Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system and membrane. Human ortholog(s) of this gene implicated in carcinoma (multiple) and lung disease (multiple). Orthologous to human CLPTM1L (CLPTM1 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
cleft lip and palate transmembrane protein 1-like protein; lipid scramblase CLPTM1L; LOC316916; RGD1307896; similar to cisplatin resistance related protein CRR9p
[CLPTM1L mutant form results in increased susceptibility to Cisplatin] which results in decreased expression of BCL2L1 protein and BCL2L1 protein inhibits the reaction [CLPTM1L mutant form results in increased susceptibility to Cisplatin]
A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC).
A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.
CLPTM1L genetic polymorphisms and interaction with smoking and alcohol drinking in lung cancer risk: a case-control study in the Han population from northwest China.
Upregulation of miR-494 Inhibits Cell Growth and Invasion and Induces Cell Apoptosis by Targeting Cleft Lip and Palate Transmembrane 1-Like in Esophageal Squamous Cell Carcinoma.