Ist1 (IST1 factor associated with ESCRT-III)

Gene: Ist1 (IST1 factor associated with ESCRT-III) Rattus norvegicus

Analyze

Symbol:

Ist1

Name:

IST1 factor associated with ESCRT-III

RGD ID:

1307799

Description:

Predicted to enable MIT domain binding activity and identical protein binding activity. Predicted to be involved in several processes, including abscission; viral capsid secondary envelopment; and viral release from host cell. Predicted to act upstream of or within positive regulation of collateral sprouting. Predicted to be located in several cellular components, including Flemming body; endoplasmic reticulum-Golgi intermediate compartment; and extracellular exosome. Predicted to be part of chromatin. Orthologous to human IST1 (IST1 factor associated with ESCRT-III); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

charged multivesicular body protein 8; CHMP8; increased sodium tolerance 1; increased sodium tolerance 1 homolog; increased sodium tolerance 1 homolog (yeast); IST1 homolog; IST1, ESCRT-III associated factor; LOC307833; MAPK activating protein PM28; MGC109331; RGD1307799; similar to RIKEN cDNA 2400003C14

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IST1 (IST1 factor associated with ESCRT-III)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ist1 (increased sodium tolerance 1 homolog (yeast))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ist1 (IST1 factor associated with ESCRT-III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IST1 (IST1 factor associated with ESCRT-III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IST1 (IST1 factor associated with ESCRT-III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101977053 (IST1 factor associated with ESCRT-III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IST1 (IST1 factor associated with ESCRT-III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IST1 (IST1 factor associated with ESCRT-III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ist1 (increased sodium tolerance 1 homolog (yeast))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	IST1 (IST1 factor associated with ESCRT-III)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ist1 (IST1 factor associated with ESCRT-III)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10103	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IST1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	istr-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ist1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	XB5993342 [provisional:ist1]	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	54,558,353 - 54,580,551 (-)	NCBI		GRCr8
mRatBN7.2	19	37,648,840 - 37,671,019 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	37,648,095 - 37,670,956 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	44,461,787 - 44,483,896 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	45,115,119 - 45,137,228 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	47,424,730 - 47,446,839 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	41,968,692 - 41,990,843 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	41,968,705 - 41,990,843 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	52,793,716 - 52,815,862 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	39,554,205 - 39,576,343 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	39,559,093 - 39,581,181 (-)	NCBI
Celera	19	37,052,746 - 37,074,884 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlorpyrifos (ISO)

decabromodiphenyl ether (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

gallic acid (ISO)

indometacin (ISO)

ivermectin (ISO)

mercury dibromide (ISO)

methamphetamine (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

methylparaben (ISO)

nickel atom (ISO)

ozone (ISO)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

trovafloxacin (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

abscission (IEA,ISO)

cell division (ISO)

collateral sprouting (IEA,ISO)

cytoskeleton-dependent cytokinesis (IEA,ISO)

establishment of protein localization (ISO)

positive regulation of collateral sprouting (IEA,ISO)

positive regulation of proteolysis (IEA,ISO)

protein localization (IBA,ISO)

protein transport (IEA)

viral capsid secondary envelopment (IEA,ISO)

viral release from host cell (IEA,ISO)

Cellular Component

centrosome (IEA,ISO)

chromatin (IEA,ISO)

cytoplasmic vesicle (IEA)

cytosol (IEA,ISO)

endoplasmic reticulum-Golgi intermediate compartment (IEA,ISO)

extracellular exosome (ISO)

Flemming body (IEA,ISO)

intracellular membrane-bounded organelle (ISO)

midbody (ISO)

nuclear envelope (IEA)

Molecular Function

identical protein binding (ISO)

MIT domain binding (IEA,ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein-containing complex binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10942595	PMID:12477932	PMID:19056867	PMID:19129479	PMID:19129480	PMID:19199708	PMID:19525971	PMID:20458337	PMID:20719964	PMID:20849418	PMID:21557262	PMID:22619377
PMID:23015756	PMID:23376485	PMID:23533145	PMID:25468996	PMID:28242692

Genomics

Comparative Map Data

Ist1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	54,558,353 - 54,580,551 (-)	NCBI		GRCr8
mRatBN7.2	19	37,648,840 - 37,671,019 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	37,648,095 - 37,670,956 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	44,461,787 - 44,483,896 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	45,115,119 - 45,137,228 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	47,424,730 - 47,446,839 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	41,968,692 - 41,990,843 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	41,968,705 - 41,990,843 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	52,793,716 - 52,815,862 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	39,554,205 - 39,576,343 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	39,559,093 - 39,581,181 (-)	NCBI
Celera	19	37,052,746 - 37,074,884 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

IST1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	71,894,408 - 71,931,199 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	71,845,996 - 71,931,199 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	71,928,311 - 71,965,102 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	70,486,947 - 70,520,407 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	56,243,371 - 56,276,822 (+)	NCBI		Celera
Cytogenetic Map	16	q22.2	NCBI
HuRef	16	57,696,177 - 57,731,724 (+)	NCBI		HuRef
CHM1_1	16	73,341,627 - 73,377,874 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	77,711,542 - 77,748,323 (+)	NCBI		T2T-CHM13v2.0

Ist1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	110,397,953 - 110,419,929 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	110,397,957 - 110,419,892 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	109,671,321 - 109,693,297 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	109,671,325 - 109,693,260 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	112,195,221 - 112,217,194 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	112,560,458 - 112,582,393 (-)	NCBI		MGSCv36	mm8
Celera	8	113,896,960 - 113,918,958 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	57.18	NCBI

Ist1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	4,589,311 - 4,630,203 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	4,589,311 - 4,630,464 (+)	NCBI	ChiLan1.0	ChiLan1.0

IST1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	82,231,091 - 82,313,273 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	88,158,887 - 88,202,426 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	53,082,530 - 53,115,965 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	71,733,868 - 71,765,969 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	71,733,302 - 71,765,969 (+)	Ensembl	panpan1.1		panPan2

IST1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	77,660,033 - 77,693,831 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	77,660,081 - 77,692,396 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	77,621,109 - 77,655,606 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	78,099,321 - 78,133,852 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	78,098,618 - 78,133,639 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	77,919,418 - 77,953,932 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	77,742,127 - 77,776,623 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	78,241,426 - 78,275,957 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101977053
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	37,680,804 - 37,699,103 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	21,890,013 - 21,908,245 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	21,890,011 - 21,908,256 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IST1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	14,836,752 - 14,911,311 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	14,868,859 - 14,910,679 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	14,465,663 - 14,489,764 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IST1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	55,030,916 - 55,063,824 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	55,050,795 - 55,064,549 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	17,832,602 - 17,864,267 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Ist1
125 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	374
Count of miRNA genes:	194
Interacting mature miRNAs:	234
Transcripts:	ENSRNOT00000020365
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	24817978	39654489	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	27530207	37947399	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	27530207	37947399	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	27530207	37947399	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	33838214	55283146	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000020365 ⟹ ENSRNOP00000020365

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	37,648,095 - 37,670,956 (-)	Ensembl
Rnor_6.0 Ensembl	19	41,968,705 - 41,990,843 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107910 ⟹ ENSRNOP00000088873

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	37,648,095 - 37,670,956 (-)	Ensembl

RefSeq Acc Id:

NM_001017454 ⟹ NP_001017454

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	54,558,353 - 54,580,491 (-)	NCBI
mRatBN7.2	19	37,648,840 - 37,670,978 (-)	NCBI
Rnor_6.0	19	41,968,705 - 41,990,843 (+)	NCBI
Rnor_5.0	19	52,793,716 - 52,815,862 (+)	NCBI
RGSC_v3.4	19	39,554,205 - 39,576,343 (-)	RGD
Celera	19	37,052,746 - 37,074,884 (-)	RGD

Sequence:

show sequence

AGTCCTCTGTGGTGAGGTCGAGGGAATCGCCATTTTGGATGCAGAACGGCTAATCGGAAATCTG
CTTCTTCCGTTTTCGCGTCTGGATCCCTCCAGGAGGAGCAGGACAACATGCTGGGCTCTGGTTT
CAAAGCTGAGCGCTTACGAGTCAATTTGAGATTAGTTATAAATCGTCTTAAACTGTTGGAGAAA
AAAAAAACGGAACTGGCTCAAAAAGCGAGGAAGGAGATTGCTGACTATCTGGCCGCTGGGAAGG
ACGAGAGAGCACGTATCCGTGTGGAGCACATAATCCGGGAAGACTACCTTGTGGAGGCCATGGA
GATCCTGGAGCTGTACTGTGACCTGCTGCTGGCTCGGTTTGGCCTTATCCAGTCTATGAAGGAG
CTAGATTCTGGTCTGGCTGAATCTGTGTCTACACTGATCTGGGCCGCTCCTCGGTTGCAGTCAG
AAGTGGCTGAGTTGAAAATAGTTGCTGATCAGCTCTGTGCCAAATACAGCAAGGAATATGGCAA
GTTGTGCAGGACCAACCAGATCGGGACTGTGAATGATAGGCTAATGCATAAACTGAGTGTAGAA
GCCCCACCCAAGATCCTAGTGGAGAGATACCTGATTGAAATTGCCAAGAATTACAATGTGCCCT
ATGAACCTGACTCTGTGGTCATGGCAGAAGCTCCCGTTGGAGTGGAGACAGATCTTATTGATGT
TGGATTTACAGATGATGTGAAGAAAGGTGGTCCTGGAAGAGGAGGAGGGGGCGGGTTCACAGCC
CCAGTTGGTGCACCTGATGGGACCATGCCCATGCCCATGCCCATGCCCATGCCCATGCCATCGC
CATCTCCAAATGCTCCCTTCGCATACCCACTGCCAAAGGGACCATCGGATTTCAGTGGATTGCC
AGTGGGGACTTACCAGGCCTTTCCTAACATTCACCCACCCCAGATACCAGCAACTCCCCCATCT
TACGAATCTGTTGATGACATTAATGCTGATAAAAATGTTTCTTCGGCACAGATTGTTGGACCCA
AGCCAGAAGCTCCTGCAAAGCCCCCTTCCAGACCTGTGGATAACTACAACACCTTTGTACTGCC
AGAGTTGCCATCGGTGCCAGACACACTCCCGACCGCATCTGCCGGAGCCAGTACCTCGGCGTCA
GAGGACATAGACTTTGATGATCTTTCCCGGAGATTTGAGGAGCTGAAAAAGAAAACATAGGTCT
CTTAAACCAGGCAACATCCACGATCTGGAAGTTGATATGGAACAGTTCTCCTTGTAACAATGAA
TCTCCATGAATTCCGTTTCCTCTGTTAACCGTCACTGAGCACTCCTCCTCGGGGCTCCTGCTGC
TCTACCAACTGTGTTGCTTTCCAGTTCTCCAGAGATCCTGAGAGACTAACAGCTAGAGGCTCTG
GCTGTGTTTGCCTGTCTGTCTTCCTCTCACATGGATCCCTTGGTTCTTTCCTGGCCATTTCATT
CACAGGGAGTGAGGAGTATTGCGGGTAGAGGTGCCAAAGATGGCTGGACCATGAAGGAGAGGAC
CCTATGATGAGTTTCAACCTTGACTTGTAAATACTTTCCTCTGCATGGGGGCGATTGTAGAAAG
AATCAAGGCTACCATGTGTGTTCTCAATGACTCAGAAAGCCACGGTCACGGTTCCTGGAGGCTG
GGCCCTCACTGACATGTACACTCCTCCTTGCTGCAGGGCACTGCTCCACCTGGATCCAGTTGCA
AAGTGTGTTTGGAAAAGTTCTTGGTCTTACTGGATTCTCAGGGAGCCCTCTGTGGCCTTTTCCT
TTATTTTGAGTGCTGTTTCCTTTCTAGGAAAGAGCAGCACTTTGGACATTTGTTTTTTCCCCAT
AGCATGTTAGGAAGGACGTGCTGGGCTTCCAGTTGCCTTAATAGAAGTACTCAAGTCTCTTGGG
TAGAGATCTGGAAGCCCCCGGGACAGGAGGGGCACGTGTTTTCATTCGAAAACTTTTATGATTA
AGGGACTCTTTACAAACTGCTATCTTGAGTTTTAGTGCCATGTAGCTGTAGTTCACTGCTTTCC
TGGTGGATGAGACTTTCTTAGGATAACTTCTGTGCTGCTTTGCCCTGGCCAAGGCTGCCCTTCC
CCAAGAGGTTAGCTGTGGGATTGGAAGATGAGATTTTTGTAATATTTCTGTACAGACCTGTTTC
CAGCAACTTCAGTGTCAATGTTTTTGATTTATTTGTAGCTCATAGCTCTAGCTGCTAATAAAGA
TCCCATCTCCTGCTTTCTCTA

hide sequence

RefSeq Acc Id:

XM_063278049 ⟹ XP_063134119

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	54,561,785 - 54,580,551 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001017454	(Get FASTA)	NCBI Sequence Viewer
	XP_063134119	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH92631	(Get FASTA)	NCBI Sequence Viewer
	EDL92508	(Get FASTA)	NCBI Sequence Viewer
	EDL92509	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020365
	ENSRNOP00000020365.4
	ENSRNOP00000088873.1
	ENSRNOP00055029576
	ENSRNOP00060016051
	ENSRNOP00065014379
GenBank Protein	Q568Z6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001017454 ⟸ NM_001017454

- UniProtKB:

Q568Z6 (UniProtKB/Swiss-Prot), A6IZ30 (UniProtKB/TrEMBL), A0A8L2QA75 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDY
LVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKY
SKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPVGVE
TDLIDVGFTDDVKKGGPGRGGGGGFTAPVGAPDGTMPMPMPMPMPMPSPSPNAPFAYPLPKGPS
DFSGLPVGTYQAFPNIHPPQIPATPPSYESVDDINADKNVSSAQIVGPKPEAPAKPPSRPVDNY
NTFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT

hide sequence

RefSeq Acc Id:

ENSRNOP00000020365 ⟸ ENSRNOT00000020365

RefSeq Acc Id:

ENSRNOP00000088873 ⟸ ENSRNOT00000107910

RefSeq Acc Id:	XP_063134119 ⟸ XM_063278049
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q568Z6-F1-model_v2	AlphaFold	Q568Z6	1-366	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701134

Promoter ID:

EPDNEW_R11658

Type:

initiation region

Name:

Ist1_1

Description:

IST1, ESCRT-III associated factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	41,968,705 - 41,968,765	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307799	AgrOrtholog
BioCyc Gene	G2FUF-5727	BioCyc
Ensembl Genes	ENSRNOG00000015144	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055021290	UniProtKB/Swiss-Prot
	ENSRNOG00060012019	UniProtKB/Swiss-Prot
	ENSRNOG00065011565	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000020365	ENTREZGENE
	ENSRNOT00000020365.6	UniProtKB/TrEMBL
	ENSRNOT00000107910.1	UniProtKB/TrEMBL
	ENSRNOT00055036385	UniProtKB/Swiss-Prot
	ENSRNOT00060020393	UniProtKB/Swiss-Prot
	ENSRNOT00065018807	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1260.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7314864	IMAGE-MGC_LOAD
InterPro	Ist1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IST1-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:307833	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:109331	IMAGE-MGC_LOAD
NCBI Gene	307833	ENTREZGENE
PANTHER	IST1 HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12161	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ist1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ist1	PhenoGen
RatGTEx	ENSRNOG00000015144	RatGTEx
	ENSRNOG00055021290	RatGTEx
	ENSRNOG00060012019	RatGTEx
	ENSRNOG00065011565	RatGTEx
UniProt	A0A8I6AJP9_RAT	UniProtKB/TrEMBL
	A0A8L2QA75	ENTREZGENE, UniProtKB/TrEMBL
	A6IZ30	ENTREZGENE, UniProtKB/TrEMBL
	IST1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-10	Ist1	IST1 factor associated with ESCRT-III	Ist1	IST1, ESCRT-III associated factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-01	Ist1	IST1, ESCRT-III associated factor	Ist1	increased sodium tolerance 1 homolog (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-31	Ist1	increased sodium tolerance 1 homolog (yeast)	RGD1307799	similar to RIKEN cDNA 2400003C14	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1307799	similar to RIKEN cDNA 2400003C14	RGD1307799_predicted	similar to RIKEN cDNA 2400003C14 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1307799_predicted	similar to RIKEN cDNA 2400003C14 (predicted)	LOC307833_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC307833_predicted	similar to RIKEN cDNA 2400003C14 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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