Ints7 (integrator complex subunit 7)

Gene: Ints7 (integrator complex subunit 7) Rattus norvegicus

Analyze

Symbol:

Ints7

Name:

integrator complex subunit 7

RGD ID:

1308014

Description:

Predicted to be involved in DNA damage checkpoint signaling; cellular response to ionizing radiation; and snRNA 3'-end processing. Predicted to be located in chromosome; cytoplasm; and nuclear body. Predicted to be part of integrator complex. Orthologous to human INTS7 (integrator complex subunit 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC289382; RGD1308014; similar to DKFZP434B168 protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INTS7 (integrator complex subunit 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ints7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ints7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	INTS7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INTS7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ints7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INTS7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	INTS7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ints7 (integrator complex subunit 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NCKAP5 (NCK associated protein 5)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Ints7 (integrator complex subunit 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	INTS7 (integrator complex subunit 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ints7 (integrator complex subunit 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	D1043.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	defl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ints7	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,686,208 - 105,739,609 (+)	NCBI		GRCr8
mRatBN7.2	13	103,155,123 - 103,207,953 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	103,155,090 - 103,208,592 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	105,675,160 - 105,727,919 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	107,059,009 - 107,111,770 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	104,274,080 - 104,326,845 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	110,257,571 - 110,310,413 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,257,571 - 110,310,413 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,821,472 - 114,873,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,641,207 - 107,696,311 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	107,830,267 - 107,884,967 (+)	NCBI
Celera	13	102,594,374 - 102,646,905 (+)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bucladesine (ISO)

C60 fullerene (EXP)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diethyl maleate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

hypochlorous acid (ISO)

ivermectin (ISO)

medroxyprogesterone acetate (ISO)

methapyrilene (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

tert-butyl hydroperoxide (ISO)

thioacetamide (EXP)

topotecan (EXP)

trimellitic anhydride (ISO)

triptonide (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to ionizing radiation (ISO)

DNA damage checkpoint signaling (ISO)

snRNA 3'-end processing (IBA)

snRNA processing (ISO)

Cellular Component

chromosome (ISO)

cytoplasm (ISO)

integrator complex (IBA,ISO)

nuclear body (IEA,ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16239144	PMID:21659603	PMID:23904267

Genomics

Comparative Map Data

Ints7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,686,208 - 105,739,609 (+)	NCBI		GRCr8
mRatBN7.2	13	103,155,123 - 103,207,953 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	103,155,090 - 103,208,592 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	105,675,160 - 105,727,919 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	107,059,009 - 107,111,770 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	104,274,080 - 104,326,845 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	110,257,571 - 110,310,413 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,257,571 - 110,310,413 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,821,472 - 114,873,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,641,207 - 107,696,311 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	107,830,267 - 107,884,967 (+)	NCBI
Celera	13	102,594,374 - 102,646,905 (+)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

INTS7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	211,940,403 - 212,035,557 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	211,940,399 - 212,035,557 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	212,113,745 - 212,208,899 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	210,181,321 - 210,275,507 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	185,341,779 - 185,435,963 (-)	NCBI		Celera
Cytogenetic Map	1	q32.3	ENTREZGENE
HuRef	1	182,790,784 - 182,886,038 (-)	NCBI		HuRef
CHM1_1	1	213,386,120 - 213,481,388 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	211,186,567 - 211,281,644 (-)	NCBI		T2T-CHM13v2.0

Ints7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	191,307,652 - 191,355,802 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	191,307,748 - 191,355,800 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	191,575,540 - 191,623,690 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	191,575,636 - 191,623,688 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	193,399,613 - 193,445,570 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	193,276,395 - 193,323,290 (+)	NCBI		MGSCv36	mm8
Celera	1	198,526,378 - 198,572,332 (+)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	96.51	NCBI

Ints7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,299,697 - 5,371,896 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,299,696 - 5,371,496 (+)	NCBI	ChiLan1.0	ChiLan1.0

INTS7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	37,367,474 - 37,462,976 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	37,331,961 - 37,427,466 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	187,508,066 - 187,603,567 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	192,372,012 - 192,466,510 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	192,372,016 - 192,466,510 (-)	Ensembl	panpan1.1		panPan2

INTS7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	10,238,809 - 10,323,699 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	10,239,711 - 10,323,611 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	9,816,473 - 9,901,338 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	9,945,253 - 10,030,174 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	9,945,257 - 10,030,159 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	9,867,362 - 9,952,291 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	9,970,424 - 10,055,230 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	10,094,891 - 10,179,712 (-)	NCBI		UU_Cfam_GSD_1.0

Ints7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	64,149,514 - 64,216,110 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	1,389,728 - 1,457,042 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	1,389,728 - 1,456,397 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INTS7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	131,275,626 - 131,354,592 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	131,275,530 - 131,364,490 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	144,330,530 - 144,374,834 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

INTS7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	17,485,353 - 17,573,178 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	17,485,316 - 17,574,144 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	18,008,259 - 18,096,226 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ints7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	17,524,459 - 17,612,131 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	17,525,471 - 17,612,260 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ints7
607 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	228
Count of miRNA genes:	165
Interacting mature miRNAs:	181
Transcripts:	ENSRNOT00000005715
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

Markers in Region

RH128521

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	13	110,310,746 - 110,310,952	NCBI	Rnor6.0
Rnor_5.0	13	114,874,148 - 114,874,354	UniSTS	Rnor5.0
Celera	13	102,647,238 - 102,647,444	UniSTS
RH 3.4 Map	13	730.6	UniSTS
Cytogenetic Map	13	q27	UniSTS

RH140141

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	103,207,945 - 103,208,139 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	110,310,406 - 110,310,599	NCBI	Rnor6.0
Rnor_5.0	13	114,873,808 - 114,874,001	UniSTS	Rnor5.0
Celera	13	102,646,898 - 102,647,091	UniSTS
RH 3.4 Map	13	728.5	UniSTS
Cytogenetic Map	13	q27	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	29	38	22	19	22	1	1	74	35	37	11	1
Low		14	19	19		19	7	10			4		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005715 ⟹ ENSRNOP00000005715

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	103,155,090 - 103,208,592 (+)	Ensembl
Rnor_6.0 Ensembl	13	110,257,571 - 110,310,413 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111811 ⟹ ENSRNOP00000082960

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	103,155,119 - 103,175,438 (+)	Ensembl

RefSeq Acc Id:

NM_001191675 ⟹ NP_001178604

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,686,208 - 105,738,967 (+)	NCBI
mRatBN7.2	13	103,155,123 - 103,207,953 (+)	NCBI
Rnor_6.0	13	110,257,571 - 110,310,413 (+)	NCBI
Rnor_5.0	13	114,821,472 - 114,873,815 (+)	NCBI
Celera	13	102,594,374 - 102,646,905 (+)	NCBI

Sequence:

show sequence

TGGCGGTGCAGGGGAAGAGTTTGCAATCTTTGTGACTAGGCGAGTCCGGTAACTATAAGGATCA
TGGCGTCAAACTCAACCAAGTCTTTCCTGGCCGATGCCGGCTATGGCGAACAGGAGCTGGACGC
TAACTCCGCTCTTATGGAACTGGACAAAGGTCTGAGGTCTGGCAAACTCGGGGAGCAGTGTGAA
GCGGTCGTGCGCTTTCCCAGGCTTTTCCAGAAGTACCCGTTCCCTATTCTCATCAATTCAGCGT
TCCTAAAGTTAGCTGACGTTTTCAGAGTTGGAAACAACTTCCTGCGGCTGTGTGTTCTCAAAGT
GACCCAGCAAAGTGAAAAGCACCTGGAGAAGATTCTAAACGTGGATGAATTTGTGAAGAGGGTT
TTCTCGGTGATTCACAGTAATGACCCTGTGGCGAGAGCCATCACCCTACGGATGTTGGGAAGTC
TGGCGTCAATCATCCCTGAGAGGAAGAATGCCCACCACAGCATCCGTCAGAGTCTGGACTCCCA
TGACAATGTAGAAGTTGAAGCTGCTGTCTTTGCAGCCGCAAACTTCTCGGCACAGTCAAAGGAT
TTTGCTGTGGGGATCTGTAACAAAATCAGCGAAATGATTCAAGGCTTAGCTACACCAGTGGACC
TGAAGCTGAAACTGATCCCCATCCTGCAGCACATGCACCATGATGCCATCTTGGCCTCCAGTGC
CCGCCAGCTCCTGCAGCAGCTGGTCACCTCATACCCCTCCACCAAAATGGTCATCGTGTCTCTA
CACACTTTCACTCTGCTCGCAGCCTCCTCTTTGGTTGACACACCCAAGCAGATTCAACTTCTGC
TGCAGTATTTGAAGAGCGACCCCAGGAAAGCTGTGAAGAGACTTGCTGTTCAGGATCTGAAGCT
GCTCGCTAGTAAGACACCACACACGTGGAGTAAAGAGAACATTCAGGCACTCTGTGAGTGTGCA
CTGCATACTCCTTATGACAGCTTGAAGCTAGGGATGTTGTCTGTCCTCTCCACACTGTCAGGGA
CCATCGCCATTAAACATTACTTCAGTGTGGCTCCAGGAAATGTAGGCTCGTCCCCCAGATCTTC
TGATTTAGTCAAATTAGCCCAAGAATGCTGTTACCATAGCAACAGGGCCATTGCAGCACATGGA
GTGAGAGTGCTGACTAATATAACTGTGTCTTGTCAAGAAAAAGATCTCTTGTCTCTGGAGCAAG
ATGCTGTCTTTGGCCTGGAATCCCTTCTGGTGCTTTGTAGTCAAGATGACAGTCCAGGTGCTCA
GTCCACTGTGAAGAGTGCTCTCAGCTGTATGGTGAAGCTGGCCAAGGGCCGCCCACATTTGAGC
CGGTCAGTGGTTGACACTCTGCTAACTCAGCTGCACAGCTCTCAGGATGCTGCCCGGATCCTCA
TGTGCCACTGCCTGGCAGCCATTGCCATGAAGCTCCCAGTACTGGGTGATGGAATGCTTGGTGA
CCTCGTGGAGCTCTACAAGGTGATTGGACGATCAGCCACAGACAAGCAACAGGAGCTTCTGGTA
AGTTTGGCTACTGTGATTTTCGTAGCCAGCCAGAAAGCATTGTCTGCGGAAGTAAAGGCAGTAA
TCAAGCAGCAACTTGAAAGCGTCTCCAGTGGGTGGACCGTATACCGGATTGCCAGGCAGGCTTC
CAGAATGGGCAACCATGACATGGCCCGAGAGCTCTACCAGAGTTTGCTGACGCAGGTCGCATCA
GAGCACTTCTACTTCTGGCTGAACAGTCTGAAGGAGTTCTCACACGCAGAGCAGTGTCTGACTG
GGCTGCAGGAGGGTAGCTTCAGCTCAGCACTTTCCTGCATTGCTGAGTCTTTGAAATTCTACCA
CAAAGGGATCGCCTCCTTAACAGCTGCCAGCACGCCACTGAATCCTTTAAGCTTTCAGTGTGAG
TTTGTGAAACTCAGGATCGATCTTCTCCAAGCCTTCTCGCAACTTATTTGTACTTGTAACAGCC
TGAAGACAAGCCCTCCCCCTGCGATCGCCACGACGATTGCCATGACCTTAGGGAATGATCTTCA
GAGGTGTGGCCGGATCTCCAATCAGATGAAGCAGTCCATGGAAGAGTTCCGAAGCCTTGCCTCC
CGGTACCGGGATCTCTATCAGGCGTCCTTCGATGCAGACTCGGCAACTCTGAGGAACGTAGAAC
TCCAGCAGCAGAGCTGCTTACTGATAGCCCACGCTATAGAAGCCCTGGTTTTGGATCCTGAATC
AGCAAGTTTCCAGGAGTATGGGTCCACAGGCGCTGCCCACGCGGACAGCGAGTATGAGAGAAGG
ATGATGTCCGTGTACAGCCACGTCCTAGAGGAGGTGGAGTCGCTTAACCGGAAGTACGCCCCAG
TTTCCTACATGCACACAGCATGCCTCTGCAATGCCATCATCGCTTTGCTGAAAGTTCCTCTCTC
ATTTCAGAGATACTTTTTCCAGAAACTGCAGTCTACCAGCATCAAGCTTGCTCTGTCACCCTCT
CCCCGGAACCCTGCAGAGCCCATTGCTGTACAGAATAACCAGCAGCTGGCATTAAAGGTAGAAG
GCGTTGTTCAGCACGGGTCTAAACCAGGACTGTTCCGCAGAATCCAATCTGTGTGTCTGAATGT
TTCTTCTACACTCCAGAGTAAATCCAGCCAGGACTACAAGATTCCCGTTGACAGCATGACCAAT
GAGATGGAGCAGAGGGTCGAGCCACATAATGATTACTTCAGCACTCAGTTTCTGTTGAACTTCG
CTGTCCTTGGAACGCACAGCATTACAGTGGAGTCATCAGTGAGAGATGCCAATGGCATCGTCTG
GAAGACGGGTCCCAGAACTACCATGTTTGTCAAATCCCTGGAAGACCCCTATTCCCAGCAGATT
CGCCTACAGCAGCAGCAAGCCCAGCAGCCTTTGCAGCCACAGCCGCAGCCGCAGCCGCAGCCTC
GCGGTGCCTACACCCGGTTTTAGCTGTGCCACAAGCATGCGGCTACCACACTGCACAGCCGTCA
GACTACAGGAAGAATCTTATCCCCGTGTGCATTAAGTGTGAATGCTACAGTGTGAAATCCAGTA
CTCACTGATTTCTGTAATGTAGCTTTCTGGTGATTATTTTCTTCTTAAAAATTTAGTGTAAGAA
ATAACCTGGCTTTTAGCCAAAAAAGTGCATTTTTCTTTTTTTTTTTTTTTTTTTTTTTTGGTTC
TTTTTTTTCGGAGCTGGGGACCGAACCCAGGGCCTTGCACTTCCTAGGTAAGCGCTCTACCACT
GAGCTAAATCCCCAGCCCCTCTTTTTTATTTCTTAAACCCAGTCTTCGCCTCACACTTAGCATT
TTTGTTGTATTATTCTTTGTGGTCGGTGAGATTTTCTTCTTCTAAGAATAGTCACAGATCTTTG
GTAAATTTGACTATGTCTCTGCC

hide sequence

RefSeq Acc Id:

XM_063272191 ⟹ XP_063128261

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,691,459 - 105,739,609 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178604	(Get FASTA)	NCBI Sequence Viewer
	XP_063128261	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95006	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005715.6
	ENSRNOP00000082960.1

RefSeq Acc Id:

NP_001178604 ⟸ NM_001191675

- UniProtKB:

A6JH00 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSA
FLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRVFSVIHSNDPVARAITLRMLGS
LASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVD
LKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLL
LQYLKSDPRKAVKRLAVQDLKLLASKTPHTWSKENIQALCECALHTPYDSLKLGMLSVLSTLSG
TIAIKHYFSVAPGNVGSSPRSSDLVKLAQECCYHSNRAIAAHGVRVLTNITVSCQEKDLLSLEQ
DAVFGLESLLVLCSQDDSPGAQSTVKSALSCMVKLAKGRPHLSRSVVDTLLTQLHSSQDAARIL
MCHCLAAIAMKLPVLGDGMLGDLVELYKVIGRSATDKQQELLVSLATVIFVASQKALSAEVKAV
IKQQLESVSSGWTVYRIARQASRMGNHDMARELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLT
GLQEGSFSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNS
LKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYRDLYQASFDADSATLRNVE
LQQQSCLLIAHAIEALVLDPESASFQEYGSTGAAHADSEYERRMMSVYSHVLEEVESLNRKYAP
VSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVE
GVVQHGSKPGLFRRIQSVCLNVSSTLQSKSSQDYKIPVDSMTNEMEQRVEPHNDYFSTQFLLNF
AVLGTHSITVESSVRDANGIVWKTGPRTTMFVKSLEDPYSQQIRLQQQQAQQPLQPQPQPQPQP
RGAYTRF

hide sequence

RefSeq Acc Id:

ENSRNOP00000005715 ⟸ ENSRNOT00000005715

RefSeq Acc Id:

ENSRNOP00000082960 ⟸ ENSRNOT00000111811

RefSeq Acc Id:	XP_063128261 ⟸ XM_063272191
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ADS6-F1-model_v2	AlphaFold	D4ADS6	1-967	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699118

Promoter ID:

EPDNEW_R9643

Type:

initiation region

Name:

Ints7_1

Description:

integrator complex subunit 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	110,257,540 - 110,257,600	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308014	AgrOrtholog
BioCyc Gene	G2FUF-16840	BioCyc
Ensembl Genes	ENSRNOG00000004263	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005715.7	UniProtKB/TrEMBL
	ENSRNOT00000111811.1	UniProtKB/TrEMBL
Gene3D-CATH	Leucine-rich Repeat Variant	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	INTS7	UniProtKB/TrEMBL
NCBI Gene	289382	ENTREZGENE
PANTHER	INTEGRATOR COMPLEX SUBUNIT 7	UniProtKB/TrEMBL
	PTHR13322	UniProtKB/TrEMBL
PhenoGen	Ints7	PhenoGen
RatGTEx	ENSRNOG00000004263	RatGTEx
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	A0A8I6GA53_RAT	UniProtKB/TrEMBL
	A6JH00	ENTREZGENE, UniProtKB/TrEMBL
	D4ADS6_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-26	Ints7	integrator complex subunit 7	RGD1308014_predicted	similar to DKFZP434B168 protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1308014_predicted	similar to DKFZP434B168 protein (predicted)	LOC289382_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC289382_predicted	similar to DKFZP434B168 protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar