Hbz (hemoglobin subunit zeta) - Rat Genome Database

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Gene: Hbz (hemoglobin subunit zeta) Rattus norvegicus
Analyze
Symbol: Hbz
Name: hemoglobin subunit zeta
RGD ID: 1307486
Description: Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process and oxygen transport. Predicted to act upstream of or within erythrocyte maturation and negative regulation of transcription by RNA polymerase II. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Orthologous to human HBZ (hemoglobin subunit zeta); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Glne1; globin e1; hemoglobin, zeta; LOC287168; RGD1307486; similar to hemoglobin:SUBUNIT=zeta; zeta-globin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,848,279 - 15,849,757 (-)NCBIGRCr8
mRatBN7.21015,343,821 - 15,345,301 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,343,831 - 15,345,312 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,089,889 - 20,091,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,578,778 - 19,580,275 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,071,632 - 15,073,116 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,609,348 - 15,610,826 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,609,358 - 15,610,826 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,504,489 - 15,505,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,590,914 - 15,592,386 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,591,971 - 15,593,427 (-)NCBI
Celera1015,011,411 - 15,012,889 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, etal., Brain Res Dev Brain Res 2003 Dec 19;146(1-2):107-18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7926723   PMID:23533145  


Genomics

Comparative Map Data
Hbz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,848,279 - 15,849,757 (-)NCBIGRCr8
mRatBN7.21015,343,821 - 15,345,301 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,343,831 - 15,345,312 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,089,889 - 20,091,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,578,778 - 19,580,275 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,071,632 - 15,073,116 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,609,348 - 15,610,826 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,609,358 - 15,610,826 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,504,489 - 15,505,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,590,914 - 15,592,386 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,591,971 - 15,593,427 (-)NCBI
Celera1015,011,411 - 15,012,889 (-)NCBICelera
Cytogenetic Map10q12NCBI
HBZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816152,644 - 154,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16142,728 - 154,503 (+)EnsemblGRCh38hg38GRCh38
GRCh3716202,643 - 204,502 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616142,854 - 144,504 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416142,853 - 144,504NCBI
Celera16404,501 - 406,151 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16120,539 - 122,186 (+)NCBIHuRef
CHM1_116202,820 - 204,446 (+)NCBICHM1_1
T2T-CHM13v2.016146,215 - 148,144 (+)NCBIT2T-CHM13v2.0
Hba-x
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,226,600 - 32,228,116 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,226,400 - 32,228,116 (+)EnsemblGRCm39 Ensembl
GRCm381132,276,600 - 32,278,116 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,276,400 - 32,278,116 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,176,600 - 32,178,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,176,602 - 32,178,113 (+)NCBIMGSCv36mm8
Celera1134,693,878 - 34,695,395 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.86NCBI
LOC100983830
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218368,285 - 369,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,159,035 - 4,163,411 (+)NCBINHGRI_mPanPan1
PanPan1.116153,942 - 155,975 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16153,991 - 155,872 (+)Ensemblpanpan1.1panPan2
LOC100855600
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,331,717 - 40,332,764 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,595,733 - 41,596,965 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,675,253 - 40,676,485 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1640,363,354 - 40,364,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,324,312 - 40,325,540 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,802,957 - 40,804,188 (-)NCBIUU_Cfam_GSD_1.0
Hbz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,639,488 - 112,641,110 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501737,406 - 738,929 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501737,406 - 738,929 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HBZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,490,328 - 41,492,120 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,490,758 - 41,492,883 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,946,253 - 40,947,482 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Hbz
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:55
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000027851
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat

Markers in Region
RH133964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,343,947 - 15,344,264 (+)MAPPERmRatBN7.2
Rnor_6.01015,609,475 - 15,609,791NCBIRnor6.0
Rnor_5.01015,504,616 - 15,504,932UniSTSRnor5.0
RGSC_v3.41015,591,041 - 15,591,357UniSTSRGSC3.4
Celera1015,011,538 - 15,011,854UniSTS
RH 3.4 Map10155.8UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High 12 6 6 6 10 8
Medium 6 8 8 8 16 8 5
Low 2 4 4 1 4 9 4 8
Below cutoff 8 6 7 6 4 1 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027851   ⟹   ENSRNOP00000027851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,343,831 - 15,345,312 (-)Ensembl
Rnor_6.0 Ensembl1015,609,358 - 15,610,826 (-)Ensembl
RefSeq Acc Id: NM_001172845   ⟹   NP_001166316
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,848,279 - 15,849,757 (-)NCBI
mRatBN7.21015,343,821 - 15,345,301 (-)NCBI
Rnor_6.01015,609,348 - 15,610,826 (-)NCBI
Rnor_5.01015,504,489 - 15,505,967 (-)NCBI
Celera1015,011,411 - 15,012,889 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001166316 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR83749 (Get FASTA)   NCBI Sequence Viewer  
  EDM04014 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027851
  ENSRNOP00000027851.5
GenBank Protein SAI82219 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001166316   ⟸   NM_001172845
- UniProtKB: G3V8R3 (UniProtKB/TrEMBL),   A6HDA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027851   ⟸   ENSRNOT00000027851
Protein Domains
Globin family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8R3-F1-model_v2 AlphaFold G3V8R3 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697080
Promoter ID:EPDNEW_R7600
Type:single initiation site
Name:AC096051_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,600,865 - 15,600,925EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307486 AgrOrtholog
BioCyc Gene G2FUF-25700 BioCyc
Ensembl Genes ENSRNOG00000020536 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027851 ENTREZGENE
  ENSRNOT00000027851.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.490.10 UniProtKB/TrEMBL
InterPro Globin-like UniProtKB/TrEMBL
  Globin/Proto UniProtKB/TrEMBL
  Globin_subset UniProtKB/TrEMBL
  Haemoglobin_a UniProtKB/TrEMBL
  Haemoglobin_zeta UniProtKB/TrEMBL
KEGG Report rno:287168 UniProtKB/TrEMBL
NCBI Gene 287168 ENTREZGENE
PANTHER HEMOGLOBIN FAMILY MEMBER UniProtKB/TrEMBL
  HEMOGLOBIN SUBUNIT ZETA UniProtKB/TrEMBL
Pfam Globin UniProtKB/TrEMBL
PhenoGen Hbz PhenoGen
PRINTS ALPHAHAEM UniProtKB/TrEMBL
  ZETAHAEM UniProtKB/TrEMBL
PROSITE GLOBIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020536 RatGTEx
Superfamily-SCOP Globin_like UniProtKB/TrEMBL
UniProt A6HDA9 ENTREZGENE, UniProtKB/TrEMBL
  G3V8R3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Hbz  hemoglobin subunit zeta  Hbz  hemoglobin, zeta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hbz  hemoglobin, zeta  RGD1307486  similar to hemoglobin:SUBUNIT=zeta  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307486  similar to hemoglobin:SUBUNIT=zeta  RGD1307486_predicted  similar to hemoglobin:SUBUNIT=zeta (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307486_predicted  similar to hemoglobin:SUBUNIT=zeta (predicted)  LOC287168_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287168_predicted  similar to hemoglobin:SUBUNIT=zeta (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL