase 1, regulatory subunit 7) - Rat Genome Database

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Gene: Ppp1r7 (protein phosphatase 1, regulatory subunit 7) Rattus norvegicus
Analyze
Symbol: Ppp1r7 (Ensembl: AABR07068351.1)
Name: protein phosphatase 1, regulatory subunit 7
RGD ID: 1308169
Description: Predicted to act upstream of or within chromosome segregation and positive regulation of protein dephosphorylation. Predicted to be located in chromosome. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105784; protein phosphatase 1 regulatory subunit 22; protein phosphatase 1 regulatory subunit 7; protein phosphatase 1, regulatory (inhibitor) subunit 7; Sds22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,333,472 - 101,358,589 (+)NCBIGRCr8
mRatBN7.2993,886,068 - 93,911,198 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,886,143 - 93,914,850 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,321,658 - 102,346,746 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,457,461 - 107,482,640 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,813,603 - 105,838,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,556,587 - 100,504,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0999,226,358 - 99,235,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.09100,116,100 - 100,160,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,624,083 - 92,648,034 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,828,851 - 92,852,802 (+)NCBI
Celera991,421,088 - 91,444,915 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA,ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7498485   PMID:12226088   PMID:12477932   PMID:12555814   PMID:15489334   PMID:16396499   PMID:19056867   PMID:21630459   PMID:22206666   PMID:22801782   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Ppp1r7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,333,472 - 101,358,589 (+)NCBIGRCr8
mRatBN7.2993,886,068 - 93,911,198 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,886,143 - 93,914,850 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,321,658 - 102,346,746 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,457,461 - 107,482,640 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,813,603 - 105,838,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,556,587 - 100,504,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0999,226,358 - 99,235,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.09100,116,100 - 100,160,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,624,083 - 92,648,034 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,828,851 - 92,852,802 (+)NCBI
Celera991,421,088 - 91,444,915 (+)NCBICelera
Cytogenetic Map9q36NCBI
PPP1R7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,149,573 - 241,183,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,149,576 - 241,183,652 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,088,988 - 242,123,067 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,738,575 - 241,771,112 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,809,891 - 241,842,429NCBI
Celera2235,759,626 - 235,792,623 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,846,344 - 233,879,486 (+)NCBIHuRef
CHM1_12242,095,958 - 242,128,538 (+)NCBICHM1_1
T2T-CHM13v2.02241,648,673 - 241,683,461 (+)NCBIT2T-CHM13v2.0
Ppp1r7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,271,350 - 93,295,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,270,576 - 93,301,211 (+)EnsemblGRCm39 Ensembl
GRCm38193,343,610 - 93,367,616 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,342,854 - 93,373,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,240,222 - 95,264,195 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,174,051 - 95,198,024 (+)NCBIMGSCv36mm8
Celera196,288,260 - 96,312,213 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.24NCBI
Ppp1r7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955542520,605 - 539,699 (-)NCBIChiLan1.0ChiLan1.0
PPP1R7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,849,616 - 143,883,834 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,864,512 - 143,898,730 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,418,212 - 128,452,417 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,214,953 - 247,248,761 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,214,882 - 247,248,761 (+)Ensemblpanpan1.1panPan2
PPP1R7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,181,092 - 51,206,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,181,053 - 51,206,193 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,393,754 - 51,418,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,375,512 - 51,400,669 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,375,474 - 51,401,299 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,223,238 - 51,248,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,962,763 - 50,987,892 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,239,231 - 51,264,386 (+)NCBIUU_Cfam_GSD_1.0
Ppp1r7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,555,414 - 192,584,880 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936745639,379 - 663,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,917,257 - 139,941,251 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115139,918,006 - 139,937,168 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215155,032,379 - 155,050,592 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,206,233 - 127,243,577 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604072,137,475 - 72,176,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,246,734 - 5,263,867 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,247,094 - 5,263,873 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r7
112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:103
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000022854
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat

Markers in Region
RH130818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,909,729 - 93,909,921 (+)MAPPERmRatBN7.2
Rnor_6.09100,503,816 - 100,504,007NCBIRnor6.0
Rnor_5.09100,160,171 - 100,160,362UniSTSRnor5.0
RGSC_v3.4992,647,773 - 92,647,964UniSTSRGSC3.4
Celera991,444,654 - 91,444,845UniSTS
RH 3.4 Map9801.0UniSTS
Cytogenetic Map9q36UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022854   ⟹   ENSRNOP00000022854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,888,313 - 93,911,195 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095497   ⟹   ENSRNOP00000081944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,886,149 - 93,911,195 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103695   ⟹   ENSRNOP00000095250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,886,143 - 93,914,850 (+)Ensembl
RefSeq Acc Id: NM_001009825   ⟹   NP_001009825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,333,497 - 101,358,589 (+)NCBI
mRatBN7.2993,886,104 - 93,911,198 (+)NCBI
Rnor_6.0999,557,511 - 100,504,077 (+)NCBI
Rnor_5.0999,226,358 - 99,235,083 (+)NCBI
Rnor_5.09100,116,100 - 100,160,432 (+)NCBI
RGSC_v3.4992,624,083 - 92,648,034 (+)RGD
Celera991,421,088 - 91,444,915 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767362   ⟹   XP_008765584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,333,472 - 101,350,755 (+)NCBI
mRatBN7.2993,886,068 - 93,902,220 (+)NCBI
Rnor_6.0999,556,587 - 100,496,306 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001009825   ⟸   NM_001009825
- UniProtKB: Q5HZV9 (UniProtKB/Swiss-Prot),   A6JQY6 (UniProtKB/TrEMBL),   A0A8I6AM99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765584   ⟸   XM_008767362
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000081944   ⟸   ENSRNOT00000095497
RefSeq Acc Id: ENSRNOP00000095250   ⟸   ENSRNOT00000103695
RefSeq Acc Id: ENSRNOP00000022854   ⟸   ENSRNOT00000022854
Protein Domains
LRRCT   U2A'/phosphoprotein 32 family A C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-R9PXV7-F1-model_v2 AlphaFold R9PXV7 1-215 view protein structure
AF-Q5HZV9-F1-model_v2 AlphaFold Q5HZV9 1-360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308169 AgrOrtholog
BioCyc Gene G2FUF-26647 BioCyc
Ensembl Genes ENSRNOG00000016974 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010177 UniProtKB/Swiss-Prot
  ENSRNOG00060009003 UniProtKB/Swiss-Prot
  ENSRNOG00065020274 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022854.8 UniProtKB/TrEMBL
  ENSRNOT00000095497 ENTREZGENE
  ENSRNOT00000095497.1 UniProtKB/Swiss-Prot
  ENSRNOT00000103695.1 UniProtKB/TrEMBL
  ENSRNOT00055017212 UniProtKB/Swiss-Prot
  ENSRNOT00060015118 UniProtKB/Swiss-Prot
  ENSRNOT00065034270 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321115 IMAGE-MGC_LOAD
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U2A'_phosphoprotein32A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301618 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105784 IMAGE-MGC_LOAD
NCBI Gene 301618 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r7 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016974 RatGTEx
  ENSRNOG00055010177 RatGTEx
  ENSRNOG00060009003 RatGTEx
  ENSRNOG00065020274 RatGTEx
SMART LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRcap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AM99 ENTREZGENE, UniProtKB/TrEMBL
  A6JQY6 ENTREZGENE, UniProtKB/TrEMBL
  A6JQY7_RAT UniProtKB/TrEMBL
  PP1R7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXV7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r7  protein phosphatase 1, regulatory subunit 7  Ppp1r7  protein phosphatase 1, regulatory (inhibitor) subunit 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ppp1r7  protein phosphatase 1, regulatory (inhibitor) subunit 7  Ppp1r7_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ppp1r7_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED