Il36b (interleukin 36, beta) - Rat Genome Database

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Gene: Il36b (interleukin 36, beta) Rattus norvegicus
Analyze
Symbol: Il36b
Name: interleukin 36, beta
RGD ID: 1307847
Description: Predicted to enable cytokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; inflammatory response to antigenic stimulus; and positive regulation of T cell differentiation. Predicted to act upstream of or within positive regulation of interleukin-6 production. Predicted to be active in extracellular space. Orthologous to human IL36B (interleukin 36 beta); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Il1f8; interleukin 1 family, member 8; interleukin-1 family member 8; interleukin-36 beta; LOC362076
RGD Orthologs
Human
Mouse
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,422,980 - 27,521,344 (-)NCBIGRCr8
mRatBN7.237,024,881 - 7,030,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,021,973 - 7,031,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,126,429 - 10,131,944 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,712,656 - 18,718,171 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,902,467 - 16,907,982 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,366,123 - 1,464,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,366,119 - 1,371,626 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,359,278 - 1,457,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,510,815 - 2,515,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,510,821 - 2,517,016 (-)NCBI
Celera31,862,042 - 1,866,888 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21860022   PMID:22968459  


Genomics

Comparative Map Data
Il36b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,422,980 - 27,521,344 (-)NCBIGRCr8
mRatBN7.237,024,881 - 7,030,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,021,973 - 7,031,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,126,429 - 10,131,944 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,712,656 - 18,718,171 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,902,467 - 16,907,982 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,366,123 - 1,464,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,366,119 - 1,371,626 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,359,278 - 1,457,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,510,815 - 2,515,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,510,821 - 2,517,016 (-)NCBI
Celera31,862,042 - 1,866,888 (-)NCBICelera
Cytogenetic Map3p13NCBI
IL36B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,022,089 - 113,052,867 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2113,022,089 - 113,052,867 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,779,666 - 113,810,444 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,496,139 - 113,526,911 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,501,366 - 113,526,671NCBI
Celera2107,164,821 - 107,195,607 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,234,584 - 106,265,349 (-)NCBIHuRef
CHM1_12113,783,819 - 113,814,595 (-)NCBICHM1_1
T2T-CHM13v2.02113,448,613 - 113,479,393 (-)NCBIT2T-CHM13v2.0
Il36b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,043,184 - 24,050,115 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,043,173 - 24,050,531 (+)EnsemblGRCm39 Ensembl
GRCm38224,153,172 - 24,160,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,153,161 - 24,160,519 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,008,692 - 24,015,623 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36223,975,176 - 23,982,528 (+)NCBIMGSCv36mm8
Celera223,880,886 - 23,887,820 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.21NCBI
IL36B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,159,276 - 37,165,841 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,159,434 - 37,165,423 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,929,297 - 36,935,851 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,936,146 - 37,942,700 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,936,072 - 37,942,708 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,071,575 - 37,078,126 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,128,064 - 37,134,618 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,341,855 - 37,348,408 (+)NCBIUU_Cfam_GSD_1.0
Il36b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,490,126 - 82,495,072 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367831,384,796 - 1,388,507 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL36B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,043,133 - 16,054,750 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660803,627,800 - 3,636,821 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il36b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474913,107,596 - 13,128,883 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il36b
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:90
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000067207
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 45 37 18 37 1 6 11
Below cutoff 1 7 5 1 2 2 25 14 12 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067207   ⟹   ENSRNOP00000059138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,024,882 - 7,031,619 (-)Ensembl
Rnor_6.0 Ensembl31,366,119 - 1,371,626 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097442   ⟹   ENSRNOP00000092507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,021,973 - 7,031,619 (-)Ensembl
RefSeq Acc Id: NM_001108570   ⟹   NP_001102040
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,423,171 - 27,428,678 (-)NCBI
mRatBN7.237,024,881 - 7,030,388 (-)NCBI
Rnor_6.031,366,123 - 1,370,969 (-)NCBI
Rnor_5.031,359,278 - 1,457,679 (-)NCBI
RGSC_v3.432,510,815 - 2,515,661 (-)RGD
Celera31,862,042 - 1,866,888 (-)RGD
Sequence:
RefSeq Acc Id: XM_063284050   ⟹   XP_063140120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,422,980 - 27,520,165 (-)NCBI
RefSeq Acc Id: XM_063284051   ⟹   XP_063140121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,422,980 - 27,520,176 (-)NCBI
RefSeq Acc Id: XM_063284052   ⟹   XP_063140122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,422,980 - 27,521,344 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102040 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140120 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140121 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140122 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93669 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059138
  ENSRNOP00000059138.2
  ENSRNOP00000092507.1
Reference Protein Sequences
RefSeq Acc Id: NP_001102040   ⟸   NM_001108570
- UniProtKB: D4A6F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059138   ⟸   ENSRNOT00000067207
RefSeq Acc Id: ENSRNOP00000092507   ⟸   ENSRNOT00000097442
RefSeq Acc Id: XP_063140122   ⟸   XM_063284052
- Peptide Label: isoform X1
- UniProtKB: D4A6F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140121   ⟸   XM_063284051
- Peptide Label: isoform X1
- UniProtKB: D4A6F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140120   ⟸   XM_063284050
- Peptide Label: isoform X1
- UniProtKB: D4A6F3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6F3-F1-model_v2 AlphaFold D4A6F3 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307847 AgrOrtholog
BioCyc Gene G2FUF-50510 BioCyc
Ensembl Genes ENSRNOG00000043323 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067207 ENTREZGENE
  ENSRNOT00000067207.3 UniProtKB/TrEMBL
  ENSRNOT00000097442.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Cytokine_IL1-like UniProtKB/TrEMBL
  IL-1RA/IL-36 UniProtKB/TrEMBL
  Interleukin-1_CS UniProtKB/TrEMBL
  Interleukin_1 UniProtKB/TrEMBL
KEGG Report rno:362076 UniProtKB/TrEMBL
NCBI Gene 362076 ENTREZGENE
PANTHER PTHR10078 UniProtKB/TrEMBL
  PTHR10078:SF24 UniProtKB/TrEMBL
Pfam IL1 UniProtKB/TrEMBL
PhenoGen Il36b PhenoGen
PRINTS INTERLEUKIN1 UniProtKB/TrEMBL
  INTRLEUKIN1B UniProtKB/TrEMBL
  INTRLEUKIN1X UniProtKB/TrEMBL
PROSITE INTERLEUKIN_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043323 RatGTEx
SMART IL1 UniProtKB/TrEMBL
Superfamily-SCOP Cytok_IL1_like UniProtKB/TrEMBL
UniProt A0A8I6AH64_RAT UniProtKB/TrEMBL
  A6JSX8_RAT UniProtKB/TrEMBL
  D4A6F3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Il36b  interleukin 36, beta  Il1f8  interleukin 1 family, member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Il1f8  interleukin 1 family, member 8   Il1f8_predicted  interleukin 1 family, member 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Il1f8_predicted  interleukin 1 family, member 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED